Title : New neurogenic lipoic-based hybrids as innovative Alzheimer's drugs with sigma-1 agonism and beta-secretase inhibition - Estrada_2016_Future.Med.Chem_8_1191 |
Author(s) : Estrada M , Perez C , Soriano E , Laurini E , Romano M , Pricl S , Morales-Garcia JA , Perez-Castillo A , Rodriguez-Franco MI |
Ref : Future Med Chem , 8 :1191 , 2016 |
Abstract : |
PubMedSearch : Estrada_2016_Future.Med.Chem_8_1191 |
PubMedID: 27402296 |
Title : Novel tacrine-grafted ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic Acid hybrids - Benchekroun_2015_ChemMedChem_10_523 |
Author(s) : Benchekroun M , Bartolini M , Egea J , Romero A , Soriano E , Pudlo M , Luzet V , Andrisano V , Jimeno ML , Lopez MG , Wehle S , Gharbi T , Refouvelet B , de Andres L , Herrera-Arozamena C , Monti B , Bolognesi ML , Rodriguez-Franco MI , Decker M , Marco-Contelles J , Ismaili L |
Ref : ChemMedChem , 10 :523 , 2015 |
Abstract : |
PubMedSearch : Benchekroun_2015_ChemMedChem_10_523 |
PubMedID: 25537267 |
Title : Purine homo-N-nucleoside+coumarin hybrids as pleiotropic agents for the potential treatment of Alzheimer's disease - Kallitsakis_2015_Future.Med.Chem_7_103 |
Author(s) : Kallitsakis MG , Yanez M , Soriano E , Marco-Contelles J , Hadjipavlou-Litina DJ , Litinas KE |
Ref : Future Med Chem , 7 :103 , 2015 |
Abstract : |
PubMedSearch : Kallitsakis_2015_Future.Med.Chem_7_103 |
PubMedID: 25686000 |
Title : Pyranopyrazolotacrines as nonneurotoxic, Abeta-anti-aggregating and neuroprotective agents for Alzheimer's disease - Chioua_2015_Future.Med.Chem_7_845 |
Author(s) : Chioua M , Perez-Pena J , Garcia-Font N , Moraleda I , Iriepa I , Soriano E , Marco-Contelles J , Oset-Gasque MJ |
Ref : Future Med Chem , 7 :845 , 2015 |
Abstract : |
PubMedSearch : Chioua_2015_Future.Med.Chem_7_845 |
PubMedID: 26061104 |
Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J |
Ref : Journal of Medicinal Chemistry , 57 :10455 , 2014 |
Abstract : |
PubMedSearch : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
PubMedID: 25418133 |
Title : Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease - Cherif_2014_Future.Med.Chem_6_1883 |
Author(s) : Cherif O , Allouche F , Chabchoub F , Chioua M , Soriano E , Yanez M , Cacabelos R , Romero A , Lopez MG , Marco-Contelles J |
Ref : Future Med Chem , 6 :1883 , 2014 |
Abstract : |
PubMedSearch : Cherif_2014_Future.Med.Chem_6_1883 |
PubMedID: 25495982 |
Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543 |
Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M |
Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014 |
Abstract : |
PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543 |
PubMedID: 24813882 |
Title : Multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids - Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
Author(s) : Bautista-Aguilera OM , Esteban G , Chioua M , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Soriano E , Samadi A , Unzeta M , Marco-Contelles J |
Ref : Drug Des Devel Ther , 8 :1893 , 2014 |
Abstract : |
PubMedSearch : Bautista-Aguilera_2014_Drug.Des.Devel.Ther_8_1893 |
PubMedID: 25378907 |
Title : Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase\/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease - Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
Author(s) : Bautista-Aguilera OM , Esteban G , Bolea I , Nikolic K , Agbaba D , Moraleda I , Iriepa I , Samadi A , Soriano E , Unzeta M , Marco-Contelles J |
Ref : Eur Journal of Medicinal Chemistry , 75C :82 , 2014 |
Abstract : |
PubMedSearch : Bautista-Aguilera_2014_Eur.J.Med.Chem_75C_82 |
PubMedID: 24530494 |
Title : The Bivalent Ligand Approach as a Tool for Improving the in vitro Anti-Alzheimer Multitarget Profile of Dimebon - Rosini_2013_ChemMedChem_8_1276 |
Author(s) : Rosini M , Simoni E , Bartolini M , Soriano E , Marco-Contelles J , Andrisano V , Monti B , Windisch M , Hutter-Paier B , McClymont DW , Mellor IR , Bolognesi ML |
Ref : ChemMedChem , 8 :1276 , 2013 |
Abstract : |
PubMedSearch : Rosini_2013_ChemMedChem_8_1276 |
PubMedID: 23824986 |
Title : Synthesis, biological assessment and molecular modeling of new dihydroquinoline-3-carboxamides and dihydroquinoline-3-carbohydrazide derivatives as cholinesterase inhibitors, and Ca channel antagonists - Tomassoli_2011_Eur.J.Med.Chem_46_1 |
Author(s) : Tomassoli I , Ismaili L , Pudlo M , de los Rios C , Soriano E , Colmena I , Gandia L , Rivas L , Samadi A , Marco-Contelles J , Refouvelet B |
Ref : Eur Journal of Medicinal Chemistry , 46 :1 , 2011 |
Abstract : |
PubMedSearch : Tomassoli_2011_Eur.J.Med.Chem_46_1 |
PubMedID: 21111515 |
Title : Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles - Samadi_2010_Bioorg.Med.Chem_18_5861 |
Author(s) : Samadi A , Marco-Contelles J , Soriano E , Alvarez-Perez M , Chioua M , Romero A , Gonzalez-Lafuente L , Gandia L , Roda JM , Lopez MG , Villarroya M , Garcia AG , Rios Cde L |
Ref : Bioorganic & Medicinal Chemistry , 18 :5861 , 2010 |
Abstract : |
PubMedSearch : Samadi_2010_Bioorg.Med.Chem_18_5861 |
PubMedID: 20656495 |
Title : Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate - Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
Author(s) : Soriano E , Samadi A , Chioua M , de los Rios C , Marco-Contelles J |
Ref : Bioorganic & Medicinal Chemistry Lett , 20 :2950 , 2010 |
Abstract : |
PubMedSearch : Soriano_2010_Bioorg.Med.Chem.Lett_20_2950 |
PubMedID: 20350807 |
Title : Transcripts encoding a neural membrane CD26 peptidase-like protein are stimulated by synaptic activity - de Lecea_1994_Brain.Res.Mol.Brain.Res_25_286 |
Author(s) : de Lecea L , Soriano E , Criado JR , Steffensen SC , Henriksen SJ , Sutcliffe JG |
Ref : Brain Research Mol Brain Res , 25 :286 , 1994 |
Abstract : |
PubMedSearch : de Lecea_1994_Brain.Res.Mol.Brain.Res_25_286 |
PubMedID: 7808228 |
Gene_locus related to this paper: mouse-DPP6 , ratno-dpp6 |