| Title : CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology - Tecle_2000_Pharm.Acta.Helv_74_141 |
| Author(s) : Tecle H , Schwarz RD , Barrett SD , Callahan MJ , Caprathe BW , Davis RE , Doyle P , Emmerling M , Lauffer DJ , Mirzadegan T , Moreland DW , Lipiniski W , Nelson C , Raby C , Spencer C , Spiegel K , Thomas AJ , Jaen JC |
| Ref : Pharm Acta Helv , 74 :141 , 2000 |
| Abstract : |
| PubMedSearch : Tecle_2000_Pharm.Acta.Helv_74_141 |
| PubMedID: 10812951 |
| Title : Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist - Tecle_1998_J.Med.Chem_41_2524 |
| Author(s) : Tecle H , Barrett SD , Lauffer DJ , Augelli-Szafran C , Brann MR , Callahan MJ , Caprathe BW , Davis RE , Doyle PD , Eubanks D , Lipiniski W , Mirzadegan T , Moos WH , Moreland DW , Nelson CB , Pavia MR , Raby C , Schwarz RD , Spencer CJ , Thomas AJ , Jaen JC |
| Ref : Journal of Medicinal Chemistry , 41 :2524 , 1998 |
| Abstract : |
| PubMedSearch : Tecle_1998_J.Med.Chem_41_2524 |
| PubMedID: 9651157 |
| Title : In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832 - Jaen_1995_Life.Sci_56(11-12)_845 |
| Author(s) : Jaen JC , Barrett S , Brann M , Callahan M , Davis R , Doyle P , Eubanks D , Lauffer DJ , Lauffer L , Lipinski W , Moreland DW , Nelson C , Raby C , Schwarz RD , Spencer CJ , Tecle H |
| Ref : Life Sciences , 56(11-12) :845 , 1995 |
| Abstract : |
| PubMedSearch : Jaen_1995_Life.Sci_56(11-12)_845 |
| PubMedID: 10188784 |
| Title : Poster: Aryleneyne 1-azabicyclo[2.2.1]heptan-3-one oximes: Potent muscarinic agonists - |
| Author(s) : Tecle H , Lauffer DJ , Davis RE , Mirzadegan T , Moreland DW , Schwarz RD , Thomas AJ , Raby C , Jaen JC |
| Ref : Life Sciences , 56(11-12) :1003 , 1995 |
| PubMedID: |
| Title : Synthesis and SAR of bulky 1-azabicyclo[2.2.1]-3-one oximes as muscarinic receptor subtype selective agonists - Tecle_1993_Life.Sci_52(5-6)_505 |
| Author(s) : Tecle H , Lauffer DJ , Mirzadegan T , Moos WH , Moreland DW , Pavia MR , Schwarz RD , Davis RE |
| Ref : Life Sciences , 52 :505 , 1993 |
| Abstract : |
| PubMedSearch : Tecle_1993_Life.Sci_52(5-6)_505 |
| PubMedID: 8382765 |
| Title : Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease - |
| Author(s) : Davis RD , Raby C , Callahan MJ , Lipinski W , Schwarz RD , Dudley DT , Lauffer DJ , Reece P , Jaen JC , Tecle H |
| Ref : Prog Brain Res , 98 :439 , 1993 |
| PubMedID: 8248534 |
| Title : Poster: Molecular modeling studies of the m1 and m2 muscarinic receptors leading to the design of selective m1 agonists - |
| Author(s) : Mirzadegan T , Tecle H , Lauffer DJ , Humblet C |
| Ref : Life Sciences , 52(5-6) :561 , 1993 |
| PubMedID: |