porgi-DPP

Porphyromonas gingivalis (Bacteroides gingivalis) dipeptidyl peptidase IV

Comment

Other strains: Porphyromonas gingivalis (strain ATCC 33277 \/ DSM 20709 \/ JCM 12257)

Relationship

Family : DPP4N_Peptidase_S9

Block : X

Position in NCBI Life Tree : Porphyromonas gingivalis

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Bacteria N E > FCB group N E > Bacteroidetes\/Chlorobi group N E > Bacteroidetes N E > Bacteroidia N E > Bacteroidales N E > Porphyromonadaceae N E > Porphyromonas N E > Porphyromonas gingivalis N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MKRPVIILLL GIVTMCAMAQ TGDKPVDLKE ITSGMFYARS AGRGIRSMPD GEHYTEMNRE RTAIVRYNYA SGKAVDTLFS VERARECPFK QIQNYEVSST GHHILLFTDM ESIYRHSYRA AVYDYDVRRN LVKPLSEHVG KVMIPTFSPD GRMVAFVRDN NIFIKKFDFD TEVQVTTDGQ INSILNGATD WVYEEEFGVT NLMSWSADNA FLAFVRSDES AVPEYRMPMY EDKIYPEDYT YKYPKAGEKN STVSLHLYNV ADRNTKSVSL PIDADGYIPR IAFTDNADEL AVMTLNRLQN DFKMYYVHPK SLVAKLILQD MNKRYVDSDW IQALKFTAGG GFAYVSEKDG FAHIYLYDNK GVMHRRITSG NWDVTKLYGV DASGTVFYQS AEESPIRRAV YAIDAKGRKT KLSLNVGTND ALFSGNYAYY INTYSSAATP TVVSVFRSKD AKELRTLEDN VALRERLKAY RYNPKEFTII KTQSGLELNA WIVKPIDFDP SRHYPVLMVQ YSGPNSQQVL DRYSFDWEHY LASKGYVVAC VDGRGTGARG EEWRKCTYMQ LGVFESDDQI AAATAIGQLP YVDAARIGIW GWSYGGYTTL MSLCRGNGTF KAGIAVAPVA DWRFYDSVYT ERFMRTPKEN ASGYKMSSAL DVASQLQGNL LIVSGSADDN VHLQNTMLFT EALVQANIPF DMAIYMDKNH SIYGGNTRYH LYIRKAKFLF DNL

References (6)

Title : Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling - Rea_2017_Eur.J.Med.Chem_139_482
Author(s) : Rea D , Van Elzen R , De Winter H , Van Goethem S , Landuyt B , Luyten W , Schoofs L , Van der Veken P , Augustyns K , De Meester I , Fulop V , Lambeir AM
Ref : Eur Journal of Medicinal Chemistry , 139 :482 , 2017
PubMedID: 28826083
Gene_locus related to this paper: porgi-DPP

Title : Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis - Naito_2008_DNA.Res_15_215
Author(s) : Naito M , Hirakawa H , Yamashita A , Ohara N , Shoji M , Yukitake H , Nakayama K , Toh H , Yoshimura F , Kuhara S , Hattori M , Hayashi T
Ref : DNA Research , 15 :215 , 2008
PubMedID: 18524787
Gene_locus related to this paper: porgi-DPP , porgi-q7mub3 , porgi-q7muw6 , porgi-q7mwa7 , porgi-q7mx03

Title : Expression, purification and preliminary crystallographic analysis of dipeptidyl peptidase IV from Porphyromonas gingivalis - Rea_2004_Acta.Crystallogr.D.Biol.Crystallogr_60_1871
Author(s) : Rea D , Lambeir AM , Kumagai Y , De Meester I , Scharpe S , Fulop V
Ref : Acta Crystallographica D Biol Crystallogr , 60 :1871 , 2004
PubMedID: 15388936
Gene_locus related to this paper: porgi-DPP

Title : Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83 - Nelson_2003_J.Bacteriol_185_5591
Author(s) : Nelson KE , Fleischmann RD , DeBoy RT , Paulsen IT , Fouts DE , Eisen JA , Daugherty SC , Dodson RJ , Durkin AS , Gwinn M , Haft DH , Kolonay JF , Nelson WC , Mason T , Tallon L , Gray J , Granger D , Tettelin H , Dong H , Galvin JL , Duncan MJ , Dewhirst FE , Fraser CM
Ref : Journal of Bacteriology , 185 :5591 , 2003
PubMedID: 12949112
Gene_locus related to this paper: 9gamm-q4a538 , porgi-DPP , porgi-q7mtk3 , porgi-q7mu18 , porgi-q7mub3 , porgi-q7muw6 , porgi-q7mvp4 , porgi-q7mwa7 , porgi-q7mx03

Title : Enzymatic properties of dipeptidyl aminopeptidase IV produced by the periodontal pathogen Porphyromonas gingivalis and its participation in virulence - Kumagai_2000_Infect.Immun_68_716
Author(s) : Kumagai Y , Konishi K , Gomi T , Yagishita H , Yajima A , Yoshikawa M
Ref : Infect Immun , 68 :716 , 2000
PubMedID: 10639438
Gene_locus related to this paper: porgi-DPP

Title : Sequence analysis of the Porphyromonas gingivalis dipeptidyl peptidase IV gene - Kiyama_1998_Biochim.Biophys.Acta_1396_39
Author(s) : Kiyama M , Hayakawa M , Shiroza T , Nakamura S , Takeuchi A , Masamoto Y , Abiko Y
Ref : Biochimica & Biophysica Acta , 1396 :39 , 1998
PubMedID: 9524216
Gene_locus related to this paper: porgi-DPP