CIB-CCG1-interacting-factor-B
Relationship
Comment
Alpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2020): lysine deacetylase
Database
Interpro : IPR026764 Alpha\/beta hydrolase domain containing protein 14B
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF12695 Abhydrolase_5
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 1IMJ | Crystal Structure Of The Human Ccg1\/TafII250-Interacting Factor B (Cib) | human-CIB |
| 3BDI | Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum at 1.45 A resolution | theac-TACID1.191 |
| Gene_locus | Name | Species |
|---|---|---|
| 9ceta-l8idy3 | Bos mutus. Abhydrolase domain-containing protein 14B | Bos mutus |
| 9cyan-a0yw29 | Lyngbya sp. PCC 8106 putative uncharacterized protein | Lyngbya sp. PCC 8106 |
| ailme-d2hau7 | Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein | Ailuropoda melanoleuca |
| ailme-d2hau8 | Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein | Ailuropoda melanoleuca |
| anoca-g1klm8 | Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein | Anolis carolinensis |
| astmx-w5kk29 | Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein | Astyanax mexicanus |
| bovin-abheb | Bos taurus (Bovine) Abhydrolase domain-containing protein 14B | Bos taurus |
| bovin-f1mr65 | Bos taurus (Bovine) Uncharacterized protein | Bos taurus |
| caebr-A8X6H9 | Caenorhabditis briggsae hypothetical protein cbg08413 | Caenorhabditis briggsae |
| caeel-Y55F3AM.10 | Caenorhabditis elegans hypothetical protein | Caenorhabditis elegans |
| calja-f7i5w3 | Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein | Callithrix jacchus |
| calja-f7ihq6 | Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein | Callithrix jacchus |
| calmi-v9kt48 | Callorhinchus milii (Elephant fish) (Australian ghost shark). Abhydrolase domain-containing protein 14B-like protein | Callorhinchus milii |
| canfa-e2rlz9 | Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein | Canis lupus familiaris |
| canfa-e2rm00 | Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein | Canis lupus familiaris |
| cavpo-h0v0r2 | Cavia porcellus (Guinea pig). Uncharacterized protein | Cavia porcellus |
| cioin-f6qcp0 | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) Uncharacterized protein | Ciona intestinalis |
| cioin-f6x584 | Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) AB hydrolase-1 domain-containing protein | Ciona intestinalis |
| ciosa-h2yha0 | Ciona savignyi (Pacific transparent sea squirt). Uncharacterized protein | Ciona savignyi |
| crigr-g3h894 | Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Abhydrolase domain-containing protein 14B | Cricetulus griseus |
| croad-j3sdx5 | Crotalus adamanteus (Eastern diamondback rattlesnake). Abhydrolase domain-containing protein 14B | Crotalus adamanteus |
| crohd-t1e7g5 | Crotalus horridus (Timber rattlesnake). Abhydrolase domain-containing protein 14B-like protein | Crotalus horridus |
| danre-AAH53212 | Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein | Danio rerio |
| danre-abhea | Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing protein 14A | Danio rerio |
| desro-k9iws2 | Desmodus rotundus (Vampire bat). Putative soluble epoxide hydrolase | Desmodus rotundus |
| ectsi-d8lca9 | Ectocarpus siliculosus (Brown alga) Abhydrolase domain containing 14B | Ectocarpus siliculosus |
| ferac-q41s54 | Ferroplasma acidarmanus Fer1 AlphaBeta_hydrolase superfamily | Ferroplasma acidarmanus Fer1 |
| ferac-q41u03 | Ferroplasma acidarmanus Fer1 hydrolase | Ferroplasma acidarmanus Fer1 |
| fical-u3k2g4 | Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). Uncharacterized protein | Ficedula albicollis |
| gasac-g3n8q7 | Gasterosteus aculeatus (Three-spined stickleback). Uncharacterized protein | Gasterosteus aculeatus |
| gorgo-g3rj06 | Gorilla gorilla gorilla (Lowland gorilla). Uncharacterized protein | Gorilla gorilla gorilla |
| horse-f6wfs9 | Equus caballus (Horse) Uncharacterized protein | Equus caballus |
| horse-f7bk45 | Equus caballus (Horse) Uncharacterized protein | Equus caballus |
| human-ABHD14A | Homo sapiens (Human) Abhydrolase domain-containing protein 14A srsq1913 | Homo sapiens |
| human-CIB |  Homo sapiens (Human) Ccg1\/TafII250-Interacting Factor B CIB MGC15429 Abhydrolase domain-containing protein 14B ABHD14B. lysine deacetylase |
Homo sapiens |
| ictpu-w5ub99 | Ictalurus punctatus (Channel catfish) (Silurus punctatus). Alpha\/beta hydrolase domain-containing protein 14B | Ictalurus punctatus |
| ixosc-b7qcu3 | Ixodes scapularis (Black-legged tick) (Deer tick) Abhydrolase domain-containing protein 14B, putative | Ixodes scapularis |
| latch-h3aik7 | Latimeria chalumnae (West Indian ocean coelacanth). Uncharacterized protein | Latimeria chalumnae |
| lepsm-c1bt01 | Lepeophtheirus salmonis (Salmon louse). Abhydrolase domain-containing protein 14B | Lepeophtheirus salmonis |
| loxaf-g3tn06 | Loxodonta africana (African elephant). Uncharacterized protein | Loxodonta africana |
| macfa-g7nzx2 | Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein | Macaca fascicularis |
| macmu-f7cnr2 | Macaca mulatta (Rhesus macaque) Uncharacterized protein | Macaca mulatta |
| macmu-f7cu68 | Macaca mulatta (Rhesus macaque) Uncharacterized protein | Macaca mulatta |
| monbe-a9vcn6 | Monosiga brevicollis (Choanoflagellate) Predicted protein | Monosiga brevicollis |
| mondo-f7cvq8 | Monodelphis domestica (Gray short-tailed gray opossum) Uncharacterized protein | Monodelphis domestica |
| mondo-f7cvr5 | Monodelphis domestica (Gray short-tailed gray opossum) Uncharacterized protein | Monodelphis domestica |
| mouse-Dorz1 | Mus musculus (Mouse)1110013B16RIK Dorz1 similar to dkfzp564o243 protein ABHD14A | Mus musculus |
| mouse-c1ib | Mus musculus (Mouse) ccg1-interacting factor b | Mus musculus |
| muspf-m1efe2 | Mustela putorius furo (European domestic ferret) (Mustela furo). Abhydrolase domain containing 14B | Mustela putorius furo |
| myods-l5lfh8 | Myotis davidii (David's myotis). Abhydrolase domain-containing protein 14B | Myotis davidii |
| nemve-a7rlg8 | Nematostella vectensis (Starlet sea anemone) Predicted protein | Nematostella vectensis |
| nemve-a7sq73 | Nematostella vectensis (Starlet sea anemone) Predicted protein | Nematostella vectensis |
| nomle-g1r5y6 | Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys). Uncharacterized protein | Nomascus leucogenys |
| oikdi-e4xa91 | Oikopleura dioica (Tunicate) Whole genome shotgun assembly, reference scaffold set, scaffold scaffold_17 | Oikopleura dioica |
| ophha-v8p9v2 | Ophiophagus hannah (King cobra) (Naja hannah). Abhydrolase domain-containing protein 14B | Ophiophagus hannah |
| oreni-i3j848 | Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). Uncharacterized protein | Oreochromis niloticus |
| ornan-f6ybp3 | Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein | Ornithorhynchus anatinus |
| ornan-f7f392 | Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein | Ornithorhynchus anatinus |
| oryla-h2lf11 | Oryzias latipes (Medaka fish) (Japanese ricefish). Uncharacterized protein | Oryzias latipes |
| pantr-k6zb01 | Pan troglodytes (Chimpanzee). Abhydrolase domain containing 14B | Pan troglodytes |
| petma-s4r6c7 | Petromyzon marinus (Sea lamprey). Uncharacterized protein | Petromyzon marinus |
| picto-q6kzp3 | Picrophilus torridus alpha\/beta family hydrolase | Picrophilus torridus |
| picto-q6l0c9 | Picrophilus torridus carboxylesterase (EC 3.1.1.1) | Picrophilus torridus |
| pig-i3laq6 | Sus scrofa (Pig). Uncharacterized protein | Sus scrofa |
| ponab-abheb | Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) CCG1-interacting factor B | Pongo abelii |
| pteal-l5kwh0 | Pteropus alecto (Black flying fox). Abhydrolase domain-containing protein 14B | Pteropus alecto |
| pyrae-PAE2936 | Pyrobaculum aerophilum hypothetical protein pae2936 | Pyrobaculum aerophilum |
| rabit-g1sye0 | Oryctolagus cuniculus (Rabbit). Uncharacterized protein | Oryctolagus cuniculus |
| rat-abhea | Rattus norvegicus (Rat) Abhydrolase domain-containing protein 14A | Rattus norvegicus |
| rat-abheb | Rattus norvegicus (Rat) Abhydrolase domain-containing protein 14B | Rattus norvegicus |
| salsa-b5x8p9 | Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14B | Salmo salar |
| salsa-b9elv0 | Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14B | Salmo salar |
| sarha-g3vyu7 | Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). Uncharacterized protein | Sarcophilus harrisii |
| sheep-w5p985 | Ovis aries (Sheep). Uncharacterized protein | Ovis aries |
| spetr-i3n0r6 | Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus). Uncharacterized protein | Spermophilus tridecemlineatus |
| strmm-t1ilb6 | Strigamia maritima (European centipede) (Geophilus maritimus). Uncharacterized protein | Strigamia maritima |
| sulac-q4j7u5 | Sulfolobus acidocaldarius conserved archaeal protein | Sulfolobus acidocaldarius |
| sulso-SSO2262 | Sulfolobus solfataricus hypothetical protein sso2262 | Sulfolobus solfataricus |
| sulto-ST2099 | Sulfolobus tokodaii putative 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase | Sulfolobus tokodaii |
| takru-h2u5j0 | Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). Uncharacterized protein | Takifugu rubripes |
| tetng-q4rx90 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodo nigroviridis) Chromosome 11 SCAF14979, whole genome shotgun sequence | Tetraodon nigroviridis |
| theac-TACID1.191 | Thermoplasma acidophilum Ta0194 TACID1_191 gene |
Thermoplasma acidophilum |
| theet-q0etk8 | Thermoanaerobacter sp. X514 hydrolase or acyltransferase (alpha\/beta hydrolase superfamily) | Thermoanaerobacter sp. X514 |
| thete-MHPC3 | Thermoanaerobacter tengcongensis Thermoanaerobacter ethanolicus ATCC 33223 MHPC3 | Thermoanaerobacter tengcongensis |
| thevo-TVG1221180 | Thermoplasma volcanium non-heme chloroheme peroxidase | Thermoplasma volcanium |
| thevo-TVG1473494 | Thermoplasma volcanium hypothetical protein tvg1473494 | Thermoplasma volcanium |
| trier-q3hba1 | Trichodesmium erythraeum IMS101 hypothetical protein | Trichodesmium erythraeum IMS101 |
| tupch-l8y5y7 | Tupaia chinensis (Chinese tree shrew). Abhydrolase domain-containing protein 14B | Tupaia chinensis |
| xenla-AAH56661 | Xenopus laevis (African clawed frog) hypothetical protein | Xenopus laevis |
| xentr-f7a4y9 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein | Xenopus tropicalis |
| xentr-q0vfb6 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Putative uncharacterized protein LOC550030 | Xenopus tropicalis |
| xipma-m4aqq9 | Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). Uncharacterized protein | Xiphophorus maculatus |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| anapl-u3iy15 | Anas platyrhynchos (Domestic duck) (Anas boschas). Uncharacterized protein | Anas platyrhynchos |
| felca-m3waw3 | Felis catus (Cat) (Felis silvestris catus). Uncharacterized protein | Felis catus |
| hetga-g5axn4 | Heterocephalus glaber (Naked mole rat). Abhydrolase domain-containing protein 14B | Heterocephalus glaber |
| melga-h9h0m4 | Meleagris gallopavo (Common turkey). Uncharacterized protein | Meleagris gallopavo |
| neovi-u6d0z0 | Neovison vison (American mink) (Mustela vison). Uncharacterized protein | Neovison vison |
| otoga-h0x690 | Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Uncharacterized protein | Otolemur garnettii |
| salsa-b5x680 | Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14A | Salmo salar |
| taegu-h0z7k6 | Taeniopygia guttata (Zebra finch) (Poephila guttata). Uncharacterized protein | Taeniopygia guttata |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Coenzyme-A | [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate | arcfu-est2 human-CES1 human-CIB |
| Paranitrophenylacetate | (4-nitrophenyl) acetate | arath-AT5G62180 9psed-q0mrg5 burgl-EstC 9bace-b3cet1 9bace-b3c9d0.2 emeni-faec 9acto-h1qtl0 strco-SCO2123 human-NOTUM pseae-PA3859 pyrbr-Q9Y7G8 9baci-EstD9 9rhiz-g9i933 malgo-a8puy1 human-CIB 9actn-EstGS1 pig-EST1 human-CES1 human-CES2 |
References (5)
| Title : Identification of sequence determinants for the ABHD14 enzymes - Vaidya_2023_Proteins__ |
| Author(s) : Vaidya K , Rodrigues G , Gupta S , Devarajan A , Yeolekar M , Madhusudhan MS , Kamat SS |
| Ref : Proteins , : , 2023 |
| Abstract : |
| PubMedSearch : Vaidya_2023_Proteins__ |
| PubMedID: 37974539 |
| Gene_locus related to this paper: human-ABHD14A , human-CIB |
| Title : A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals - Rajendran_2022_J.Biol.Chem_298_102128 |
| Author(s) : Rajendran A , Soory A , Khandelwal N , Ratnaparkhi G , Kamat SS |
| Ref : Journal of Biological Chemistry , 298 :102128 , 2022 |
| Abstract : |
| PubMedSearch : Rajendran_2022_J.Biol.Chem_298_102128 |
| PubMedID: 35700823 |
| Gene_locus related to this paper: human-CIB |
| Title : Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme - Rajendran_2020_Biochemistry_59_183 |
| Author(s) : Rajendran A , Vaidya K , Mendoza J , Bridwell-Rabb J , Kamat SS |
| Ref : Biochemistry , 59 :183 , 2020 |
| Abstract : |
| PubMedSearch : Rajendran_2020_Biochemistry_59_183 |
| PubMedID: 31478652 |
| Gene_locus related to this paper: human-CIB |
| Title : The crystal structure of CCG1\/TAF(II)250-interacting factor B (CIB) - Padmanabhan_2004_J.Biol.Chem_279_9615 |
| Author(s) : Padmanabhan B , Kuzuhara T , Adachi N , Horikoshi M |
| Ref : Journal of Biological Chemistry , 279 :9615 , 2004 |
| Abstract : |
| PubMedSearch : Padmanabhan_2004_J.Biol.Chem_279_9615 |
| PubMedID: 14672934 |
| Gene_locus related to this paper: human-CIB |
| Title : Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse - Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| Author(s) : Hoshino J , Aruga J , Ishiguro A , Mikoshiba K |
| Ref : Brain Research Mol Brain Res , 120 :57 , 2003 |
| Abstract : |
| PubMedSearch : Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57 |
| PubMedID: 14667578 |
| Gene_locus related to this paper: human-ABHD14A , mouse-Dorz1 |