Papke RL

General

Full name : Papke Roger Lee

First name : Roger Lee

Mail : Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, PO 100267 1200 Newell Dr., 32610 Gainesville, Florida

Zip Code :

City :

Country : USA

Email : rlpapke@ufl.edu

Phone : 352-392-4712

Fax : 352-392-9696

Website : \/\/pharmacology.med.ufl.edu\/faculty\/primary-faculty-2\/roger-papke-ph-d\/

Directory :

References (62)

Title : Cholinergic Receptors and Addiction - Papke_2020_Curr.Top.Behav.Neurosci_45_123
Author(s) : Papke RL , Brunzell DH , De Biasi M
Ref : Curr Top Behavioral Neuroscience , 45 :123 , 2020
PubMedID: 32451953

Title : Heteromeric Neuronal Nicotinic Acetylcholine Receptors with Mutant beta Subunits Acquire Sensitivity to alpha7-Selective Positive Allosteric Modulators - Stokes_2019_J.Pharmacol.Exp.Ther_370_252
Author(s) : Stokes C , Garai S , Kulkarni AR , Cantwell LN , Noviello CM , Hibbs RE , Horenstein NA , Abboud KA , Thakur GA , Papke RL
Ref : Journal of Pharmacology & Experimental Therapeutics , 370 :252 , 2019
PubMedID: 31175218

Title : The alpha7 nicotinic receptor agonist ABT-107 protects against nigrostriatal damage in rats with unilateral 6-hydroxydopamine lesions - Bordia_2015_Exp.Neurol_263_277
Author(s) : Bordia T , McGregor M , Papke RL , Decker MW , McIntosh JM , Quik M
Ref : Experimental Neurology , 263 :277 , 2015
PubMedID: 25261754

Title : The cytisine derivatives, CC4 and CC26, reduce nicotine-induced conditioned place preference in zebrafish by acting on heteromeric neuronal nicotinic acetylcholine receptors - Ponzoni_2014_Psychopharmacology.(Berl)_231_4681
Author(s) : Ponzoni L , Braida D , Pucci L , Andrea D , Fasoli F , Manfredi I , Papke RL , Stokes C , Cannazza G , Clementi F , Gotti C , Sala M
Ref : Psychopharmacology (Berl) , 231 :4681 , 2014
PubMedID: 24862365

Title : Rare Human Nicotinic Acetylcholine Receptor alpha4 Subunit (CHRNA4) Variants Affect Expression and Function of High-Affinity Nicotinic Acetylcholine Receptors - McClure-Begley_2014_J.Pharmacol.Exp.Ther_348_410
Author(s) : McClure-Begley TD , Papke RL , Stone KL , Stokes C , Levy AD , Gelernter J , Xie P , Lindstrom JM , Picciotto MR
Ref : Journal of Pharmacology & Experimental Therapeutics , 348 :410 , 2014
PubMedID: 24385388

Title : The Activity of GAT107, an Allosteric Activator and Positive Modulator of alpha7 Nicotinic Acetylcholine Receptors (nAChR), Is Regulated by Aromatic Amino Acids That Span the Subunit Interface - Papke_2014_J.Biol.Chem_289_4515
Author(s) : Papke RL , Horenstein NA , Kulkarni AR , Stokes C , Corrie LW , Maeng CY , Thakur GA
Ref : Journal of Biological Chemistry , 289 :4515 , 2014
PubMedID: 24362025

Title : Merging old and new perspectives on nicotinic acetylcholine receptors - Papke_2014_Biochem.Pharmacol_89_1
Author(s) : Papke RL
Ref : Biochemical Pharmacology , 89 :1 , 2014
PubMedID: 24486571

Title : Synthesis and evaluation of a conditionally-silent agonist for the alpha7 nicotinic acetylcholine receptor - Chojnacka_2013_Bioorg.Med.Chem.Lett_23_4145
Author(s) : Chojnacka K , Papke RL , Horenstein NA
Ref : Bioorganic & Medicinal Chemistry Lett , 23 :4145 , 2013
PubMedID: 23746476

Title : Point-to-point ligand-receptor interactions across the subunit interface modulate the induction and stabilization of conformational states of alpha7 nAChR by benzylidene anabaseines - Isaacson_2013_Biochem.Pharmacol_85_817
Author(s) : Isaacson MD , Horenstein NA , Stokes C , Kem WR , Papke RL
Ref : Biochemical Pharmacology , 85 :817 , 2013
PubMedID: 23352650

Title : Multiple Modes of alpha7 nAChR Noncompetitive Antagonism of Control Agonist-Evoked and Allosterically Enhanced Currents - Peng_2013_Mol.Pharmacol_84_459
Author(s) : Peng C , Kimbrell MR , Tian C , Pack TF , Crooks PA , Fifer EK , Papke RL
Ref : Molecular Pharmacology , 84 :459 , 2013
PubMedID: 23839567

Title : Poster: Discovery of Lu AF58801, a novel, selective and brain penetrant positive allosteric modulator of alpha-7 nicotinic acetylcholine receptors: Attenuation of subchronic phencyclidine (PCP)-induced cognitive deficits in rats following oral administration -
Author(s) : Bastlund JF , Bundgaard C , Dekermendjian K , Papke RL , Redrobe JP , Frederiksen K , Eskildsen J
Ref : Biochemical Pharmacology , 86 :1231 , 2013
PubMedID:

Title : Differential modulation of brain nicotinic acetylcholine receptor function by cytisine, varenicline, and two novel bispidine compounds: emergent properties of a hybrid molecule - Peng_2013_J.Pharmacol.Exp.Ther_347_424
Author(s) : Peng C , Stokes C , Mineur YS , Picciotto MR , Tian C , Eibl C , Tomassoli I , Guendisch D , Papke RL
Ref : Journal of Pharmacology & Experimental Therapeutics , 347 :424 , 2013
PubMedID: 23959137

Title : Expeditious synthesis, enantiomeric resolution, and enantiomer functional characterization of (4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide (4BP-TQS): an allosteric agonist-positive allosteric modulator of alpha7 nicotinic acetylcholine receptors - Thakur_2013_J.Med.Chem_56_8943
Author(s) : Thakur GA , Kulkarni AR , Deschamps JR , Papke RL
Ref : Journal of Medicinal Chemistry , 56 :8943 , 2013
PubMedID: 24090443

Title : alpha7beta2 nicotinic acetylcholine receptors assemble, function, and are activated primarily via their alpha7-alpha7 interfaces - Murray_2012_Mol.Pharmacol_81_175
Author(s) : Murray TA , Bertrand D , Papke RL , George AA , Pantoja R , Srinivasan R , Liu Q , Wu J , Whiteaker P , Lester HA , Lukas RJ
Ref : Molecular Pharmacology , 81 :175 , 2012
PubMedID: 22039094

Title : Use of an alpha3beta4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties - Stokes_2012_Neuropharmacol_63_538
Author(s) : Stokes C , Papke RL
Ref : Neuropharmacology , 63 :538 , 2012
PubMedID: 22580377

Title : The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study - Papke_2012_Biochem.Pharmacol_84_352
Author(s) : Papke RL , Ono F , Stokes C , Urban JM , Boyd RT
Ref : Biochemical Pharmacology , 84 :352 , 2012
PubMedID: 22580045

Title : Potential state-selective hydrogen bond formation can modulate activation and desensitization of the alpha7 nicotinic acetylcholine receptor - Wang_2012_J.Biol.Chem_287_21957
Author(s) : Wang J , Papke RL , Stokes C , Horenstein NA
Ref : Journal of Biological Chemistry , 287 :21957 , 2012
PubMedID: 22556416

Title : Intrinsically low open probability of alpha7 nicotinic acetylcholine receptors can be overcome by positive allosteric modulation and serum factors leading to the generation of excitotoxic currents at physiological temperatures - Williams_2012_Mol.Pharmacol_82_746
Author(s) : Williams DK , Peng C , Kimbrell MR , Papke RL
Ref : Molecular Pharmacology , 82 :746 , 2012
PubMedID: 22828799

Title : Poster: Positive and negative cooperativity of agonist and allosteric modulator binding in alpha7 nAChR: Looking for the therapeutic window -
Author(s) : Papke RL , Williams DK , Wang J , Horenstein NA
Ref : Biochemical Pharmacology , 82 :1031 , 2011
PubMedID:

Title : Cysteine accessibility analysis of the human alpha7 nicotinic acetylcholine receptor ligand-binding domain identifies L119 as a gatekeeper - Papke_2011_Neuropharmacol_60_159
Author(s) : Papke RL , Stokes C , Williams DK , Wang J , Horenstein NA
Ref : Neuropharmacology , 60 :159 , 2011
PubMedID: 20650284

Title : Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists - Papke_2011_J.Pharmacol.Exp.Ther_337_367
Author(s) : Papke RL , Trocme-Thibierge C , Guendisch D , Al Rubaiy SA , Bloom SA
Ref : Journal of Pharmacology & Experimental Therapeutics , 337 :367 , 2011
PubMedID: 21285282

Title : Poster: The twin drug approach for novel nicotinic acetylcholine receptor (nAChR) ligands: Synthesis and structure-affinity relationships -
Author(s) : Tomassoli I , Eibl C , Wulf M , Papke RL , Picciotto MR , Gndisch D
Ref : Biochemical Pharmacology , 82 :1028 , 2011
PubMedID:

Title : The effective opening of nicotinic acetylcholine receptors with single agonist binding sites - Williams_2011_J.Gen.Physiol_137_369
Author(s) : Williams DK , Stokes C , Horenstein NA , Papke RL
Ref : Journal of General Physiology , 137 :369 , 2011
PubMedID: 21444659

Title : Investigation of the molecular mechanism of the alpha7 nicotinic acetylcholine receptor positive allosteric modulator PNU-120596 provides evidence for two distinct desensitized states - Williams_2011_Mol.Pharmacol_80_1013
Author(s) : Williams DK , Wang J , Papke RL
Ref : Molecular Pharmacology , 80 :1013 , 2011
PubMedID: 21885620

Title : Positive allosteric modulators as an approach to nicotinic acetylcholine receptor-targeted therapeutics: advantages and limitations - Williams_2011_Biochem.Pharmacol_82(8)_915
Author(s) : Williams DK , Wang J , Papke RL
Ref : Biochemical Pharmacology , 82 :915 , 2011
PubMedID: 21575610

Title : Tricks of perspective: insights and limitations to the study of macroscopic currents for the analysis of nAChR activation and desensitization - Papke_2010_J.Mol.Neurosci_40_77
Author(s) : Papke RL
Ref : Journal of Molecular Neuroscience , 40 :77 , 2010
PubMedID: 19672724

Title : alpha4beta2 Nicotinic acetylcholine receptors, willing if able - Papke_2010_Br.J.Pharmacol_160_1903
Author(s) : Papke RL
Ref : British Journal of Pharmacology , 160 :1903 , 2010
PubMedID: 20649588

Title : Discovery of novel alpha7 nicotinic receptor antagonists - Peng_2010_Bioorg.Med.Chem.Lett_20_4825
Author(s) : Peng Y , Zhang Q , Snyder GL , Zhu H , Yao W , Tomesch J , Papke RL , O'Callaghan JP , Welsh WJ , Wennogle LP
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :4825 , 2010
PubMedID: 20638843

Title : Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes - Papke_2010_J.Pharmacol.Exp.Ther_333_501
Author(s) : Papke RL , Wecker L , Stitzel JA
Ref : Journal of Pharmacology & Experimental Therapeutics , 333 :501 , 2010
PubMedID: 20100906

Title : Tethered agonist analogs as site-specific probes for domains of the human alpha7 nicotinic acetylcholine receptor that differentially regulate activation and desensitization - Wang_2010_Mol.Pharmacol_78_1012
Author(s) : Wang J , Horenstein NA , Stokes C , Papke RL
Ref : Molecular Pharmacology , 78 :1012 , 2010
PubMedID: 20823218

Title : Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes - David_2010_Eur.J.Neurosci_31_978
Author(s) : David R , Ciuraszkiewicz A , Simeone X , Orr-Urtreger A , Papke RL , McIntosh JM , Huck S , Scholze P
Ref : European Journal of Neuroscience , 31 :978 , 2010
PubMedID: 20377613

Title : Activation and desensitization of nicotinic alpha7-type acetylcholine receptors by benzylidene anabaseines and nicotine - Papke_2009_J.Pharmacol.Exp.Ther_329_791
Author(s) : Papke RL , Kem WR , Soti F , Lopez-Hernandez GY , Horenstein NA
Ref : Journal of Pharmacology & Experimental Therapeutics , 329 :791 , 2009
PubMedID: 19223664

Title : Cytisine-based nicotinic partial agonists as novel antidepressant compounds - Mineur_2009_J.Pharmacol.Exp.Ther_329_377
Author(s) : Mineur YS , Eibl C , Young G , Kochevar C , Papke RL , Gundisch D , Picciotto MR
Ref : Journal of Pharmacology & Experimental Therapeutics , 329 :377 , 2009
PubMedID: 19164465

Title : TC-5619: an alpha7 neuronal nicotinic receptor-selective agonist that demonstrates efficacy in animal models of the positive and negative symptoms and cognitive dysfunction of schizophrenia - Hauser_2009_Biochem.Pharmacol_78(7)_803
Author(s) : Hauser TA , Kucinski A , Jordan KG , Gatto GJ , Wersinger SR , Hesse RA , Stachowiak EK , Stachowiak MK , Papke RL , Lippiello PM , Bencherif M
Ref : Biochemical Pharmacology , 78 :803 , 2009
PubMedID: 19482012

Title : Positive modulation of alpha7 nAChR responses in rat hippocampal interneurons to full agonists and the alpha7-selective partial agonists, 4OH-GTS-21 and S 24795 - Lopez-Hernandez_2009_Neuropharmacol_56_821
Author(s) : Lopez-Hernandez GY , Thinschmidt JS , Morain P , Trocme-Thibierge C , Kem WR , Soti F , Papke RL
Ref : Neuropharmacology , 56 :821 , 2009
PubMedID: 19705574

Title : Selective inhibition of acetylcholine-evoked responses of alpha7 neuronal nicotinic acetylcholine receptors by novel tris- and tetrakis-azaaromatic quaternary ammonium antagonists - Lopez-Hernandez_2009_Mol.Pharmacol_76_652
Author(s) : Lopez-Hernandez GY , Thinschmidt JS , Zheng G , Zhang Z , Crooks PA , Dwoskin LP , Papke RL
Ref : Molecular Pharmacology , 76 :652 , 2009
PubMedID: 19556356

Title : Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction - Rahman_2008_CNS.Neurol.Disord.Drug.Targets_7_422
Author(s) : Rahman S , Lopez-Hernandez GY , Corrigall WA , Papke RL
Ref : CNS Neurol Disord Drug Targets , 7 :422 , 2008
PubMedID: 19128201

Title : Region-specific effects of N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide on nicotine-induced increase in extracellular dopamine in vivo - Rahman_2008_Br.J.Pharmacol_153_792
Author(s) : Rahman S , Zhang Z , Papke RL , Crooks PA , Dwoskin LP , Bardo MT
Ref : British Journal of Pharmacology , 153 :792 , 2008
PubMedID: 18059317

Title : Multiple pharmacophores for the selective activation of nicotinic alpha7-type acetylcholine receptors - Horenstein_2008_Mol.Pharmacol_74_1496
Author(s) : Horenstein NA , Leonik FM , Papke RL
Ref : Molecular Pharmacology , 74 :1496 , 2008
PubMedID: 18768388

Title : Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras - Papke_2008_Neuropharmacol_54_1189
Author(s) : Papke RL , Dwoskin LP , Crooks PA , Zheng G , Zhang Z , McIntosh JM , Stokes C
Ref : Neuropharmacology , 54 :1189 , 2008
PubMedID: 18448138

Title : Modeling binding modes of alpha7 nicotinic acetylcholine receptor with ligands: the roles of Gln117 and other residues of the receptor in agonist binding - Huang_2008_J.Med.Chem_51_6293
Author(s) : Huang X , Zheng F , Stokes C , Papke RL , Zhan CG
Ref : Journal of Medicinal Chemistry , 51 :6293 , 2008
PubMedID: 18826295

Title : Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD) - Dwoskin_2007_Biochem.Pharmacol_74(8)_1271
Author(s) : Dwoskin LP , Joyce BM , Zheng G , Neugebauer NM , Manda VK , Lockman P , Papke RL , Bardo MT , Crooks PA
Ref : Biochemical Pharmacology , 74 :1271 , 2007
PubMedID: 17727820

Title : The pharmacological activity of nicotine and nornicotine on nAChRs subtypes: relevance to nicotine dependence and drug discovery - Papke_2007_J.Neurochem_101_160
Author(s) : Papke RL , Dwoskin LP , Crooks PA
Ref : Journal of Neurochemistry , 101 :160 , 2007
PubMedID: 17241116

Title : The effects of subunit composition on the inhibition of nicotinic receptors by the amphipathic blocker 2,2,6,6-tetramethylpiperidin-4-yl heptanoate - Papke_2005_Mol.Pharmacol_67_1977
Author(s) : Papke RL , Buhr JD , Francis MM , Choi KI , Thinschmidt JS , Horenstein NA
Ref : Molecular Pharmacology , 67 :1977 , 2005
PubMedID: 15761116

Title : Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes - Papke_2005_Eur.J.Pharmacol_524_11
Author(s) : Papke RL , McCormack TJ , Jack BA , Wang D , Bugaj-Gaweda B , Schiff HC , Buhr JD , Waber AJ , Stokes C
Ref : European Journal of Pharmacology , 524 :11 , 2005
PubMedID: 16266703

Title : An alpha7 nicotinic acetylcholine receptor gain-of-function mutant that retains pharmacological fidelity - Placzek_2005_Mol.Pharmacol_68_1863
Author(s) : Placzek AN , Grassi F , Meyer EM , Papke RL
Ref : Molecular Pharmacology , 68 :1863 , 2005
PubMedID: 16186249

Title : The characterization of a novel rigid nicotine analog with alpha7-selective nAChR agonist activity and modulation of agonist properties by boron inclusion - Papke_2005_Bioorg.Med.Chem.Lett_15_3874
Author(s) : Papke RL , Zheng G , Horenstein NA , Dwoskin LP , Crooks PA
Ref : Bioorganic & Medicinal Chemistry Lett , 15 :3874 , 2005
PubMedID: 16005216

Title : In vivo characterization of a novel inhibitor of CNS nicotinic receptors - Damaj_2005_Eur.J.Pharmacol_521_43
Author(s) : Damaj MI , Wiley JL , Martin BR , Papke RL
Ref : European Journal of Pharmacology , 521 :43 , 2005
PubMedID: 16181622

Title : The structural basis for GTS-21 selectivity between human and rat nicotinic alpha7 receptors - Stokes_2004_Mol.Pharmacol_66_14
Author(s) : Stokes C , Papke JK , Horenstein NA , Kem WR , McCormack TJ , Papke RL
Ref : Molecular Pharmacology , 66 :14 , 2004
PubMedID: 15213292

Title : A single point mutation confers properties of the muscle-type nicotinic acetylcholine receptor to homomeric alpha7 receptors - Placzek_2004_Mol.Pharmacol_66_169
Author(s) : Placzek AN , Grassi F , Papke T , Meyer EM , Papke RL
Ref : Molecular Pharmacology , 66 :169 , 2004
PubMedID: 15213309

Title : Inhibition of wild-type and mutant neuronal nicotinic acetylcholine receptors by local anesthetics - Papke_2001_Mol.Pharmacol_60_1365
Author(s) : Papke RL , Horenstein BA , Placzek AN
Ref : Molecular Pharmacology , 60 :1365 , 2001
PubMedID: 11723244

Title : alpha7 receptor-selective agonists and modes of alpha7 receptor activation - Papke_2000_Eur.J.Pharmacol_393_179
Author(s) : Papke RL , Meyer E , Nutter T , Uteshev VV
Ref : European Journal of Pharmacology , 393 :179 , 2000
PubMedID: 10771012

Title : Subtype-selective inhibition of neuronal nicotinic acetylcholine receptors by cocaine is determined by the alpha4 and beta4 subunits - Francis_2000_Mol.Pharmacol_58_109
Author(s) : Francis MM , Vazquez RW , Papke RL , Oswald RE
Ref : Molecular Pharmacology , 58 :109 , 2000
PubMedID: 10860932

Title : The Functional Diversity of Nicotinic Receptors in the Nervous System: Perspectives on Receptor Subtypes and Receptor Specialization -
Author(s) : Francis MM , Papke RL
Ref : Handbook of Experimental Pharmacology , 144 :301 , 2000
PubMedID:

Title : Partial agonist properties of cytisine on neuronal nicotinic receptors containing the beta 2 subunit - Papke_1994_Mol.Pharmacol_45_142
Author(s) : Papke RL , Heinemann SF
Ref : Molecular Pharmacology , 45 :142 , 1994
PubMedID: 8302273

Title : The amino terminal half of the nicotinic beta-subunit extracellular domain regulates the kinetics of inhibition by neuronal bungarotoxin - Papke_1993_Proc.Biol.Sci_252_141
Author(s) : Papke RL , Duvoisin RM , Heinemann SF
Ref : Proc Biol Sci , 252 :141 , 1993
PubMedID: 8391703

Title : The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors - Papke_1991_J.Physiol_440_95
Author(s) : Papke RL , Heinemann SF
Ref : The Journal of Physiology , 440 :95 , 1991
PubMedID: 1725184

Title : The nicotinic receptor genes - Heinemann_1991_Clin.Neuropharmacol_14 Suppl 1_S45
Author(s) : Heinemann S , Boulter J , Connolly J , Deneris E , Duvoisin R , Hartley M , Hermans-Borgmeyer I , Hollmann M , O'Shea-Greenfield A , Papke RL , Rogers SW , Patrick J
Ref : Clinical Neuropharmacology , 14 Suppl 1 :S45 , 1991
PubMedID: 1913709

Title : Brain nicotinic receptor genes -
Author(s) : Heinemann SF , Boulter J , Connolly J , Deneris E , Duvoisin R , Hartley M , Hermans-Borgmeyer I , Hollmann M , O'Shea-Greenfield A , Papke RL , Rogers SW , Patrick J
Ref : NIDA Res Monogr , 111 :3 , 1991
PubMedID: 1775184

Title : The brain nicotinic acetylcholine receptor gene family -
Author(s) : Heinemann S , Boulter J , Deneris E , Conolly J , Duvoisin R , Papke RL , Patrick J
Ref : Prog Brain Res , 86 :195 , 1990
PubMedID: 2087557

Title : Single-channel currents of rat neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes - Papke_1989_Neuron_3_589
Author(s) : Papke RL , Boulter J , Patrick J , Heinemann S
Ref : Neuron , 3 :589 , 1989
PubMedID: 2484342

Title : Characterization of nicotinic acetylcholine receptor channels of the TE671 human medulloblastoma clonal line - Oswald_1989_Neurosci.Lett_96_207
Author(s) : Oswald RE , Papke RL , Lukas RJ
Ref : Neuroscience Letters , 96 :207 , 1989
PubMedID: 2467233