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human-CIB

Homo sapiens (Human) Ccg1/TafII250-Interacting Factor B CIB MGC15429 Abhydrolase domain-containing protein 14B ABHD14B. lysine deacetylase

Comment

Alpha\/beta hydrolase domain-containing protein 14B. The general transcription initiation factor TFIID and its interactors play critical roles in regulating the transcription. TFIID interactor CCG1\/TAF(II)250-interacting factor B (CIB) activates transcription and has hydrolase activity towards p-nitrophenyl butyrate (in vitro). ABHD14B is able to transfer an acetyl group from a post-translationally acetylated-lysine to coenzyme A (CoA) and yield acetyl-CoA, while re-generating the free amine of protein lysine residues: lysine deacetylase (Rajendran et al. 2019)

Relationship

Family : CIB-CCG1-interacting-factor-B

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No inhibitor

Database

Sequence

Peptide

MAASVEQREG TIQVQGQALF FREALPGSGQ ARFSVLLLHG IRFSSETWQN LGTLHRLAQA GYRAVAIDLP GLGHSKEAAA PAPIGELAPG SFLAAVVDAL ELGPPVVISP SLSGMYSLPF LTAPGSQLPG FVPVAPICTD KINAANYASV KTPALIVYGD QDPMGQTSFE HLKQLPNHRV LIMKGAGHPC YLDKPEEWHT GLLDFLQGLQ

References (7)

Title : Identification of sequence determinants for the ABHD14 enzymes - Vaidya_2023_Proteins__
Author(s) : Vaidya K , Rodrigues G , Gupta S , Devarajan A , Yeolekar M , Madhusudhan MS , Kamat SS
Ref : Proteins , : , 2023
PubMedID: 37974539
Gene_locus related to this paper: human-ABHD14A , human-CIB

Title : In-depth Proteomic Signature of Parathyroid Carcinoma - Kong_2023_Eur.J.Endocrinol__
Author(s) : Kong SH , Lee JH , Bae JM , Hong N , Kim H , Park SY , Choi YJ , Lee S , Rhee Y , Kim SW , Han D , Kim JH , Shin CS
Ref : European Journal of Endocrinology , : , 2023
PubMedID: 36995894
Gene_locus related to this paper: human-CIB

Title : A multi-omics analysis reveals that the lysine deacetylase ABHD14B influences glucose metabolism in mammals - Rajendran_2022_J.Biol.Chem_298_102128
Author(s) : Rajendran A , Soory A , Khandelwal N , Ratnaparkhi G , Kamat SS
Ref : Journal of Biological Chemistry , 298 :102128 , 2022
PubMedID: 35700823
Gene_locus related to this paper: human-CIB

Title : Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme - Rajendran_2020_Biochemistry_59_183
Author(s) : Rajendran A , Vaidya K , Mendoza J , Bridwell-Rabb J , Kamat SS
Ref : Biochemistry , 59 :183 , 2020
PubMedID: 31478652
Gene_locus related to this paper: human-CIB

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : The crystal structure of CCG1\/TAF(II)250-interacting factor B (CIB) - Padmanabhan_2004_J.Biol.Chem_279_9615
Author(s) : Padmanabhan B , Kuzuhara T , Adachi N , Horikoshi M
Ref : Journal of Biological Chemistry , 279 :9615 , 2004
PubMedID: 14672934
Gene_locus related to this paper: human-CIB

Title : Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B - Padmanabhan_2000_Acta.Crystallogr.D.Biol.Crystallogr_56_1479
Author(s) : Padmanabhan B , Kuzuhara T , Mizuno H , Horikoshi M
Ref : Acta Crystallographica D Biol Crystallogr , 56 :1479 , 2000
PubMedID: 11053859
Gene_locus related to this paper: human-CIB