Family

Go to basket

Tree Display

AceDB Schema

XML Display

Feedback

Family Report for: Epoxide_hydrolase

Epoxide_hydrolase



Relationship
Block X
Parent Family : Epoxide-hydrolase_like

Comment
Epoxide hydrolases catalyze the conversion of epoxides to corresponding diols. The catalytic triad nucleophile is an invariable aspartate that opens the epoxide ring by nuclophile attack. The mammalian soluble EHs contain 2 evolutionarily distinct domains, the N-terminal domain is similar to bacterial haloacid dehalogenase (not related to alpha/beta-hydrolase fold), while the C-terminal domain is similar to soluble plant EH, microsomal EH, and bacterial haloalkane_dehalogenase (HLD). In InterPro IPR000639 groups Epoxide hydrolase and Haloalkane dehalogenase. IPR000639; Epoxide hydrolase contains some Carboxymethylbutenolide_lactonase (trembl Q9WWZ4) Carbon-carbon_bond_hydrolase (trembl Q98I15 Q9KH20 Q9K5C1 Q9KWQ6 Q9ZAY1 Q9ZNJ3 Q9RBF3 Q9RBT0) Monoglyceridelipase_lysophospholip (trembl Q97TG8). In ESTHER they are classified in the later sub family. (there are also epoxide hydrolases not related to a/b hydrolases ex: 1NWW limonene-1,2-epoxide hydrolase Arand et al. 2003) Zhu et al. (2003) identified compound heterozygosity for 2 mutations in the EPHX1 gene, which resulted in a significant decrease in EPHX1 promoter activity.
2 Disease(s)

1 Risk(s) factors

1 Xenobiotic(s) sensitivity


Database
Sequences
Interpro
|
IPR000639 (Epoxide hydrolase-like), IPR016292 (Epoxide hydrolase), IPR010497 (Epoxide hydrolase, N-terminal)
PIRSF
|
Pdoc
|
PFam
|
PF06441 (EHN), PF00561 (Abhydrolase_1)
Prints
|
Prosite
|
EC at KEGG
|
EC at EXPASY
|


Peptide in
|Fasta
Nucleotide in
|Fasta
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
Dendrogram
|Graphical display, obtained with the dnd file produced by Clustalw

References
3 more
    Title: Diversity and biocatalytic potential of epoxide hydrolases identified by genome analysis
    van Loo B, Kingma J, Arand M, Wubbolts MG, Janssen DB
    Ref: Applied Environmental Microbiology, 72:2905, 2006 : PubMed

            

    Title: Gene evolution of epoxide hydrolases and recommended nomenclature
    Beetham JK, Grant D, Arand M, Garbarino J, Kiyosue T, Pinot F, Oesch F, Belknap WR, Shinozaki K, Hammock BD
    Ref: DNA & Cell Biology, 14:61, 1995 : PubMed

            

    Title: cDNA cloning and expression of a soluble epoxide hydrolase from human liver
    Beetham JK, Tian T, Hammock BD
    Ref: Archives of Biochemistry & Biophysics, 305:197, 1993 : PubMed

            

Other Papers


No structure scheme yet for this family

Structures in Epoxide_hydrolase family (155)

Genes Proteins in Epoxide_hydrolase family (1154)

Fragments of genes in Epoxide_hydrolase family (81)

Substrates of some enzymes in the Epoxide_hydrolase family (31)

Inhibitors of some enzymes in the Epoxide_hydrolase family (112)



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer