CIB-CCG1-interacting-factor-B

Relationship

Family: CIB-CCG1-interacting-factor-B

Block: X

Parent Family: Abhydrolase_6

Comment

Alpha/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). Dorz1 (ABHD14A,ABHEA) was identified and characterized as one of the most significantly down-regulated genes in Zic1-deficient cerebellum (Zic1: zinc finger protein that controls vertebrate neural development) Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum has also been released. ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues (Rajendran et al. 2020): lysine deacetylase

Database

Interpro : IPR026764 Alpha\/beta hydrolase domain containing protein 14B

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF12695 Abhydrolase_5

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
3BDI Crystal structure of predicted CIB-like hydrolase (NP_393672.1) from Thermoplasma acidophilum at 1.45 A resolution theac-TACID1.191
1IMJ Crystal Structure Of The Human Ccg1\/TafII250-Interacting Factor B (Cib) human-CIB

Gene_locus Name Species
9cyan-a0yw29 Lyngbya sp. PCC 8106 putative uncharacterized protein Lyngbya sp. PCC 8106
ailme-d2hau7 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
ailme-d2hau8 Ailuropoda melanoleuca (Giant panda) Putative uncharacterized protein Ailuropoda melanoleuca
bovin-abheb Bos taurus (Bovine) Abhydrolase domain-containing protein 14B Bos taurus
bovin-f1mr65 Bos taurus (Bovine) Uncharacterized protein Bos taurus
caebr-A8X6H9 Caenorhabditis briggsae hypothetical protein cbg08413 Caenorhabditis briggsae
caeel-Y55F3AM.10 Caenorhabditis elegans hypothetical protein Caenorhabditis elegans
calja-f7i5w3 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
calja-f7ihq6 Callithrix jacchus (White-tufted-ear marmoset) Uncharacterized protein Callithrix jacchus
canfa-e2rlz9 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
canfa-e2rm00 Canis lupus familiaris (Dog) (Canis familiaris) Uncharacterized protein Canis lupus familiaris
cioin-f6qcp0 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) Uncharacterized protein Ciona intestinalis
cioin-f6x584 Ciona intestinalis (Transparent sea squirt) (Ascidia intestinalis) AB hydrolase-1 domain-containing protein Ciona intestinalis
danre-AAH53212 Danio rerio (Zebrafish) (Brachydanio rerio) hypothetical protein Danio rerio
danre-abhea Danio rerio (Zebrafish) (Brachydanio rerio) Abhydrolase domain-containing protein 14A Danio rerio
ectsi-d8lca9 Ectocarpus siliculosus (Brown alga) Abhydrolase domain containing 14B Ectocarpus siliculosus
ferac-q41s54 Ferroplasma acidarmanus Fer1 AlphaBeta_hydrolase superfamily Ferroplasma acidarmanus Fer1
ferac-q41u03 Ferroplasma acidarmanus Fer1 hydrolase Ferroplasma acidarmanus Fer1
horse-f6wfs9 Equus caballus (Horse) Uncharacterized protein Equus caballus
horse-f7bk45 Equus caballus (Horse) Uncharacterized protein Equus caballus
human-ABHD14A Homo sapiens (Human) Abhydrolase domain-containing protein 14A srsq1913 Homo sapiens
human-CIB Homo sapiens (Human) Ccg1\/TafII250-Interacting Factor B CIB MGC15429 Abhydrolase domain-containing protein 14B ABHD14B. lysine deacetylase Homo sapiens
ixosc-b7qcu3 Ixodes scapularis (Black-legged tick) (Deer tick) Abhydrolase domain-containing protein 14B, putative Ixodes scapularis
macmu-f7cnr2 Macaca mulatta (Rhesus macaque) Uncharacterized protein Macaca mulatta
macmu-f7cu68 Macaca mulatta (Rhesus macaque) Uncharacterized protein Macaca mulatta
monbe-a9vcn6 Monosiga brevicollis (Choanoflagellate) Predicted protein Monosiga brevicollis
mondo-f7cvq8 Monodelphis domestica (Gray short-tailed gray opossum) Uncharacterized protein Monodelphis domestica
mondo-f7cvr5 Monodelphis domestica (Gray short-tailed gray opossum) Uncharacterized protein Monodelphis domestica
mouse-c1ib Mus musculus (Mouse) ccg1-interacting factor b Mus musculus
mouse-Dorz1 Mus musculus (Mouse)1110013B16RIK Dorz1 similar to dkfzp564o243 protein Mus musculus
nemve-a7rlg8 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
nemve-a7sq73 Nematostella vectensis (Starlet sea anemone) Predicted protein Nematostella vectensis
oikdi-e4xa91 Oikopleura dioica (Tunicate) Whole genome shotgun assembly, reference scaffold set, scaffold scaffold_17 Oikopleura dioica
ornan-f6ybp3 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
ornan-f7f392 Ornithorhynchus anatinus (Duckbill platypus) Uncharacterized protein Ornithorhynchus anatinus
picto-q6kzp3 Picrophilus torridus alpha\/beta family hydrolase Picrophilus torridus
picto-q6l0c9 Picrophilus torridus carboxylesterase (EC 3.1.1.1) Picrophilus torridus
ponab-abheb Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) CCG1-interacting factor B Pongo abelii
pyrae-PAE2936 Pyrobaculum aerophilum hypothetical protein pae2936 Pyrobaculum aerophilum
rat-abhea Rattus norvegicus (Rat) Abhydrolase domain-containing protein 14A Rattus norvegicus
rat-abheb Rattus norvegicus (Rat) Abhydrolase domain-containing protein 14B Rattus norvegicus
salsa-b5x8p9 Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14B Salmo salar
salsa-b9elv0 Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14B Salmo salar
sulac-q4j7u5 Sulfolobus acidocaldarius conserved archaeal protein Sulfolobus acidocaldarius
sulso-SSO2262 Sulfolobus solfataricus hypothetical protein sso2262 Sulfolobus solfataricus
sulto-ST2099 Sulfolobus tokodaii putative 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase Sulfolobus tokodaii
tetng-q4rx90 Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodo nigroviridis) Chromosome 11 SCAF14979, whole genome shotgun sequence Tetraodon nigroviridis
theac-TACID1.191 Thermoplasma acidophilum Ta0194 TACID1_191 gene Thermoplasma acidophilum
theet-q0etk8 Thermoanaerobacter sp. X514 hydrolase or acyltransferase (alpha\/beta hydrolase superfamily) Thermoanaerobacter sp. X514
thete-MHPC3 Thermoanaerobacter tengcongensis Thermoanaerobacter ethanolicus ATCC 33223 MHPC3 Thermoanaerobacter tengcongensis
thevo-TVG1221180 Thermoplasma volcanium non-heme chloroheme peroxidase Thermoplasma volcanium
thevo-TVG1473494 Thermoplasma volcanium hypothetical protein tvg1473494 Thermoplasma volcanium
trier-q3hba1 Trichodesmium erythraeum IMS101 hypothetical protein Trichodesmium erythraeum IMS101
xenla-AAH56661 Xenopus laevis (African clawed frog) hypothetical protein Xenopus laevis
xentr-f7a4y9 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Uncharacterized protein Xenopus tropicalis
xentr-q0vfb6 Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) Putative uncharacterized protein LOC550030 Xenopus tropicalis
pteal-l5kwh0 Pteropus alecto (Black flying fox). Abhydrolase domain-containing protein 14B Pteropus alecto
pantr-k6zb01 Pan troglodytes (Chimpanzee). Abhydrolase domain containing 14B Pan troglodytes
sheep-w5p985 Ovis aries (Sheep). Uncharacterized protein Ovis aries
9ceta-l8idy3 Bos mutus. Abhydrolase domain-containing protein 14B Bos mutus
nomle-g1r5y6 Nomascus leucogenys (Northern white-cheeked gibbon) (Hylobates leucogenys). Uncharacterized protein Nomascus leucogenys
gorgo-g3rj06 Gorilla gorilla gorilla (Lowland gorilla). Uncharacterized protein Gorilla gorilla gorilla
macfa-g7nzx2 Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey). Putative uncharacterized protein Macaca fascicularis
muspf-m1efe2 Mustela putorius furo (European domestic ferret) (Mustela furo). Abhydrolase domain containing 14B Mustela putorius furo
ictpu-w5ub99 Ictalurus punctatus (Channel catfish) (Silurus punctatus). Alpha\/beta hydrolase domain-containing protein 14B Ictalurus punctatus
oryla-h2lf11 Oryzias latipes (Medaka fish) (Japanese ricefish). Uncharacterized protein Oryzias latipes
takru-h2u5j0 Takifugu rubripes (Japanese pufferfish) (Fugu rubripes). Uncharacterized protein Takifugu rubripes
spetr-i3n0r6 Spermophilus tridecemlineatus (Thirteen-lined ground squirrel) (Ictidomys tridecemlineatus). Uncharacterized protein Spermophilus tridecemlineatus
oreni-i3j848 Oreochromis niloticus (Nile tilapia) (Tilapia nilotica). Uncharacterized protein Oreochromis niloticus
sarha-g3vyu7 Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius). Uncharacterized protein Sarcophilus harrisii
anoca-g1klm8 Anolis carolinensis (Green anole) (American chameleon). Uncharacterized protein Anolis carolinensis
xipma-m4aqq9 Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus). Uncharacterized protein Xiphophorus maculatus
latch-h3aik7 Latimeria chalumnae (West Indian ocean coelacanth). Uncharacterized protein Latimeria chalumnae
rabit-g1sye0 Oryctolagus cuniculus (Rabbit). Uncharacterized protein Oryctolagus cuniculus
lepsm-c1bt01 Lepeophtheirus salmonis (Salmon louse). Abhydrolase domain-containing protein 14B Lepeophtheirus salmonis
calmi-v9kt48 Callorhinchus milii (Elephant fish) (Australian ghost shark). Abhydrolase domain-containing protein 14B-like protein Callorhinchus milii
crohd-t1e7g5 Crotalus horridus (Timber rattlesnake). Abhydrolase domain-containing protein 14B-like protein Crotalus horridus
croad-j3sdx5 Crotalus adamanteus (Eastern diamondback rattlesnake). Abhydrolase domain-containing protein 14B Crotalus adamanteus
ophha-v8p9v2 Ophiophagus hannah (King cobra) (Naja hannah). Abhydrolase domain-containing protein 14B Ophiophagus hannah
loxaf-g3tn06 Loxodonta africana (African elephant). Uncharacterized protein Loxodonta africana
crigr-g3h894 Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus). Abhydrolase domain-containing protein 14B Cricetulus griseus
fical-u3k2g4 Ficedula albicollis (Collared flycatcher) (Muscicapa albicollis). Uncharacterized protein Ficedula albicollis
tupch-l8y5y7 Tupaia chinensis (Chinese tree shrew). Abhydrolase domain-containing protein 14B Tupaia chinensis
cavpo-h0v0r2 Cavia porcellus (Guinea pig). Uncharacterized protein Cavia porcellus
desro-k9iws2 Desmodus rotundus (Vampire bat). Putative soluble epoxide hydrolase Desmodus rotundus
strmm-t1ilb6 Strigamia maritima (European centipede) (Geophilus maritimus). Uncharacterized protein Strigamia maritima
myods-l5lfh8 Myotis davidii (David's myotis). Abhydrolase domain-containing protein 14B Myotis davidii
ciosa-h2yha0 Ciona savignyi (Pacific transparent sea squirt). Uncharacterized protein Ciona savignyi
pig-i3laq6 Sus scrofa (Pig). Uncharacterized protein Sus scrofa
gasac-g3n8q7 Gasterosteus aculeatus (Three-spined stickleback). Uncharacterized protein Gasterosteus aculeatus
astmx-w5kk29 Astyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus). Uncharacterized protein Astyanax mexicanus
petma-s4r6c7 Petromyzon marinus (Sea lamprey). Uncharacterized protein Petromyzon marinus

Gene_locus_frgt Name Species
salsa-b5x680 Salmo salar (Atlantic salmon) Abhydrolase domain-containing protein 14A Salmo salar
neovi-u6d0z0 Neovison vison (American mink) (Mustela vison). Uncharacterized protein Neovison vison
felca-m3waw3 Felis catus (Cat) (Felis silvestris catus). Uncharacterized protein Felis catus
hetga-g5axn4 Heterocephalus glaber (Naked mole rat). Abhydrolase domain-containing protein 14B Heterocephalus glaber
anapl-u3iy15 Anas platyrhynchos (Domestic duck) (Anas boschas). Uncharacterized protein Anas platyrhynchos
taegu-h0z7k6 Taeniopygia guttata (Zebra finch) (Poephila guttata). Uncharacterized protein Taeniopygia guttata
otoga-h0x690 Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby). Uncharacterized protein Otolemur garnettii
melga-h9h0m4 Meleagris gallopavo (Common turkey). Uncharacterized protein Meleagris gallopavo

Substrate Chemical Nomenclature Proteins
Paranitrophenylacetate (4-nitrophenyl) acetate arath-AT5G62180    9psed-q0mrg5    burgl-EstC    9bace-b3cet1    9bace-b3c9d0.2    emeni-faec    9acto-h1qtl0    strco-SCO2123    human-NOTUM    pseae-PA3859    pyrbr-Q9Y7G8    9baci-EstD9    9rhiz-g9i933    malgo-a8puy1    human-CIB    9actn-EstGS1
Coenzyme-A [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[[3-oxo-3-(2-sulfanylethylamino)propyl]amino]butyl] hydrogen phosphate arcfu-est2    human-CES1    human-CIB

References (5)

Title : Identification of sequence determinants for the ABHD14 enzymes - Vaidya_2023_Proteins__
Author(s) : Vaidya K , Rodrigues G , Gupta S , Devarajan A , Yeolekar M , Madhusudhan MS , Kamat SS
Ref : Proteins , : , 2023
Abstract :
PubMedSearch : Vaidya_2023_Proteins__
PubMedID: 37974539
Gene_locus related to this paper: human-ABHD14A , human-CIB

Title : A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals - Rajendran_2022_J.Biol.Chem_298_102128
Author(s) : Rajendran A , Soory A , Khandelwal N , Ratnaparkhi G , Kamat SS
Ref : Journal of Biological Chemistry , 298 :102128 , 2022
Abstract :
PubMedSearch : Rajendran_2022_J.Biol.Chem_298_102128
PubMedID: 35700823
Gene_locus related to this paper: human-CIB

Title : Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme - Rajendran_2020_Biochemistry_59_183
Author(s) : Rajendran A , Vaidya K , Mendoza J , Bridwell-Rabb J , Kamat SS
Ref : Biochemistry , 59 :183 , 2020
Abstract :
PubMedSearch : Rajendran_2020_Biochemistry_59_183
PubMedID: 31478652
Gene_locus related to this paper: human-CIB

Title : The crystal structure of CCG1\/TAF(II)250-interacting factor B (CIB) - Padmanabhan_2004_J.Biol.Chem_279_9615
Author(s) : Padmanabhan B , Kuzuhara T , Adachi N , Horikoshi M
Ref : Journal of Biological Chemistry , 279 :9615 , 2004
Abstract :
PubMedSearch : Padmanabhan_2004_J.Biol.Chem_279_9615
PubMedID: 14672934
Gene_locus related to this paper: human-CIB

Title : Dorz1, a novel gene expressed in differentiating cerebellar granule neurons, is down-regulated in Zic1-deficient mouse - Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57
Author(s) : Hoshino J , Aruga J , Ishiguro A , Mikoshiba K
Ref : Brain Research Mol Brain Res , 120 :57 , 2003
Abstract :
PubMedSearch : Hoshino_2003_Brain.Res.Mol.Brain.Res_120_57
PubMedID: 14667578
Gene_locus related to this paper: human-ABHD14A , mouse-Dorz1