Homocysteine-thiolactone
General
Type : Natural, Sulfur Compound, Not A\/B H target
Chemical_Nomenclature : (3S)-3-aminothiolan-2-one
Canonical SMILES : C1CSC(=O)C1N
InChI : InChI=1S\/C4H7NOS\/c5-3-1-2-7-4(3)6\/h3H,1-2,5H2\/t3-\/m0\/s1
InChIKey : KIWQWJKWBHZMDT-VKHMYHEASA-N
Other name(s) : Homocysteine thiolactone || (S)-3-Aminodihydrothiophen-2(3H)-one || L-Homocysteine thiolactone || SCHEMBL2167191 || CHEMBL4078313 || BDBM86198 || CHEBI:60315 || DL-Homocysteine thiolactone || (3R)-3-aminothiolan-2-one || D-Homocysteinethiolactone
MW : 117.17
Formula : C4H7NOS
CAS_number : 2338-04-7, 10593-85-8, 14007-10-4, 130548-06-0
PubChem : 134505, 107712, 7057932
UniChem : KIWQWJKWBHZMDT-VKHMYHEASA-N
Wikipedia : Homocysteine_thiolactone
Target
Structures : No structure
Families : Valacyclovir-hydrolase, BCHE
References (10)
| Title : Discovery of a novel homocysteine thiolactone hydrolase and the catalytic activity of its natural variants - Hou_2024_Protein.Sci_33_e5098 |
| Author(s) : Hou S , Liu H , Hu Y , Zhang J , Deng X , Li Z , Zhang Y , Li X , Li Y , Ma L , Yao J , Chen X |
| Ref : Protein Science , 33 :e5098 , 2024 |
| Abstract : |
| PubMedSearch : Hou_2024_Protein.Sci_33_e5098 |
| PubMedID: 38980003 |
| Title : Deletion of the Homocysteine Thiolactone Detoxifying Enzyme Bleomycin Hydrolase, in Mice, Causes Memory and Neurological Deficits and Worsens Alzheimer's Disease-Related Behavioral and Biochemical Traits in the 5xFAD Model of Alzheimer's Disease - Witucki_2023_J.Alzheimers.Dis_95_1735 |
| Author(s) : Witucki L , Borowczyk K , Suszynska-Zajczyk J , Warzych E , Pawlak P , Jakubowski H |
| Ref : J Alzheimers Dis , 95 :1735 , 2023 |
| Abstract : |
| PubMedSearch : Witucki_2023_J.Alzheimers.Dis_95_1735 |
| PubMedID: 37718819 |
| Title : Functionally active cross-linked protein oligomers formed by homocysteine thiolactone - Kumari_2023_Sci.Rep_13_5620 |
| Author(s) : Kumari K , Sharma GS , Gupta A , Singh KS , Singh LR |
| Ref : Sci Rep , 13 :5620 , 2023 |
| Abstract : |
| PubMedSearch : Kumari_2023_Sci.Rep_13_5620 |
| PubMedID: 37024663 |
| Title : Hydrolysis of homocysteine thiolactone results in the formation of Protein-Cys-S-S-homocysteinylation - Silla_2019_Proteins_87_625 |
| Author(s) : Silla Y , Varshney S , Ray A , Basak T , Zinellu A , Sabareesh V , Carru C , Sengupta S |
| Ref : Proteins , 87 :625 , 2019 |
| Abstract : |
| PubMedSearch : Silla_2019_Proteins_87_625 |
| PubMedID: 30869815 |
| Title : Human valacyclovir hydrolase\/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase - Marsillach_2014_PLoS.One_9_e110054 |
| Author(s) : Marsillach J , Suzuki SM , Richter RJ , McDonald MG , Rademacher PM , Maccoss MJ , Hsieh EJ , Rettie AE , Furlong CE |
| Ref : PLoS ONE , 9 :e110054 , 2014 |
| Abstract : |
| PubMedSearch : Marsillach_2014_PLoS.One_9_e110054 |
| PubMedID: 25333274 |
| Gene_locus related to this paper: human-BPHL |
| Title : Paraoxonase 1 and homocysteine metabolism - Perla-Kajan_2012_Amino.Acids_43_1405 |
| Author(s) : Perla-Kajan J , Jakubowski H |
| Ref : Amino Acids , 43 :1405 , 2012 |
| Abstract : |
| PubMedSearch : Perla-Kajan_2012_Amino.Acids_43_1405 |
| PubMedID: 22643843 |
| Title : Metabolism and neurotoxicity of homocysteine thiolactone in mice: evidence for a protective role of paraoxonase 1 - Borowczyk_2012_J.Alzheimers.Dis_30_225 |
| Author(s) : Borowczyk K , Shih DM , Jakubowski H |
| Ref : J Alzheimers Dis , 30 :225 , 2012 |
| Abstract : |
| PubMedSearch : Borowczyk_2012_J.Alzheimers.Dis_30_225 |
| PubMedID: 22406444 |
| Title : The role of paraoxonase 1 in the detoxification of homocysteine thiolactone - Jakubowski_2010_Adv.Exp.Med.Biol_660_113 |
| Author(s) : Jakubowski H |
| Ref : Advances in Experimental Medicine & Biology , 660 :113 , 2010 |
| Abstract : |
| PubMedSearch : Jakubowski_2010_Adv.Exp.Med.Biol_660_113 |
| PubMedID: 20221875 |
| Title : Homocysteine thiolactone and human cholinesterases - Darvesh_2007_Cell.Mol.Neurobiol_27_33 |
| Author(s) : Darvesh S , Walsh R , Martin E |
| Ref : Cellular Molecular Neurobiology , 27 :33 , 2007 |
| Abstract : |
| PubMedSearch : Darvesh_2007_Cell.Mol.Neurobiol_27_33 |
| PubMedID: 16955366 |
| Title : A versatile equation to describe reversible enzyme inhibition and activation kinetics: modeling beta-galactosidase and butyrylcholinesterase - Walsh_2007_Biochim.Biophys.Acta_1770_733 |
| Author(s) : Walsh R , Martin E , Darvesh S |
| Ref : Biochimica & Biophysica Acta , 1770 :733 , 2007 |
| Abstract : |
| PubMedSearch : Walsh_2007_Biochim.Biophys.Acta_1770_733 |
| PubMedID: 17307293 |