human-LIPH

Homo sapiens (Human) membrane-bound phosphatidic acid-selective phospholipase a1-alpha, LPD lipase-related protein mPA-PLA1 alpha

Comment

Hypotrichosis, or woolly hair with or without hypotrichosis (deficiency of hair growth), can be caused by homozygous or compound heterozygous mutation in the LIPH (human-LIPH) gene on chromosome 3q27 (LIPH is not hepatic lipase which is human-LIPC). First mutation described by Kazantseva et al

Relationship

Family : Phospholipase

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No inhibitor

Sequence

Peptide

MLRFYLFISL LCLSRSDAEE TCPSFTRLSF HSAVVGTGLN VRLMLYTRKN LTCAQTINSS AFGNLNVTKK TTFIVHGFRP TGSPPVWMDD LVKGLLSVED MNVVVVDWNR GATTLIYTHA SSKTRKVAMV LKEFIDQMLA EGASLDDIYM IGVSLGAHIS GFVGEMYDGW LGRITGLDPA GPLFNGKPHQ DRLDPSDAQF VDVIHSDTDA LGYKEPLGNI DFYPNGGLDQ PGCPKTILGG FQYFKCDHQR SVYLYLSSLR ESCTITAYPC DSYQDYRNGK CVSCGTSQKE SCPLLGYYAD NWKDHLRGKD PPMTKAFFDT AEESPFCMYH YFVDIITWNK NVRRGDITIK LRDKAGNTTE SKINHEPTTF QKYHQVSLLA RFNQDLDKVA AISLMFSTGS LIGPRYKLRI LRMKLRSLAH PERPQLCRYD LVLMENVETV FQPILCPELQ L

References (48)

Title : In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis - Khan_2023_Pharmaceuticals.(Basel)_16_803
Author(s) : Khan HA , Asif MU , Ijaz MK , Alharbi M , Ali Y , Ahmad F , Azhar R , Ahmad S , Irfan M , Javed M , Naseer N , Aziz A
Ref : Pharmaceuticals (Basel) , 16 :803 , 2023
PubMedID: 37375751
Gene_locus related to this paper: human-LIPH

Title : Identification of a novel splice site mutation in the LIPH gene in a Japanese family with autosomal recessive woolly hair -
Author(s) : Asano N , Okita T , Yasuno S , Yamaguchi M , Kashiwagi K , Kanekura T , Shimomura Y
Ref : J Dermatol , 46 :e19 , 2019
PubMedID: 29974973
Gene_locus related to this paper: human-LIPH

Title : Novel sequence variants in the LIPH and LPAR6 genes underlies autosomal recessive woolly hair\/hypotrichosis in consanguineous families - Ahmad_2018_Congenit.Anom.(Kyoto)_58_24
Author(s) : Ahmad F , Sharif S , Furqan Ubaid M , Shah K , Khan MN , Umair M , Azeem Z , Ahmad W
Ref : Congenit Anom (Kyoto) , 58 :24 , 2018
PubMedID: 28425126
Gene_locus related to this paper: human-LIPH

Title : Novel splice site mutation in the LIPH gene in a patient with autosomal recessive woolly hair\/hypotrichosis: Case report and published work review - Mizukami_2018_J.Dermatol_45_613
Author(s) : Mizukami Y , Hayashi R , Tsuruta D , Shimomura Y , Sugawara K
Ref : J Dermatol , 45 :613 , 2018
PubMedID: 29464811
Gene_locus related to this paper: human-LIPH

Title : Mutational analysis of 29 patients with autosomal-recessive woolly hair and hypotrichosis: LIPH mutations are extremely predominant in autosomal-recessive woolly hair and hypotrichosis in Japan -
Author(s) : Takeichi T , Tanahashi K , Taki T , Kono M , Sugiura K , Akiyama M
Ref : Br J Dermatol , 177 :290 , 2017
PubMedID: 27641630
Gene_locus related to this paper: human-LIPH

Title : Novel mutations in the lipase H gene lead to secretion defects of LIPH in Chinese patients with autosomal recessive woolly hair\/hypotrichosis (ARWH\/HT) - Chang_2017_Mutagenesis_32_599
Author(s) : Chang XD , Gu YJ , Dai S , Chen XR , Zhang CL , Zhao HS , Song QH
Ref : Mutagenesis , 32 :599 , 2017
PubMedID: 29346610
Gene_locus related to this paper: human-LIPH

Title : Case of autosomal recessive woolly hair\/hypotrichosis with atopic dermatitis -
Author(s) : Itoh E , Nakahara T , Furumura M , Furue M , Shimomura Y
Ref : J Dermatol , 44 :1185 , 2017
PubMedID: 27774676
Gene_locus related to this paper: human-LIPH

Title : Identification of factors contributing to phenotypic divergence via quantitative image analyses of autosomal recessive woolly hair\/hypotrichosis with homozygous c.736T>A LIPH mutation - Kinoshita-Ise_2017_Br.J.Dermatol_176_138
Author(s) : Kinoshita-Ise M , Kubo A , Sasaki T , Umegaki-Arao N , Amagai M , Ohyama M
Ref : Br J Dermatol , 176 :138 , 2017
PubMedID: 27375176
Gene_locus related to this paper: human-LIPH

Title : Novel splice site mutation in LIPH identified in a Japanese patient with autosomal recessive woolly hair -
Author(s) : Matsuo Y , Tanaka A , Shimomura Y , Hide M
Ref : J Dermatol , 43 :1384 , 2016
PubMedID: 27094727
Gene_locus related to this paper: human-LIPH

Title : Frameshift Sequence Variants in the Human Lipase-H Gene Causing Hypotrichosis - Mehmood_2016_Pediatr.Dermatol_33_e40
Author(s) : Mehmood S , Shah SH , Jan A , Younus M , Ahmad F , Ayub M , Ahmad W
Ref : Pediatr Dermatol , 33 :e40 , 2016
PubMedID: 26645693
Gene_locus related to this paper: human-LIPH

Title : Topical minoxidil improves congenital hypotrichosis caused by LIPH mutations -
Author(s) : Tanahashi K , Sugiura K , Akiyama M
Ref : Br J Dermatol , 173 :865 , 2015
PubMedID: 25819726
Gene_locus related to this paper: human-LIPH

Title : Identification of a novel mutation, c.686delAins18 (p.Asp229Glyfs*22), in the LIPH gene as a compound heterozygote with c.736T>A (p.Cys246Ser) in autosomal recessive woolly hair\/hypotrichosis -
Author(s) : Ito T , Shimomura Y , Hayashi R , Tokura Y
Ref : J Dermatol , 42 :752 , 2015
PubMedID: 25899282
Gene_locus related to this paper: human-LIPH

Title : Mutations in the lipase-H gene causing autosomal recessive hypotrichosis and woolly hair - Mehmood_2015_Australas.J.Dermatol_56_e66
Author(s) : Mehmood S , Jan A , Muhammad D , Ahmad F , Mir H , Younus M , Ali G , Ayub M , Ansar M , Ahmad W
Ref : Australas J Dermatol , 56 :e66 , 2015
PubMedID: 24628704
Gene_locus related to this paper: human-LIPH

Title : Novel mutation in LIPH in a Lebanese patient with autosomal recessive woolly hair\/hypotrichosis -
Author(s) : Sleiman MB , Abbas O , Btadini W , Najjar T , Tofaili M , Chedraoui A , Khalil S , Kibbi AG , Kurban M
Ref : J Dermatol , 42 :822 , 2015
PubMedID: 26046953
Gene_locus related to this paper: human-LIPH

Title : A homozygous mutation, c.736T>A (p.C246S), in LIPH gene in a patient manifesting woolly hair, hypotrichosis, hearing difficulty, cleft palate and amblyopia -
Author(s) : Hamada K , Kubo R , Nishio D , Nakamura M
Ref : Eur J Dermatol , 24 :272 , 2014
PubMedID: 24722066
Gene_locus related to this paper: human-LIPH

Title : Expression studies of a novel splice site mutation in the LIPH gene identified in a Japanese patient with autosomal recessive woolly hair - Hayashi_2014_J.Dermatol_41_890
Author(s) : Hayashi R , Inui S , Farooq M , Ito M , Shimomura Y
Ref : J Dermatol , 41 :890 , 2014
PubMedID: 25271093
Gene_locus related to this paper: human-LIPH

Title : Highly prevalent LIPH founder mutations causing autosomal recessive woolly hair\/hypotrichosis in Japan and the genotype\/phenotype correlations - Tanahashi_2014_PLoS.One_9_e89261
Author(s) : Tanahashi K , Sugiura K , Kono M , Takama H , Hamajima N , Akiyama M
Ref : PLoS ONE , 9 :e89261 , 2014
PubMedID: 24586639
Gene_locus related to this paper: human-LIPH

Title : Lipase member H is a novel secreted protein selectively upregulated in human lung adenocarcinomas and bronchioloalveolar carcinomas - Seki_2014_Biochem.Biophys.Res.Commun_443_1141
Author(s) : Seki Y , Yoshida Y , Ishimine H , Shinozaki-Ushiku A , Ito Y , Sumitomo K , Nakajima J , Fukayama M , Michiue T , Asashima M , Kurisaki A
Ref : Biochemical & Biophysical Research Communications , 443 :1141 , 2014
PubMedID: 24380866
Gene_locus related to this paper: human-LIPH

Title : Prevalent founder mutation c.736T>A of LIPH in autosomal recessive woolly hair of Japanese leads to variable severity of hypotrichosis in adulthood - Tanahashi_2013_J.Eur.Acad.Dermatol.Venereol_27_1182
Author(s) : Tanahashi K , Sugiura K , Takeichi T , Takama H , Shinkuma S , Shimizu H , Akiyama M
Ref : J Eur Acad Dermatol Venereol , 27 :1182 , 2013
PubMedID: 22449147
Gene_locus related to this paper: human-LIPH

Title : A novel mutation, c.699C>G (p.C233W), in the LIPH gene leads to a loss of the hydrolytic activity and the LPA6 activation ability of PA-PLA1alpha in autosomal recessive wooly hair\/hypotrichosis -
Author(s) : Yoshizawa M , Nakamura M , Farooq M , Inoue A , Aoki J , Shimomura Y
Ref : J Dermatol Sci , 72 :61 , 2013
PubMedID: 23768866
Gene_locus related to this paper: human-LIPH

Title : Two cases of autosomal recessive woolly hair with LIPH gene mutations - Harada_2013_Int.J.Dermatol_52_572
Author(s) : Harada K , Inozume T , Kawamura T , Shibagaki N , Kinoshita T , Deguchi N , Shimada S
Ref : Int J Dermatol , 52 :572 , 2013
PubMedID: 23590372
Gene_locus related to this paper: human-LIPH

Title : A case of autosomal recessive woolly hair\/hypotrichosis with alternation in severity: deterioration and improvement with age - Matsuno_2013_Case.Rep.Dermatol_5_363
Author(s) : Matsuno N , Kunisada M , Kanki H , Simomura Y , Nishigori C
Ref : Case Rep Dermatol , 5 :363 , 2013
PubMedID: 24474919
Gene_locus related to this paper: human-LIPH

Title : Mutations in LPAR6\/P2RY5 and LIPH are associated with woolly hair and\/or hypotrichosis - Kurban_2013_J.Eur.Acad.Dermatol.Venereol_27_545
Author(s) : Kurban M , Wajid M , Shimomura Y , Christiano AM
Ref : J Eur Acad Dermatol Venereol , 27 :545 , 2013
PubMedID: 22385360
Gene_locus related to this paper: human-LIPH

Title : A novel mutation in the Lipase H gene underlies autosomal recessive hypotrichosis and woolly hair - Tariq_2012_Sci.Rep_2_730
Author(s) : Tariq M , Azhar A , Baig SM , Dahl N , Klar J
Ref : Sci Rep , 2 :730 , 2012
PubMedID: 23066499
Gene_locus related to this paper: human-LIPH

Title : The beta9 loop domain of PA-PLA1alpha has a crucial role in autosomal recessive woolly hair\/hypotrichosis -
Author(s) : Shinkuma S , Inoue A , Aoki J , Nishie W , Natsuga K , Ujiie H , Nomura T , Abe R , Akiyama M , Shimizu H
Ref : Journal of Investigative Dermatology , 132 :2093 , 2012
PubMedID: 22475755
Gene_locus related to this paper: human-LIPH

Title : A deletion in exon 9 of the LIPH gene is responsible for the rex hair coat phenotype in rabbits (Oryctolagus cuniculus) - Diribarne_2011_PLoS.One_6_e19281
Author(s) : Diribarne M , Mata X , Chantry-Darmon C , Vaiman A , Auvinet G , Bouet S , Deretz S , Cribiu EP , de Rochambeau H , Allain D , Guerin G
Ref : PLoS ONE , 6 :e19281 , 2011
PubMedID: 21552526
Gene_locus related to this paper: rabit-LIPH , human-LIPH

Title : Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis\/woolly hair in 17 consanguineous families from Pakistan - Khan_2011_Clin.Exp.Dermatol_36_652
Author(s) : Khan S , Habib R , Mir H , Umm e K , Naz G , Ayub M , Shafique S , Yamin T , Ali N , Basit S , Wasif N , Kamran-ul-Hassan Naqvi S , Ali G , Wali A , Ansar M , Ahmad W
Ref : Clinical & Experimental Dermatologyatol , 36 :652 , 2011
PubMedID: 21426374
Gene_locus related to this paper: human-LIPH

Title : Identification of 736T>A mutation of lipase H in Japanese siblings with autosomal recessive woolly hair - Yoshimasu_2011_J.Dermatol_38_900
Author(s) : Yoshimasu T , Kanazawa N , Kambe N , Nakamura M , Furukawa F
Ref : J Dermatol , 38 :900 , 2011
PubMedID: 21352330
Gene_locus related to this paper: human-LIPH

Title : Identification of LIPH gene mutation in a consanguineous family segregating the woolly hair\/hypotrichosis phenotype - Shah_2011_J.Pak.Med.Assoc_61_1060
Author(s) : Shah SH , Abid A , Shahid S , Khaliq S
Ref : J Pak Med Assoc , 61 :1060 , 2011
PubMedID: 22125978
Gene_locus related to this paper: human-LIPH

Title : Mutations in lipase H gene underlie autosomal recessive hypotrichosis in five Pakistani families -
Author(s) : Kalsoom UE , Habib R , Khan B , Ali G , Ali N , Ansar M , Ahmad W
Ref : Acta Derm Venereol , 90 :93 , 2010
PubMedID: 20107739
Gene_locus related to this paper: human-LIPH

Title : Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis - Shinkuma_2010_Hum.Mutat_31_602
Author(s) : Shinkuma S , Akiyama M , Inoue A , Aoki J , Natsuga K , Nomura T , Arita K , Abe R , Ito K , Nakamura H , Ujiie H , Shibaki A , Suga H , Tsunemi Y , Nishie W , Shimizu H
Ref : Hum Mutat , 31 :602 , 2010
PubMedID: 20213768
Gene_locus related to this paper: human-LIPH

Title : In vitro analysis of LIPH mutations causing hypotrichosis simplex: evidence confirming the role of lipase H and lysophosphatidic acid in hair growth - Pasternack_2009_J.Invest.Dermatol_129_2772
Author(s) : Pasternack SM , von Kugelgen I , Muller M , Oji V , Traupe H , Sprecher E , Nothen MM , Janecke AR , Betz RC
Ref : Journal of Investigative Dermatology , 129 :2772 , 2009
PubMedID: 19536142
Gene_locus related to this paper: human-LIPH

Title : Founder mutations in the lipase h gene in families with autosomal recessive woolly hair\/hypotrichosis - Shimomura_2009_J.Invest.Dermatol_129_1927
Author(s) : Shimomura Y , Wajid M , Zlotogorski A , Lee YJ , Rice RH , Christiano AM
Ref : Journal of Investigative Dermatology , 129 :1927 , 2009
PubMedID: 19262606
Gene_locus related to this paper: human-LIPH

Title : Mutations in the lipase H gene underlie autosomal recessive woolly hair\/hypotrichosis - Shimomura_2009_J.Invest.Dermatol_129_622
Author(s) : Shimomura Y , Wajid M , Petukhova L , Shapiro L , Christiano AM
Ref : Journal of Investigative Dermatology , 129 :622 , 2009
PubMedID: 18830268
Gene_locus related to this paper: human-LIPH

Title : A large duplication in LIPH underlies autosomal recessive hypotrichosis simplex in four Middle Eastern families - Nahum_2009_Arch.Dermatol.Res_301_391
Author(s) : Nahum S , Pasternack SM , Pforr J , Indelman M , Wollnik B , Bergman R , Nothen MM , Konig A , Khamaysi Z , Betz RC , Sprecher E
Ref : Arch Dermatol Res , 301 :391 , 2009
PubMedID: 18820939
Gene_locus related to this paper: human-LIPH

Title : Mutations in the LIPH gene in three Japanese families with autosomal recessive woolly hair\/hypotrichosis -
Author(s) : Shimomura Y , Ito M , Christiano AM
Ref : J Dermatol Sci , 56 :205 , 2009
PubMedID: 19892526
Gene_locus related to this paper: human-LIPH

Title : A novel deletion mutation in the phospholipase H (LIPH) gene in a consanguineous Pakistani family with autosomal recessive hypotrichosis (LAH2) -
Author(s) : Kamran-ul-Hassan Naqvi S , Raza SI , Naveed AK , John P , Ahmad W
Ref : Br J Dermatol , 160 :194 , 2009
PubMedID: 18795930
Gene_locus related to this paper: human-LIPH

Title : Mutations in lipase H cause autosomal recessive hypotrichosis simplex with woolly hair - Horev_2009_J.Am.Acad.Dermatol_61_813
Author(s) : Horev L , Tosti A , Rosen I , Hershko K , Vincenzi C , Nanova K , Mali A , Potikha T , Zlotogorski A
Ref : J Am Acad Dermatol , 61 :813 , 2009
PubMedID: 19766349
Gene_locus related to this paper: human-LIPH

Title : Novel missense mutations in lipase H (LIPH) gene causing autosomal recessive hypotrichosis (LAH2) - Naz_2009_J.Dermatol.Sci_54_12
Author(s) : Naz G , Khan B , Ali G , Azeem Z , Wali A , Ansar M , Ahmad W
Ref : J Dermatol Sci , 54 :12 , 2009
PubMedID: 19167195
Gene_locus related to this paper: human-LIPH

Title : The effect of inbreeding on the distribution of compound heterozygotes: a lesson from Lipase H mutations in autosomal recessive woolly hair\/hypotrichosis - Petukhova_2009_Hum.Hered_68_117
Author(s) : Petukhova L , Shimomura Y , Wajid M , Gorroochurn P , Hodge SE , Christiano AM
Ref : Hum Hered , 68 :117 , 2009
PubMedID: 19365138
Gene_locus related to this paper: human-LIPH

Title : A novel deletion mutation in LIPH gene causes autosomal recessive hypotrichosis (LAH2) - Jelani_2008_Clin.Genet_74_184
Author(s) : Jelani M , Wasif N , Ali G , Chishti M , Ahmad W
Ref : Clin Genet , 74 :184 , 2008
PubMedID: 18445047
Gene_locus related to this paper: human-LIPH

Title : Two pathways for lysophosphatidic acid production - Aoki_2008_Biochim.Biophys.Acta_1781_513
Author(s) : Aoki J , Inoue A , Okudaira S
Ref : Biochimica & Biophysica Acta , 1781 :513 , 2008
PubMedID: 18621144
Gene_locus related to this paper: human-LIPH

Title : A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis - Ali_2007_Hum.Genet_121_319
Author(s) : Ali G , Chishti MS , Raza SI , John P , Ahmad W
Ref : Hum Genet , 121 :319 , 2007
PubMedID: 17333281
Gene_locus related to this paper: human-LIPH

Title : Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH - Kazantseva_2006_Science_314_982
Author(s) : Kazantseva A , Goltsov A , Zinchenko R , Grigorenko AP , Abrukova AV , Moliaka YK , Kirillov AG , Guo Z , Lyle S , Ginter EK , Rogaev EI
Ref : Science , 314 :982 , 2006
PubMedID: 17095700
Gene_locus related to this paper: human-LIPH

Title : The DNA sequence, annotation and analysis of human chromosome 3 - Muzny_2006_Nature_440_1194
Author(s) : Muzny DM , Scherer SE , Kaul R , Wang J , Yu J , Sudbrak R , Buhay CJ , Chen R , Cree A , Ding Y , Dugan-Rocha S , Gill R , Gunaratne P , Harris RA , Hawes AC , Hernandez J , Hodgson AV , Hume J , Jackson A , Khan ZM , Kovar-Smith C , Lewis LR , Lozado RJ , Metzker ML , Milosavljevic A , Miner GR , Morgan MB , Nazareth LV , Scott G , Sodergren E , Song XZ , Steffen D , Wei S , Wheeler DA , Wright MW , Worley KC , Yuan Y , Zhang Z , Adams CQ , Ansari-Lari MA , Ayele M , Brown MJ , Chen G , Chen Z , Clendenning J , Clerc-Blankenburg KP , Davis C , Delgado O , Dinh HH , Dong W , Draper H , Ernst S , Fu G , Gonzalez-Garay ML , Garcia DK , Gillett W , Gu J , Hao B , Haugen E , Havlak P , He X , Hennig S , Hu S , Huang W , Jackson LR , Jacob LS , Kelly SH , Kube M , Levy R , Li Z , Liu B , Liu J , Liu W , Lu J , Maheshwari M , Nguyen BV , Okwuonu GO , Palmeiri A , Pasternak S , Perez LM , Phelps KA , Plopper FJ , Qiang B , Raymond C , Rodriguez R , Saenphimmachak C , Santibanez J , Shen H , Shen Y , Subramanian S , Tabor PE , Verduzco D , Waldron L , Wang Q , Williams GA , Wong GK , Yao Z , Zhang J , Zhang X , Zhao G , Zhou J , Zhou Y , Nelson D , Lehrach H , Reinhardt R , Naylor SL , Yang H , Olson M , Weinstock G , Gibbs RA
Ref : Nature , 440 :1194 , 2006
PubMedID: 16641997
Gene_locus related to this paper: human-AADAC , human-AADACL2 , human-ABHD5 , human-ABHD6 , human-ABHD10 , human-ABHD14A , human-APEH , human-BCHE , human-CIB , human-LIPH , human-MGLL , human-NLGN1 , human-PLA1A

Title : A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid - Sonoda_2002_J.Biol.Chem_277_34254
Author(s) : Sonoda H , Aoki J , Hiramatsu T , Ishida M , Bandoh K , Nagai Y , Taguchi R , Inoue K , Arai H
Ref : Journal of Biological Chemistry , 277 :34254 , 2002
PubMedID: 12063250
Gene_locus related to this paper: human-LIPH

Title : Lipase H, a new member of the triglyceride lipase family synthesized by the intestine - Jin_2002_Genomics_80_268
Author(s) : Jin W , Broedl UC , Monajemi H , Glick JM , Rader DJ
Ref : Genomics , 80 :268 , 2002
PubMedID: 12213196
Gene_locus related to this paper: human-LIPH , mouse-LIPH

Title : Total hypotrichosis: genetic form of alopecia not linked to hairless gene - Rogaev_1999_Lancet_354_1097
Author(s) : Rogaev EI , Zinchenko RA , Dvoryachikov G , Sherbatich T , Ginter EK
Ref : Lancet , 354 :1097 , 1999
PubMedID: 10509509
Gene_locus related to this paper: human-LIPH