mouse-Ces2c
Mus musculus (Mouse) Ces2c similar to carboxylesterase 2 (intestine, liver) Acylcarnitine hydrolase
Comment
Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. Furihata et al.
Relationship
Family : Carb_B_Chordata
Block : C
Position in NCBI Life Tree : Mus musculus
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Glires N E > Rodentia N E > Myomorpha N E > Muroidea N E > Muridae N E > Murinae N E > Mus [genus] N E > Mus [subgenus] N E > Mus musculus N EMolecular evidence
Sequence
Peptide
MTRNQLHNWL NAGFFGLLLL LIHVQGQDSP EANPIRNTHT GQIQGSLIHV KDTKAGVHTF LGIPFAKPPV GPLRFAPPEA PEPWSGVRDG TAHPAMCLQN LDMLNEAGLP DMKMMLSSFP MSEDCLYLNI YTPAHAHEGS NLPVMVWIHG GALVIGMASM FDGSLLTVNE DLVVVTIQYR LGVLGFFSTG DQHARGNWGY LDQAAALRWV QQNIAHFGGN PDRVTIFGES AGGTSVSSHV VSPMSQGLFH GAIMESGVAL LPDLISETSE MVSTTVAKLS GCEAMDSQAL VRCLRGKSEA EILAINKVFK MIPAVVDGEF FPRHPKELLA SEDFHPVPSI IGVNNDEFGW SIPVVMGSAQ MIKGITRENL QAVLKDTAVQ MMLPPECSDL LMEEYMGDTE DAQTLQIQFT EMMGDFMFVI PALQVAHFQR SHAPVYFYEF QHPPSYFKDV RPPHVKADHA DEIPFVFASF FWGMKLDFTE EEELLSRRMM KYWANFARHG NPNSEGLPYW PVMDHDEQYL QLDIQPAVGR ALKAGRLQFW TKTLPQKIQE LKASQDKHRE L
References (7)
| Title : Intestinal human carboxylesterase 2 (CES2) expression rescues drug metabolism and most metabolic syndrome phenotypes in global Ces2 cluster knockout mice - Wang_2024_Acta.Pharmacol.Sin__ |
| Author(s) : Wang YG , Gan CP , Beukers-Korver J , Rosing H , Li WL , Wagenaar E , Lebre MC , Song JY , Pritchard C , Bin Ali R , Huijbers I , Beijnen JH , Schinkel AH |
| Ref : Acta Pharmacol Sin , : , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Acta.Pharmacol.Sin__ |
| PubMedID: 39496863 |
| Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c , mouse-Ces2d-ps , mouse-Ces2e , mouse-Ces2f , mouse-Ces2g , mouse-Ces2h |
| Title : The Crystal Structure of Mouse Ces2c, a Potential Ortholog of Human CES2, Shows Structural Similarities in Substrate Regulation and Product Release to Human CES1 - Eisner_2022_Int.J.Mol.Sci_23_13101 |
| Author(s) : Eisner H , Riegler-Berket L , Gamez CFR , Sagmeister T , Chalhoub G , Darnhofer B , Jazleena PJ , Birner-Gruenberger R , Pavkov-Keller T , Haemmerle G , Schoiswohl G , Oberer M |
| Ref : Int J Mol Sci , 23 : , 2022 |
| Abstract : |
| PubMedSearch : Eisner_2022_Int.J.Mol.Sci_23_13101 |
| PubMedID: 36361897 |
| Gene_locus related to this paper: mouse-Ces2c |
| Title : Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease - Chalhoub_2021_J.Lipid.Res__100075 |
| Author(s) : Chalhoub G , Kolleritsch S , Maresch LK , Taschler U , Pajed L , Tilp A , Natmessnig H , Rosina P , Kien B , Radner FPW , Schicho R , Oberer M , Schoiswohl G , Haemmerle G |
| Ref : J Lipid Res , :100075 , 2021 |
| Abstract : |
| PubMedSearch : Chalhoub_2021_J.Lipid.Res__100075 |
| PubMedID: 33872605 |
| Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c |
| Title : Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity - Maresch_2019_Hepatol.Commun_3_227 |
| Author(s) : Maresch LK , Benedikt P , Feiler U , Eder S , Zierler KA , Taschler U , Kolleritsch S , Eichmann TO , Schoiswohl G , Leopold C , Wieser BI , Lackner C , Rulicke T , van Klinken J , Kratky D , Moustafa T , Hoefler G , Haemmerle G |
| Ref : Hepatol Commun , 3 :227 , 2019 |
| Abstract : |
| PubMedSearch : Maresch_2019_Hepatol.Commun_3_227 |
| PubMedID: 30766961 |
| Gene_locus related to this paper: mouse-Ces2c |
| Title : Intestinal Lipolysis Mitigates Nonalcoholic Fatty Liver Disease: New Roles for Carboxylesterase 2c in the Intestine - Pimienta_2019_Hepatol.Commun_3_177 |
| Author(s) : Pimienta M , Beletsky A , Seki E |
| Ref : Hepatol Commun , 3 :177 , 2019 |
| Abstract : |
| PubMedSearch : Pimienta_2019_Hepatol.Commun_3_177 |
| PubMedID: 30766955 |
| Gene_locus related to this paper: mouse-Ces2c |
| Title : Purification, molecular cloning, and functional expression of inducible liver acylcarnitine hydrolase in C57BL\/6 mouse, belonging to the carboxylesterase multigene family - Furihata_2003_Arch.Biochem.Biophys_416_101 |
| Author(s) : Furihata T , Hosokawa M , Nakata F , Satoh T , Chiba K |
| Ref : Archives of Biochemistry & Biophysics , 416 :101 , 2003 |
| Abstract : |
| PubMedSearch : Furihata_2003_Arch.Biochem.Biophys_416_101 |
| PubMedID: 12859986 |
| Gene_locus related to this paper: mouse-Ces2c |