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Substrate Report for: Ferulic-acid

Ferulic acid is the most abundant hydroxycinnamic acid derivative in plant cell walls. Ferulic acid is the product of hydrolysis of ethyl ferulate used as model substrate for the Ferulic-acid esterase. Cinnamic acids have been demonstrated to be covalently bound to polysaccharides (arabinoxylans and pectins) in cell walls of gramineous plants. They have a possible function in decreasing cell wall biodegradability and in regulating cell growth by covalently cross-linking cell wall polymers. To degrade these cell wall polymers, many bacteria and fungi produce a wide range of hemicellulases, as well as cinnamic acid esterases. Several cinnamic acid esterases have been isolated from Aspergillus niger. Most of these esterases are active on methyl esters of ferulic and p-coumaric acids, but other hemicellulases increase the hydrolysis of these cinnamic acids from xylan. Ferulic acid is also a substrate of the esterification of alcohols by lipases


General
Type Acrylate, Hydroxycinnamic-ester
Chemical_Nomenclature (E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoic acid
Canonical SMILES COC1=C(C=CC(=C1)C=CC(=O)O)O
InChI InChI=1S/C10H10O4/c1-14-9-6-7(2-4-8(9)11)3-5-10(12)13/h2-6,11H,1H3,(H,12,13)/b5-3+
InChIKey KSEBMYQBYZTDHS-HWKANZROSA-N
Other name(s) Ferulic acid ; Trans-Ferulic Acid ; 4-Hydroxy-3-methoxycinnamic acid ; Trans-4-Hydroxy-3-methoxycinnamic acid ; 3-(4-hydroxy-3-methoxyphenyl)-2-propenoic acis ; FER
________________________________________________________________________________________________
MW|194.18
Formula|C10H10O4
CAS_number|1135-24-6, 537-98-4
PubChem|445858
UniChem|KSEBMYQBYZTDHS-HWKANZROSA-N
IUPHAR|
Wikipedia|

Target
Families | Ferulic-acid ligand of proteins in family: A85-Feruloyl-Esterase, AlphaBeta_hydrolase, Lipase_3
Stucture | 9 structures (e.g. : 7Z2U, 6G21, 5CXX... more)
Protein | clotm-xynz, lacjo-q74hk5, aspni-FAEA

References:
Search PubMed for references concerning: Ferulic-acid

4 more
    Title: Therapeutic Potential of Ferulic Acid in Alzheimer's Disease
    Turkez H, Arslan ME, Barboza JN, Kahraman CY, de Sousa DP, Mardinoglu A
    Ref: Curr Drug Deliv, :, 2021 : PubMed

            

    Title: Lipase-catalyzed esterification of ferulic acid with lauryl alcohol in ionic liquids and antibacterial properties in vitro against three food-related bacteria
    Shi YG, Wu Y, Lu XY, Ren YP, Wang Q, Zhu CM, Yu D, Wang H
    Ref: Food Chem, 220:249, 2017 : PubMed

            

    Title: Heterologous production of a feruloyl esterase from Pleurotus sapidus synthesizing feruloyl-saccharide esters
    Kelle S, Nieter A, Krings U, Zelena K, Linke D, Berger RG
    Ref: Biotechnol Appl Biochem, 63:852, 2016 : PubMed