Homo sapiens (Human) biphenyl hydrolase-like DJ40E16.6.3, breast epithelial mucin-associated antigen AG BPHL (mcnaa), Valacyclovir hydrolase VACVase
Valacyclovir hydrolase, biphenyl hydrolase-like, breast epithelial mucin-associated antigen AG BPHL (mcnaa) VACVase. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It hydrolyzes the prodrugs of a broad range of antiviral and anticancer nucleoside analogues such as zidovudine, floxuridine, and gemcitabine || OTTHUMG00000014140
MVAVLGGRGV LRLRLLLSAL KPGIHVPRAG PAAAFGTSVT SAKVAVNGVQ LHYQQTGEGD HAVLLLPGML GSGETDFGPQ LKNLNKKLFT VVAWDPRGYG HSRPPDRDFP ADFFERDAKD AVDLMKALKF KKVSLLGWSD GGITALIAAA KYPSYIHKMV IWGANAYVTD EDSMIYEGIR DVSKWSERTR KPLEALYGYD YFARTCEKWV DGIRQFKHLP DGNICRHLLP RVQCPALIVH GEKDPLVPRF HADFIHKHVK GSRLHLMPEG KHNLHLRFAD EFNKLAEDFL Q
Title : Effect of biphenyl hydrolase-like (BPHL) gene disruption on the intestinal stability, permeability and absorption of valacyclovir in wildtype and Bphl knockout mice - Hu_2018_Biochem.Pharmacol_156_147 |
Author(s) : Hu Y , Epling D , Shi J , Song F , Tsume Y , Zhu HJ , Amidon GL , Smith DE |
Ref : Biochemical Pharmacology , 156 :147 , 2018 |
Abstract : Hu_2018_Biochem.Pharmacol_156_147 |
ESTHER : Hu_2018_Biochem.Pharmacol_156_147 |
PubMedSearch : Hu_2018_Biochem.Pharmacol_156_147 |
PubMedID: 30121252 |
Gene_locus related to this paper: human-BPHL |
Title : Human valacyclovir hydrolase\/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase - Marsillach_2014_PLoS.One_9_e110054 |
Author(s) : Marsillach J , Suzuki SM , Richter RJ , McDonald MG , Rademacher PM , Maccoss MJ , Hsieh EJ , Rettie AE , Furlong CE |
Ref : PLoS ONE , 9 :e110054 , 2014 |
Abstract : Marsillach_2014_PLoS.One_9_e110054 |
ESTHER : Marsillach_2014_PLoS.One_9_e110054 |
PubMedSearch : Marsillach_2014_PLoS.One_9_e110054 |
PubMedID: 25333274 |
Gene_locus related to this paper: human-BPHL |
Title : Specificity of a prodrug-activating enzyme hVACVase: the leaving group effect - Sun_2010_Mol.Pharm_7_2362 |
Author(s) : Sun J , Dahan A , Walls ZF , Lai L , Lee KD , Amidon GL |
Ref : Mol Pharm , 7 :2362 , 2010 |
Abstract : Sun_2010_Mol.Pharm_7_2362 |
ESTHER : Sun_2010_Mol.Pharm_7_2362 |
PubMedSearch : Sun_2010_Mol.Pharm_7_2362 |
PubMedID: 21028903 |
Gene_locus related to this paper: human-BPHL |
Title : Molecular basis of prodrug activation by human valacyclovirase, an alpha-amino acid ester hydrolase - Lai_2008_J.Biol.Chem_283_9318 |
Author(s) : Lai L , Xu Z , Zhou J , Lee KD , Amidon GL |
Ref : Journal of Biological Chemistry , 283 :9318 , 2008 |
Abstract : Lai_2008_J.Biol.Chem_283_9318 |
ESTHER : Lai_2008_J.Biol.Chem_283_9318 |
PubMedSearch : Lai_2008_J.Biol.Chem_283_9318 |
PubMedID: 18256025 |
Gene_locus related to this paper: human-BPHL |
Title : A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein - Kim_2004_Mol.Pharm_1_117 |
Author(s) : Kim I , Song X , Vig BS , Mittal S , Shin HC , Lorenzi PJ , Amidon GL |
Ref : Mol Pharm , 1 :117 , 2004 |
Abstract : Kim_2004_Mol.Pharm_1_117 |
ESTHER : Kim_2004_Mol.Pharm_1_117 |
PubMedSearch : Kim_2004_Mol.Pharm_1_117 |
PubMedID: 15832508 |
Gene_locus related to this paper: human-BPHL |
Title : Identification of a human valacyclovirase: biphenyl hydrolase-like protein as valacyclovir hydrolase - Kim_2003_J.Biol.Chem_278_25348 |
Author(s) : Kim I , Chu XY , Kim S , Provoda CJ , Lee KD , Amidon GL |
Ref : Journal of Biological Chemistry , 278 :25348 , 2003 |
Abstract : Kim_2003_J.Biol.Chem_278_25348 |
ESTHER : Kim_2003_J.Biol.Chem_278_25348 |
PubMedSearch : Kim_2003_J.Biol.Chem_278_25348 |
PubMedID: 12732646 |
Gene_locus related to this paper: human-BPHL |
Title : Structural characterization and chromosomal localization of the gene encoding human biphenyl hydrolase-related protein (BPHL) - Puente_1998_Genomics_51_459 |
Author(s) : Puente XS , Pendas AM , Lopez-Otin C |
Ref : Genomics , 51 :459 , 1998 |
Abstract : Puente_1998_Genomics_51_459 |
ESTHER : Puente_1998_Genomics_51_459 |
PubMedSearch : Puente_1998_Genomics_51_459 |
PubMedID: 9721218 |
Gene_locus related to this paper: human-BPHL |
Title : Cloning and expression analysis of a novel human serine hydrolase with sequence similarity to prokaryotic enzymes involved in the degradation of aromatic compounds - Puente_1995_J.Biol.Chem_270_12926 |
Author(s) : Puente XS , Lopez-Otin C |
Ref : Journal of Biological Chemistry , 270 :12926 , 1995 |
Abstract : Puente_1995_J.Biol.Chem_270_12926 |
ESTHER : Puente_1995_J.Biol.Chem_270_12926 |
PubMedSearch : Puente_1995_J.Biol.Chem_270_12926 |
PubMedID: 7759552 |
Gene_locus related to this paper: human-BPHL |
Title : Cloning and sequencing of a complementary DNA encoding a Mr 70,000 human breast epithelial mucin-associated antigen - Larocca_1990_Cancer.Res_50_5925 |
Author(s) : Larocca D , Peterson JA , Walkup G , Urrea R , Ceriani RL |
Ref : Cancer Research , 50 :5925 , 1990 |
Abstract : Larocca_1990_Cancer.Res_50_5925 |
ESTHER : Larocca_1990_Cancer.Res_50_5925 |
PubMedSearch : Larocca_1990_Cancer.Res_50_5925 |
PubMedID: 2393862 |
Gene_locus related to this paper: human-BPHL |