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Substrate Report for: Imidapril

Imidapril is a prodrug. imidapril is converted by human-CES1 (not CES2 or AADAC) into its active form imidaprilat: an angiotensin-converting enzyme (ACE) inhibitor



General
Type: Pro-Drug, Drug, Not A/B H target
Chemical_Nomenclature: (4S)-3-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid
Canonical SMILES: CCOC(=O)C(CCC1=CC=CC=C1)NC(C)C(=O)N2C(CN(C2=O)C)C(=O)O
InChI: InChI=1S/C20H27N3O6/c1-4-29-19(27)15(11-10-14-8-6-5-7-9-14)21-13(2)17(24)23-16(18(25)26)12-22(3)20(23)28/h5-9,13,15-16,21H,4,10-12H2,1-3H3,(H,25,26)/t13-,15-,16-/m0/s1
InChIKey: KLZWOWYOHUKJIG-BPUTZDHNSA-N
Other name(s): Imidaprilum ; UNII-BW7H1TJS22 ; Tanatril ; CHEMBL317094 ; SCHEMBL34098 ; CHEBI:135654 ; ZINC3784427 ; DB11783
MW: 405.4
Formula: C20H27N3O6
CAS_number: 89371-37-9
PubChem: 5464343
IUPHAR:
Wikipedia:

Target families
Imidapril ligand of proteins in family: Carb_B_Chordata
No structure

Protein target
Enzyme: human-CES1

References
Search PubMed for references concerning: Imidapril

8 more
    Title: Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases
    Fukami T, Kariya M, Kurokawa T, Iida A, Nakajima M
    Ref: Eur J Pharm Sci, 78:47, 2015 : PubMed

            

    Title: A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity
    Geshi E, Kimura T, Yoshimura M, Suzuki H, Koba S, Sakai T, Saito T, Koga A, Muramatsu M, Katagiri T
    Ref: Hypertens Res, 28:719, 2005 : PubMed

            

    Title: Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver
    Takai S, Matsuda A, Usami Y, Adachi T, Sugiyama T, Katagiri Y, Tatematsu M, Hirano K
    Ref: Biol Pharm Bull, 20:869, 1997 : PubMed