Homoserine_transacetylase_like_est
Relationship
Comment
Toelzer et al. showed that MekB (9psed-q0mrg5) from Pseudomonas veronii and CgHle (corgl-CGL0839) from Corynebacteriumglutamicum are esterases that hydrolyse preferentially acetic acid esters. MekB and CgHle cannot bind homoserine and acetyl-CoA. Accordingly a novel esterase subfamily was extracted from the Homoserine_transacetylase family
Database
Interpro : IPR008220 Homoserine\/serine acetyltransferase MetX-like HAT_MetX-like , IPR000073 Alpha\/beta hydrolase fold-1
PIRSF : PIRSF000443 homoserine acetyltransferase
Pdoc : No Pdoc
Pfam : PF00561 Abhydrolase_1
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Structure | Name | Proteins |
|---|---|---|
| 5EFZ | Monoclinic structure of the acetyl esterase MekB | 9psed-q0mrg5 |
| 5E4Y | Orthorhombic structure of the acetyl esterase MekB | 9psed-q0mrg5 |
| 5D6O | Orthorhombic crystal structure of an acetylester hydrolase from Corynebacterium glutamicum | corgl-CGL0839 |
| 5D7B | Trigonal Crystal structure of an acetylester hydrolase from Corynebacterium glutamicum | corgl-CGL0839 |
| Gene_locus | Name | Species |
|---|---|---|
| mycs2-i7gg46 | Mycobacterium smegmatis Homoserine O-acetyltransferase MSMEG_6772 | Mycobacterium smegmatis |
| 9psed-q0mrg5 |  Pseudomonas veronii Homoserine O-acetyltransferase like esterase MekB |
Pseudomonas veronii |
| 9baci-q2bd09 | Bacillus sp. NRRL B-14911 homoserine o-acetyltransferase like | Bacillus sp. NRRL B-14911 |
| brasb-a5et73 | Bradyrhizobium sp. BTAi1 homoserine o-acetyltransferase like | Bradyrhizobium sp. BTAi1 |
| 9burk-q4av60 | Polaromonas sp. JS666 alpha\/beta hydrolase fold | Polaromonas sp. JS666 |
| 9noca-q6rej1 | Rhodococcus sp. DK17 putative homoserine acetyltransferase like | Rhodococcus sp. DK17 |
| aspcl-a1cns2 | Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT3887 \/ NRRL 1) Homoserine acetyltransferase like | Aspergillus clavatus |
| braja-BLL7862 | Bradyrhizobium japonicum bll7862 protein | Bradyrhizobium japonicum |
| corgl-CGL0839 | Corynebacterium glutamicum (Brevibacterium flavum)CgHle CGL0839 homoserine acetyltransferase like esterase |
Corynebacterium glutamicum |
| glovi-GLL2500 | Gloeobacter violaceus proable homoserine o-acetyltransferase like | Gloeobacter violaceus |
| solus-q43s18 | Solibacter usitatus Ellin6076 homoserine o-acetyltransferase like | Solibacter usitatus Ellin6076 |
| strcl-CVM4 | Streptomyces clavuligerus putative deacetylcephalosporin c acetyltransferase like | Streptomyces clavuligerus |
| synjb-q2jhu6 | Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) putative homoserine o-acetyltransferase | Synechococcus sp. |
| synp6-q5mzf3 | Synechococcus sp. (strain PCC 6301) (Anacystis nidulans) (strain PCC 7942) (Anacystis nidulans R2) homoserine o-acetyltransferase like | Synechococcus sp. |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Paranitrophenylacetate | (4-nitrophenyl) acetate | arath-AT5G62180 9psed-q0mrg5 burgl-EstC 9bace-b3cet1 9bace-b3c9d0.2 emeni-faec 9acto-h1qtl0 strco-SCO2123 human-NOTUM pseae-PA3859 pyrbr-Q9Y7G8 9baci-EstD9 9rhiz-g9i933 malgo-a8puy1 human-CIB 9actn-EstGS1 |
| Ethylacetate | ethyl acetate | eleel-ACHE 9psed-q0mrg5 human-CES1 |
| Vinyl-acetate | ethenyl acetate | 9psed-q0mrg5 bovin-balip rabit-1cxes |
References (1)
| Title : A novel esterase subfamily with alpha\/beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases - Tolzer_2016_FEBS.Lett_590_174 |
| Author(s) : Tolzer C , Pal S , Watzlawick H , Altenbuchner J , Niefind K |
| Ref : FEBS Letters , 590 :174 , 2016 |
| Abstract : |
| PubMedSearch : Tolzer_2016_FEBS.Lett_590_174 |
| PubMedID: 26787467 |
| Gene_locus related to this paper: 9psed-q0mrg5 |