Phenylvalerate

General

Type : Aryl ester

Chemical_Nomenclature : phenyl pentanoate

Canonical SMILES : CCCCC(=O)OC1=CC=CC=C1

InChI : InChI=1S\/C11H14O2\/c1-2-3-9-11(12)13-10-7-5-4-6-8-10\/h4-8H,2-3,9H2,1H3

InChIKey : MVIMPQVBUPCHEV-UHFFFAOYSA-N

Other name(s) : Phenyl valerate  ||  Phenyl-valerate  ||  Phenyl pentanoate  ||  Pentanoic acid, phenyl ester  ||  Valeric acid, phenyl ester  ||  EINECS 243-521-0


MW : 178.23

Formula : C11H14O2

CAS_number : 20115-23-5

PubChem : 29950

UniChem : MVIMPQVBUPCHEV-UHFFFAOYSA-N

Target

Families : Carb_B_Chordata

References (24)

Title : Interactions of human butyrylcholinesterase with phenylvalerate and acetylthiocholine as substrates and inhibitors: kinetic and molecular modeling approaches - Estevez_2019_Arch.Toxicol_93_1281
Author(s) : Estevez J , Rodrigues de Souza F , Romo M , Mangas I , Franca TCC , Vilanova E
Ref : Archives of Toxicology , 93 :1281 , 2019
Abstract :
PubMedSearch : Estevez_2019_Arch.Toxicol_93_1281
PubMedID: 30877329

Title : Butyrylcholinesterase identification in a phenylvalerate esterase-enriched fraction sensitive to low mipafox concentrations in chicken brain - Mangas_2017_Arch.Toxicol_91_909
Author(s) : Mangas I , Radic Z , Taylor P , Ghassemian M , Candela H , Vilanova E , Estevez J
Ref : Archives of Toxicology , 91 :909 , 2017
Abstract :
PubMedSearch : Mangas_2017_Arch.Toxicol_91_909
PubMedID: 26838044

Title : New insights on molecular interactions of organophosphorus pesticides with esterases - Mangas_2017_Toxicology_376_30
Author(s) : Mangas I , Estevez J , Vilanova E , Franca TCC
Ref : Toxicology , 376 :30 , 2017
Abstract :
PubMedSearch : Mangas_2017_Toxicology_376_30
PubMedID: 27311923

Title : Esterases hydrolyze phenyl valerate activity as targets of organophosphorus compounds - Mangas_2016_Chem.Biol.Interact_259_358
Author(s) : Mangas I , Estevez J , Vilanova E
Ref : Chemico-Biological Interactions , 259 :358 , 2016
Abstract :
PubMedSearch : Mangas_2016_Chem.Biol.Interact_259_358
PubMedID: 27087132

Title : Resolving pathways of interaction of mipafox and a sarin analog with human acetylcholinesterase by kinetics, mass spectrometry and molecular modeling approaches - Mangas_2016_Arch.Toxicol_90_603
Author(s) : Mangas I , Taylor P , Vilanova E , Estevez J , Franca TCC , Komives E , Radic Z
Ref : Archives of Toxicology , 90 :603 , 2016
Abstract :
PubMedSearch : Mangas_2016_Arch.Toxicol_90_603
PubMedID: 25743373

Title : Interaction between substrates suggests a relationship between organophosphorus-sensitive phenylvalerate- and acetylcholine-hydrolyzing activities in chicken brain - Benabent_2014_Toxicol.Lett_230_132
Author(s) : Benabent M , Vilanova E , Mangas I , Sogorb MA , Estevez J
Ref : Toxicol Lett , 230 :132 , 2014
Abstract :
PubMedSearch : Benabent_2014_Toxicol.Lett_230_132
PubMedID: 24576786

Title : Soluble phenyl valerate esterases of hen sciatic nerve and the potentiation of organophosphate induced delayed polyneuropathy - Gambalunga_2010_Chem.Biol.Interact_187_340
Author(s) : Gambalunga A , Pasqualato F , Lotti M
Ref : Chemico-Biological Interactions , 187 :340 , 2010
Abstract :
PubMedSearch : Gambalunga_2010_Chem.Biol.Interact_187_340
PubMedID: 20097189

Title : Specificity of procaine and ester hydrolysis by human, minipig, and rat skin and liver - Jewell_2007_Drug.Metab.Dispos_35_2015
Author(s) : Jewell C , Ackermann C , Payne NA , Fate G , Voorman R , Williams FM
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :2015 , 2007
Abstract :
PubMedSearch : Jewell_2007_Drug.Metab.Dispos_35_2015
PubMedID: 17664252

Title : Inter-individual variability in esterases in human liver - Jewell_2007_Biochem.Pharmacol_74_932
Author(s) : Jewell C , Bennett P , Mutch E , Ackermann C , Williams FM
Ref : Biochemical Pharmacology , 74 :932 , 2007
Abstract :
PubMedSearch : Jewell_2007_Biochem.Pharmacol_74_932
PubMedID: 17651701

Title : The inhibition of the high sensitive peripheral nerve soluble esterases by mipafox. A new mathematical processing for the kinetics of inhibition of esterases by organophosphorus compounds - Estevez_2004_Toxicol.Lett_151_171
Author(s) : Estevez J , Garcia-Perez AG , Barril J , Pellin M , Vilanova E
Ref : Toxicol Lett , 151 :171 , 2004
Abstract :
PubMedSearch : Estevez_2004_Toxicol.Lett_151_171
PubMedID: 15177652

Title : Properties of phenyl valerate esterase activities from chicken serum are comparable with soluble esterases of peripheral nerves in relation with organophosphorus compounds inhibition - Garcia-Perez_2003_Toxicol.Lett_142_1
Author(s) : Garcia-Perez AG , Barril J , Estevez J , Vilanova E
Ref : Toxicol Lett , 142 :1 , 2003
Abstract :
PubMedSearch : Garcia-Perez_2003_Toxicol.Lett_142_1
PubMedID: 12765233

Title : Paraoxon sensitive phenylvalerate hydrolase in assessing the severity of acute paraoxon poisoning - Petroianu_2001_J.Toxicol.Clin.Toxicol_39_27
Author(s) : Petroianu GA , Karcher B , Kern N , Bergler W , Rufer R
Ref : J Toxicol Clinical Toxicology , 39 :27 , 2001
Abstract :
PubMedSearch : Petroianu_2001_J.Toxicol.Clin.Toxicol_39_27
PubMedID: 11327223

Title : Reversible inhibition can profoundly mislead studies on progressive inhibition of enzymes: the interaction of paraoxon with soluble neuropathy target esterase - Barril_1997_Chem.Biol.Interact_108_19
Author(s) : Barril J , Vilanova E
Ref : Chemico-Biological Interactions , 108 :19 , 1997
Abstract :
PubMedSearch : Barril_1997_Chem.Biol.Interact_108_19
PubMedID: 9463518

Title : Chromatographic discrimination of soluble neuropathy target esterase isoenzymes and related phenyl valerate esterases from chicken brain, spinal cord, and sciatic nerve - Escudero_1997_J.Neurochem_68_2170
Author(s) : Escudero MA , Cespedes MV , Vilanova E
Ref : Journal of Neurochemistry , 68 :2170 , 1997
Abstract :
PubMedSearch : Escudero_1997_J.Neurochem_68_2170
PubMedID: 9109545

Title : Phenyl valerate esterases other than neuropathy target esterase and the promotion of organophosphate polyneuropathy - Milatovic_1997_Chem.Res.Toxicol_10_1045
Author(s) : Milatovic D , Moretto A , Osman KA , Lotti M
Ref : Chemical Research in Toxicology , 10 :1045 , 1997
Abstract :
PubMedSearch : Milatovic_1997_Chem.Res.Toxicol_10_1045
PubMedID: 9305588

Title : An automatable microassay for phenyl valerate esterase activities sensitive to organophosphorus compounds - Escudero_1996_Toxicol.Lett_89_241
Author(s) : Escudero MA , Sogorb MA , Vilanova E
Ref : Toxicol Lett , 89 :241 , 1996
Abstract :
PubMedSearch : Escudero_1996_Toxicol.Lett_89_241
PubMedID: 9001593

Title : Organophosphorus inhibition and heat inactivation kinetics of particulate and soluble forms of peripheral nerve neuropathy target esterase - Barril_1995_J.Biochem.Toxicol_10_211
Author(s) : Barril J , Tormo N , Diaz-Alejo N , Vilanova E
Ref : Journal of Biochemical Toxicology , 10 :211 , 1995
Abstract :
PubMedSearch : Barril_1995_J.Biochem.Toxicol_10_211
PubMedID: 8568835

Title : Comparative studies of two organophosphorus compounds in the mouse - Mutch_1995_Toxicol.Lett_81_45
Author(s) : Mutch E , Kelly SS , Blain PG , Williams FM
Ref : Toxicology Letters , 81 :45 , 1995
Abstract :
PubMedSearch : Mutch_1995_Toxicol.Lett_81_45
PubMedID: 8525498

Title : Partial characterization of neuropathy target esterase and related phenyl valerate esterases from bovine adrenal medulla - Sogorb_1994_J.Biochem.Toxicol_9_145
Author(s) : Sogorb MA , Viniegra S , Reig JA , Vilanova E
Ref : Journal of Biochemical Toxicology , 9 :145 , 1994
Abstract :
PubMedSearch : Sogorb_1994_J.Biochem.Toxicol_9_145
PubMedID: 7983680

Title : Phenyl valerate and choline ester hydrolases in the platelets of human, hen, rat and mouse - Husain_1994_Human.Exp.Toxicol_13_157
Author(s) : Husain K
Ref : Hum Exp Toxicol , 13 :157 , 1994
Abstract :
PubMedSearch : Husain_1994_Human.Exp.Toxicol_13_157
PubMedID: 7909676

Title : Soluble and particulate organophosphorus neuropathy target esterase in brain and sciatic nerve of the hen, cat, rat, and chick - Tormo_1993_J.Neurochem_61_2164
Author(s) : Tormo N , Gimeno JR , Sogorb MA , Diaz-Alejo N , Vilanova E
Ref : Journal of Neurochemistry , 61 :2164 , 1993
Abstract :
PubMedSearch : Tormo_1993_J.Neurochem_61_2164
PubMedID: 8245968

Title : Histochemical demonstration of neurotoxic esterase - Koelle_1989_J.Histochem.Cytochem_37_589
Author(s) : Koelle GB , Thampi NS , Han MS , Olajos EJ
Ref : Journal of Histochemistry & Cytochemistry , 37 :589 , 1989
Abstract :
PubMedSearch : Koelle_1989_J.Histochem.Cytochem_37_589
PubMedID: 2703698

Title : Kinetics of heat inactivation of phenyl valerate hydrolases from hen and rat brain - Reiner_1987_Biochem.Pharmacol_36_3181
Author(s) : Reiner E , Davis CS , Schwab BW , Schopfer LM , Richardson RJ
Ref : Biochemical Pharmacology , 36 :3181 , 1987
Abstract :
PubMedSearch : Reiner_1987_Biochem.Pharmacol_36_3181
PubMedID: 3663234

Title : Neural microtubular and lysosomal phenyl valerate esterases and proteases in relation to organophosphate-induced delayed neurotoxicity - Seifert_1984_Comp.Biochem.Physiol.C_78_271
Author(s) : Seifert J , Casida JE
Ref : Comparative Biochemistry & Physiology C Pharmacol Toxicol , 78 :271 , 1984
Abstract :
PubMedSearch : Seifert_1984_Comp.Biochem.Physiol.C_78_271
PubMedID: 6149065