cioin-ACHE1

Ciona intestinalis (Transparent sea squirt) Acetylcholinesterase ci0100132088

Comment

Dr Leo Pezzementi cloned this gene and corrected the sequence which present many differences with the conceptually derived sequence of Q7RTL6. It is closer to other AChE so we called acche1 . The second AChE cioin-ACHE2 is farther related is found only in adult cDNA library and might be a contaminant ?!

Relationship

Family : ACHE

Block : C

Position in NCBI Life Tree : Ciona intestinalis

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Tunicata N E > Ascidiacea N E > Enterogona N E > Phlebobranchia N E > Cionidae N E > Ciona N E > Ciona intestinalis N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MLDLSPCVPS LLCCIFVCVI YEVQASSNGL VVQTMYGSVR GKHVESPPRH QRIAAFLGIP FASPPVGELR FAAPQPPLSW EPDVRQTTEF GNSCVQIDDE VFGNFRGSQM WNAPNLKSED CLYLNIWTPR IPTSTRSQPL AVMVWIYGGS FYSGTTALAL YDGRYLAAQG GVVVVSINYR LGPLGFLAPL AGTPGNAGLL DQQLALKWVR DNIRAFGGNP DNVTLMGESA GAASIGLHTV APSSRGLFNR VIFQSGNQMT PWSTISLPTS LNRTRILAAN LRCPNPRTSS ELDVLTCLRS HSAVDVFSNS WITQEIFDFP FVPVHGTSFL PEHPHEVTRK GEQADVDVMA GHNTNEGSYF TLYTVPGFNI SSQSILSKKE YIDGIALSGI KTNELGRSGA AFMYADWENP DNVLQYRDGV NEIVGDFHVV CPTVLLTKRH SRTFSNNNVY LYHLSYRLSN NPWPAWMGVM HGYEIELMFG TPWFGTSQFT SGYNDVDRSV SRRMVHYWTN FAKFGNPNGL RSANELDLRS TDWPRFDDVR QRYLEIGIDD DVMGPFPNSF RCAFWERYLP SLKLASSDMD EVETKWKIEF NRWTESMDLW DRSFKAYSKD GKQSSCPN

References (4)

Title : Acetylcholinesterase from the invertebrate Ciona intestinalis is capable of assembling into asymmetric forms when co-expressed with vertebrate collagenic tail peptide - Frederick_2008_FEBS.J_275_1309
Author(s) : Frederick A , Tsigelny I , Cohenour F , Spiker C , Krejci E , Chatonnet A , Bourgoin S , Richards G , Allen T , Whitlock MH , Pezzementi L
Ref : Febs J , 275 :1309 , 2008
PubMedID: 18279391
Gene_locus related to this paper: cioin-ACHE1 , cioin-ACHE2

Title : The draft genome of Ciona intestinalis: insights into chordate and vertebrate origins - Dehal_2002_Science_298_2157
Author(s) : Dehal P , Satou Y , Campbell RK , Chapman J , Degnan B , De Tomaso A , Davidson B , Di Gregorio A , Gelpke M , Goodstein DM , Harafuji N , Hastings KE , Ho I , Hotta K , Huang W , Kawashima T , Lemaire P , Martinez D , Meinertzhagen IA , Necula S , Nonaka M , Putnam N , Rash S , Saiga H , Satake M , Terry A , Yamada L , Wang HG , Awazu S , Azumi K , Boore J , Branno M , Chin-Bow S , DeSantis R , Doyle S , Francino P , Keys DN , Haga S , Hayashi H , Hino K , Imai KS , Inaba K , Kano S , Kobayashi K , Kobayashi M , Lee BI , Makabe KW , Manohar C , Matassi G , Medina M , Mochizuki Y , Mount S , Morishita T , Miura S , Nakayama A , Nishizaka S , Nomoto H , Ohta F , Oishi K , Rigoutsos I , Sano M , Sasaki A , Sasakura Y , Shoguchi E , Shin-I T , Spagnuolo A , Stainier D , Suzuki MM , Tassy O , Takatori N , Tokuoka M , Yagi K , Yoshizaki F , Wada S , Zhang C , Hyatt PD , Larimer F , Detter C , Doggett N , Glavina T , Hawkins T , Richardson P , Lucas S , Kohara Y , Levine M , Satoh N , Rokhsar DS
Ref : Science , 298 :2157 , 2002
PubMedID: 12481130
Gene_locus related to this paper: cioin-141645 , cioin-147959 , cioin-150181 , cioin-154370 , cioin-ACHE1 , cioin-ACHE2 , cioin-cxest , cioin-f6qcp0 , cioin-f6r8z1 , cioin-f6u176 , cioin-f6vac9 , cioin-f6x584 , cioin-f6xa69 , cioin-f6y403 , cioin-h2xqb4 , cioin-H2XTI0 , cioin-F6T1M3 , cioin-H2XUP7 , cioin-CIN.7233 , cioin-F6V269 , cioin-Cin16330 , cioin-h2xua2 , cioin-f6vaa5 , cioin-f6v9x6 , cioin-f6swc9 , cioin-f7amz2 , cioin-f6s021 , cioin-h2xxq9 , cioin-h2xne6 , cioin-f6ynr2

Title : A cDNA resource from the basal chordate Ciona intestinalis -
Author(s) : Satou Y , Yamada L , Mochizuki Y , Takatori N , Kawashima T , Sasaki A , Hamaguchi M , Awazu S , Yagi K , Sasakura Y , Nakayama A , Ishikawa H , Inaba K , Satoh N
Ref : Genesis , 33 :153 , 2002
PubMedID: 12203911
Gene_locus related to this paper: cioin-141645 , cioin-147959 , cioin-150181 , cioin-154370 , cioin-ACHE1 , cioin-ACHE2 , cioin-cxest , cioin-F6V269

Title : A novel acetylcholinesterase gene in mosquitoes codes for the insecticide target and is non-homologous to the ace gene Drosophila - Weill_2002_Proc.R.Soc.Lond.B.Biol.Sci_269_2007
Author(s) : Weill M , Fort P , Berthomieu A , Dubois MP , Pasteur N , Raymond M
Ref : Proc R Soc Lond B Biol Sci , 269 :2007 , 2002
PubMedID: 12396499
Gene_locus related to this paper: aedae-ACHE1 , anoga-ACHE1 , anoga-ACHE2 , cioin-ACHE1 , ciosa-ACHE , culpi-ACHE1