Homo sapiens (Human) NCEH1 KIAA1363 AADACL1 neutral cholesterol ester hydrolase 1
Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low levels of chlorpyrifos oxon CPO the activated metabolite of a major insecticide. It is also the primary CPO-hydrolyzing enzyme in spinal cord, kidney ,heart: see mouse-Q8BLF1 and papers by Nomura et al Nomura et al.2005<\/A>, Nomura et al.2008<\/A>
Family : Arylacetamide_deacetylase
Block : H
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EGGLRVVSPFP LCQPAGEPSR GKMRSSCVLL TALVALATYY VYIPLPGSVS DPWKLMLLDA TFRGAQQVSN LIHYLGLSHH LLALNFIIVS FGKKSAWSSA QVKVTDTDFD GVEVRVFEGP PKPEEPLKRS VVYIHGGGWA LASAKIRYYD ELCTAMAEEL NAVIVSIEYR LVPKVYFPEQ IHDVVRATKY FLKPEVLQKY MVDPGRICIS GDSAGGNLAA ALGQQFTQDA SLKNKLKLQA LIYPVLQALD FNTPSYQQNV NTPILPRYVM VKYWVDYFKG NYDFVQAMIV NNHTSLDVEE AAAVRARLNW TSLLPASFTK NYKPVVQTTG NARIVQELPQ LLDARSAPLI ADQAVLQLLP KTYILTCEHD VLRDDGIMYA KRLESAGVEV TLDHFEDGFH GCMIFTSWPT NFSVGIRTRN SYIKWLDQNL
| Title : KIAA1363-A Multifunctional Enzyme in Xenobiotic Detoxification and Lipid Ester Hydrolysis - Wagner_2022_Metabolites_12_516 |
| Author(s) : Wagner C , Hois V , Taschler U , Schupp M , Lass A |
| Ref : Metabolites , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Wagner_2022_Metabolites_12_516 |
| PubMedID: 35736449 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells - Yamazaki_2019_J.Atheroscler.Thromb_26_246 |
| Author(s) : Yamazaki H , Takahashi M , Wakabayashi T , Sakai K , Yamamuro D , Takei A , Takei S , Nagashima S , Yagyu H , Sekiya M , Ebihara K , Ishibashi S |
| Ref : J Atheroscler Thromb , 26 :246 , 2019 |
| Abstract : |
| PubMedSearch : Yamazaki_2019_J.Atheroscler.Thromb_26_246 |
| PubMedID: 30282838 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : NCEH-1 modulates cholesterol metabolism and protects against alpha-synuclein toxicity in a C. elegans model of Parkinson's disease - Zhang_2017_Hum.Mol.Genet_26_3823 |
| Author(s) : Zhang S , Glukhova SA , Caldwell KA , Caldwell GA |
| Ref : Hum Mol Genet , 26 :3823 , 2017 |
| Abstract : |
| PubMedSearch : Zhang_2017_Hum.Mol.Genet_26_3823 |
| PubMedID: 28934392 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting - Fan_2017_Chem.Commun.(Camb)_53_4857 |
| Author(s) : Fan J , Guo S , Wang S , Kang Y , Yao Q , Wang J , Gao X , Wang H , Du J , Peng X |
| Ref : Chem Commun (Camb) , 53 :4857 , 2017 |
| Abstract : |
| PubMedSearch : Fan_2017_Chem.Commun.(Camb)_53_4857 |
| PubMedID: 28421217 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation - El Asmar_2016_J.Biol.Chem_291_5116 |
| Author(s) : El Asmar Z , Terrand J , Jenty M , Host L , Mlih M , Zerr A , Justiniano H , Matz RL , Boudier C , Scholler E , Garnier JM , Bertaccini D , Thierse D , Schaeffer C , Van Dorsselaer A , Herz J , Bruban V , Boucher P |
| Ref : Journal of Biological Chemistry , 291 :5116 , 2016 |
| Abstract : |
| PubMedSearch : El Asmar_2016_J.Biol.Chem_291_5116 |
| PubMedID: 26792864 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue - Cheung_2016_J.Invest.Dermatol_136_640 |
| Author(s) : Cheung L , Fisher RM , Kuzmina N , Li D , Li X , Werngren O , Blomqvist L , Stahle M , Landen NX |
| Ref : Journal of Investigative Dermatology , 136 :640 , 2016 |
| Abstract : |
| PubMedSearch : Cheung_2016_J.Invest.Dermatol_136_640 |
| PubMedID: 27015452 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics - Ross_2016_Arch.Biochem.Biophys_590_72 |
| Author(s) : Ross MK , Pluta K , Bittles V , Borazjani A , Allen Crow J |
| Ref : Archives of Biochemistry & Biophysics , 590 :72 , 2016 |
| Abstract : |
| PubMedSearch : Ross_2016_Arch.Biochem.Biophys_590_72 |
| PubMedID: 26617293 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target - Hunerdosse_2014_ACS.Chem.Biol_9_2905 |
| Author(s) : Hunerdosse DM , Morris PJ , Miyamoto DK , Fisher KJ , Bateman LA , Ghazaleh JR , Zhong S , Nomura DK |
| Ref : ACS Chemical Biology , 9 :2905 , 2014 |
| Abstract : |
| PubMedSearch : Hunerdosse_2014_ACS.Chem.Biol_9_2905 |
| PubMedID: 25343321 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages - Sekiya_2014_J.Lipid.Res_55_2082 |
| Author(s) : Sekiya M , Yamamuro D , Ohshiro T , Honda A , Takahashi M , Kumagai M , Sakai K , Nagashima S , Tomoda H , Igarashi M , Okazaki H , Yagyu H , Osuga J , Ishibashi S |
| Ref : J Lipid Res , 55 :2082 , 2014 |
| Abstract : |
| PubMedSearch : Sekiya_2014_J.Lipid.Res_55_2082 |
| PubMedID: 24891333 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation - Holly_2013_Chem.Biol_20_1125 |
| Author(s) : Holly SP , Chang JW , Li W , Niessen S , Phillips RM , Piatt R , Black JL , Smith MC , Boulaftali Y , Weyrich AS , Bergmeier W , Cravatt BF , Parise LV |
| Ref : Chemical Biology , 20 :1125 , 2013 |
| Abstract : |
| PubMedSearch : Holly_2013_Chem.Biol_20_1125 |
| PubMedID: 23993462 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : An activity-based imaging probe for the integral membrane hydrolase KIAA1363 - |
| Author(s) : Chang JW , Moellering RE , Cravatt BF |
| Ref : Angew Chem Int Ed Engl , 51 :966 , 2012 |
| PubMedID: 22162147 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1\/AADACL1) - Shreder_2012_Bioorg.Med.Chem.Lett_22_5748 |
| Author(s) : Shreder KR , Lin EC , Wu J , Cajica J , Amantea CM , Hu Y , Okerberg E , Brown HE , Pham LM , Chung de M , Fraser AS , McGee E , Rosenblum JS , Kozarich JW |
| Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5748 , 2012 |
| Abstract : |
| PubMedSearch : Shreder_2012_Bioorg.Med.Chem.Lett_22_5748 |
| PubMedID: 22877630 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement - Ohta_2011_Biochem.Biophys.Res.Commun_404_254 |
| Author(s) : Ohta K , Sekiya M , Uozaki H , Igarashi M , Takase S , Kumagai M , Takanashi M , Takeuchi Y , Izumida Y , Kubota M , Nishi M , Okazaki H , Iizuka Y , Yahagi N , Yagyu H , Fukayama M , Kadowaki T , Ohashi K , Ishibashi S , Osuga J |
| Ref : Biochemical & Biophysical Research Communications , 404 :254 , 2011 |
| Abstract : |
| PubMedSearch : Ohta_2011_Biochem.Biophys.Res.Commun_404_254 |
| PubMedID: 21111707 |
| Gene_locus related to this paper: human-LIPE , human-NCEH1 |
| Title : The role of neutral cholesterol ester hydrolysis in macrophage foam cells - Sekiya_2011_J.Atheroscler.Thromb_18_359 |
| Author(s) : Sekiya M , Osuga J , Igarashi M , Okazaki H , Ishibashi S |
| Ref : J Atheroscler Thromb , 18 :359 , 2011 |
| Abstract : |
| PubMedSearch : Sekiya_2011_J.Atheroscler.Thromb_18_359 |
| PubMedID: 21467808 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : A potent and selective inhibitor of KIAA1363\/AADACL1 that impairs prostate cancer pathogenesis - Chang_2011_Chem.Biol_18_476 |
| Author(s) : Chang JW , Nomura DK , Cravatt BF |
| Ref : Chemical Biology , 18 :476 , 2011 |
| Abstract : |
| PubMedSearch : Chang_2011_Chem.Biol_18_476 |
| PubMedID: 21513884 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Cholesteryl ester hydrolase activity is abolished in HSL-\/- macrophages but unchanged in macrophages lacking KIAA1363 - Buchebner_2010_J.Lipid.Res_51_2896 |
| Author(s) : Buchebner M , Pfeifer T , Rathke N , Chandak PG , Lass A , Schreiber R , Kratzer A , Zimmermann R , Sattler W , Koefeler H , Frohlich E , Kostner GM , Birner-Gruenberger R , Chiang KP , Haemmerle G , Zechner R , Levak-Frank S , Cravatt B , Kratky D |
| Ref : J Lipid Res , 51 :2896 , 2010 |
| Abstract : |
| PubMedSearch : Buchebner_2010_J.Lipid.Res_51_2896 |
| PubMedID: 20625037 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis - Sekiya_2009_Cell.Metab_10_219 |
| Author(s) : Sekiya M , Osuga J , Nagashima S , Ohshiro T , Igarashi M , Okazaki H , Takahashi M , Tazoe F , Wada T , Ohta K , Takanashi M , Kumagai M , Nishi M , Takase S , Yahagi N , Yagyu H , Ohashi K , Nagai R , Kadowaki T , Furukawa Y , Ishibashi S |
| Ref : Cell Metab , 10 :219 , 2009 |
| Abstract : |
| PubMedSearch : Sekiya_2009_Cell.Metab_10_219 |
| PubMedID: 19723498 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification - Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| Author(s) : Nomura DK , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE |
| Ref : Toxicol Appl Pharmacol , 228 :42 , 2008 |
| Abstract : |
| PubMedSearch : Nomura_2008_Toxicol.Appl.Pharmacol_228_42 |
| PubMedID: 18164358 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages - Okazaki_2008_J.Biol.Chem_283_33357 |
| Author(s) : Okazaki H , Igarashi M , Nishi M , Sekiya M , Tajima M , Takase S , Takanashi M , Ohta K , Tamura Y , Okazaki S , Yahagi N , Ohashi K , Amemiya-Kudo M , Nakagawa Y , Nagai R , Kadowaki T , Osuga J , Ishibashi S |
| Ref : Journal of Biological Chemistry , 283 :33357 , 2008 |
| Abstract : |
| PubMedSearch : Okazaki_2008_J.Biol.Chem_283_33357 |
| PubMedID: 18782767 |
| Gene_locus related to this paper: human-NCEH1 |
| Title : Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids - Casida_2008_Chem.Biol.Interact_175_355 |
| Author(s) : Casida JE , Nomura DK , Vose SC , Fujioka K |
| Ref : Chemico-Biological Interactions , 175 :355 , 2008 |
| Abstract : |
| PubMedSearch : Casida_2008_Chem.Biol.Interact_175_355 |
| PubMedID: 18495101 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling - Chiang_2006_Chem.Biol_13_1041 |
| Author(s) : Chiang KP , Niessen S , Saghatelian A , Cravatt BF |
| Ref : Chemical Biology , 13 :1041 , 2006 |
| Abstract : |
| PubMedSearch : Chiang_2006_Chem.Biol_13_1041 |
| PubMedID: 17052608 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions - Nomura_2006_Chem.Res.Toxicol_19_1142 |
| Author(s) : Nomura DK , Durkin KA , Chiang KP , Quistad GB , Cravatt BF , Casida JE |
| Ref : Chemical Research in Toxicology , 19 :1142 , 2006 |
| Abstract : |
| PubMedSearch : Nomura_2006_Chem.Res.Toxicol_19_1142 |
| PubMedID: 16978018 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : A brain detoxifying enzyme for organophosphorus nerve poisons - Nomura_2005_Proc.Natl.Acad.Sci.U.S.A_102_6195 |
| Author(s) : Nomura DK , Leung D , Chiang KP , Quistad GB , Cravatt BF , Casida JE |
| Ref : Proc Natl Acad Sci U S A , 102 :6195 , 2005 |
| Abstract : |
| PubMedSearch : Nomura_2005_Proc.Natl.Acad.Sci.U.S.A_102_6195 |
| PubMedID: 15840715 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness - Jessani_2002_Proc.Natl.Acad.Sci.U.S.A_99_10335 |
| Author(s) : Jessani N , Liu Y , Humphrey M , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 99 :10335 , 2002 |
| Abstract : |
| PubMedSearch : Jessani_2002_Proc.Natl.Acad.Sci.U.S.A_99_10335 |
| PubMedID: 12149457 |
| Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1 |
| Title : Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro - Nagase_2000_DNA.Res_7_65 |
| Author(s) : Nagase T , Kikuno R , Ishikawa KI , Hirosawa M , Ohara O |
| Ref : DNA Research , 7 :65 , 2000 |
| Abstract : |
| PubMedSearch : Nagase_2000_DNA.Res_7_65 |
| PubMedID: 10718198 |
| Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NCEH1 , human-NLGN2 |