Mus musculus Kynurenine formamidase (EC 3.5.1.9) Afmid Ammd cDNA 9030621K19 gene (9030621K19Rik)
Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. Q8R1K6 differences in 3' and 5' alternative splicings?
Family : Kynurenine-formamidase
Block : H
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMAFPSLSAGQ NPWRNLSSEE LEKQYSPSRW VIHTKPEEVV GNFVQIGSQA TQKARATRRN QLDVPYGDGE GEKLDIYFPD EDSKAFPLFL FLHGGYWQSG SKDDSAFMVN PLTAQGIVVV IVAYDIAPKG TLDQMVDQVT RSVVFLQRRY PSNEGIYLCG HSAGAHLAAM VLLARWTKHG VTPNLQGFLL VSGIYDLEPL IATSQNDPLR MTLEDAQRNS PQRHLDVVPA QPVAPACPVL VLVGQHDSPE FHRQSKEFYE TLLRVGWKAS FQQLRGVDHF DIIENLTRED DVLTQIILKT VFQKL
| Title : Alternate activation of two divergently transcribed mouse genes from a bidirectional promoter is linked to changes in histone modification - Schuettengruber_2003_J.Biol.Chem_278_1784 |
| Author(s) : Schuettengruber B , Doetzlhofer A , Kroboth K , Wintersberger E , Seiser C |
| Ref : Journal of Biological Chemistry , 278 :1784 , 2003 |
| PubMedID: 12411446 |
| Gene_locus related to this paper: mouse-KFA |
| Title : Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad - Pabarcus_2002_Biochim.Biophys.Acta_1596_201 |
| Author(s) : Pabarcus MK , Casida JE |
| Ref : Biochimica & Biophysica Acta , 1596 :201 , 2002 |
| PubMedID: 12007602 |
| Gene_locus related to this paper: human-AFMID , mouse-KFA |