Arb2_domain

Relationship

Family: Arb2_domain

Block: X

Parent Family: Arb2

Comment

This domain is found at the C-terminal of Clr3 (Cryptic loci regulator 3) also known as histone deacetylase clr3 (EC:3.5.1.98). Structure analysis reveals that the Arb2 domain has clear homology to alpha/beta-hydrolases but that it is lacking the catalytic triad of these enzymes. Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae was published (Shen et al.) and from Saccharomyces pombe (Job et al.). Functional studies show that the Arb2 domain is necessary for centromeric heterochromatin silencing suggesting a model where the Arb2 domain, through residues N562 and Y563, acts as an anchor that connects the HDAC activity of Clr3 to the SHREC complex. SHREC (Snf2/Hdac Repressive) complex in fission yeast drives transcriptional gene silencing in heterochromatin (Job et al.)

Database

Interpro : IPR019154 Arb2 domain

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF09757 Arb2

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

Structures (2)

Genes Proteins in Arb2_domain family (297)

Fragments of genes in Arb2_domain family (5)

Structures in Arb2_domain family (2)

No substrate

No Inhibitor

References (3)

Title : SHREC Silences Heterochromatin via Distinct Remodeling and Deacetylation Modules - Job_2016_Mol.Cell_62_207
Author(s) : Job G , Brugger C , Xu T , Lowe BR , Pfister Y , Qu C , Shanker S , Banos Sanz JI , Partridge JF , Schalch T
Ref : Mol Cell , 62 :207 , 2016
PubMedID: 27105116
Gene_locus related to this paper: schpo-clr3

Title : Structural and histone binding ability characterization of the ARB2 domain of a histone deacetylase Hda1 from Saccharomyces cerevisiae - Shen_2016_Sci.Rep_6_33905
Author(s) : Shen H , Zhu Y , Wang C , Yan H , Teng M , Li X
Ref : Sci Rep , 6 :33905 , 2016
PubMedID: 27665728
Gene_locus related to this paper: yeast-hda1

Title : Two different Argonaute complexes are required for siRNA generation and heterochromatin assembly in fission yeast - Buker_2007_Nat.Struct.Mol.Biol_14_200
Author(s) : Buker SM , Iida T , Buhler M , Villen J , Gygi SP , Nakayama J , Moazed D
Ref : Nat Struct Mol Biol , 14 :200 , 2007
PubMedID: 17310250