Full name : Jaen Juan C
First name : Juan C
Mail : ChemoCentryx Inc., 850 Maude Ave, Mountain View, CA 94043
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Country : USA
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Comment
| Title : CI-1017, a functionally M1-selective muscarinic agonist: design, synthesis, and preclinical pharmacology - Tecle_2000_Pharm.Acta.Helv_74_141 |
| Author(s) : Tecle H , Schwarz RD , Barrett SD , Callahan MJ , Caprathe BW , Davis RE , Doyle P , Emmerling M , Lauffer DJ , Mirzadegan T , Moreland DW , Lipiniski W , Nelson C , Raby C , Spencer C , Spiegel K , Thomas AJ , Jaen JC |
| Ref : Pharm Acta Helv , 74 :141 , 2000 |
| Abstract : |
| PubMedSearch : Tecle_2000_Pharm.Acta.Helv_74_141 |
| PubMedID: 10812951 |
| Title : Identification and characterization of m1 selective muscarinic receptor antagonists1 - Augelli-Szafran_1999_J.Med.Chem_42_356 |
| Author(s) : Augelli-Szafran CE , Blankley CJ , Jaen JC , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD , Thomas AJ |
| Ref : Journal of Medicinal Chemistry , 42 :356 , 1999 |
| Abstract : |
| PubMedSearch : Augelli-Szafran_1999_J.Med.Chem_42_356 |
| PubMedID: 9986705 |
| Title : Identification and characterization of m4 selective muscarinic antagonists - Augelli-Szafran_1998_Bioorg.Med.Chem.Lett_8_1991 |
| Author(s) : Augelli-Szafran CE , Jaen JC , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD |
| Ref : Bioorganic & Medicinal Chemistry Lett , 8 :1991 , 1998 |
| Abstract : |
| PubMedSearch : Augelli-Szafran_1998_Bioorg.Med.Chem.Lett_8_1991 |
| PubMedID: 9873472 |
| Title : Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist - Tecle_1998_J.Med.Chem_41_2524 |
| Author(s) : Tecle H , Barrett SD , Lauffer DJ , Augelli-Szafran C , Brann MR , Callahan MJ , Caprathe BW , Davis RE , Doyle PD , Eubanks D , Lipiniski W , Mirzadegan T , Moos WH , Moreland DW , Nelson CB , Pavia MR , Raby C , Schwarz RD , Spencer CJ , Thomas AJ , Jaen JC |
| Ref : Journal of Medicinal Chemistry , 41 :2524 , 1998 |
| Abstract : |
| PubMedSearch : Tecle_1998_J.Med.Chem_41_2524 |
| PubMedID: 9651157 |
| Title : Poster: Pharmacological characterization of PD102807: An m4 subtype selective muscarinic antagonist - |
| Author(s) : Schwarz RD , Nelson CB , Augelli-Szafran CE , Penvose-Yi JR , Jaen JC , Wiley J , Frey KA |
| Ref : Life Sciences , 60 :1167 , 1997 |
| PubMedID: |
| Title : Poster: Functional characterisation of PD102807: A novel M4-selective muscarinic antagonist - |
| Author(s) : Gross J , Augelli-Szafran CE , Czeche S , Friebe T , Jaen JC , Penvose-Yi JR , Schwarz RD , Mutschler E , Lambrecht G |
| Ref : Life Sciences , 60 :1168 , 1997 |
| PubMedID: |
| Title : Poster: Identification and characterization of m4 selective muscarinic antagonists - |
| Author(s) : Augelli-Szafran CE , Moreland DW , Nelson CB , Penvose-Yi JR , Schwarz RD , Jaen JC |
| Ref : Life Sciences , 60 :1168 , 1997 |
| PubMedID: |
| Title : Identification of a 3-hydroxylated tacrine metabolite in rat and man: metabolic profiling implications and pharmacology - Pool_1996_J.Med.Chem_39_3014 |
| Author(s) : Pool WF , Woolf TF , Reily MD , Caprathe BW , Emmerling MR , Jaen JC |
| Ref : Journal of Medicinal Chemistry , 39 :3014 , 1996 |
| Abstract : |
| PubMedSearch : Pool_1996_J.Med.Chem_39_3014 |
| PubMedID: 8709135 |
| Title : In vitro and in vivo evaluation of the subtype-selective muscarinic agonist PD 151832 - Jaen_1995_Life.Sci_56(11-12)_845 |
| Author(s) : Jaen JC , Barrett S , Brann M , Callahan M , Davis R , Doyle P , Eubanks D , Lauffer DJ , Lauffer L , Lipinski W , Moreland DW , Nelson C , Raby C , Schwarz RD , Spencer CJ , Tecle H |
| Ref : Life Sciences , 56(11-12) :845 , 1995 |
| Abstract : |
| PubMedSearch : Jaen_1995_Life.Sci_56(11-12)_845 |
| PubMedID: 10188784 |
| Title : Poster: Autoradiographic distinction of high and low affinity muscarinic receptors by the m1-selective ligand PD150714 - |
| Author(s) : Frey KA , Desmond T , Augelli-Szafran CE , Jaen JC , Schwarz RD |
| Ref : Life Sciences , 56(11-12) :1036 , 1995 |
| PubMedID: |
| Title : Mutations of aspartate 103 in the Hm2 receptor and alterations in receptor binding properties of muscarinic agonists - Schwarz_1995_Life.Sci_56(11-12)_923 |
| Author(s) : Schwarz RD , Spencer CJ , Jaen JC , Mirzadegan T , Moreland DW , Tecle H , Thomas AJ |
| Ref : Life Sciences , 56(11-12) :923 , 1995 |
| Abstract : |
| PubMedSearch : Schwarz_1995_Life.Sci_56(11-12)_923 |
| PubMedID: 10188794 |
| Title : Poster: Aryleneyne 1-azabicyclo[2.2.1]heptan-3-one oximes: Potent muscarinic agonists - |
| Author(s) : Tecle H , Lauffer DJ , Davis RE , Mirzadegan T , Moreland DW , Schwarz RD , Thomas AJ , Raby C , Jaen JC |
| Ref : Life Sciences , 56(11-12) :1003 , 1995 |
| PubMedID: |
| Title : Poster: Identification and characterization of m1 selective muscarinic antagonists - |
| Author(s) : Augelli-Szafran CE , Blankley CJ , Jaen JC , Moreland DW , Nelson CB , Penvose JR , Schwarz RD , Thomas AJ |
| Ref : Life Sciences , 56(11-12) :1017 , 1995 |
| PubMedID: |
| Title : Poster: Pharmacological characterization of PD150714: An m1 selective muscarinic antagonist - |
| Author(s) : Nelson CB , Augelli-Szafran CE , Callahan MJ , Christoffersen C , Jaen JC , Meltzer LT , Penvose JR , Schwarz RD , Thomas AJ , Wiley J |
| Ref : Life Sciences , 56(11-12) :1017 , 1995 |
| PubMedID: |
| Title : Characterization of muscarinic agonists in recombinant cell lines - Schwarz_1993_Life.Sci_52(5-6)_465 |
| Author(s) : Schwarz RD , Davis RE , Jaen JC , Spencer CJ , Tecle H , Thomas AJ |
| Ref : Life Sciences , 52 :465 , 1993 |
| Abstract : |
| PubMedSearch : Schwarz_1993_Life.Sci_52(5-6)_465 |
| PubMedID: 8382764 |
| Title : Subtype selective muscarinic agonists: potential therapeutic agents for Alzheimer's disease - |
| Author(s) : Davis RD , Raby C , Callahan MJ , Lipinski W , Schwarz RD , Dudley DT , Lauffer DJ , Reece P , Jaen JC , Tecle H |
| Ref : Prog Brain Res , 98 :439 , 1993 |
| PubMedID: 8248534 |