Lysophosphatidylserine
General
Type : Phospholipid, Lysophospholipid, Acyl-Glycerol, Fatty acid ester
Chemical_Nomenclature : (2~{S})-2-amino-3-[hydroxy-[(2~{R})-2-hydroxy-3-octadecanoyloxypropoxy]phosphoryl]oxypropanoic acid
Canonical SMILES : CCCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OCC(C(=O)O)N)O
InChI : InChI=1S\/C24H48NO9P\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)32-18-21(26)19-33-35(30,31)34-20-22(25)24(28)29\/h21-22,26H,2-20,25H2,1H3,(H,28,29)(H,30,31)\/t21-,22+\/m1\/s1 || InChI=1S\/C24H48NO9P.2Na\/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-23(27)32-18-21(26)19-33-35(30,31)34-20-22(25)24(28)29\;\;\/h21-22,26H,2-20,25H2,1H3,(H,28,29)(H,30,31)\;\;\/q\;2*+1\/p-2\/t21-,22+\;\;\/m1..\/s1
InChIKey : ZPDQFUYPBVXUKS-YADHBBJMSA-N || WOPQBWVVTXNCFU-ZZYOSWMOSA-L
Other name(s) : 1-Octadecanoyl-sn-glycero-3-phosphoserine || LysoPS || Lyso-PS || Lysophosphatidyl-L-serine || CHEBI:85403 || PS(18:0\/0:0) || LPS(18:0) || CHEMBL582985 || SCHEMBL17482440 || ZINC49722989 || C18-0-Lyso-PS || C18:0 Lyso-PS || 4,6,10-Trioxa-5-phosphaoctacosanoic acid, 2-amino-5,8-dihydroxy-11-oxo-, 5-oxide, sodium salt, (2S,8R)- disodium || (2S)-2-amino-3-[[(2R)-2-hydroxy-3-octadecanoyloxypropoxy]-oxidophosphoryl]oxypropanoate
MW : 525.62
Formula : C24H48NO9P
CAS_number : 1246298-16-7
UniChem : ZPDQFUYPBVXUKS-YADHBBJMSA-N, WOPQBWVVTXNCFU-ZZYOSWMOSA-L
Target
Structures : No structure
Families : ABHD12-PHARC, Phospholipase, FSH1, ABHD6-Lip
References (7)
| Title : Lactylation Converts ABHD6 into a Mitochondrial Regulator that Drives Lenvatinib Resistance in Hepatocellular Carcinoma - Sun_2026_Cancer.Res__ |
| Author(s) : Sun Y , Luo C , Yang H , Ye J , Song F , Yi Q , Zou W , Huang Y , Fan X , Wang L , Zhang Y , Ding Q , Zhu Y , Tang Z |
| Ref : Cancer Research , : , 2026 |
| Abstract : |
| PubMedSearch : Sun_2026_Cancer.Res__ |
| PubMedID: 41861279 |
| Title : Mapping the neuroanatomy of ABHD16A-ABHD12 & lysophosphatidylserines provides new insights into the pathophysiology of the human neurological disorder PHARC - Singh_2020_Biochemistry_59_2299 |
| Author(s) : Singh S , Joshi A , Kamat SS |
| Ref : Biochemistry , 59 :2299 , 2020 |
| Abstract : |
| PubMedSearch : Singh_2020_Biochemistry_59_2299 |
| PubMedID: 32462874 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A |
| Title : The Lysophosphatidylserines-An Emerging Class of Signalling Lysophospholipids - Shanbhag_2020_J.Membr.Biol_253_381 |
| Author(s) : Shanbhag K , Mhetre A , Khandelwal N , Kamat SS |
| Ref : J Membr Biol , 253 :381 , 2020 |
| Abstract : |
| PubMedSearch : Shanbhag_2020_J.Membr.Biol_253_381 |
| PubMedID: 32767057 |
| Title : Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase alpha\/beta-Hydrolase Domain-Containing 12 (ABHD12) - Ogasawara_2019_J.Med.Chem_62_1643 |
| Author(s) : Ogasawara D , Ichu TA , Jing H , Hulce JJ , Reed A , Ulanovskaya OA , Cravatt BF |
| Ref : Journal of Medicinal Chemistry , 62 :1643 , 2019 |
| Abstract : |
| PubMedSearch : Ogasawara_2019_J.Med.Chem_62_1643 |
| PubMedID: 30720278 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay - Kamat_2015_Nat.Chem.Biol_11_164 |
| Author(s) : Kamat SS , Camara K , Parsons WH , Chen DH , Dix MM , Bird TD , Howell AR , Cravatt BF |
| Ref : Nat Chemical Biology , 11 :164 , 2015 |
| Abstract : |
| PubMedSearch : Kamat_2015_Nat.Chem.Biol_11_164 |
| PubMedID: 25580854 |
| Gene_locus related to this paper: human-ABHD12 , human-ABHD16A , mouse-abd12 , mouse-Abhd16a |
| Title : ABHD12 controls brain lysophosphatidylserine pathways that are deregulated in a murine model of the neurodegenerative disease PHARC - Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| Author(s) : Blankman JL , Long JZ , Trauger SA , Siuzdak G , Cravatt BF |
| Ref : Proc Natl Acad Sci U S A , 110 :1500 , 2013 |
| Abstract : |
| PubMedSearch : Blankman_2013_Proc.Natl.Acad.Sci.U.S.A_110_1500 |
| PubMedID: 23297193 |
| Gene_locus related to this paper: human-ABHD12 |
| Title : An alternative splicing form of phosphatidylserine-specific phospholipase A1 that exhibits lysophosphatidylserine-specific lysophospholipase activity in humans - Nagai_1999_J.Biol.Chem_274_11053 |
| Author(s) : Nagai Y , Aoki J , Sato T , Amano K , Matsuda Y , Arai H and |
| Ref : Journal of Biological Chemistry , 274 :11053 , 1999 |
| Abstract : |
| PubMedSearch : Nagai_1999_J.Biol.Chem_274_11053 |
| PubMedID: 10196188 |
| Gene_locus related to this paper: human-PLA1A |