Lawrence C

References (2)

Title : Genomic architecture of human neuroanatomical diversity - Toro_2015_Mol.Psychiatry_20_1011
Author(s) : Toro R , Poline JB , Huguet G , Loth E , Frouin V , Banaschewski T , Barker GJ , Bokde A , Buchel C , Carvalho FM , Conrod P , Fauth-Buhler M , Flor H , Gallinat J , Garavan H , Gowland P , Heinz A , Ittermann B , Lawrence C , Lemaitre H , Mann K , Nees F , Paus T , Pausova Z , Rietschel M , Robbins T , Smolka MN , Strohle A , Schumann G , Bourgeron T
Ref : Mol Psychiatry , 20 :1011 , 2015
Abstract : Human brain anatomy is strikingly diverse and highly inheritable: genetic factors may explain up to 80% of its variability. Prior studies have tried to detect genetic variants with a large effect on neuroanatomical diversity, but those currently identified account for <5% of the variance. Here, based on our analyses of neuroimaging and whole-genome genotyping data from 1765 subjects, we show that up to 54% of this heritability is captured by large numbers of single-nucleotide polymorphisms of small-effect spread throughout the genome, especially within genes and close regulatory regions. The genetic bases of neuroanatomical diversity appear to be relatively independent of those of body size (height), but shared with those of verbal intelligence scores. The study of this genomic architecture should help us better understand brain evolution and disease.
ESTHER : Toro_2015_Mol.Psychiatry_20_1011
PubMedSearch : Toro_2015_Mol.Psychiatry_20_1011
PubMedID: 25224261

Title : Diverse lifestyles and strategies of plant pathogenesis encoded in the genomes of eighteen Dothideomycetes fungi - Ohm_2012_PLoS.Pathog_8_e1003037
Author(s) : Ohm RA , Feau N , Henrissat B , Schoch CL , Horwitz BA , Barry KW , Condon BJ , Copeland AC , Dhillon B , Glaser F , Hesse CN , Kosti I , LaButti K , Lindquist EA , Lucas S , Salamov AA , Bradshaw RE , Ciuffetti L , Hamelin RC , Kema GH , Lawrence C , Scott JA , Spatafora JW , Turgeon BG , de Wit PJ , Zhong S , Goodwin SB , Grigoriev IV
Ref : PLoS Pathog , 8 :e1003037 , 2012
Abstract : The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core) genes. Gene order appears to have been rearranged mostly within chromosomal boundaries by multiple inversions, in extant genomes frequently demarcated by adjacent simple repeats. Several Dothideomycetes contain one or more gene-poor, transposable element (TE)-rich putatively dispensable chromosomes of unknown function. The 18 Dothideomycetes offer an extensive catalogue of genes involved in cellulose degradation, proteolysis, secondary metabolism, and cysteine-rich small secreted proteins. Ancestors of the two major orders of plant pathogens in the Dothideomycetes, the Capnodiales and Pleosporales, may have had different modes of pathogenesis, with the former having fewer of these genes than the latter. Many of these genes are enriched in proximity to transposable elements, suggesting faster evolution because of the effects of repeat induced point (RIP) mutations. A syntenic block of genes, including oxidoreductases, is conserved in most Dothideomycetes and upregulated during infection in L. maculans, suggesting a possible function in response to oxidative stress.
ESTHER : Ohm_2012_PLoS.Pathog_8_e1003037
PubMedSearch : Ohm_2012_PLoS.Pathog_8_e1003037
PubMedID: 23236275
Gene_locus related to this paper: mycpj-q30dw8 , sphms-m3db71 , bauco-m2n3p9 , cocsn-m2rnc6 , coch5-m2tnl8 , coch4-n4xap8 , sett2-r0j560 , bauco-m2lw45 , cocsn-m2thl9 , bauco-m2nan7 , sphms-m3asf7 , coch5-m2v1s2 , mycfi-m3am36 , coch4-n4xzy1 , mycfi-m3b3x0 , cocsn-m2sqr3 , cocsn-m2rnk8 , mycp1-n1pnd6 , bauco-m2n7y7 , coch4-n4xdv7 , coch5-m2uds0 , coch5-m2um94 , sett2-r0i8c5 , coch4-n4wlc8 , coch4-n4x9p3 , cocsn-m2rh47 , cocsn-m2qz08 , sett2-r0jqq6 , mycfi-m2yiq2 , sett2-r0imb6 , sphms-m3b727 , coch4-n4x7u3 , cocsn-m2rv02 , cocsn-m2sy95 , coch5-m2ubd5 , mycp1-n1per0 , mycp1-n1pg49 , mycfi-n1q8u1 , mycp1-n1pwj1 , mycp1-n1pcl8 , bauco-m2n330 , cocsn-m2t3d2 , mycfi-m3b223 , sett2-r0kl84 , bauco-m2lu86 , mycfi-m3b1s8 , sett2-r0jts7 , mycfi-m3amn9 , bauco-m2nf03 , mycfi-m3a015 , sphms-n1qgv4 , coch4-n4x2h3 , mycp1-m2y2b1 , sett2-r0jxt9 , mycfi-m2zg05 , sphms-m3cr09 , coch4-n4x7r9 , mycfi-m2yip7 , mycp1-n1pwu7 , cocsn-m2sh75 , cocsn-m2t5z2 , coch5-m2ucf6 , sphms-m3c9s8 , sphms-m3c383 , mycp1-n1ppa8 , sett2-r0k664 , cocsn-m2t3q1 , sett2-r0k4b4 , cocsn-m2t4i1 , bauco-m2lzw1 , coch5-m2th93 , cocsn-m2svm8 , sphms-m3d7h2 , sphms-m3cwc3 , mycfi-m3b329 , bauco-m2n4x9 , cocsn-m2s6q4 , mycfi-m3b7x7 , mycp1-m2yk59 , cocsn-m2s5h5 , bauco-m2nfr9 , bauco-m2myk4 , coch4-n4xf94 , mycfi-m3a252 , sphms-n1qes8 , mycp1-n1pps5 , sett2-r0kdl8 , cocsn-m2qvi9 , sett2-r0kfg6 , bauco-m2n1q0 , cocsn-m2szq4 , sett2-r0j437 , coch4-n4x7j4 , mycfi-m3b4h3 , coch5-m2twk3 , coch5-m2usf2 , sett2-r0kjt7 , mycfi-m2yrk1 , bauco-m2n4g8 , sett2-r0k7y2 , cocsn-m2th03 , sett2-r0iy92 , sett2-r0kbr9 , sett2-r0k997 , coch5-m2sik6 , bauco-m2n0g0 , bauco-m2lkk0 , sett2-r0jzj5 , sphms-m3bs21 , mycfi-m3a3h8 , mycp1-n1pw13 , cocsn-m2r0j6 , mycp1-n1pe19 , coch4-n4x6a4 , mycp1-m2xhl1 , cocsn-m2s7a5 , cocsn-m2sv79 , mycfi-n1qbd7 , mycp1-n1pnh6 , sphms-m3cz62 , sett2-r0knx4 , bauco-m2nlz2 , mycp1-n1psn5 , sett2-r0ksh8 , bauco-m2n3v9 , bauco-m2n9y7 , mycp1-n1puh9 , sett2-r0ip86 , sphms-m3c6j1 , sphms-n1qnq9 , cocsn-m2sqe4 , coch4-n4xzc8 , mycfi-m3ali0 , mycfi-m3a5j4 , mycp1-n1phf7 , bauco-m2myw5 , mycp1-m2y2h4 , mycfi-m3as05 , sphms-m3ccg5 , cocsn-m2rtg8 , sphms-n1qny5 , mycfi-n1q7c3 , mycp1-n1q523 , bauco-m2m190 , psefd-m3awp8 , sphms-n1qfl1 , dotsn-n1q1b1 , sphms-m3dcu2 , bauco-m2m7v7 , psefd-m3bad8 , bauco-m2nft5 , psefd-m3b4x7 , sphms-n1qdh4 , sphms-m3cq38 , bauco-m2mz43 , coch5-m2t2x3 , cocsn-m2sze4 , sphms-n1qfm9 , sett2-r0kjg6 , sett2-r0k5q0 , cocvi-w7ezb7 , sett2-r0jtm1 , cocmi-w6ywa1 , psefd-m3a663 , baupa-m2mxl2 , cocsn-m2t3e8 , coch5-m2ulw5 , coch5-m2urw9 , sett2-r0knn5 , cocca-w6y1v2 , baupa-m2nq79 , sett2-r0i9k2 , coch5-m2uul8 , dotsn-n1q415 , psefd-n1qcy3 , cocsn-m2sl21 , baupa-m2luc8 , dotsn-est1