Family: Homoserine_transacetylase_like_est

Block: X

Parent Family: Abhydrolase_6


Toelzer et al. showed that MekB (9psed-q0mrg5) from Pseudomonas veronii and CgHle (corgl-CGL0839) from Corynebacteriumglutamicum are esterases that hydrolyse preferentially acetic acid esters. MekB and CgHle cannot bind homoserine and acetyl-CoA. Accordingly a novel esterase subfamily was extracted from the Homoserine_transacetylase family


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour / coloured with Mview
Alignment with MAFFT No colour / coloured with Mview
Dendrogram The dnd file

Structure Name Proteins
5EFZ Monoclinic structure of the acetyl esterase MekB 9psed-q0mrg5
5E4Y Orthorhombic structure of the acetyl esterase MekB 9psed-q0mrg5
5D6O Orthorhombic crystal structure of an acetylester hydrolase from Corynebacterium glutamicum corgl-CGL0839
5D7B Trigonal Crystal structure of an acetylester hydrolase from Corynebacterium glutamicum corgl-CGL0839

Gene_locus Name Species
mycs2-i7gg46 Mycobacterium smegmatis Homoserine O-acetyltransferase MSMEG_6772 Mycobacterium smegmatis
9psed-q0mrg5 Pseudomonas veronii Homoserine O-acetyltransferase like esterase MekB Pseudomonas veronii
9baci-q2bd09 Bacillus sp. NRRL B-14911 homoserine o-acetyltransferase like Bacillus sp. NRRL B-14911
brasb-a5et73 Bradyrhizobium sp. BTAi1 homoserine o-acetyltransferase like Bradyrhizobium sp. BTAi1
9burk-q4av60 Polaromonas sp. JS666 alpha\/beta hydrolase fold Polaromonas sp. JS666
9noca-q6rej1 Rhodococcus sp. DK17 putative homoserine acetyltransferase like Rhodococcus sp. DK17
aspcl-a1cns2 Aspergillus clavatus (strain ATCC 1007 \/ CBS 513.65 \/ DSM 816 \/ NCT3887 \/ NRRL 1) Homoserine acetyltransferase like Aspergillus clavatus
braja-BLL7862 Bradyrhizobium japonicum bll7862 protein Bradyrhizobium japonicum
corgl-CGL0839 Corynebacterium glutamicum (Brevibacterium flavum)CgHle CGL0839 homoserine acetyltransferase like esterase Corynebacterium glutamicum
glovi-GLL2500 Gloeobacter violaceus proable homoserine o-acetyltransferase like Gloeobacter violaceus
solus-q43s18 Solibacter usitatus Ellin6076 homoserine o-acetyltransferase like Solibacter usitatus Ellin6076
strcl-CVM4 Streptomyces clavuligerus putative deacetylcephalosporin c acetyltransferase like Streptomyces clavuligerus
synjb-q2jhu6 Synechococcus sp. (strain JA-2-3B'a(2-13)) (Cyanobacteria bacterium Yellowstone B-Prime) putative homoserine o-acetyltransferase Synechococcus sp.
synp6-q5mzf3 Synechococcus sp. (strain PCC 6301) (Anacystis nidulans) (strain PCC 7942) (Anacystis nidulans R2) homoserine o-acetyltransferase like Synechococcus sp.

Substrate Chemical Nomenclature Proteins
Paranitrophenylacetate (4-nitrophenyl) acetate arath-AT5G62180    9psed-q0mrg5    burgl-EstC    9bace-b3cet1    9bace-b3c9d0.2    emeni-faec    9acto-h1qtl0    strco-SCO2123    human-NOTUM    pseae-PA3859    pyrbr-Q9Y7G8    9baci-EstD9    9rhiz-g9i933    malgo-a8puy1    human-CIB    9actn-EstGS1
Ethylacetate ethyl acetate eleel-ACHE    9psed-q0mrg5    human-CES1
Vinyl-acetate ethenyl acetate 9psed-q0mrg5    bovin-balip    rabit-1cxes

References (1)

Title : A novel esterase subfamily with alpha\/beta-hydrolase fold suggested by structures of two bacterial enzymes homologous to l-homoserine O-acetyl transferases - Tolzer_2016_FEBS.Lett_590_174
Author(s) : Tolzer C , Pal S , Watzlawick H , Altenbuchner J , Niefind K
Ref : FEBS Letters , 590 :174 , 2016
Abstract :
PubMedSearch : Tolzer_2016_FEBS.Lett_590_174
PubMedID: 26787467
Gene_locus related to this paper: 9psed-q0mrg5