human-LIPF
Homo sapiens (Human) human gastric lipase
Comment
Gastric lipase, which is stable and active despite the highly acidic stomach environment, plays an important role in the digestion of dietary triglycerides in the gastrointestinal tract, especially in patients suffering from pancreatic lipase deficiencies. The enzyme is secreted by the fundic mucosa of the stomach and hydrolyzes the ester bonds of triglycerides while cholesteryl esters are not attacked
Relationship
Molecular evidence
Sequence
Peptide
MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK
References
| Title : Identification of a new natural gastric lipase inhibitor from star anise - Kamoun_2019_Food.Funct_10_469 |
| Author(s) : Kamoun J , Rahier R , Sellami M , Koubaa I , Mansuelle P , Lebrun R , Berlioz-Barbier A , Fiore M , Alvarez K , Abousalham A , Carriere F , Aloulou A |
| Ref : Food Funct , 10 :469 , 2019 |
| Abstract : Kamoun_2019_Food.Funct_10_469 |
| ESTHER : Kamoun_2019_Food.Funct_10_469 |
| PubMedSearch : Kamoun_2019_Food.Funct_10_469 |
| PubMedID: 30632597 |
| Gene_locus related to this paper: human-LIPF |
| Title : Constitutive expression of human gastric lipase in Pichia pastoris and site-directed mutagenesis of key lid-stabilizing residues - Sams_2017_Biochim.Biophys.Acta_1862_1025 |
| Author(s) : Sams L , Amara S , Chakroun A , Coudre S , Paume J , Giallo J , Carriere F |
| Ref : Biochimica & Biophysica Acta , 1862 :1025 , 2017 |
| Abstract : Sams_2017_Biochim.Biophys.Acta_1862_1025 |
| ESTHER : Sams_2017_Biochim.Biophys.Acta_1862_1025 |
| PubMedSearch : Sams_2017_Biochim.Biophys.Acta_1862_1025 |
| PubMedID: 28694218 |
| Gene_locus related to this paper: human-LIPF |
| Title : Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis - Point_2016_Eur.J.Med.Chem_123_834 |
| Author(s) : Point V , Benarouche A , Zarrillo J , Guy A , Magnez R , Fonseca L , Raux B , Leclaire J , Buono G , Fotiadu F , Durand T , Carriere F , Vaysse C , Couedelo L , Cavalier JF |
| Ref : Eur Journal of Medicinal Chemistry , 123 :834 , 2016 |
| Abstract : Point_2016_Eur.J.Med.Chem_123_834 |
| ESTHER : Point_2016_Eur.J.Med.Chem_123_834 |
| PubMedSearch : Point_2016_Eur.J.Med.Chem_123_834 |
| PubMedID: 27543878 |
| Gene_locus related to this paper: canfa-1lipg , human-LIPF |
| Title : Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer - Kong_2016_Oncol.Rep_36_1852 |
| Author(s) : Kong Y , Zheng Y , Jia Y , Li P , Wang Y |
| Ref : Oncol Rep , 36 :1852 , 2016 |
| Abstract : Kong_2016_Oncol.Rep_36_1852 |
| ESTHER : Kong_2016_Oncol.Rep_36_1852 |
| PubMedSearch : Kong_2016_Oncol.Rep_36_1852 |
| PubMedID: 27498782 |
| Gene_locus related to this paper: human-LIPF |
| Title : Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system - Vardakou_2012_Protein.Expr.Purif_81_69 |
| Author(s) : Vardakou M , Sainsbury F , Rigby N , Mulholland F , Lomonossoff GP |
| Ref : Protein Expr Purif , 81 :69 , 2012 |
| Abstract : Vardakou_2012_Protein.Expr.Purif_81_69 |
| ESTHER : Vardakou_2012_Protein.Expr.Purif_81_69 |
| PubMedSearch : Vardakou_2012_Protein.Expr.Purif_81_69 |
| PubMedID: 21945702 |
| Gene_locus related to this paper: human-LIPF |
| Title : Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo) - Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| Author(s) : Holmes RS , Cox LA , Vandeberg JL |
| Ref : Comparative Biochemistry & Physiology Part D Genomics Proteomics , 5 :217 , 2010 |
| Abstract : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| ESTHER : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| PubMedSearch : Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217 |
| PubMedID: 20598663 |
| Gene_locus related to this paper: human-LIPF , human-LIPJ , human-LIPK , human-LIPM , human-LIPN , mouse-LIPK |
| Title : Importance of the lid and cap domains for the catalytic activity of gastric lipases - Miled_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_131 |
| Author(s) : Miled N , Bussetta C , de Caro A , Riviere M , Berti L , Canaan S |
| Ref : Comparative Biochemistry & Physiology B Biochem Mol Biol , 136 :131 , 2003 |
| Abstract : Miled_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_131 |
| ESTHER : Miled_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_131 |
| PubMedSearch : Miled_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_131 |
| PubMedID: 12941646 |
| Gene_locus related to this paper: human-LIPF |
| Title : Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase - Pafumi_2002_J.Biol.Chem_277_28070 |
| Author(s) : Pafumi Y , Lairon D , de la Porte PL , Juhel C , Storch J , Hamosh M , Armand M |
| Ref : Journal of Biological Chemistry , 277 :28070 , 2002 |
| Abstract : Pafumi_2002_J.Biol.Chem_277_28070 |
| ESTHER : Pafumi_2002_J.Biol.Chem_277_28070 |
| PubMedSearch : Pafumi_2002_J.Biol.Chem_277_28070 |
| PubMedID: 11940604 |
| Gene_locus related to this paper: human-LIPF |
| Title : Gastric lipase: crystal structure and activity - Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| Author(s) : Canaan S , Roussel A , Verger R , Cambillau C |
| Ref : Biochimica & Biophysica Acta , 1441 :197 , 1999 |
| Abstract : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| ESTHER : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| PubMedSearch : Canaan_1999_Biochim.Biophys.Acta_1441_197 |
| PubMedID: 10570247 |
| Gene_locus related to this paper: human-LIPF |
| Title : Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest - Roussel_1999_J.Biol.Chem_274_16995 |
| Author(s) : Roussel A , Canaan S , Egloff MP , Riviere M , Dupuis L , Verger R , Cambillau C |
| Ref : Journal of Biological Chemistry , 274 :16995 , 1999 |
| Abstract : Roussel_1999_J.Biol.Chem_274_16995 |
| ESTHER : Roussel_1999_J.Biol.Chem_274_16995 |
| PubMedSearch : Roussel_1999_J.Biol.Chem_274_16995 |
| PubMedID: 10358049 |
| Gene_locus related to this paper: human-LIPF |
| Title : The acid lipase gene family: three enzymes, one highly conserved gene structure - Lohse_1997_J.Lipid.Res_38_880 |
| Author(s) : Lohse P , Chahrokh-Zadeh S , Seidel D |
| Ref : J Lipid Res , 38 :880 , 1997 |
| Abstract : Lohse_1997_J.Lipid.Res_38_880 |
| ESTHER : Lohse_1997_J.Lipid.Res_38_880 |
| PubMedSearch : Lohse_1997_J.Lipid.Res_38_880 |
| PubMedID: 9186906 |
| Gene_locus related to this paper: human-LIPF |
| Title : Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library - Suzuki_1997_Gene_200_149 |
| Author(s) : Suzuki Y , Yoshitomo-Nakagawa K , Maruyama K , Suyama A , Sugano S |
| Ref : Gene , 200 :149 , 1997 |
| Abstract : Suzuki_1997_Gene_200_149 |
| ESTHER : Suzuki_1997_Gene_200_149 |
| PubMedSearch : Suzuki_1997_Gene_200_149 |
| PubMedID: 9373149 |
| Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15 |
| Title : Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides - Maruyama_1994_Gene_138_171 |
| Author(s) : Maruyama K , Sugano S |
| Ref : Gene , 138 :171 , 1994 |
| Abstract : Maruyama_1994_Gene_138_171 |
| ESTHER : Maruyama_1994_Gene_138_171 |
| PubMedSearch : Maruyama_1994_Gene_138_171 |
| PubMedID: 8125298 |
| Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15 |
| Title : Inactivation of gastric and pancreatic lipases by diethyl p-nitrophenyl phosphate - Moreau_1991_Biochemistry_30_1037 |
| Author(s) : Moreau H , Moulin A , Gargouri Y , Noel JP , Verger R |
| Ref : Biochemistry , 30 :1037 , 1991 |
| Abstract : Moreau_1991_Biochemistry_30_1037 |
| ESTHER : Moreau_1991_Biochemistry_30_1037 |
| PubMedSearch : Moreau_1991_Biochemistry_30_1037 |
| PubMedID: 1989675 |
| Gene_locus related to this paper: human-LIPF , human-PNLIP |
| Title : Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity - Bernback_1989_Eur.J.Biochem_182_495 |
| Author(s) : Bernback S , Blackberg L |
| Ref : European Journal of Biochemistry , 182 :495 , 1989 |
| Abstract : Bernback_1989_Eur.J.Biochem_182_495 |
| ESTHER : Bernback_1989_Eur.J.Biochem_182_495 |
| PubMedSearch : Bernback_1989_Eur.J.Biochem_182_495 |
| PubMedID: 2753032 |
| Gene_locus related to this paper: human-LIPF |
| Title : Molecular cloning of a human gastric lipase and expression of the enzyme in yeast - Bodmer_1987_Biochim.Biophys.Acta_909_237 |
| Author(s) : Bodmer MW , Angal S , Yarranton GT , Harris TJ , Lyons A , King DJ , Pieroni G , Riviere C , Verger R , Lowe PA |
| Ref : Biochimica & Biophysica Acta , 909 :237 , 1987 |
| Abstract : Bodmer_1987_Biochim.Biophys.Acta_909_237 |
| ESTHER : Bodmer_1987_Biochim.Biophys.Acta_909_237 |
| PubMedSearch : Bodmer_1987_Biochim.Biophys.Acta_909_237 |
| PubMedID: 3304425 |
| Gene_locus related to this paper: human-LIPF |