Full name : Brann Mark R
First name : Mark R
Mail : ACADIA Pharmaceuticals Inc., San Diego, CA
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Country : USA
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| Title : Structural requirements of transmembrane domain 3 for activation by the M1 muscarinic receptor agonists AC-42, AC-260584, clozapine, and N-desmethylclozapine: evidence for three distinct modes of receptor activation - Spalding_2006_Mol.Pharmacol_70_1974 |
| Author(s) : Spalding TA , Ma JN , Ott TR , Friberg M , Bajpai A , Bradley SR , Davis RE , Brann MR , Burstein ES |
| Ref : Molecular Pharmacology , 70 :1974 , 2006 |
| PubMedID: 16959945 |
| Title : Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias - Weiner_2004_Am.J.Pharmacogenomics_4_119 |
| Author(s) : Weiner DM , Goodman MW , Colpitts TM , Feddock MA , Duggento KL , Nash NR , Levey AI , Brann MR |
| Ref : Am J Pharmacogenomics , 4 :119 , 2004 |
| PubMedID: 15059034 |
| Title : The role of M1 muscarinic receptor agonism of N-desmethylclozapine in the unique clinical effects of clozapine - Weiner_2004_Psychopharmacology.(Berl)_177_207 |
| Author(s) : Weiner DM , Meltzer HY , Veinbergs I , Donohue EM , Spalding TA , Smith TT , Mohell N , Harvey SC , Lameh J , Nash N , Vanover KE , Olsson R , Jayathilake K , Lee M , Levey AI , Hacksell U , Burstein ES , Davis RE , Brann MR |
| Ref : Psychopharmacology (Berl) , 177 :207 , 2004 |
| PubMedID: 15258717 |
| Title : Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist - Tecle_1998_J.Med.Chem_41_2524 |
| Author(s) : Tecle H , Barrett SD , Lauffer DJ , Augelli-Szafran C , Brann MR , Callahan MJ , Caprathe BW , Davis RE , Doyle PD , Eubanks D , Lipiniski W , Mirzadegan T , Moos WH , Moreland DW , Nelson CB , Pavia MR , Raby C , Schwarz RD , Spencer CJ , Thomas AJ , Jaen JC |
| Ref : Journal of Medicinal Chemistry , 41 :2524 , 1998 |
| PubMedID: 9651157 |
| Title : The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors - Burstein_1998_Oncogene_17_1617 |
| Author(s) : Burstein ES , Hesterberg DJ , Gutkind JS , Brann MR , Currier EA , Messier TL |
| Ref : Oncogene , 17 :1617 , 1998 |
| PubMedID: 9794239 |
| Title : Constitutive activation of the m5 muscarinic receptor by a series of mutations at the extracellular end of transmembrane 6 - Spalding_1997_Biochemistry_36_10109 |
| Author(s) : Spalding TA , Burstein ES , Wells JW , Brann MR |
| Ref : Biochemistry , 36 :10109 , 1997 |
| PubMedID: 9254607 |
| Title : Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: transduction of proliferative signals - Burstein_1997_J.Neurochem_68_525 |
| Author(s) : Burstein ES , Brauner-Osborne H , Spalding TA , Conklin BR , Brann MR |
| Ref : Journal of Neurochemistry , 68 :525 , 1997 |
| PubMedID: 9003037 |
| Title : Functional partial agonism at cloned human muscarinic acetylcholine receptors - Brauner-Osborne_1996_Eur.J.Pharmacol_313_145 |
| Author(s) : Brauner-Osborne H , Ebert B , Brann MR , Falch E , Krogsgaard-Larsen P |
| Ref : European Journal of Pharmacology , 313 :145 , 1996 |
| PubMedID: 8905341 |
| Title : Poster: Molecular pharmacology of O-alkyl-thao compounds using the five cloned muscarinic acetylcholine receptors - |
| Author(s) : Jorgensen HB , Ebert B , Krogsgaard-Larsen P , Brann MR , Falch E |
| Ref : Life Sciences , 56(11-12) :1007 , 1995 |
| PubMedID: |
| Title : Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors - Brauner-Osborne_1995_J.Med.Chem_38_2188 |
| Author(s) : Brauner-Osborne H , Ebert B , Brann MR , Falch E , Krogsgaard-Larsen P |
| Ref : Journal of Medicinal Chemistry , 38 :2188 , 1995 |
| PubMedID: 7783150 |
| Title : Poster: Pharmacology of a constitutively activated m5 muscarinic receptor - |
| Author(s) : Spalding TA , Burstein ES , Jorgensen HB , Hill-Eubanks D , Brann MR |
| Ref : Life Sciences , 56(11-12) :1021 , 1995 |
| PubMedID: |
| Title : Poster: Structure\/function of muscarinic receptor coupling to G proteins: random-saturation mutagenesis identifies a critical determinant of receptor affinity for G proteins - |
| Author(s) : Burstein ES , Spalding TA , Jorgensen HB , Hill-Eubanks D , Brann MR |
| Ref : Life Sciences , 56(11-12) :1029 , 1995 |
| PubMedID: |
| Title : Muscarinic acetylcholine receptor subtypes: localization and structure\/function - Brann_1993_Prog.Brain.Res_98_121 |
| Author(s) : Brann MR , Ellis J , Jorgensen H , Hill-Eubanks D , Jones SV |
| Ref : Prog Brain Res , 98 :121 , 1993 |
| PubMedID: 8248499 |
| Title : Transforming G protein-coupled receptors transduce potent mitogenic signals in NIH 3T3 cells independent on cAMP inhibition or conventional protein kinase C - Stephens_1993_Oncogene_8_19 |
| Author(s) : Stephens EV , Kalinec G , Brann MR , Gutkind JS |
| Ref : Oncogene , 8 :19 , 1993 |
| PubMedID: 8380916 |
| Title : Studies of the pharmacology, localization, and structure of muscarinic acetylcholine receptors - |
| Author(s) : Brann MR , Jorgensen HB , Burstein ES , Spalding TA , Ellis J , Jones SV , Hill-Eubanks D |
| Ref : Annals of the New York Academy of Sciences , 707 :225 , 1993 |
| PubMedID: 9137555 |
| Title : Poster: Human M1 receptor-transfected RBL cells: A novel test system for the characterization of muscarinic agonists - |
| Author(s) : Mendla KD , Jones SV , Arndts D , Ensinger HA , Brann MR |
| Ref : Life Sciences , 52(5-6) :571 , 1993 |
| PubMedID: |
| Title : Structure\/function relationships of muscarinic acetylcholine receptors - Brann_1993_Life.Sci_52(5-6)_405 |
| Author(s) : Brann MR , Klimkowski VJ , Ellis J |
| Ref : Life Sciences , 52 :405 , 1993 |
| PubMedID: 7680090 |
| Title : Antagonist binding profiles of five cloned human muscarinic receptor subtypes - Dorje_1991_J.Pharmacol.Exp.Ther_256_727 |
| Author(s) : Dorje F , Wess J , Lambrecht G , Tacke R , Mutschler E , Brann MR |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 256 :727 , 1991 |
| PubMedID: 1994002 |
| Title : Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes - Gutkind_1991_Proc.Natl.Acad.Sci.U.S.A_88_4703 |
| Author(s) : Gutkind JS , Novotny EA , Brann MR , Robbins KC |
| Ref : Proc Natl Acad Sci U S A , 88 :4703 , 1991 |
| PubMedID: 1905013 |
| Title : Functional responses of cloned muscarinic receptors expressed in CHO-K1 cells - Jones_1991_Mol.Pharmacol_40_242 |
| Author(s) : Jones SV , Heilman CJ , Brann MR |
| Ref : Molecular Pharmacology , 40 :242 , 1991 |
| PubMedID: 1652053 |
| Title : Selectivity profile of the novel muscarinic antagonist UH-AH 37 determined by the use of cloned receptors and isolated tissue preparations - Wess_1991_Br.J.Pharmacol_102_246 |
| Author(s) : Wess J , Lambrecht G , Mutschler E , Brann MR , Dorje F |
| Ref : British Journal of Pharmacology , 102 :246 , 1991 |
| PubMedID: 2043926 |
| Title : Chimeric m2\/m3 muscarinic receptors: role of carboxyl terminal receptor domains in selectivity of ligand binding and coupling to phosphoinositide hydrolysis - Wess_1990_Mol.Pharmacol_38_872 |
| Author(s) : Wess J , Bonner TI , Brann MR |
| Ref : Molecular Pharmacology , 38 :872 , 1990 |
| PubMedID: 2174507 |
| Title : Inositol trisphosphate mediates cloned muscarinic receptor-activated conductances in transfected mouse fibroblast A9 L cells - Jones_1990_J.Physiol_421_499 |
| Author(s) : Jones SV , Barker JL , Goodman MB , Brann MR |
| Ref : Journal of Physiology , 421 :499 , 1990 |
| PubMedID: 1693402 |
| Title : Identification of a small intracellular region of the muscarinic m3 receptor as a determinant of selective coupling to PI turnover - Wess_1989_FEBS.Lett_258_133 |
| Author(s) : Wess J , Brann MR , Bonner TI |
| Ref : FEBS Letters , 258 :133 , 1989 |
| PubMedID: 2556294 |
| Title : Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells - Buckley_1989_Mol.Pharmacol_35_469 |
| Author(s) : Buckley NJ , Bonner TI , Buckley CM , Brann MR |
| Ref : Molecular Pharmacology , 35 :469 , 1989 |
| PubMedID: 2704370 |
| Title : Poster: Carbachol stimulation causes inhibition of mitogenesis and cell elongation in CHO cells transfected with muscarinrc receptor genes - |
| Author(s) : Conklin BR , Brann MR , Buckley NJ , Bonner TI , Ma AL , Felder CC , Axelrod J |
| Ref : Trends in Pharmacological Sciences , Suppl :117 , 1989 |
| PubMedID: |
| Title : Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes - Bonner_1988_Neuron_1_403 |
| Author(s) : Bonner TI , Young AC , Brann MR , Buckley NJ |
| Ref : Neuron , 1 :403 , 1988 |
| PubMedID: 3272174 |
| Title : The striatum and cerebral cortex express different muscarinic receptor mRNAs - Brann_1988_FEBS.Lett_230_90 |
| Author(s) : Brann MR , Buckley NJ , Bonner TI |
| Ref : FEBS Letters , 230 :90 , 1988 |
| PubMedID: 3350153 |
| Title : Electrophysiological characterization of cloned m1 muscarinic receptors expressed in A9 L cells - Jones_1988_Proc.Natl.Acad.Sci.U.S.A_85_4056 |
| Author(s) : Jones SV , Barker JL , Bonner TI , Buckley NJ , Brann MR |
| Ref : Proc Natl Acad Sci U S A , 85 :4056 , 1988 |
| PubMedID: 2453885 |
| Title : Localization of a family of muscarinic receptor mRNAs in rat brain - Buckley_1988_J.Neurosci_8_4646 |
| Author(s) : Buckley NJ , Bonner TI , Brann MR |
| Ref : Journal of Neuroscience , 8 :4646 , 1988 |
| PubMedID: 3199198 |
| Title : Cloned muscarinic receptor subtypes expressed in A9 L cells differ in their coupling to electrical responses - Jones_1988_Mol.Pharmacol_34_421 |
| Author(s) : Jones SV , Barker JL , Buckley NJ , Bonner TI , Collins RM , Brann MR |
| Ref : Molecular Pharmacology , 34 :421 , 1988 |
| PubMedID: 3173332 |
| Title : Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes for muscarinic receptor subtypes stably expressed in A9 L cells - Conklin_1988_Proc.Natl.Acad.Sci.U.S.A_85_8698 |
| Author(s) : Conklin BR , Brann MR , Buckley NJ , Ma AL , Bonner TI , Axelrod J |
| Ref : Proc Natl Acad Sci U S A , 85 :8698 , 1988 |
| PubMedID: 2847172 |
| Title : Identification of a family of muscarinic acetylcholine receptor genes - Bonner_1987_Science_237_527 |
| Author(s) : Bonner TI , Buckley NJ , Young AC , Brann MR |
| Ref : Science , 237 :527 , 1987 |
| PubMedID: 3037705 |
| Title : Expression of a cloned muscarinic receptor in A9 L cells - Brann_1987_Mol.Pharmacol_32_450 |
| Author(s) : Brann MR , Buckley NJ , Jones SV , Bonner TI |
| Ref : Molecular Pharmacology , 32 :450 , 1987 |
| PubMedID: 2444870 |