Trandolapril

General

Type : Not A\/B H target, Drug, Pro-Drug, Pyrrolidine, Angiotensin-converting enzyme inhibitor

Chemical_Nomenclature : (2S,3aR,7aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carboxylic acid

Canonical SMILES : CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C3CCCCC3CC2C(=O)O

InChI : InChI=1S\/C24H34N2O5\/c1-3-31-24(30)19(14-13-17-9-5-4-6-10-17)25-16(2)22(27)26-20-12-8-7-11-18(20)15-21(26)23(28)29\/h4-6,9-10,16,18-21,25H,3,7-8,11-15H2,1-2H3,(H,28,29)\/t16-,18+,19-,20-,21-\/m0\/s1

InChIKey : VXFJYXUZANRPDJ-WTNASJBWSA-N

Other name(s) : Mavik  ||  Gopten  ||  Odrik  ||  CHEMBL1519  ||  SCHEMBL16610  ||  CHEBI:9649


MW : 430.54

Formula : C24H34N2O5

CAS_number : 87679-37-6

PubChem : 5484727

UniChem : VXFJYXUZANRPDJ-WTNASJBWSA-N

Target

Structures : No structure

Families : Carb_B_Chordata

References (5)

Title : Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers - Wang_2021_Clin.Transl.Sci__
Author(s) : Wang X , Her L , Xiao J , Shi J , Wu AH , Bleske BE , Zhu HJ
Ref : Clin Transl Sci , : , 2021
Abstract :
PubMedSearch : Wang_2021_Clin.Transl.Sci__
PubMedID: 33660934

Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681
Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS
Ref : European Journal of Clinical Pharmacology , 72 :681 , 2016
Abstract :
PubMedSearch : Zhu_2016_Eur.J.Clin.Pharmacol_72_681
PubMedID: 26915813
Gene_locus related to this paper: human-CES1

Title : Clopidogrel Bioactivation and Risk of Bleeding in Patients Cotreated With Angiotensin-Converting Enzyme Inhibitors After Myocardial Infarction: A Proof-of-Concept Study - Kristensen_2014_Clin.Pharmacol.Ther_96_713
Author(s) : Kristensen KE , Zhu HJ , Wang X , Gislason GH , Torp-Pedersen C , Rasmussen HB , Markowitz JS , Hansen PR
Ref : Clinical Pharmacology & Therapeutics , 96 :713 , 2014
Abstract :
PubMedSearch : Kristensen_2014_Clin.Pharmacol.Ther_96_713
PubMedID: 25222620

Title : In vitro drug metabolism by human carboxylesterase 1: focus on Angiotensin-converting enzyme inhibitors - Thomsen_2014_Drug.Metab.Dispos_42_126
Author(s) : Thomsen R , Rasmussen HB , Linnet K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :126 , 2014
Abstract :
PubMedSearch : Thomsen_2014_Drug.Metab.Dispos_42_126
PubMedID: 24141856
Gene_locus related to this paper: human-CES1

Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266
Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS
Ref : Biochemical Pharmacology , 77 :1266 , 2009
Abstract :
PubMedSearch : Zhu_2009_Biochem.Pharmacol_77_1266
PubMedID: 19185566
Gene_locus related to this paper: human-CES1