| Title : Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases - Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| Author(s) : Bautista-Aguilera OM , Hagenow S , Palomino-Antolin A , Farre-Alins V , Ismaili L , Joffrin PL , Jimeno ML , Soukup O , Janockova J , Kalinowsky L , Proschak E , Iriepa I , Moraleda I , Schwed JS , Romero Martinez A , Lopez-Munoz F , Chioua M , Egea J , Ramsay RR , Marco-Contelles J , Stark H |
| Ref : Angew Chem Int Ed Engl , 56 :12765 , 2017 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2017_Angew.Chem.Int.Ed.Engl_56_12765 |
| PubMedID: 28861918 |
| Title : Assessment of Enzyme Inhibition: A Review with Examples from the Development of Monoamine Oxidase and Cholinesterase Inhibitory Drugs - Ramsay_2017_Molecules_22_ |
| Author(s) : Ramsay RR , Tipton KF |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Ramsay_2017_Molecules_22_ |
| PubMedID: 28714881 |
| Title : ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy - Marco-Contelles_2016_Front.Neurosci_10_294 |
| Author(s) : Marco-Contelles J , Unzeta M , Bolea I , Esteban G , Ramsay RR , Romero A , Martinez-Murillo R , Carreiras MC , Ismaili L |
| Ref : Front Neurosci , 10 :294 , 2016 |
| Abstract : |
| PubMedSearch : Marco-Contelles_2016_Front.Neurosci_10_294 |
| PubMedID: 27445665 |
| Title : Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease - Benek_2016_ChemMedChem_11_1264 |
| Author(s) : Benek O , Soukup O , Pasdiorova M , Hroch L , Sepsova V , Jost P , Hrabinova M , Jun D , Kuca K , Zala D , Ramsay RR , Marco-Contelles J , Musilek K |
| Ref : ChemMedChem , 11 :1264 , 2016 |
| Abstract : |
| PubMedSearch : Benek_2016_ChemMedChem_11_1264 |
| PubMedID: 26427608 |
| Title : Multi-Target Directed Donepezil-Like Ligands for Alzheimer's Disease - Unzeta_2016_Front.Neurosci_10_205 |
| Author(s) : Unzeta M , Esteban G , Bolea I , Fogel WA , Ramsay RR , Youdim MB , Tipton KF , Marco-Contelles J |
| Ref : Front Neurosci , 10 :205 , 2016 |
| Abstract : |
| PubMedSearch : Unzeta_2016_Front.Neurosci_10_205 |
| PubMedID: 27252617 |
| Title : Key Targets for Multi-Target Ligands Designed to Combat Neurodegeneration - Ramsay_2016_Front.Neurosci_10_375 |
| Author(s) : Ramsay RR , Majekova M , Medina M , Valoti M |
| Ref : Front Neurosci , 10 :375 , 2016 |
| Abstract : |
| PubMedSearch : Ramsay_2016_Front.Neurosci_10_375 |
| PubMedID: 27597816 |
| Title : One for All? Hitting Multiple Alzheimer's Disease Targets with One Drug - Hughes_2016_Front.Neurosci_10_177 |
| Author(s) : Hughes RE , Nikolic K , Ramsay RR |
| Ref : Front Neurosci , 10 :177 , 2016 |
| Abstract : |
| PubMedSearch : Hughes_2016_Front.Neurosci_10_177 |
| PubMedID: 27199640 |
| Title : Predicting targets of compounds against neurological diseases using cheminformatic methodology - Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| Author(s) : Nikolic K , Mavridis L , Bautista-Aguilera OM , Marco-Contelles J , Stark H , do Carmo Carreiras M , Rossi I , Massarelli P , Agbaba D , Ramsay RR , Mitchell JB |
| Ref : J Comput Aided Mol Des , 29 :183 , 2015 |
| Abstract : |
| PubMedSearch : Nikolic_2015_J.Comput.Aided.Mol.Des_29_183 |
| PubMedID: 25425329 |
| Title : Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease - Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| Author(s) : Esteban G , Allan J , Samadi A , Mattevi A , Unzeta M , Marco-Contelles J , Binda C , Ramsay RR |
| Ref : Biochimica & Biophysica Acta , 1844 :1104 , 2014 |
| Abstract : |
| PubMedSearch : Esteban_2014_Biochim.Biophys.Acta_1844_1104 |
| PubMedID: 24642166 |
| Title : N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2- yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor - Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| Author(s) : Bautista-Aguilera OM , Samadi A , Chioua M , Nikolic K , Filipic S , Agbaba D , Soriano E , de Andres L , Rodriguez-Franco MI , Alcaro S , Ramsay RR , Ortuso F , Yanez M , Marco-Contelles J |
| Ref : Journal of Medicinal Chemistry , 57 :10455 , 2014 |
| Abstract : |
| PubMedSearch : Bautista-Aguilera_2014_J.Med.Chem_57_10455 |
| PubMedID: 25418133 |