McIntosh JM

General

Full name : McIntosh J Michael

First name : J Michael

Mail : George E. Whalen Veterans Affairs Medical Center, University of Utah, Salt Lake City, UT

Zip Code :

City :

Country : USA

Email : mcintosh.mike@gmail.com

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References (118)

Title : SLPI Inhibits ATP-Mediated Maturation of IL-1beta in Human Monocytic Leukocytes: A Novel Function of an Old Player - Zakrzewicz_2019_Front.Immunol_10_664
Author(s) : Zakrzewicz A , Richter K , Zakrzewicz D , Siebers K , Damm J , Agne A , Hecker A , McIntosh JM , Chamulitrat W , Krasteva-Christ G , Manzini I , Tikkanen R , Padberg W , Janciauskiene S , Grau V
Ref : Front Immunol , 10 :664 , 2019
PubMedID: 31019507

Title : Phosphocholine-Modified Lipooligosaccharides of Haemophilus influenzae Inhibit ATP-Induced IL-1beta Release by Pulmonary Epithelial Cells - Richter_2018_Molecules_23_
Author(s) : Richter K , Koch C , Perniss A , Wolf PM , Schweda EKH , Wichmann S , Wilker S , Magel I , Sander M , McIntosh JM , Padberg W , Grau V
Ref : Molecules , 23 : , 2018
PubMedID: 30096783

Title : Alpha-1 Antitrypsin Inhibits ATP-Mediated Release of Interleukin-1beta via CD36 and Nicotinic Acetylcholine Receptors - Siebers_2018_Front.Immunol_9_877
Author(s) : Siebers K , Fink B , Zakrzewicz A , Agne A , Richter K , Konzok S , Hecker A , Zukunft S , Kullmar M , Klein J , McIntosh JM , Timm T , Sewald K , Padberg W , Aggarwal N , Chamulitrat W , Santoso S , Xia W , Janciauskiene S , Grau V
Ref : Front Immunol , 9 :877 , 2018
PubMedID: 29922281

Title : Canonical and Novel Non-Canonical Cholinergic Agonists Inhibit ATP-Induced Release of Monocytic Interleukin-1beta via Different Combinations of Nicotinic Acetylcholine Receptor Subunits alpha7, alpha9 and alpha10 - Zakrzewicz_2017_Front.Cell.Neurosci_11_189
Author(s) : Zakrzewicz A , Richter K , Agne A , Wilker S , Siebers K , Fink B , Krasteva-Christ G , Althaus M , Padberg W , Hone AJ , McIntosh JM , Grau V
Ref : Front Cell Neurosci , 11 :189 , 2017
PubMedID: 28725182

Title : Varenicline enhances dopamine release facilitation more than nicotine after long-term nicotine treatment and withdrawal - Perez_2015_Pharmacol.Res.Perspect_3_e00105
Author(s) : Perez XA , Khroyan TV , McIntosh JM , Quik M
Ref : Pharmacol Res Perspect , 3 :e00105 , 2015
PubMedID: 25692023

Title : Cloning, synthesis, and characterization of alphaO-conotoxin GeXIVA, a potent alpha9alpha10 nicotinic acetylcholine receptor antagonist - Luo_2015_Proc.Natl.Acad.Sci.U.S.A_112_E4026
Author(s) : Luo S , Zhangsun D , Harvey PJ , Kaas Q , Wu Y , Zhu X , Hu Y , Li X , Tsetlin VI , Christensen S , Romero HK , McIntyre M , Dowell C , Baxter JC , Elmslie KS , Craik DJ , McIntosh JM
Ref : Proc Natl Acad Sci U S A , 112 :E4026 , 2015
PubMedID: 26170295

Title : Key residues in the nicotinic acetylcholine receptor beta2 subunit contribute to alpha-conotoxin LvIA binding - Zhangsun_2015_J.Biol.Chem_290_9855
Author(s) : Zhangsun D , Zhu X , Wu Y , Hu Y , Kaas Q , Craik DJ , McIntosh JM , Luo S
Ref : Journal of Biological Chemistry , 290 :9855 , 2015
PubMedID: 25713061

Title : Evidence for a role for alpha6( *) nAChRs in l-dopa-induced dyskinesias using Parkinsonian alpha6( *) nAChR gain-of-function mice - Bordia_2015_Neurosci_295_187
Author(s) : Bordia T , McGregor M , McIntosh JM , Drenan RM , Quik M
Ref : Neuroscience , 295 :187 , 2015
PubMedID: 25813704

Title : The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions - Bordia_2015_Exp.Neurol_263_277
Author(s) : Bordia T , McGregor M , Papke RL , Decker MW , McIntosh JM , Quik M
Ref : Experimental Neurology , 263 :277 , 2015
PubMedID: 25261754

Title : Presence of multiple binding sites on alpha9alpha10 nAChR receptors alludes to stoichiometric-dependent action of the alpha-conotoxin, Vc1.1 - Indurthi_2014_Biochem.Pharmacol_89_131
Author(s) : Indurthi DC , Pera E , Kim HL , Chu C , McLeod MD , McIntosh JM , Absalom NL , Chebib M
Ref : Biochemical Pharmacology , 89 :131 , 2014
PubMedID: 24548457

Title : A novel alpha4\/7-conotoxin LvIA from Conus lividus that selectively blocks alpha3beta2 vs. alpha6\/alpha3beta2beta3 nicotinic acetylcholine receptors - Luo_2014_FASEB.J_28_1842
Author(s) : Luo S , Zhangsun D , Schroeder CI , Zhu X , Hu Y , Wu Y , Weltzin MM , Eberhard S , Kaas Q , Craik DJ , McIntosh JM , Whiteaker P
Ref : FASEB Journal , 28 :1842 , 2014
PubMedID: 24398291

Title : Monkey adrenal chromaffin cells express alpha6beta4* nicotinic acetylcholine receptors - Hernandez-Vivanco_2014_PLoS.One_9_e94142
Author(s) : Hernandez-Vivanco A , Hone AJ , Scadden ML , Carmona-Hidalgo B , McIntosh JM , Albillos A
Ref : PLoS ONE , 9 :e94142 , 2014
PubMedID: 24727685

Title : ABT-089 and ABT-894 reduce levodopa-induced dyskinesias in a monkey model of Parkinson's disease - Zhang_2014_Mov.Disord_29_508
Author(s) : Zhang D , Bordia T , McGregor M , McIntosh JM , Decker MW , Quik M
Ref : Movement Disorders , 29 :508 , 2014
PubMedID: 24515328

Title : Nicotinic acetylcholine receptors containing the alpha6 subunit contribute to ethanol activation of ventral tegmental area dopaminergic neurons - Liu_2013_Biochem.Pharmacol_86(8)_1194
Author(s) : Liu L , Zhao-Shea R , McIntosh JM , Tapper AR
Ref : Biochemical Pharmacology , 86 :1194 , 2013
PubMedID: 23811312

Title : Striatal dopamine transmission is reduced after chronic nicotine with a decrease in alpha6-nicotinic receptor control in nucleus accumbens - Exley_2013_Eur.J.Neurosci_38_3036
Author(s) : Exley R , Clements MA , Hartung H , McIntosh JM , Franklin M , Bermudez I , Cragg SJ
Ref : European Journal of Neuroscience , 38 :3036 , 2013
PubMedID: 23841846

Title : Long-term nicotine treatment down-regulates alpha6beta2* nicotinic receptor expression and function in nucleus accumbens - Perez_2013_J.Neurochem_127_762
Author(s) : Perez XA , McIntosh JM , Quik M
Ref : Journal of Neurochemistry , 127 :762 , 2013
PubMedID: 23992036

Title : Ventral tegmental area alpha6beta2 nicotinic acetylcholine receptors modulate phasic dopamine release in the nucleus accumbens core - Wickham_2013_Psychopharmacology.(Berl)_229_73
Author(s) : Wickham R , Solecki W , Rathbun L , McIntosh JM , Addy NA
Ref : Psychopharmacology (Berl) , 229 :73 , 2013
PubMedID: 23624852

Title : Mice expressing the ADNFLE valine 287 leucine mutation of the Beta2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function - O'Neill_2013_Pharmacol.Biochem.Behav_103_603
Author(s) : O'Neill HC , Laverty DC , Patzlaff NE , Cohen BN , Fonck C , McKinney S , McIntosh JM , Lindstrom JM , Lester HA , Grady SR , Marks MJ
Ref : Pharmacol Biochem Behav , 103 :603 , 2013
PubMedID: 23123803

Title : Comparative functional expression of nAChR subtypes in rodent DRG neurons - Smith_2013_Front.Cell.Neurosci_7_225
Author(s) : Smith NJ , Hone AJ , Memon T , Bossi S , Smith TE , McIntosh JM , Olivera BM , Teichert RW
Ref : Front Cell Neurosci , 7 :225 , 2013
PubMedID: 24348328

Title : The alpha3beta4* nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the alpha5 subunit in the mouse - Jackson_2013_Neuropharmacol_70_228
Author(s) : Jackson KJ , Sanjakdar SS , Muldoon PP , McIntosh JM , Damaj MI
Ref : Neuropharmacology , 70 :228 , 2013
PubMedID: 23416040

Title : Poster: Nicotinic acetylcholine receptor regulation of striatal dopamine transmission: The different requirement for diverse subtypes in ventral versus dorsal striatum -
Author(s) : Exley R , McIntosh JM , Marks M , Maskos U , Cragg SJ
Ref : Biochemical Pharmacology , 86 :1228 , 2013
PubMedID:

Title : Alpha4beta2 nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats - Quik_2013_Neuropharmacol_71_191
Author(s) : Quik M , Campos C , Bordia T , Strachan JP , Zhang J , McIntosh JM , Letchworth SR , Jordan K
Ref : Neuropharmacology , 71 :191 , 2013
PubMedID: 23583932

Title : Nicotine-mediated improvement in L-dopa-induced dyskinesias in MPTP-lesioned monkeys is dependent on dopamine nerve terminal function - Quik_2013_Neurobiol.Dis_50_30
Author(s) : Quik M , Mallela A , Chin M , McIntosh JM , Perez XA , Bordia T
Ref : Neurobiol Dis , 50 :30 , 2013
PubMedID: 23009753

Title : Positional scanning mutagenesis of alpha-conotoxin PeIA identifies critical residues that confer potency and selectivity for alpha6\/alpha3beta2beta3 and alpha3beta2 nicotinic acetylcholine receptors - Hone_2013_J.Biol.Chem_288_25428
Author(s) : Hone AJ , Ruiz M , Scadden M , Christensen S , Gajewiak J , Azam L , McIntosh JM
Ref : Journal of Biological Chemistry , 288 :25428 , 2013
PubMedID: 23846688

Title : The nicotine-mediated decline in l-dopa-induced dyskinesias is associated with a decrease in striatal dopamine release - Bordia_2013_J.Neurochem_125_291
Author(s) : Bordia T , McIntosh JM , Quik M
Ref : Journal of Neurochemistry , :291 , 2013
PubMedID: 23373725

Title : Striatal alpha5 nicotinic receptor subunit regulates dopamine transmission in dorsal striatum - Exley_2012_J.Neurosci_32_2352
Author(s) : Exley R , McIntosh JM , Marks MJ , Maskos U , Cragg SJ
Ref : Journal of Neuroscience , 32 :2352 , 2012
PubMedID: 22396410

Title : Alpha7 nicotinic acetylcholine receptors modulate motivation to self-administer nicotine: implications for smoking and schizophrenia - Brunzell_2012_Neuropsychopharmacology_37_1134
Author(s) : Brunzell DH , McIntosh JM
Ref : Neuropsychopharmacology , 37 :1134 , 2012
PubMedID: 22169946

Title : alpha6* nicotinic acetylcholine receptor expression and function in a visual salience circuit - Mackey_2012_J.Neurosci_32_10226
Author(s) : Mackey ED , Engle SE , Kim MR , O'Neill HC , Wageman CR , Patzlaff NE , Wang Y , Grady SR , McIntosh JM , Marks MJ , Lester HA , Drenan RM
Ref : Journal of Neuroscience , 32 :10226 , 2012
PubMedID: 22836257

Title : Long-term nicotine exposure depresses dopamine release in nonhuman primate nucleus accumbens - Perez_2012_J.Pharmacol.Exp.Ther_342_335
Author(s) : Perez XA , Ly J , McIntosh JM , Quik M
Ref : Journal of Pharmacology & Experimental Therapeutics , 342 :335 , 2012
PubMedID: 22562772

Title : The antinociceptive effects of nicotinic partial agonists varenicline and sazetidine-A in murine acute and tonic pain models - AlSharari_2012_J.Pharmacol.Exp.Ther_342_742
Author(s) : AlSharari SD , Carroll FI , McIntosh JM , Damaj MI
Ref : Journal of Pharmacology & Experimental Therapeutics , 342 :742 , 2012
PubMedID: 22678099

Title : Role for alpha6 nicotinic receptors in l-dopa-induced dyskinesias in parkinsonian mice - Quik_2012_Neuropharmacol_63_450
Author(s) : Quik M , Park KM , Hrachova M , Mallela A , Huang LZ , McIntosh JM , Grady SR
Ref : Neuropharmacology , 63 :450 , 2012
PubMedID: 22579614

Title : Nicotinic acetylcholine receptors in dorsal root ganglion neurons include the alpha6beta4* subtype - Hone_2012_FASEB.J_26_917
Author(s) : Hone AJ , Meyer EL , McIntyre M , McIntosh JM
Ref : FASEB Journal , 26 :917 , 2012
PubMedID: 22024738

Title : alpha-Conotoxin PeIA[S9H,V10A,E14N] potently and selectively blocks alpha6beta2beta3 versus alpha6beta4 nicotinic acetylcholine receptors - Hone_2012_Mol.Pharmacol_82_972
Author(s) : Hone AJ , Scadden M , Gajewiak J , Christensen S , Lindstrom JM , McIntosh JM
Ref : Molecular Pharmacology , 82 :972 , 2012
PubMedID: 22914547

Title : Nicotinic cholinergic mechanisms causing elevated dopamine release and abnormal locomotor behavior - Cohen_2012_Neurosci_200_31
Author(s) : Cohen BN , Mackey ED , Grady SR , McKinney S , Patzlaff NE , Wageman CR , McIntosh JM , Marks MJ , Lester HA , Drenan RM
Ref : Neuroscience , 200 :31 , 2012
PubMedID: 22079576

Title : Nicotine persistently activates ventral tegmental area dopaminergic neurons via nicotinic acetylcholine receptors containing alpha4 and alpha6 subunits - Liu_2012_Mol.Pharmacol_81_541
Author(s) : Liu L , Zhao-Shea R , McIntosh JM , Gardner PD , Tapper AR
Ref : Molecular Pharmacology , 81 :541 , 2012
PubMedID: 22222765

Title : Varenicline is a potent partial agonist at alpha6beta2* nicotinic acetylcholine receptors in rat and monkey striatum - Bordia_2012_J.Pharmacol.Exp.Ther_342_327
Author(s) : Bordia T , Hrachova M , Chin M , McIntosh JM , Quik M
Ref : Journal of Pharmacology & Experimental Therapeutics , 342 :327 , 2012
PubMedID: 22550286

Title : Nicotine reduces antipsychotic-induced orofacial dyskinesia in rats - Bordia_2012_J.Pharmacol.Exp.Ther_340_612
Author(s) : Bordia T , McIntosh JM , Quik M
Ref : Journal of Pharmacology & Experimental Therapeutics , 340 :612 , 2012
PubMedID: 22144565

Title : Characterizing functional alpha6beta2 nicotinic acetylcholine receptors in vitro: mutant beta2 subunits improve membrane expression, and fluorescent proteins reveal responsive cells - Xiao_2011_Biochem.Pharmacol_82(8)_852
Author(s) : Xiao C , Srinivasan R , Drenan RM , Mackey ED , McIntosh JM , Lester HA
Ref : Biochemical Pharmacology , 82 :852 , 2011
PubMedID: 21609715

Title : Poster: alpha6* nAChR expression and function in brain areas influencing DA transmission probed with alpha6-GFP transgenic mice -
Author(s) : Drenan RM , Mackey EDW , Grady SR , Patzlaff NE , Wageman CR , McIntosh JM , Marks MJ , Lester HA
Ref : Biochemical Pharmacology , 82 :1035 , 2011
PubMedID:

Title : Discovery of non-peptide, small molecule antagonists of alpha9alpha10 nicotinic acetylcholine receptors as novel analgesics for the treatment of neuropathic and tonic inflammatory pain - Zheng_2011_Bioorg.Med.Chem.Lett_21_2476
Author(s) : Zheng G , Zhang Z , Dowell C , Wala E , Dwoskin LP , Holtman JR , McIntosh JM , Crooks PA
Ref : Bioorganic & Medicinal Chemistry Lett , 21 :2476 , 2011
PubMedID: 21397497

Title : Distinct contributions of nicotinic acetylcholine receptor subunit alpha4 and subunit alpha6 to the reinforcing effects of nicotine - Exley_2011_Proc.Natl.Acad.Sci.U.S.A_108_7577
Author(s) : Exley R , Maubourguet N , David V , Eddine R , Evrard A , Pons S , Marti F , Threlfell S , Cazala P , McIntosh JM , Changeux JP , Maskos U , Cragg SJ , Faure P
Ref : Proc Natl Acad Sci U S A , 108 :7577 , 2011
PubMedID: 21502501

Title : Poster: Nicotinic cholinergic receptors in dorsal root ganglion neurons include the alpha6\/beta4 subtype -
Author(s) : Hone AJ , Meyer EL , McIntyre M , McIntosh JM
Ref : Biochemical Pharmacology , 82 :1033 , 2011
PubMedID:

Title : Nicotine-mediated activation of dopaminergic neurons in distinct regions of the ventral tegmental area - Zhao-Shea_2011_Neuropsychopharmacology_36_1021
Author(s) : Zhao-Shea R , Liu L , Soll LG , Improgo MR , Meyers EE , McIntosh JM , Grady SR , Marks MJ , Gardner PD , Tapper AR
Ref : Neuropsychopharmacology , 36 :1021 , 2011
PubMedID: 21289604

Title : Onset of cholinergic efferent synaptic function in sensory hair cells of the rat cochlea - Roux_2011_J.Neurosci_31_15092
Author(s) : Roux I , Wersinger E , McIntosh JM , Fuchs PA , Glowatzki E
Ref : Journal of Neuroscience , 31 :15092 , 2011
PubMedID: 22016543

Title : alpha4beta2 nicotinic acetylcholine receptors in the early postnatal mouse superior cervical ganglion - Scholze_2011_Dev.Neurobiol_71_390
Author(s) : Scholze P , Ciuraszkiewicz A , Groessl F , Orr-Urtreger A , McIntosh JM , Huck S
Ref : Dev Neurobiol , 71 :390 , 2011
PubMedID: 21485013

Title : The novel small molecule alpha9alpha10 nicotinic acetylcholine receptor antagonist ZZ-204G is analgesic - Holtman_2011_Eur.J.Pharmacol_670_500
Author(s) : Holtman JR , Dwoskin LP , Dowell C , Wala EP , Zhang Z , Crooks PA , McIntosh JM
Ref : European Journal of Pharmacology , 670 :500 , 2011
PubMedID: 21944926

Title : Functional nicotinic acetylcholine receptors containing alpha6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons - Yang_2011_J.Neurosci_31_2537
Author(s) : Yang K , Buhlman L , Khan GM , Nichols RA , Jin G , McIntosh JM , Whiteaker P , Lukas RJ , Wu J
Ref : Journal of Neuroscience , 31 :2537 , 2011
PubMedID: 21325521

Title : bPiDI: a novel selective alpha6beta2* nicotinic receptor antagonist and preclinical candidate treatment for nicotine abuse - Wooters_2011_Br.J.Pharmacol_163_346
Author(s) : Wooters TE , Smith AM , Pivavarchyk M , Siripurapu KB , McIntosh JM , Zhang Z , Crooks PA , Bardo MT , Dwoskin LP
Ref : British Journal of Pharmacology , 163 :346 , 2011
PubMedID: 21232049

Title : Indolizidine (-)-235B' and related structural analogs: discovery of nicotinic receptor antagonists that inhibit nicotine-evoked [3H]dopamine release - Pivavarchyk_2011_Eur.J.Pharmacol_658_132
Author(s) : Pivavarchyk M , Smith AM , Zhang Z , Zhou D , Wang X , Toyooka N , Tsuneki H , Sasaoka T , McIntosh JM , Crooks PA , Dwoskin LP
Ref : European Journal of Pharmacology , 658 :132 , 2011
PubMedID: 21371454

Title : Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by alpha7 and beta2* nicotinic stimulation - Del Barrio_2011_Toxicol.Sci_123_193
Author(s) : Del Barrio L , Martin-de-Saavedra MD , Romero A , Parada E , Egea J , Avila J , McIntosh JM , Wonnacott S , Lopez MG
Ref : Toxicol Sci , 123 :193 , 2011
PubMedID: 21715663

Title : John Daly's compound, epibatidine, facilitates identification of nicotinic receptor subtypes - Marks_2010_J.Mol.Neurosci_40_96
Author(s) : Marks MJ , Laverty DS , Whiteaker P , Salminen O , Grady SR , McIntosh JM , Collins AC
Ref : Journal of Molecular Neuroscience , 40 :96 , 2010
PubMedID: 19672723

Title : Chronic nicotine treatment increases nAChRs and microglial expression in monkey substantia nigra after nigrostriatal damage - Quik_2010_J.Mol.Neurosci_40_105
Author(s) : Quik M , Campos C , Parameswaran N , Langston JW , McIntosh JM , Yeluashvili M
Ref : Journal of Molecular Neuroscience , 40 :105 , 2010
PubMedID: 19685015

Title : Cholinergic modulation of locomotion and striatal dopamine release is mediated by alpha6alpha4* nicotinic acetylcholine receptors - Drenan_2010_J.Neurosci_30_9877
Author(s) : Drenan RM , Grady SR , Steele AD , McKinney S , Patzlaff NE , McIntosh JM , Marks MJ , Miwa JM , Lester HA
Ref : Journal of Neuroscience , 30 :9877 , 2010
PubMedID: 20660270

Title : Alpha-conotoxin MII-sensitive nicotinic acetylcholine receptors in the nucleus accumbens shell regulate progressive ratio responding maintained by nicotine - Brunzell_2010_Neuropsychopharmacology_35_665
Author(s) : Brunzell DH , Boschen KE , Hendrick ES , Beardsley PM , McIntosh JM
Ref : Neuropsychopharmacology , 35 :665 , 2010
PubMedID: 19890263

Title : Repeated nicotine administration robustly increases bPiDDB inhibitory potency at alpha6beta2-containing nicotinic receptors mediating nicotine-evoked dopamine release - Smith_2010_Biochem.Pharmacol_80_402
Author(s) : Smith AM , Pivavarchyk M , Wooters TE , Zhang Z , Zheng G , McIntosh JM , Crooks PA , Bardo MT , Dwoskin LP
Ref : Biochemical Pharmacology , 80 :402 , 2010
PubMedID: 20346923

Title : alpha6ss2* and alpha4ss2* nicotinic receptors both regulate dopamine signaling with increased nigrostriatal damage: relevance to Parkinson's disease - Perez_2010_Mol.Pharmacol_78_971
Author(s) : Perez XA , Bordia T , McIntosh JM , Quik M
Ref : Molecular Pharmacology , 78 :971 , 2010
PubMedID: 20732972

Title : alpha-Conotoxin BuIA[T5A\;P6O]: a novel ligand that discriminates between alpha6ss4 and alpha6ss2 nicotinic acetylcholine receptors and blocks nicotine-stimulated norepinephrine release - Azam_2010_FASEB.J_24_5113
Author(s) : Azam L , Maskos U , Changeux JP , Dowell CD , Christensen S , De Biasi M , McIntosh JM
Ref : FASEB Journal , 24 :5113 , 2010
PubMedID: 20739611

Title : Alexa Fluor 546-ArIB[V11L\;V16A] is a potent ligand for selectively labeling alpha 7 nicotinic acetylcholine receptors - Hone_2010_J.Neurochem_114_994
Author(s) : Hone AJ , Whiteaker P , Mohn JL , Jacob MH , McIntosh JM
Ref : Journal of Neurochemistry , 114 :994 , 2010
PubMedID: 20492354

Title : Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes - David_2010_Eur.J.Neurosci_31_978
Author(s) : David R , Ciuraszkiewicz A , Simeone X , Orr-Urtreger A , Papke RL , McIntosh JM , Huck S , Scholze P
Ref : European Journal of Neuroscience , 31 :978 , 2010
PubMedID: 20377613

Title : Mouse striatal dopamine nerve terminals express alpha4alpha5beta2 and two stoichiometric forms of alpha4beta2*-nicotinic acetylcholine receptors - Grady_2010_J.Mol.Neurosci_40_91
Author(s) : Grady SR , Salminen O , McIntosh JM , Marks MJ , Collins AC
Ref : Journal of Molecular Neuroscience , 40 :91 , 2010
PubMedID: 19693710

Title : Nicotinic receptor-mediated reduction in L-DOPA-induced dyskinesias may occur via desensitization - Bordia_2010_J.Pharmacol.Exp.Ther_333_929
Author(s) : Bordia T , Campos C , McIntosh JM , Quik M
Ref : Journal of Pharmacology & Experimental Therapeutics , 333 :929 , 2010
PubMedID: 20200117

Title : Localized low-level re-expression of high-affinity mesolimbic nicotinic acetylcholine receptors restores nicotine-induced locomotion but not place conditioning - Mineur_2009_Genes.Brain.Behav_8_257
Author(s) : Mineur YS , Brunzell DH , Grady SR , Lindstrom JM , McIntosh JM , Marks MJ , King SL , Picciotto MR
Ref : Genes Brain Behav , 8 :257 , 2009
PubMedID: 19077117

Title : Alpha9 nicotinic acetylcholine receptors and the treatment of pain - McIntosh_2009_Biochem.Pharmacol_78(7)_693
Author(s) : McIntosh JM , Absalom N , Chebib M , Elgoyhen AB , Vincler M
Ref : Biochemical Pharmacology , 78 :693 , 2009
PubMedID: 19477168

Title : UBXD4, a UBX-containing protein, regulates the cell surface number and stability of alpha3-containing nicotinic acetylcholine receptors - Rezvani_2009_J.Neurosci_29_6883
Author(s) : Rezvani K , Teng Y , Pan Y , Dani JA , Lindstrom JM , Garcia Gras EA , McIntosh JM , De Biasi M
Ref : Journal of Neuroscience , 29 :6883 , 2009
PubMedID: 19474315

Title : Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys - Huang_2009_J.Neurochem_109_826
Author(s) : Huang LZ , Parameswaran N , Bordia T , McIntosh JM , Quik M
Ref : Journal of Neurochemistry , 109 :826 , 2009
PubMedID: 19250334

Title : Poster: Mutation of proline enables subtype selectivity of alpha-conotoxin BuIA -
Author(s) : Filchakova Y , Godoy AB , Christensen S , McIntosh JM
Ref : Biochemical Pharmacology , 78 :906 , 2009
PubMedID:

Title : Prominent role of alpha3\/alpha6beta2* nAChRs in regulating evoked dopamine release in primate putamen: effect of long-term nicotine treatment - Perez_2009_Mol.Pharmacol_75_938
Author(s) : Perez XA , O'Leary KT , Parameswaran N , McIntosh JM , Quik M
Ref : Molecular Pharmacology , 75 :938 , 2009
PubMedID: 19144785

Title : Poster: Labeling alpha7 nAChRs on hippocampal neurons using fluorescent analogs of alpha-conotoxin ArIB[V11L\;V16A] -
Author(s) : Hone AJ , Mohn JL , Jacob M , Whiteaker P , McIntosh JM
Ref : Biochemical Pharmacology , 78 :903 , 2009
PubMedID:

Title : Chronic nicotine selectively enhances alpha4beta2* nicotinic acetylcholine receptors in the nigrostriatal dopamine pathway - Xiao_2009_J.Neurosci_29_12428
Author(s) : Xiao C , Nashmi R , McKinney S , Cai H , McIntosh JM , Lester HA
Ref : Journal of Neuroscience , 29 :12428 , 2009
PubMedID: 19812319

Title : The role of alpha6-containing nicotinic acetylcholine receptors in nicotine reward and withdrawal - Jackson_2009_J.Pharmacol.Exp.Ther_331_547
Author(s) : Jackson KJ , McIntosh JM , Brunzell DH , Sanjakdar SS , Damaj MI
Ref : Journal of Pharmacology & Experimental Therapeutics , 331 :547 , 2009
PubMedID: 19644040

Title : Poster: GZ556A and ZZ204G are novel small molecule antagonists of alpha9alpha10 nAChRs and are analgesic in rats -
Author(s) : McIntosh JM , Dwoskin LP , Crooks PA , Holtman Jr JR
Ref : Biochemical Pharmacology , 78 :921 , 2009
PubMedID:

Title : A novel fluorescent alpha-conotoxin for the study of alpha7 nicotinic acetylcholine receptors - Hone_2009_J.Neurochem_111_80
Author(s) : Hone AJ , Whiteaker P , Christensen S , Xiao Y , Meyer EL , McIntosh JM
Ref : Journal of Neurochemistry , 111 :80 , 2009
PubMedID: 19650873

Title : Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration - Pons_2008_J.Neurosci_28_12318
Author(s) : Pons S , Fattore L , Cossu G , Tolu S , Porcu E , McIntosh JM , Changeux JP , Maskos U , Fratta W
Ref : Journal of Neuroscience , 28 :12318 , 2008
PubMedID: 19020025

Title : N,N'-Alkane-diyl-bis-3-picoliniums as nicotinic receptor antagonists: inhibition of nicotine-evoked dopamine release and hyperactivity - Dwoskin_2008_J.Pharmacol.Exp.Ther_326_563
Author(s) : Dwoskin LP , Wooters TE , Sumithran SP , Siripurapu KB , Joyce BM , Lockman PR , Manda VK , Ayers JT , Zhang Z , Deaciuc AG , McIntosh JM , Crooks PA , Bardo MT
Ref : Journal of Pharmacology & Experimental Therapeutics , 326 :563 , 2008
PubMedID: 18460644

Title : Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens - Exley_2008_Neuropsychopharmacology_33_2158
Author(s) : Exley R , Clements MA , Hartung H , McIntosh JM , Cragg SJ
Ref : Neuropsychopharmacology , 33 :2158 , 2008
PubMedID: 18033235

Title : Alpha-conotoxin Arenatus IB[V11L,V16D] [corrected] is a potent and selective antagonist at rat and human native alpha7 nicotinic acetylcholine receptors - Innocent_2008_J.Pharmacol.Exp.Ther_327_529
Author(s) : Innocent N , Livingstone PD , Hone A , Kimura A , Young T , Whiteaker P , McIntosh JM , Wonnacott S
Ref : Journal of Pharmacology & Experimental Therapeutics , 327 :529 , 2008
PubMedID: 18664588

Title : In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors - Drenan_2008_Neuron_60_123
Author(s) : Drenan RM , Grady SR , Whiteaker P , McClure-Begley TD , McKinney S , Miwa JM , Bupp S , Heintz N , McIntosh JM , Bencherif M , Marks MJ , Lester HA
Ref : Neuron , 60 :123 , 2008
PubMedID: 18940593

Title : Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras - Papke_2008_Neuropharmacol_54_1189
Author(s) : Papke RL , Dwoskin LP , Crooks PA , Zheng G , Zhang Z , McIntosh JM , Stokes C
Ref : Neuropharmacology , 54 :1189 , 2008
PubMedID: 18448138

Title : Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation - Scholze_2007_Br.J.Pharmacol_151_414
Author(s) : Scholze P , Orr-Urtreger A , Changeux JP , McIntosh JM , Huck S
Ref : British Journal of Pharmacology , 151 :414 , 2007
PubMedID: 17401441

Title : Chronic nicotine differentially regulates alpha6- and beta3-containing nicotinic cholinergic receptors in rat brain - Perry_2007_J.Pharmacol.Exp.Ther_322_306
Author(s) : Perry DC , Mao D , Gold AB , McIntosh JM , Pezzullo JC , Kellar KJ
Ref : Journal of Pharmacology & Experimental Therapeutics , 322 :306 , 2007
PubMedID: 17446303

Title : Nicotine partially protects against paraquat-induced nigrostriatal damage in mice\; link to alpha6beta2* nAChRs - Khwaja_2007_J.Neurochem_100_180
Author(s) : Khwaja M , McCormack A , McIntosh JM , Di Monte DA , Quik M
Ref : Journal of Neurochemistry , 100 :180 , 2007
PubMedID: 17227438

Title : The subtypes of nicotinic acetylcholine receptors on dopaminergic terminals of mouse striatum - Grady_2007_Biochem.Pharmacol_74(8)_1235
Author(s) : Grady SR , Salminen O , Laverty DC , Whiteaker P , McIntosh JM , Collins AC , Marks MJ
Ref : Biochemical Pharmacology , 74 :1235 , 2007
PubMedID: 17825262

Title : Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum - Bordia_2007_Mol.Pharmacol_72_52
Author(s) : Bordia T , Grady SR , McIntosh JM , Quik M
Ref : Molecular Pharmacology , 72 :52 , 2007
PubMedID: 17409284

Title : Nicotine-induced dystonic arousal complex in a mouse line harboring a human autosomal-dominant nocturnal frontal lobe epilepsy mutation - Teper_2007_J.Neurosci_27_10128
Author(s) : Teper Y , Whyte D , Cahir E , Lester HA , Grady SR , Marks MJ , Cohen BN , Fonck C , McClure-Begley TD , McIntosh JM , Labarca C , Lawrence A , Chen F , Gantois I , Davies PJ , Petrou S , Murphy M , Waddington J , Horne MK , Berkovic SF , Drago J
Ref : Journal of Neuroscience , 27 :10128 , 2007
PubMedID: 17881519

Title : Alpha-RgIA: a novel conotoxin that specifically and potently blocks the alpha9alpha10 nAChR - Ellison_2006_Biochemistry_45_1511
Author(s) : Ellison M , Haberlandt C , Gomez-Casati ME , Watkins M , Elgoyhen AB , McIntosh JM , Olivera BM
Ref : Biochemistry , 45 :1511 , 2006
PubMedID: 16445293

Title : Increases in alpha4* but not alpha3*\/alpha6* nicotinic receptor sites and function in the primate striatum following chronic oral nicotine treatment - McCallum_2006_J.Neurochem_96_1028
Author(s) : McCallum SE , Parameswaran N , Bordia T , Fan H , Tyndale RF , Langston JW , McIntosh JM , Quik M
Ref : Journal of Neurochemistry , 96 :1028 , 2006
PubMedID: 16412091

Title : Nicotinic cholinergic receptors in the rat retina: simple and mixed heteromeric subtypes - Marritt_2005_Mol.Pharmacol_68_1656
Author(s) : Marritt AM , Cox BC , Yasuda RP , McIntosh JM , Xiao Y , Wolfe BB , Kellar KJ
Ref : Molecular Pharmacology , 68 :1656 , 2005
PubMedID: 16129735

Title : Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA - Quik_2005_Mol.Pharmacol_67_32
Author(s) : Quik M , Vailati S , Bordia T , Kulak JM , Fan H , McIntosh JM , Clementi F , Gotti C
Ref : Molecular Pharmacology , 67 :32 , 2005
PubMedID: 15470079

Title : Decrease in alpha3*\/alpha6* nicotinic receptors but not nicotine-evoked dopamine release in monkey brain after nigrostriatal damage - McCallum_2005_Mol.Pharmacol_68_737
Author(s) : McCallum SE , Parameswaran N , Bordia T , McIntosh JM , Grady SR , Quik M
Ref : Molecular Pharmacology , 68 :737 , 2005
PubMedID: 15933214

Title : A novel alpha-conotoxin, PeIA, cloned from Conus pergrandis, discriminates between rat alpha9alpha10 and alpha7 nicotinic cholinergic receptors - McIntosh_2005_J.Biol.Chem_280_30107
Author(s) : McIntosh JM , Plazas PV , Watkins M , Gomez-Casati ME , Olivera BM , Elgoyhen AB
Ref : Journal of Biological Chemistry , 280 :30107 , 2005
PubMedID: 15983035

Title : Cholinergic nicotinic receptor involvement in movement disorders associated with Lewy body diseases. An autoradiography study using [(125)I]alpha-conotoxinMII in the striatum and thalamus - Bohr_2005_Exp.Neurol_191_292
Author(s) : Bohr IJ , Ray MA , McIntosh JM , Chalon S , Guilloteau D , McKeith IG , Perry RH , Clementi F , Perry EK , Court JA , Piggott MA
Ref : Experimental Neurology , 191 :292 , 2005
PubMedID: 15649484

Title : Expression of nigrostriatal alpha 6-containing nicotinic acetylcholine receptors is selectively reduced, but not eliminated, by beta 3 subunit gene deletion - Gotti_2005_Mol.Pharmacol_67_2007
Author(s) : Gotti C , Moretti M , Clementi F , Riganti L , McIntosh JM , Collins AC , Marks MJ , Whiteaker P
Ref : Molecular Pharmacology , 67 :2007 , 2005
PubMedID: 15749993

Title : Functional properties of neuronal nicotinic acetylcholine receptors in the chick retina during development - Lecchi_2005_Eur.J.Neurosci_21_3182
Author(s) : Lecchi M , McIntosh JM , Bertrand S , Safran AB , Bertrand D
Ref : European Journal of Neuroscience , 21 :3182 , 2005
PubMedID: 15978026

Title : Long-term nicotine treatment decreases striatal alpha 6* nicotinic acetylcholine receptor sites and function in mice - Lai_2005_Mol.Pharmacol_67_1639
Author(s) : Lai A , Parameswaran N , Khwaja M , Whiteaker P , Lindstrom JM , Fan H , McIntosh JM , Grady SR , Quik M
Ref : Molecular Pharmacology , 67 :1639 , 2005
PubMedID: 15681595

Title : Analogs of alpha-conotoxin MII are selective for alpha6-containing nicotinic acetylcholine receptors - McIntosh_2004_Mol.Pharmacol_65_944
Author(s) : McIntosh JM , Azam L , Staheli S , Dowell C , Lindstrom JM , Kuryatov A , Garrett JE , Marks MJ , Whiteaker P
Ref : Molecular Pharmacology , 65 :944 , 2004
PubMedID: 15044624

Title : Alpha-conotoxins ImI and ImII target distinct regions of the human alpha7 nicotinic acetylcholine receptor and distinguish human nicotinic receptor subtypes - Ellison_2004_Biochemistry_43_16019
Author(s) : Ellison M , Gao F , Wang HL , Sine SM , McIntosh JM , Olivera BM
Ref : Biochemistry , 43 :16019 , 2004
PubMedID: 15609996

Title : Up-regulation of brain nicotinic acetylcholine receptors in the rat during long-term self-administration of nicotine: disproportionate increase of the alpha6 subunit - Parker_2004_Mol.Pharmacol_65_611
Author(s) : Parker SL , Fu Y , McAllen K , Luo J , McIntosh JM , Lindstrom JM , Sharp BM
Ref : Molecular Pharmacology , 65 :611 , 2004
PubMedID: 14978239

Title : Selective recovery of striatal 125I-alpha-conotoxinmii nicotinic receptors after nigrostriatal damage in monkeys - Lai_2004_Neurosci_127_399
Author(s) : Lai A , Sum J , Fan H , McIntosh JM , Quik M
Ref : Neuroscience , 127 :399 , 2004
PubMedID: 15262330

Title : Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice - Salminen_2004_Mol.Pharmacol_65_1526
Author(s) : Salminen O , Murphy KL , McIntosh JM , Drago J , Marks MJ , Collins AC , Grady SR
Ref : Molecular Pharmacology , 65 :1526 , 2004
PubMedID: 15155845

Title : Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex - Amtage_2004_Brain.Res.Bull_62_413
Author(s) : Amtage F , Neughebauer B , McIntosh JM , Freiman T , Zentner J , Feuerstein TJ , Jackisch R
Ref : Brain Research Bulletin , 62 :413 , 2004
PubMedID: 15168907

Title : Alpha-conotoxin PIA is selective for alpha6 subunit-containing nicotinic acetylcholine receptors - Dowell_2003_J.Neurosci_23_8445
Author(s) : Dowell C , Olivera BM , Garrett JE , Staheli ST , Watkins M , Kuryatov A , Yoshikami D , Lindstrom JM , McIntosh JM
Ref : Journal of Neuroscience , 23 :8445 , 2003
PubMedID: 13679412

Title : Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice - Champtiaux_2003_J.Neurosci_23_7820
Author(s) : Champtiaux N , Gotti C , Cordero-Erausquin M , David DJ , Przybylski C , Lena C , Clementi F , Moretti M , Rossi FM , Le Novere N , McIntosh JM , Gardier AM , Changeux JP
Ref : Journal of Neuroscience , 23 :7820 , 2003
PubMedID: 12944511

Title : The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors - Cui_2003_J.Neurosci_23_11045
Author(s) : Cui C , Booker TK , Allen RS , Grady SR , Whiteaker P , Marks MJ , Salminen O , Tritto T , Butt CM , Allen WR , Stitzel JA , McIntosh JM , Boulter J , Collins AC , Heinemann SF
Ref : Journal of Neuroscience , 23 :11045 , 2003
PubMedID: 14657161

Title : Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice - Marks_2002_J.Neurochem_81_1102
Author(s) : Marks MJ , Whiteaker P , Grady SR , Picciotto MR , McIntosh JM , Collins AC
Ref : Journal of Neurochemistry , 81 :1102 , 2002
PubMedID: 12065623

Title : Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum - Zoli_2002_J.Neurosci_22_8785
Author(s) : Zoli M , Moretti M , Zanardi A , McIntosh JM , Clementi F , Gotti C
Ref : Journal of Neuroscience , 22 :8785 , 2002
PubMedID: 12388584

Title : Methyllycaconitine is a potent antagonist of alpha-conotoxin-MII-sensitive presynaptic nicotinic acetylcholine receptors in rat striatum - Mogg_2002_J.Pharmacol.Exp.Ther_302_197
Author(s) : Mogg AJ , Whiteaker P , McIntosh JM , Marks M , Collins AC , Wonnacott S
Ref : Journal of Pharmacology & Experimental Therapeutics , 302 :197 , 2002
PubMedID: 12065717

Title : Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in alpha-conotoxin MII sites - Kulak_2002_Mol.Pharmacol_61_230
Author(s) : Kulak JM , McIntosh JM , Quik M
Ref : Molecular Pharmacology , 61 :230 , 2002
PubMedID: 11752225

Title : Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage - Quik_2002_Neurosci_112_619
Author(s) : Quik M , Polonskaya Y , McIntosh JM , Kulak JM
Ref : Neuroscience , 112 :619 , 2002
PubMedID: 12074903

Title : An alpha4beta4 nicotinic receptor subtype is present in chick retina: identification, characterization and pharmacological comparison with the transfected alpha4beta4 and alpha6beta4 subtypes - Barabino_2001_Mol.Pharmacol_59_1410
Author(s) : Barabino B , Vailati S , Moretti M , McIntosh JM , Longhi R , Clementi F , Gotti C
Ref : Molecular Pharmacology , 59 :1410 , 2001
PubMedID: 11353800

Title : Vulnerability of 125I-alpha-conotoxin MII binding sites to nigrostriatal damage in monkey - Quik_2001_J.Neurosci_21_5494
Author(s) : Quik M , Polonskaya Y , Kulak JM , McIntosh JM
Ref : Journal of Neuroscience , 21 :5494 , 2001
PubMedID: 11466420

Title : Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum - Grady_2001_J.Neurochem_76_258
Author(s) : Grady SR , Meinerz NM , Cao J , Reynolds AM , Picciotto MR , Changeux JP , McIntosh JM , Marks MJ , Collins AC
Ref : Journal of Neurochemistry , 76 :258 , 2001
PubMedID: 11145999

Title : Ca(2+) changes induced by different presynaptic nicotinic receptors in separate populations of individual striatal nerve terminals - Nayak_2001_J.Neurochem_76_1860
Author(s) : Nayak SV , Dougherty JJ , McIntosh JM , Nichols RA
Ref : Journal of Neurochemistry , 76 :1860 , 2001
PubMedID: 11259504

Title : Pairwise interactions between neuronal alpha(7) acetylcholine receptors and alpha-conotoxin PnIB - Quiram_2000_J.Biol.Chem_275_4889
Author(s) : Quiram PA , McIntosh JM , Sine SM
Ref : Journal of Biological Chemistry , 275 :4889 , 2000
PubMedID: 10671525

Title : Toxin Antagonists of the Neuronal Nicotinic Acetylcholine Receptor -
Author(s) : McIntosh JM
Ref : Handbook of Experimental Pharmacology , 144 :455 , 2000
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Title : Conus peptides: novel probes for nicotinic acetylcholine receptor structure and function - McIntosh_2000_Eur.J.Pharmacol_393_205
Author(s) : McIntosh JM , Gardner S , Luo S , Garrett JE , Yoshikami D
Ref : European Journal of Pharmacology , 393 :205 , 2000
PubMedID: 10771014

Title : Neuronal-type acetylcholine receptors and regulation of alpha 7 gene expression in vertebrate skeletal muscle - Romano_1997_J.Neurobiol_32_69
Author(s) : Romano SJ , Pugh PC , McIntosh JM , Berg DK
Ref : Journal of Neurobiology , 32 :69 , 1997
PubMedID: 8989664

Title : Alpha-conotoxin-ImI: a competitive antagonist at alpha-bungarotoxin-sensitive neuronal nicotinic receptors in hippocampal neurons - Pereira_1996_J.Pharmacol.Exp.Ther_278_1472
Author(s) : Pereira EF , Alkondon M , McIntosh JM , Albuquerque EX
Ref : Journal of Pharmacology & Experimental Therapeutics , 278 :1472 , 1996
PubMedID: 8819535

Title : alpha-Conotoxin ImI exhibits subtype-specific nicotinic acetylcholine receptor blockade: preferential inhibition of homomeric alpha 7 and alpha 9 receptors - Johnson_1995_Mol.Pharmacol_48_194
Author(s) : Johnson DS , Martinez J , Elgoyhen AB , Heinemann SF , McIntosh JM
Ref : Molecular Pharmacology , 48 :194 , 1995
PubMedID: 7651351