LIDHydrolase
Relationship
Comment
Family LIDHydrolase DUF2305 UPF0554 This family of proteins is conserved from plants to humans. The function is unknown. A lipid droplet hydrolase LD-associated hydrolase (LDAH) (C2orf43) with weak in vitro cholesterol hydrolase was described by Goo et al. The name DUF_2305 was replaced by LIDHydrolase
Database
Interpro : IPR019363 Lipid droplet-associated hydrolase DUF2305
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF10230 LIDHydrolase DUF2305
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9alve-c5lgf1 | Perkinsus marinus ATCC 50983 Putative uncharacterized protein | Perkinsus marinus ATCC 50983 |
| 9chlo-c1fhv2 | Micromonas sp. RCC299 Esterase\/lipase | Micromonas sp. RCC299 |
| acypi-c4wsr5 | Acyrthosiphon pisum (Pea aphid) ACYPI006997 protein | Acyrthosiphon pisum |
| aedae-q1hqe6 | Aedes aegypti (Yellowfever mosquito) (Culex aegypti) Uncharacterized conerved protein | Aedes aegypti |
| ajecg-c0ndw0 | Ajellomyces capsulata (Darling's disease fungus) (Histoplasma capsulatum) Putative uncharacterized protein | Ajellomyces capsulata |
| ajedr-c5gxq5 | Ajellomyces dermatitidis (strain ER-3) (strain SLH14081) (Blastomyces dermatitidis) Putative uncharacterized protein | Ajellomyces dermatitidis |
| anoga-q7qa52 | Anopheles gambiae (African malaria mosquito) AGAP004435-PA | Anopheles gambiae |
| arath-T19F11.2 | Arabidopsis thaliana (Mouse-ear cress), Arabidopsis lyrata subsp. lyrata (Lyre-leaved rock-cress) t19f11.2 At3g11620 protein | Arabidopsis thaliana |
| ashgo-q753k6 | Ashbya gossypii (Yeast) (Eremothecium gossypii) AFR306Cp | Ashbya gossypii |
| aspcl-a1cas0 | Aspergillus clavatus Putative uncharacterized protein | Aspergillus clavatus |
| aspfn-b8nfb2 | Aspergillus flavus (strain ATCC 200026 \/ FGSC A1120 \/ NRRL 3357 \/ JC12722 \/ SRRC 167) Putative uncharacterized protein | Aspergillus flavus |
| aspfu-q4wub2 | Aspergillus fumigatus (strain CEA10 \/ CBS 144.89 \/ FGSC A1163 (Sartorya fumigata) Putative uncharacterized protein | Aspergillus fumigatus |
| aspnc-a2qgm6 | Aspergillus niger (strain CBS 513.88 \/ FGSC A1513) Similarity to hypothetical membrane protein YPR147c - Saccharomyces cerevisiae | Aspergillus niger |
| aspor-q2u7v0 | Aspergillus oryzae Predicted protein | Aspergillus oryzae |
| asptn-q0cd92 | Aspergillus terreus (strain NIH 2624 \/ FGSC A1156) Putative uncharacterized protein | Aspergillus terreus |
| brafl-c3yr72 | Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein | Branchiostoma floridae |
| caebr-a8xq21 | Caenorhabditis briggsae Putative uncharacterized protein | Caenorhabditis briggsae |
| caebr-a8y1r7 | Caenorhabditis briggsae Putative uncharacterized protein | Caenorhabditis briggsae |
| caeel-F11C1.4 | Caenorhabditis elegans f11c1.4 protein | Caenorhabditis elegans |
| caeel-F26A3.1 | Caenorhabditis elegans f26a3.1 protein | Caenorhabditis elegans |
| canal-q5a042 | Candida albicans (Yeast) Putative uncharacterized protein | Candida albicans |
| candc-b9wlf0 | Candida dubliniensis (strain CD36 \/ CBS 7987 \/ NCPF 3949 \/ NRRY-17841) (Yeast) Putative uncharacterized protein | Candida dubliniensis |
| canga-q6fku7 | Candida glabrata (Yeast) (Torulopsis glabrata) Similar to uniprot|Q06522 Saccharomyces cerevisiae YPR147c | Candida glabrata |
| cantt-c5m3y5 | Candida tropicalis (strain ATCC MYA-3404 \/ T1) (Yeast) Putative uncharacterized protein | Candida tropicalis |
| chagb-q2gx87 | Chaetomium globosum (Soil fungus) Putative uncharacterized protein | Chaetomium globosum |
| chick-cb043 | Gallus gallus (Chicken) UPF0554 protein C2orf43 LDAH homolog | Gallus gallus |
| chlre-a8j143 | Chlamydomonas reinhardtii Predicted protein | Chlamydomonas reinhardtii |
| clal4-c4xvt8 | Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae) Putative uncharacterized protein | Clavispora lusitaniae |
| copc7-a8n2c2 | Coprinopsis cinerea (strain Okayama-7 \/ 130 \/ FGSC 9003) (Inky ca fungus) (Hormographiella aspergillata) Predicted protein | Coprinopsis cinerea |
| cryne-q560g9 | Cryptococcus neoformans (Filobasidiella neoformans) Putative uncharacterized protein | Cryptococcus neoformans |
| culqu-b0wiv0 | Culex quinquefasciatus (Southern house mosquito) (Culex pungens) Putative uncharacterized protein | Culex quinquefasciatus |
| danre-b3dii8 | Danio rerio (Zebrafish) (Brachydanio rerio) Zgc:195062 | Danio rerio |
| debha-q6bxr7 | Debaryomyces hansenii (Yeast) (Torulaspora hansenii) DEHA2B00792p | Debaryomyces hansenii |
| dicdi-u554 | Dictyostelium discoideum (Slime mold) UPF0554 protein | Dictyostelium discoideum |
| droan-b3m524 | Drosophila ananassae (Fruit fly) GF10065 | Drosophila ananassae |
| droer-b3nb91 | Drosophila erecta (Fruit fly) GG14609 | Drosophila erecta |
| drogr-b4ixh4 | Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi) GH16231 | Drosophila grimshawi |
| drome-CG9186 | Drosophila melanogaster (Fruit fly) cg9186 protein sturkopf | Drosophila melanogaster |
| dromo-b4l0n8 | Drosophila mojavensis (Fruit fly) GI12271 | Drosophila mojavensis |
| drope-b4h5l3 | Drosophila persimilis (Fruit fly) GL16075 | Drosophila persimilis |
| drops-q29ew0 | Drosophila pseudoobscura pseudoobscura (Fruit fly) GA21598 | Drosophila pseudoobscura pseudoobscura |
| drose-b4hvr5 | Drosophila sechellia (Fruit fly) GM14223 | Drosophila sechellia |
| drosi-b4qlz9 | Drosophila simulans (Fruit fly) GD13485 | Drosophila simulans |
| drovi-b4lg72 | Drosophila virilis (Fruit fly) GJ13207 | Drosophila virilis |
| drowi-b4n543 | Drosophila willistoni (Fruit fly) GK20500 | Drosophila willistoni |
| droya-b4pd70 | Drosophila yakuba (Fruit fly) GE20970 | Drosophila yakuba |
| emeni-q5avd3 | Emericella nidulans (Aspergillus nidulans) Putative uncharacterized protein | Emericella nidulans |
| entdi-b0ee33 | Entamoeba dispar SAW760 Putative uncharacterized protein | Entamoeba dispar SAW760 |
| entdi-b0efs6 | Entamoeba dispar SAW760 Putative uncharacterized protein | Entamoeba dispar SAW760 |
| enthi-c4lve4 | Entamoeba histolytica Putative uncharacterized protein | Entamoeba histolytica |
| enthi-c4m3r1 | Entamoeba histolytica Putative uncharacterized protein | Entamoeba histolytica |
| human-LDAH | Homo sapiens (Human) lipid droplet-associated hydrolase (LDAH) C2orf43 | Homo sapiens |
| ixosc-b7qa78 | Ixodes scapularis (Black-legged tick) (Deer tick) Putative uncharacterized protein | Ixodes scapularis |
| lacbs-b0cr66 | Laccaria bicolor (strain S238N-H82) (Bicoloured deceiver) (Laccaria laccata var. bicolor) Predicted protein | Laccaria bicolor |
| lactc-c5dja0 | Lachancea thermotolerans (strain CBS 6340) (Yeast) (Kluyveromyces thermotolerans) KLTH0F14740p | Lachancea thermotolerans |
| leibr-a4hen1 | Leishmania braziliensis Putative uncharacterized protein | Leishmania braziliensis |
| leiin-a4i1v9 | Leishmania infantum, Leishmania donovani, Putative uncharacterized protein | Leishmania infantum |
| leima-q4q9g9 | Leishmania major Putative uncharacterized protein | Leishmania major |
| lodel-a5dsc0 | Lodderomyces elongisporus (Yeast) (Saccharomyces elongisporus) Putative uncharacterized protein | Lodderomyces elongisporus |
| maggr-a4r257 | Magnaporthe grisea (Rice blast fungus) (Pyricularia grisea) Putative uncharacterized protein | Magnaporthe grisea |
| maize-b4fuv1 | Zea mays (Maize) Putative uncharacterized protein | Zea mays |
| malgo-a8pvh8 | Malassezia globosa (strain ATCC 96807 \/ CBS 7966) (Dandruff-associated fungus) Putative uncharacterized protein | Malassezia globosa |
| monbe-a9uy95 | Monosiga brevicollis (Choanoflagellate) Predicted protein | Monosiga brevicollis |
| mouse-Ldah | Mus musculus (Mouse) lipid droplet-associated hydrolase (LDAH) C2orf43 CB043 UPF0554 | Mus musculus |
| nanot-c5fjb6 | Nannizzia otae (strain CBS 113480) (Microsporum canis) (Arthroderma otae) Putative uncharacterized protein | Nannizzia otae |
| nemve-a7rqa8 | Nematostella vectensis (Starlet sea anemone) Predicted protein | Nematostella vectensis |
| nemve-a7sqk0 | Nematostella vectensis (Starlet sea anemone) Predicted protein | Nematostella vectensis |
| neofi-a1df46 | Neosartorya fischeri (strain ATCC 1020 \/ DSM 3700 \/ FGSC A1164 \/ NRR181) (Aspergillus fischerianus) Putative uncharacterized protein | Neosartorya fischeri |
| neucr-q7s070 | Neurospora crassa Predicted protein | Neurospora crassa |
| orysa-B9EWJ8 | Oryza sativa (Rice) (japonica cultivar-group)(subsp. indica) p0401g10.7 protein | Oryza sativa |
| ostlu-a4s8s1 | Ostreococcus lucimarinus (strain CCE9901) Predicted protein | Ostreococcus lucimarinus |
| ostta-q00tt1 | Ostreococcus tauri Homology to unknown gene | Ostreococcus tauri |
| parbd-c1g6a8 | Paracoccidioides brasiliensis (strain Pb18) (strain Pb03) Putative uncharacterized protein | Paracoccidioides brasiliensis |
| pencw-b6hpz6 | Penicillium chrysogenum (strain ATCC 28089 \/ DSM 1075 \/ Wisconsin 54-1255) (Penicillium notatum) Pc22g15600 protein | Penicillium chrysogenum |
| penmq-b6qkg9 | Penicillium marneffei (strain ATCC 18224 \/ CBS 334.59 \/ QM 7333) Putative uncharacterized protein | Penicillium marneffei |
| phano-q0udr2 | Phaeosphaeria nodorum (Glume blotch fungus) (Septoria nodorum) Putative uncharacterized protein | Phaeosphaeria nodorum |
| phano-q0ufs1 | Phaeosphaeria nodorum (Glume blotch fungus) (Septoria nodorum) Putative uncharacterized protein | Phaeosphaeria nodorum |
| phatr-b7frs5 | Phaeodactylum tricornutum (strain CCAP 1055\/1) Predicted protein | Phaeodactylum tricornutum CCAP 1055\/1 |
| phypa-a9s6w1 | Physcomitrella patens subsp. patens Predicted protein | Physcomitrella patens subsp. patens |
| picgu-a5d9u2 | Pichia guilliermondii (Yeast) (Candida guilliermondii) Putative uncharacterized protein | Pichia guilliermondii |
| picpg-c4r7h5 | Pichia pastoris (strain GS115) (Yeast) Putative uncharacterized protein | Pichia pastoris |
| picst-a3lqt4 | Pichia stipitis (Yeast) Predicted protein | Pichia stipitis |
| podan-b2b5e4 | Podospora anserina Predicted CDS Pa_2_4420 | Podospora anserina |
| ponab-cb043 | Pongo abelii (Sumatran orangutan) UPF0554 protein LDAH C2orf43 homolog | Pongo abelii |
| poptr-b9iip0 | Populus trichocarpa (Western balsam poplar) (Populus balsamifera subsp. trichocarpa) Predicted protein | Populus trichocarpa |
| pyrtr-b2vvk1 | Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis) Putative uncharacterized protein | Pyrenophora tritici-repentis |
| rat-Ldah | Rattus norvegicus (Rat) UPF0554 protein LDAH C2orf43 homolog | Rattus norvegicus |
| ricco-b9svy8 | Ricinus communis (Castor bean) Catalytic, putative | Ricinus communis |
| talsn-b8mh07 | Talaromyces stipitatus (strain ATCC 10500 \/ CBS 375.48 \/ QM 6759 \/ NRRL 1006) (Penicillium stipitatum) Putative uncharacterized protein | Talaromyces stipitatus |
| tetng-q4t826 | Tetraodon nigroviridis (Spotted green pufferfish) (Chelonodon nigroviridis) Chromosome undetermined SCAF7912, whole genome shotgun sequence | Tetraodon nigroviridis |
| triad-b3s478 | Trichoplax adhaerens Putative uncharacterized protein | Trichoplax adhaerens |
| tryb2-q57v42 | Trypanosoma brucei Putative uncharacterized protein | Trypanosoma brucei |
| trycr-q4dp03 | Trypanosoma cruzi Putative uncharacterized protein | Trypanosoma cruzi |
| trycr-q4dvl8 | Trypanosoma cruzi Putative uncharacterized protein | Trypanosoma cruzi |
| uncre-c4jn26 | Uncinocarpus reesii (strain UAMH 1704) Predicted protein | Uncinocarpus reesii |
| vanpo-a7tp79 | Vanderwaltozyma polyspora (strain ATCC 22028 \/ DSM 70294) (Kluyveromyces polysporus) Putative uncharacterized protein | Vanderwaltozyma polyspora |
| xentr-q0vfe8 | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) LOC779625 protein | Xenopus tropicalis |
| yarli-q6c1f5 | Yarrowia lipolytica (Candida lipolytica) YALI0F16731p | Yarrowia lipolytica |
| yarli-q6c1f7 | Yarrowia lipolytica (Candida lipolytica) YALI0F16687p | Yarrowia lipolytica |
| yeast-YPR147C | Saccharomyces cerevisiae (Baker's yeast) YPR147cp lipid droplet associated enzyme triacylglycerol lipase and ester hydrolase | Saccharomyces cerevisiae |
| zygrc-c5dvx0 | Zygosaccharomyces rouxii (strain ATCC 2623 \/ CBS 732 \/ IFO 1130 \/ NBR1623 \/ NCYC 568) ZYRO0D10076p | Zygosaccharomyces rouxii |
| wheat-a0a077s5c0 | Triticum aestivum, Chromosome 3B, genomic scaffold, cultivar Chinese Spring \; Uncharacterized protein | Triticum aestivum |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| 9alve-c5lpw8 | Perkinsus marinus ATCC 50983 Putative uncharacterized protein | Perkinsus marinus ATCC 50983 |
| 9pelo-b6vbv8 | Caenorhabditis sp. PS1010 Putative uncharacterized protein | Caenorhabditis sp. PS1010 |
| bovin-q3szr7 | Bos taurus (Bovine) Putative uncharacterized protein C2orf43 LDAH | Bos taurus |
| brafl-c3zsv2 | Branchiostoma floridae (Florida lancelet) (Amphioxus) Putative uncharacterized protein | Branchiostoma floridae |
| camjd-a7h5d3 | Campylobacter jejuni subsp. doylei (strain ATCC BAA-1458 \/ RM4099 269.97) Putative uncharacterized protein | Campylobacter jejuni subsp. doylei |
| drope-b4hdd1 | Drosophila persimilis (Fruit fly) GL20677 | Drosophila persimilis |
| parba-c1ha98 | Paracoccidioides brasiliensis (strain ATCC MYA-826 \/ Pb01) Putative uncharacterized protein | Paracoccidioides brasiliensis |
| ricco-b9svy9 | Ricinus communis (Castor bean) Catalytic, putative | Ricinus communis |
| scls1-a7epn4 | Sclerotinia sclerotiorum (strain ATCC 18683 \/ 1980 \/ Ss-1) (White mold) (Whetzelinia sclerotiorum) Putative uncharacterized protein | Sclerotinia sclerotiorum |
| vitvi-a5b1p7 | Vitis vinifera (Grape) Putative uncharacterized protein | Vitis vinifera |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Cholesteryl-oleate | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate | human-NCEH1 |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| FP-Desthiobiotin | Ethyl (10-(6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanamido)decyl)phosphonofluoridate |
References (4)
| Title : Saccharomyces cerevisiae lipid droplet associated enzyme Ypr147cp shows both TAG lipase and ester hydrolase activities - Manda_2018_J.Gen.Appl.Microbiol_64_76 |
| Author(s) : Manda NK , Thunuguntla VBSC , Bokka CS , Singh BJ |
| Ref : J Gen Appl Microbiol , 64 :76 , 2018 |
| Abstract : |
| PubMedSearch : Manda_2018_J.Gen.Appl.Microbiol_64_76 |
| PubMedID: 29491250 |
| Gene_locus related to this paper: aspnc-a2qgm6 , yeast-YPR147C |
| Title : Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism - Kory_2017_J.Lipid.Res_58_226 |
| Author(s) : Kory N , Grond S , Kamat SS , Li Z , Krahmer N , Chitraju C , Zhou P , Frohlich F , Semova I , Ejsing C , Zechner R , Cravatt BF , Farese RV, Jr. , Walther TC |
| Ref : J Lipid Res , 58 :226 , 2017 |
| Abstract : |
| PubMedSearch : Kory_2017_J.Lipid.Res_58_226 |
| PubMedID: 27836991 |
| Gene_locus related to this paper: human-LDAH , mouse-Ldah |
| Title : Novel lipid droplet-associated serine hydrolase regulates macrophage cholesterol mobilization - Goo_2014_Arterioscler.Thromb.Vasc.Biol_34_386 |
| Author(s) : Goo YH , Son SH , Kreienberg PB , Paul A |
| Ref : Arterioscler Thromb Vasc Biol , 34 :386 , 2014 |
| Abstract : |
| PubMedSearch : Goo_2014_Arterioscler.Thromb.Vasc.Biol_34_386 |
| PubMedID: 24357060 |
| Gene_locus related to this paper: human-LDAH |
| Title : Roles and origins of leukocyte lipid bodies: proteomic and ultrastructural studies - Wan_2007_FASEB.J_21_167 |
| Author(s) : Wan HC , Melo RC , Jin Z , Dvorak AM , Weller PF |
| Ref : FASEB Journal , 21 :167 , 2007 |
| Abstract : |
| PubMedSearch : Wan_2007_FASEB.J_21_167 |
| PubMedID: 17135363 |
| Gene_locus related to this paper: human-LDAH |