human-NCEH1

Homo sapiens (Human) NCEH1 KIAA1363 AADACL1 neutral cholesterol ester hydrolase 1

Comment

Serine hydrolase KIAA1363 is highly expressed in invasive cancer cells and is the major protein in mouse brain diethylphosphorylated by and hydrolyzing low levels of chlorpyrifos oxon CPO the activated metabolite of a major insecticide. It is also the primary CPO-hydrolyzing enzyme in spinal cord, kidney ,heart: see mouse-Q8BLF1 and papers by Nomura et al Nomura et al.2005<\/A>, Nomura et al.2008<\/A>

Relationship

Family : Arylacetamide_deacetylase

Block : H

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

Database

Sequence

Peptide

GGLRVVSPFP LCQPAGEPSR GKMRSSCVLL TALVALATYY VYIPLPGSVS DPWKLMLLDA TFRGAQQVSN LIHYLGLSHH LLALNFIIVS FGKKSAWSSA QVKVTDTDFD GVEVRVFEGP PKPEEPLKRS VVYIHGGGWA LASAKIRYYD ELCTAMAEEL NAVIVSIEYR LVPKVYFPEQ IHDVVRATKY FLKPEVLQKY MVDPGRICIS GDSAGGNLAA ALGQQFTQDA SLKNKLKLQA LIYPVLQALD FNTPSYQQNV NTPILPRYVM VKYWVDYFKG NYDFVQAMIV NNHTSLDVEE AAAVRARLNW TSLLPASFTK NYKPVVQTTG NARIVQELPQ LLDARSAPLI ADQAVLQLLP KTYILTCEHD VLRDDGIMYA KRLESAGVEV TLDHFEDGFH GCMIFTSWPT NFSVGIRTRN SYIKWLDQNL

References (25)

Title : KIAA1363-A Multifunctional Enzyme in Xenobiotic Detoxification and Lipid Ester Hydrolysis - Wagner_2022_Metabolites_12_516
Author(s) : Wagner C , Hois V , Taschler U , Schupp M , Lass A
Ref : Metabolites , 12 : , 2022
PubMedID: 35736449
Gene_locus related to this paper: human-NCEH1

Title : Loss of ACAT1 Attenuates Atherosclerosis Aggravated by Loss of NCEH1 in Bone Marrow-Derived Cells - Yamazaki_2019_J.Atheroscler.Thromb_26_246
Author(s) : Yamazaki H , Takahashi M , Wakabayashi T , Sakai K , Yamamuro D , Takei A , Takei S , Nagashima S , Yagyu H , Sekiya M , Ebihara K , Ishibashi S
Ref : J Atheroscler Thromb , 26 :246 , 2019
PubMedID: 30282838
Gene_locus related to this paper: human-NCEH1

Title : Lighting-up breast cancer cells by a near-infrared fluorescent probe based on KIAA1363 enzyme-targeting - Fan_2017_Chem.Commun.(Camb)_53_4857
Author(s) : Fan J , Guo S , Wang S , Kang Y , Yao Q , Wang J , Gao X , Wang H , Du J , Peng X
Ref : Chem Commun (Camb) , 53 :4857 , 2017
PubMedID: 28421217
Gene_locus related to this paper: human-NCEH1

Title : NCEH-1 modulates cholesterol metabolism and protects against alpha-synuclein toxicity in a C. elegans model of Parkinson's disease - Zhang_2017_Hum.Mol.Genet_26_3823
Author(s) : Zhang S , Glukhova SA , Caldwell KA , Caldwell GA
Ref : Hum Mol Genet , 26 :3823 , 2017
PubMedID: 28934392
Gene_locus related to this paper: human-NCEH1

Title : Convergent Signaling Pathways Controlled by LRP1 (Receptor-related Protein 1) Cytoplasmic and Extracellular Domains Limit Cellular Cholesterol Accumulation - El Asmar_2016_J.Biol.Chem_291_5116
Author(s) : El Asmar Z , Terrand J , Jenty M , Host L , Mlih M , Zerr A , Justiniano H , Matz RL , Boudier C , Scholler E , Garnier JM , Bertaccini D , Thierse D , Schaeffer C , Van Dorsselaer A , Herz J , Bruban V , Boucher P
Ref : Journal of Biological Chemistry , 291 :5116 , 2016
PubMedID: 26792864
Gene_locus related to this paper: human-NCEH1

Title : Psoriasis Skin Inflammation-Induced microRNA-26b Targets NCEH1 in Underlying Subcutaneous Adipose Tissue - Cheung_2016_J.Invest.Dermatol_136_640
Author(s) : Cheung L , Fisher RM , Kuzmina N , Li D , Li X , Werngren O , Blomqvist L , Stahle M , Landen NX
Ref : Journal of Investigative Dermatology , 136 :640 , 2016
PubMedID: 27015452
Gene_locus related to this paper: human-NCEH1

Title : Interaction of the serine hydrolase KIAA1363 with organophosphorus agents: Evaluation of potency and kinetics - Ross_2016_Arch.Biochem.Biophys_590_72
Author(s) : Ross MK , Pluta K , Bittles V , Borazjani A , Allen Crow J
Ref : Archives of Biochemistry & Biophysics , 590 :72 , 2016
PubMedID: 26617293
Gene_locus related to this paper: human-NCEH1

Title : Chemical genetics screening reveals KIAA1363 as a cytokine-lowering target - Hunerdosse_2014_ACS.Chem.Biol_9_2905
Author(s) : Hunerdosse DM , Morris PJ , Miyamoto DK , Fisher KJ , Bateman LA , Ghazaleh JR , Zhong S , Nomura DK
Ref : ACS Chemical Biology , 9 :2905 , 2014
PubMedID: 25343321
Gene_locus related to this paper: human-NCEH1

Title : Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages - Sekiya_2014_J.Lipid.Res_55_2082
Author(s) : Sekiya M , Yamamuro D , Ohshiro T , Honda A , Takahashi M , Kumagai M , Sakai K , Nagashima S , Tomoda H , Igarashi M , Okazaki H , Yagyu H , Osuga J , Ishibashi S
Ref : J Lipid Res , 55 :2082 , 2014
PubMedID: 24891333
Gene_locus related to this paper: human-NCEH1

Title : Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation - Holly_2013_Chem.Biol_20_1125
Author(s) : Holly SP , Chang JW , Li W , Niessen S , Phillips RM , Piatt R , Black JL , Smith MC , Boulaftali Y , Weyrich AS , Bergmeier W , Cravatt BF , Parise LV
Ref : Chemical Biology , 20 :1125 , 2013
PubMedID: 23993462
Gene_locus related to this paper: human-NCEH1

Title : An activity-based imaging probe for the integral membrane hydrolase KIAA1363 -
Author(s) : Chang JW , Moellering RE , Cravatt BF
Ref : Angew Chem Int Ed Engl , 51 :966 , 2012
PubMedID: 22162147
Gene_locus related to this paper: human-NCEH1

Title : Synthesis and structure-activity relationship of (1-halo-2-naphthyl) carbamate-based inhibitors of KIAA1363 (NCEH1\/AADACL1) - Shreder_2012_Bioorg.Med.Chem.Lett_22_5748
Author(s) : Shreder KR , Lin EC , Wu J , Cajica J , Amantea CM , Hu Y , Okerberg E , Brown HE , Pham LM , Chung de M , Fraser AS , McGee E , Rosenblum JS , Kozarich JW
Ref : Bioorganic & Medicinal Chemistry Lett , 22 :5748 , 2012
PubMedID: 22877630
Gene_locus related to this paper: human-NCEH1

Title : The role of neutral cholesterol ester hydrolysis in macrophage foam cells - Sekiya_2011_J.Atheroscler.Thromb_18_359
Author(s) : Sekiya M , Osuga J , Igarashi M , Okazaki H , Ishibashi S
Ref : J Atheroscler Thromb , 18 :359 , 2011
PubMedID: 21467808
Gene_locus related to this paper: human-NCEH1

Title : A potent and selective inhibitor of KIAA1363\/AADACL1 that impairs prostate cancer pathogenesis - Chang_2011_Chem.Biol_18_476
Author(s) : Chang JW , Nomura DK , Cravatt BF
Ref : Chemical Biology , 18 :476 , 2011
PubMedID: 21513884
Gene_locus related to this paper: human-NCEH1

Title : Abrogation of neutral cholesterol ester hydrolytic activity causes adrenal enlargement - Ohta_2011_Biochem.Biophys.Res.Commun_404_254
Author(s) : Ohta K , Sekiya M , Uozaki H , Igarashi M , Takase S , Kumagai M , Takanashi M , Takeuchi Y , Izumida Y , Kubota M , Nishi M , Okazaki H , Iizuka Y , Yahagi N , Yagyu H , Fukayama M , Kadowaki T , Ohashi K , Ishibashi S , Osuga J
Ref : Biochemical & Biophysical Research Communications , 404 :254 , 2011
PubMedID: 21111707
Gene_locus related to this paper: human-LIPE , human-NCEH1

Title : Cholesteryl ester hydrolase activity is abolished in HSL-\/- macrophages but unchanged in macrophages lacking KIAA1363 - Buchebner_2010_J.Lipid.Res_51_2896
Author(s) : Buchebner M , Pfeifer T , Rathke N , Chandak PG , Lass A , Schreiber R , Kratzer A , Zimmermann R , Sattler W , Koefeler H , Frohlich E , Kostner GM , Birner-Gruenberger R , Chiang KP , Haemmerle G , Zechner R , Levak-Frank S , Cravatt B , Kratky D
Ref : J Lipid Res , 51 :2896 , 2010
PubMedID: 20625037
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis - Sekiya_2009_Cell.Metab_10_219
Author(s) : Sekiya M , Osuga J , Nagashima S , Ohshiro T , Igarashi M , Okazaki H , Takahashi M , Tazoe F , Wada T , Ohta K , Takanashi M , Kumagai M , Nishi M , Takase S , Yahagi N , Yagyu H , Ohashi K , Nagai R , Kadowaki T , Furukawa Y , Ishibashi S
Ref : Cell Metab , 10 :219 , 2009
PubMedID: 19723498
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Identification of neutral cholesterol ester hydrolase, a key enzyme removing cholesterol from macrophages - Okazaki_2008_J.Biol.Chem_283_33357
Author(s) : Okazaki H , Igarashi M , Nishi M , Sekiya M , Tajima M , Takase S , Takanashi M , Ohta K , Tamura Y , Okazaki S , Yahagi N , Ohashi K , Amemiya-Kudo M , Nakagawa Y , Nagai R , Kadowaki T , Osuga J , Ishibashi S
Ref : Journal of Biological Chemistry , 283 :33357 , 2008
PubMedID: 18782767
Gene_locus related to this paper: human-NCEH1

Title : Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids - Casida_2008_Chem.Biol.Interact_175_355
Author(s) : Casida JE , Nomura DK , Vose SC , Fujioka K
Ref : Chemico-Biological Interactions , 175 :355 , 2008
PubMedID: 18495101
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Dual roles of brain serine hydrolase KIAA1363 in ether lipid metabolism and organophosphate detoxification - Nomura_2008_Toxicol.Appl.Pharmacol_228_42
Author(s) : Nomura DK , Fujioka K , Issa RS , Ward AM , Cravatt BF , Casida JE
Ref : Toxicol Appl Pharmacol , 228 :42 , 2008
PubMedID: 18164358
Gene_locus related to this paper: human-NCEH1

Title : Serine hydrolase KIAA1363: toxicological and structural features with emphasis on organophosphate interactions - Nomura_2006_Chem.Res.Toxicol_19_1142
Author(s) : Nomura DK , Durkin KA , Chiang KP , Quistad GB , Cravatt BF , Casida JE
Ref : Chemical Research in Toxicology , 19 :1142 , 2006
PubMedID: 16978018
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling - Chiang_2006_Chem.Biol_13_1041
Author(s) : Chiang KP , Niessen S , Saghatelian A , Cravatt BF
Ref : Chemical Biology , 13 :1041 , 2006
PubMedID: 17052608
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : A brain detoxifying enzyme for organophosphorus nerve poisons - Nomura_2005_Proc.Natl.Acad.Sci.U.S.A_102_6195
Author(s) : Nomura DK , Leung D , Chiang KP , Quistad GB , Cravatt BF , Casida JE
Ref : Proc Natl Acad Sci U S A , 102 :6195 , 2005
PubMedID: 15840715
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness - Jessani_2002_Proc.Natl.Acad.Sci.U.S.A_99_10335
Author(s) : Jessani N , Liu Y , Humphrey M , Cravatt BF
Ref : Proc Natl Acad Sci U S A , 99 :10335 , 2002
PubMedID: 12149457
Gene_locus related to this paper: human-NCEH1 , mouse-Q8BLF1

Title : Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro - Nagase_2000_DNA.Res_7_65
Author(s) : Nagase T , Kikuno R , Ishikawa KI , Hirosawa M , Ohara O
Ref : DNA Research , 7 :65 , 2000
PubMedID: 10718198
Gene_locus related to this paper: human-FAM135A , human-KANSL3 , human-NCEH1 , human-NLGN2