FAE-Bacterial-promiscuous
Relationship
Comment
Family extracted from the large AlphaBeta hydrolase family. Promiscuous Feruloyl Esterase (Est1E) from the Rumen Bacterium Butyrivibrio Proteoclasticus structure reveals a new lid domain. Polyethylene-terephthalate hydrolases. Pinotsis et al. shows that this family also contains non-canonical prototype long-chain monoacylglycerol lipases
Database
Interpro : IPR053145 AB hydrolase superfamily Esterase 10 AB_hydrolase_Est10
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 8B4U | The crystal structure of PET46 archaeal lid-containing feruloyl-esterase PETase | 9arch-PET46 |
| 8SLJ | K164A mutant of a chlorogenic acid esterase from Lactobacillus helveticus | lache-u6f2k7 |
| 8SKM | Wild type chlorogenic acid esterase from Lactobacillus helveticus | lache-u6f2k7 |
| 7Z2V | Ferulic acid esterase variant S114A from Lactobacillus buchneri | lenbu-d7ru28 |
| 7Z2X | Wild-type ferulic acid esterase from Lactobacillus buchneri | lenbu-d7ru28 |
| 7Z2U | Wild-type ferulic acid esterase from Lactobacillus buchneri in complex with ferulate | lenbu-d7ru28 |
| 7WWH | Crystal structure of the Geobacillus thermoglucosidasius feruloyl esterase GthFAE | partm-GthFAE |
| 7Q4H | A thermostable lipase from Thermoanaerobacter thermohydrosulfuricus in complex with PMSF | theet-q3ch51 |
| 8B9S | A thermostable lipase from Thermoanaerobacter thermohydrosulfuricus native form | theet-q3ch51 |
| 7Q4J | A thermostable lipase from Thermoanaerobacter thermohydrosulfuricus in complex a monoacylglycerol intermediate | theet-q3ch51 |
| 7XRH | Crystal structure of ferulic acid esterase (LaFae) from Lactobacillus acidophilus (7DOS withdrawn) | lacac-q5fi30 |
| 7XRI | Crystal structure of ferulic acid esterase (LaFae) from Lactobacillus acidophilus mutant -S106A (7DOT withdrawn) complex with ethyl ferulate | lacac-q5fi30 |
| 3PF8 | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 | lacjo-q74hk5 |
| 3PF9 | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 S106A mutant | lacjo-q74hk5 |
| 3PFB | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 S106A mutant in complex with ethylferulate | lacjo-q74hk5 |
| 3PFC | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 S106A mutant in complex with ferulic acid | lacjo-q74hk5 |
| 3QM1 | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 S106A mutant in complex with ethylferulate, Form II | lacjo-q74hk5 |
| 3S2Z | Crystal structure of the Lactobacillus johnsonii cinnamoyl esterase LJ0536 S106A mutant in complex with caffeic acid (replaced 3PFA: withdrawn) | lacjo-q74hk5 |
| 2WTM | Promiscuous Feruloyl Esterase (Est1E) from the Rumen Bacterium Butyrivibrio Proteoclasticus. | 9firm-Est1E |
| 2WTN | Ferulic acid bound Promiscuous Feruloyl Esterase (Est1E) from the Rumen Bacterium Butyrivibrio Proteoclasticus. | 9firm-Est1E |
| Gene_locus | Name | Species |
|---|---|---|
| lacam-a0a1c9u7k7 | Lactobacillus amylovorus Feruloyl esterase | Lactobacillus amylovorus |
| 9clot-a0a3r6ruf5 | Clostridiaceae bacterium AF18-31LB Alpha\/beta fold hydrolase HG-3 PET-hydrolase | Clostridiaceae bacterium AF18-31LB |
| 9firm-a0a413uca3 | Holdemanella biformis Alpha\/beta fold hydrolase HG-2 PET-hydrolase | Holdemanella biformis |
| 9arch-PETcan211 | Candidatus Bathyarchaeota archaeon MAG: alpha\/beta fold hydrolase | Candidatus Bathyarchaeota archaeon |
| 9cren-PETcan204 | Thermofilum adornatum alpha\/beta fold hydrolase PETcan204 | Thermofilum adornatum |
| 9arch-PET46 |  Candidatus Bathyarchaeota archaeon, archaeal lid-containing feruloyl-esterase, polyethylene terephthalate hydrolase (PET)PET46 PETase\/FAE |
Candidatus Bathyarchaeota archaeon |
| limf3-b2gdc2 | Limosilactobacillus fermentum (strain NBRC 3956 \/ LMG 18251) (Lactobacillus fermentum) ferulic acid esterase | Limosilactobacillus fermentum IFO 3956 |
| lache-u6f2k7 | Lactobacillus helveticus highly active esterase. hydrolyzes chlorogenic acid |
Lactobacillus helveticus |
| lenbu-d7ru28 | Lentilactobacillus buchneri (Lactobacillus buchneri) Ferulic acid esterase faeA LbFAE |
Lentilactobacillus buchneri |
| partm-GthFAE | Parageobacillus thermoglucosidasius (Geobacillus thermoglucosidasius) strain DSM 2542 feruloyl esterase |
Parageobacillus thermoglucosidasius |
| bifa0-b8du06 | Bifidobacterium animalis subsp. Alpha\/beta hydrolase fold family protein lactis BLA_1197 Balat_0669 | Bifidobacterium animalis subsp. lactis |
| geoth-g8myf3 | Geobacillus thermoleovorans EH68 Uncharacterized protein | Geobacillus thermoleovorans CCB_US3_UF5 |
| 9zzzz-KY203030 | uncultured prokaryote, EH31 esterase\/lipase | uncultured prokaryote |
| 9baci-q2bay3 | Bacillus sp. NRRL B-14911 alpha\/beta superfamily hydrolase | Bacillus sp. NRRL B-14911 |
| 9firm-Est1E | Butyrivibrio proteoclasticus (strain ATCC 51982 \/ DSM 14932 \/ B316) (Clostridium proteoclasticum) Promiscuous Feruloyl Esterase (Est1E) from the Rumen Bacterium |
Butyrivibrio Proteoclasticus B316 |
| butfi-CINI | Butyrivibrio fibrisolvens cinnamoyl ester hydrolase cinI | Butyrivibrio fibrisolvens |
| butfi-CINII | Butyrivibrio fibrisolvens cinii | Butyrivibrio fibrisolvens |
| cloac-CAC3665 | Clostridium acetobutylicum alpha\/beta superfamily hydrolase | Clostridium acetobutylicum |
| deira-DR1053 | Deinococcus radiodurans hydrolase, putative | Deinococcus radiodurans |
| frasc-q2j9z1 | Frankia sp. (strain CcI3) alpha\/beta hydrolase fold | Frankia sp. CcI3 |
| frasc-q2jel7 | Frankia sp. (strain CcI3) alpha\/beta hydrolase fold | Frankia sp. CcI3 |
| ignaa-e0snk2 | Ignisphaera aggregans strain (strain DSM 17230 \/ JCM 13409 \/ AQ1.S1) Dienelactone hydrolase | Ignisphaera aggregans |
| lacac-q5fi30 | Lactobacillus acidophilus ferulic acid esterase (LaFae) |
Lactobacillus acidophilus |
| lacac-q5fje7 | Lactobacillus acidophilus putative alpha-beta superfamily hydrolase | Lactobacillus acidophilus |
| lacga-q040s2 | Lactobacillus gasseri (strain ATCC 33323 \/ DSM 20243) alpha\/beta superfamily hydrolase | Lactobacillus gasseri |
| lacjo-q74hk5 | Lactobacillus johnsonii NCC 533 Hydrolase_4 domain-containing protein cinnamoyl esterase |
Lactobacillus johnsonii NCC 533 |
| lacjo-q74j82 | Lactobacillus johnsonii NCC 533 hypothetical protein | Lactobacillus johnsonii NCC 533 |
| lacpl-LP.2953 | Lactobacillus plantarum esterase (putative) | Lactobacillus plantarum |
| lacre-q2bvr2 | Lactobacillus reuteri JCM 1112 and 100-23 hypothetical protein | Lactobacillus reuteri JCM 1112 |
| meslo-MLR6657 | Rhizobium loti (Mesorhizobium loti) hypothetical protein mlr6657 | Rhizobium loti |
| parde-O54025 | Paracoccus denitrificans (and PD1222) orf2 protein | Paracoccus denitrificans |
| paruw-q6mcu6 | Parachlamydia sp. subsp. Acanthamoeba sp. (strain UWE25) hypothetical protein | Candidatus Protochlamydia amoebophila UWE25 |
| theet-q3ch51 | Thermoanaerobacter thermohydrosulfuricus\; Thermoanaerobacter ethanolicus TTL lipase LipTth |
Thermoanaerobacter ethanolicus ATCC 33223 |
| thete-TTE1809 | Thermoanaerobacter tengcongensis Caldanaerobacter subterraneus subsp. tengcongensis Thermostable lipase LipCst | Thermoanaerobacter tengcongensis |
| trede-q73qt5 | Treponema denticola cinnamoyl ester hydrolase | Treponema denticola |
| dict6-b5yfh9 | Dictyoglomus thermophilum (strain ATCC 35947 \/ DSM 3960 \/ H-6-12). EstDZ3 Hydrolases of the alpha\/beta superfamily | Dictyoglomus thermophilum |
| dictd-b8e2k8 | Dictyoglomus turgidum (strain Z-1310 \/ DSM 6724). Dienelactone hydrolase | Dictyoglomus turgidum |
| 9arch-a0a0n8pwm8 | Candidatus Bathyarchaeota archaeon BA1. Esterase | Candidatus Bathyarchaeota archaeon BA1 |
| wadcw-d6ywc6 | Waddlia chondrophila. Uncharacterized protein | Waddlia chondrophila |
| 9chla-a0a0c1h3n5 | Candidatus Protochlamydia amoebophila. Uncharacterized protein | Candidatus Protochlamydia amoebophila |
| 9chla-a0a078l8a9 | Candidatus Rubidus massiliensis. Fermentation\/respiration switch protein | Candidatus Rubidus massiliensis |
| parav-f8kzh9 | Parachlamydia acanthamoebae Uncharacterized protein | Parachlamydia acanthamoebae |
| 9bacl-a0a0p9gq96 | Alicyclobacillus ferrooxydans. Alpha\/beta hydrolase | Alicyclobacillus ferrooxydans |
| 9chla-a0a090cyn4 | Criblamydia sequanensis CRIB-18. Uncharacterized protein | Criblamydia sequanensis CRIB-18 |
| 9bact-h8xw45 | uncultured bacterium. Carboxylesterase | uncultured bacterium |
| 9chla-a0a0u5jg21 | Protochlamydia naegleriophila. Uncharacterized protein | Protochlamydia naegleriophila |
| aceaz-d9qqr0 | Acetohalobium arabaticum (strain ATCC 49924 \/ DSM 5501 \/ Z-7288). BAAT\/Acyl-CoA thioester hydrolase | Acetohalobium arabaticum |
| 9baci-a0a023dfm7 | Parageobacillus caldoxylosilyticus NBRC 107762 (Geobacillus caldoxylosilyticus NBRC 107762). Hydrolase_4 domain-containing protein | Geobacillus caldoxylosilyticus NBRC 107762 |
| 9chla-a0a0h5dp67 | Estrella lausannensis. Uncharacterized protein | Estrella lausannensis |
| 9bact-a0a0g2zfb4 | Kosmotoga pacifica. Uncharacterized protein | Kosmotoga pacifica |
| 9bact-estC76.221 | uncultured bacterium. Lipolytic protein | uncultured bacterium |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| 9firm-a0a139clv2 | Halobacteroidaceae bacterium T328-2. BAAT\/Acyl-CoA thioester hydrolase | Halobacteroidaceae bacterium T328-2 |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| Caffeic-acid | (E)-3-(3,4-dihydroxyphenyl)prop-2-enoic acid | lacjo-q74hk5 |
| PMSF | Phenylmethylsulfonyl fluoride | theet-q3ch51 emeni-q5avy9 human-ABHD10 human-PREPL myctu-Rv1430 psefl-cxest 9bact-E40 thefu-q6a0i4 ecoli-Aes orysj-Q10QA5 bac25-mglp 9bact-Q0GMU2 bacsu-FENB psepu-clcd1 thema-TM0077 bacsu-RsbQ ecoli-bioh drome-CG9542 human-FAP tubmm-TmEst2 human-NOTUM cutac-e6dae5 9gamm-urc15994 9baci-EstD9 geost-est30 pholl-AntI |
References (8)
| Title : Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex - Pinotsis_2023_Nat.Commun_14_7649 |
| Author(s) : Pinotsis N , Kruger A , Tomas N , Chatziefthymiou SD , Litz C , Mortensen SA , Daffe M , Marrakchi H , Antranikian G , Wilmanns M |
| Ref : Nat Commun , 14 :7649 , 2023 |
| Abstract : |
| PubMedSearch : Pinotsis_2023_Nat.Commun_14_7649 |
| PubMedID: 38012138 |
| Title : An archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate - Perez-Garcia_2023_Commun.Chem_6_193 |
| Author(s) : Perez-Garcia P , Chow J , Costanzi E , Gurschke M , Dittrich J , Dierkes RF , Molitor R , Applegate V , Feuerriegel G , Tete P , Danso D , Thies S , Schumacher J , Pfleger C , Jaeger KE , Gohlke H , Smits SHJ , Schmitz RA , Streit WR |
| Ref : Commun Chem , 6 :193 , 2023 |
| Abstract : |
| PubMedSearch : Perez-Garcia_2023_Commun.Chem_6_193 |
| PubMedID: 37697032 |
| Gene_locus related to this paper: 9arch-PETcan211 , 9cren-PETcan204 , 9arch-PET46 |
| Title : Crystal structure of the feruloyl esterase from Lentilactobacillus buchneri reveals a novel homodimeric state - Kasmaei_2022_Front.Microbiol_13_1050160 |
| Author(s) : Kasmaei KM , Kalyani DC , Reichenbach T , Jimenez-Quero A , Vilaplana F , Divne C |
| Ref : Front Microbiol , 13 :1050160 , 2022 |
| Abstract : |
| PubMedSearch : Kasmaei_2022_Front.Microbiol_13_1050160 |
| PubMedID: 36569051 |
| Gene_locus related to this paper: lenbu-d7ru28 |
| Title : Structure-guided rational design of the Geobacillus thermoglucosidasius feruloyl esterase GthFAE to improve its thermostability - Yang_2022_Biochem.Biophys.Res.Commun_600_117 |
| Author(s) : Yang W , Sun L , Dong P , Chen Y , Zhang H , Huang X , Wu L , Chen L , Jing D , Wu Y |
| Ref : Biochemical & Biophysical Research Communications , 600 :117 , 2022 |
| Abstract : |
| PubMedSearch : Yang_2022_Biochem.Biophys.Res.Commun_600_117 |
| PubMedID: 35219099 |
| Gene_locus related to this paper: partm-GthFAE |
| Title : Biochemical characterization of a novel thermostable feruloyl esterase from Geobacillus thermoglucosidasius DSM 2542(T) - Ay Sal_2019_Mol.Biol.Rep_46_4385 |
| Author(s) : Ay Sal F , Colak DN , Guler HI , Canakci S , Belduz AO |
| Ref : Mol Biol Rep , 46 :4385 , 2019 |
| Abstract : |
| PubMedSearch : Ay Sal_2019_Mol.Biol.Rep_46_4385 |
| PubMedID: 31201678 |
| Gene_locus related to this paper: partm-GthFAE |
| Title : Characterization of Cinnamoyl Esterases from Different Lactobacilli and Bifidobacteria - Fritsch_2017_Curr.Microbiol_74_247 |
| Author(s) : Fritsch C , Jansch A , Ehrmann MA , Toelstede S , Vogel RF |
| Ref : Curr Microbiol , 74 :247 , 2017 |
| Abstract : |
| PubMedSearch : Fritsch_2017_Curr.Microbiol_74_247 |
| PubMedID: 27999938 |
| Gene_locus related to this paper: limf3-b2gdc2 , lache-u6f2k7 , bifa0-b8du06 , lacac-q5fi30 , lacga-q040s2 , lacpl-LP.2953 , lacre-q2bvr2 |
| Title : An inserted alpha\/beta subdomain shapes the catalytic pocket of Lactobacillus johnsonii cinnamoyl esterase - Lai_2011_PLoS.One_6_e23269 |
| Author(s) : Lai KK , Stogios PJ , Vu C , Xu X , Cui H , Molloy S , Savchenko A , Yakunin A , Gonzalez CF |
| Ref : PLoS ONE , 6 :e23269 , 2011 |
| Abstract : |
| PubMedSearch : Lai_2011_PLoS.One_6_e23269 |
| PubMedID: 21876742 |
| Gene_locus related to this paper: lacjo-q74hk5 |
| Title : Structural and functional characterization of a promiscuous feruloyl esterase (Est1E) from the rumen bacterium Butyrivibrio proteoclasticus - Goldstone_2010_Proteins_78_1457 |
| Author(s) : Goldstone DC , Villas-Boas SG , Till M , Kelly WJ , Attwood GT , Arcus VL |
| Ref : Proteins , 78 :1457 , 2010 |
| Abstract : |
| PubMedSearch : Goldstone_2010_Proteins_78_1457 |
| PubMedID: 20058325 |
| Gene_locus related to this paper: 9firm-Est1E |