Temocapril
Temocapril is a prodrug-type angiotensin-I converting enzyme (ACE) inhibitor. Temocapril can also be used in hemodialysis patients without risk of serious accumulation
General
Type : Not A\/B H target, Pro-Drug, Drug, Angiotensin-converting enzyme inhibitor, Azepane, Thiophen
Chemical_Nomenclature : 2-[6-[(1-ethoxy-1-oxo-4-phenylbutan-2-yl)amino]-5-oxo-2-thiophen-2-yl-1,4-thiazepan-4-yl]acetic acid
Canonical SMILES : CCOC(=O)C(CCC1=CC=CC=C1)NC2CSC(CN(C2=O)CC(=O)O)C3=CC=CS3
InChI : InChI=1S\/C23H28N2O5S2\/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27\/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)
InChIKey : FIQOFIRCTOWDOW-UHFFFAOYSA-N
Other name(s) : ACMC-20bntp || AC1L1K98 || CHEMBL3303989
MW : 476.60
Formula : C23H28N2O5S2
CAS_number : 111902-57-9
PubChem : 5393
UniChem : FIQOFIRCTOWDOW-UHFFFAOYSA-N
Wikipedia : Temocapril
Target
Structures : No structure
Families : Carb_B_Chordata
References (5)
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity - Nozawa_2011_Drug.Metab.Dispos_39_1263 |
| Author(s) : Nozawa T , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 39 :1263 , 2011 |
| Abstract : |
| PubMedSearch : Nozawa_2011_Drug.Metab.Dispos_39_1263 |
| PubMedID: 21474683 |
| Title : Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case - Ohura_2011_J.Pharm.Sci_100_3985 |
| Author(s) : Ohura K , Nozawa T , Murakami K , Imai T |
| Ref : J Pharm Sci , 100 :3985 , 2011 |
| Abstract : |
| PubMedSearch : Ohura_2011_J.Pharm.Sci_100_3985 |
| PubMedID: 21618543 |
| Title : Influence of ionization state on the activation of temocapril by hCES1: a molecular-dynamics study - Vistoli_2009_Chem.Biodivers_6_2092 |
| Author(s) : Vistoli G , Pedretti A , Mazzolari A , Bolchi C , Testa B |
| Ref : Chem Biodivers , 6 :2092 , 2009 |
| Abstract : |
| PubMedSearch : Vistoli_2009_Chem.Biodivers_6_2092 |
| PubMedID: 19937843 |
| Title : Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver - Takai_1997_Biol.Pharm.Bull_20_869 |
| Author(s) : Takai S , Matsuda A , Usami Y , Adachi T , Sugiyama T , Katagiri Y , Tatematsu M , Hirano K |
| Ref : Biol Pharm Bull , 20 :869 , 1997 |
| Abstract : |
| PubMedSearch : Takai_1997_Biol.Pharm.Bull_20_869 |
| PubMedID: 9300133 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |