(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) > cellular organisms: NE > Eukaryota: NE > Opisthokonta: NE > Metazoa: NE > Eumetazoa: NE > Bilateria: NE > Deuterostomia: NE > Chordata: NE > Craniata: NE > Vertebrata: NE > Gnathostomata: NE > Teleostomi: NE > Euteleostomi: NE > Sarcopterygii: NE > Dipnotetrapodomorpha: NE > Tetrapoda: NE > Amniota: NE > Mammalia: NE > Theria: NE > Eutheria: NE > Boreoeutheria: NE > Euarchontoglires: NE > Glires: NE > Rodentia: NE > Hystricomorpha: NE > Caviidae: NE > Cavia: NE > Cavia porcellus: NE
LegendThis sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA MRVYIFLCLMCCIRSGYFSLSTKSTPVSRKSFENRRLCLEFSKLNVKDSL KELFIHRLKIILMLYTRNNFNCAEPLFQQNNSVNINFNKHRKTVWLIHGY RPVGSTPSWLHKFVWTLLNKEDVNLIVVDWNQGAATFIYNRAVKNTRKVA EVLSRYIQNLLVQGASLENFHFIGISLGAHICGFVGKIFHGELGRITGLD PAGPKFSGKPSNSRLDYTDAKLVDVIHSDVDGLGIQEPLGHIDFYPNGGK NQPGCPTSIFSGIEYIKCDHQRAVYLFMAALQTNCSFVSFPCHSYKDYKT SLCVDCGSSQKNSCPRLEYYTEHWEHSLKTRTKKWPVRITTFFDTSGRYP FCAYYFVLSITALDESMNDGYISFKVLNQLGVAEYSRVYEKSKPFHKLQE VNILAQFLNDVVNISSIVLRYFQTSNIQCPTNKHRIQRLMLKSLTYPERP PVCSYNFVIKESEELFLKCHMHRE
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering approximately 4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for approximately 60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease.
Cavia porcellus (Guinea pig) phospolipase [PLRP2 like]