Gene_locus Report for: myolu-g1pds0 Myotis lucifugus; Myotis davidii; Myotis brandtii (Little brown bat, David's myotis, Brandt's bat). Uncharacterized protein
Comment
Other strains: Myotis lucifugus; Myotis davidii; Myotis brandtii (Little brown bat, David's myotis, Brandt's bat) Relationship
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) cellular organisms: N E > Eukaryota: N E > Opisthokonta: N E > Metazoa: N E > Eumetazoa: N E > Bilateria: N E > Deuterostomia: N E > Chordata: N E > Craniata: N E > Vertebrata: N E > Gnathostomata: N E > Teleostomi: N E > Euteleostomi: N E > Sarcopterygii: N E > Dipnotetrapodomorpha: N E > Tetrapoda: N E > Amniota: N E > Mammalia: N E > Theria: N E > Eutheria: N E > Boreoeutheria: N E > Laurasiatheria: N E > Chiroptera: N E > Microchiroptera: N E > Vespertilionidae: N E > Myotis: N E > Myotis lucifugus: N E ABHD6-Lip :
myolu-g1pay8 Myotis lucifugus (Little brown bat) Uncharacterized protein .
ABHD8 :
myolu-g1p1e9 Myotis lucifugus (Little brown bat). Abhydrolase domain containing 8 .
ABHD10 :
myolu-g1nzg3 Myotis lucifugus (Little brown bat). Abhydrolase domain containing 10 .
ABHD11-Acetyl_transferase :
myolu-g1qc57 Myotis lucifugus (Little brown bat). Abhydrolase domain containing 11 .
ABHD12-PHARC :
myolu-g1pqr8 Myotis lucifugus (Little brown bat) Uncharacterized protein .
ABHD16 :
myolu-g1pdp2 Myotis lucifugus (Little brown bat); Myotis davidii (David's myotis). Abhydrolase domain containing 16A ,
myolu-g1nth4 Myotis lucifugus (Little brown bat); Myotis brandtii (Brandt's bat); Myotis davidii (David's myotis). Abhydrolase domain containing 16B .
ABHD18 :
myolu-g1p4p3 Myotis lucifugus (Little brown bat). ABHD18 Uncharacterized protein .
ACHE :
myolu-g1q073 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Arylacetamide_deacetylase :
myolu-g1pg61 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1pnb1 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1pu06 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1qa15 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1qfu0 Myotis lucifugus (Little brown bat). Uncharacterized protein .
BCHE :
myolu-g1p1d8 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Carb_B_Chordata :
myolu-g1nw29 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1pjm4 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1py65 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1q4p0 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1qaf3 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Cholesterol_esterase :
myolu-g1p7m1 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1q8x7 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1q522 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1qca1 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-l7n1c2 Myotis lucifugus (Little brown bat) Uncharacterized protein .
CMBL :
myolu-g1q4e3 Myotis lucifugus (Little brown bat); Myotis davidii (David's myotis); Myotis brandtii (Brandt's bat). Carboxymethylenebutenolidase homolog .
FSH1 :
myolu-g1q061 Myotis lucifugus (Little brown bat). FSH1 domain-containing protein .
Hepatic_Lipase :
myolu-g1q2n9 Myotis lucifugus (Little brown bat). Lipase C, hepatic type .
Lipoprotein_Lipase :
myolu-g1nty6 Myotis lucifugus (Little brown bat). Lipoprotein lipase ,
myolu-g1p1p3 Myotis lucifugus (Little brown bat). Lipase G, endothelial type .
Maspardin-ACP33-SPG21_like :
myolu-g1puj0 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Ndr_family :
myolu-g1pqd9 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1p5c0 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Neuroligin :
myolu-g1p8a4 Myotis lucifugus (Little brown bat) Uncharacterized protein .
NLS3-Tex30 :
myolu-g1pb63 Myotis lucifugus (Little brown bat) Uncharacterized protein ,
myolu-g1pl95 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Pancreatic_lipase :
myolu-g1pan8 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-g1paq0 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-g1par4 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-g1prn3 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1q3i0 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-g1q463 Myotis lucifugus (Little brown bat). Uncharacterized protein ,
myolu-g1pat6 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-g1q859 Myotis lucifugus (Little brown bat). Pancreatic lipase ,
myolu-l7n125 Myotis lucifugus (Little brown bat). Pancreatic lipase .
Phospholipase :
myolu-g1pan2 Myotis lucifugus (Little brown bat). Phospholipase A1 member A ,
myolu-g1p353 Myotis lucifugus (Little brown bat); Myotis brandtii (Brandt's bat). Lipase H .
SERHL :
myolu-g1pkg5 Myotis lucifugus (Little brown bat). Uncharacterized protein .
Thyroglobulin :
myolu-g1nvv4 Myotis lucifugus (Little brown bat) Uncharacterized protein .
Valacyclovir-hydrolase :
myolu-g1ptz8 Myotis lucifugus (Little brown bat) Uncharacterized protein Warning: This entry is a compilation of different species or line or strain with more than 90% amino acid identity. You can
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(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.) Myotis davidii:
N ,
E .
Myotis brandtii:
N ,
E .
Molecular evidence
Database
No mutation No structure No kinetic No Substrate No inhibitor
Sequence
Graphical view for this peptide sequence: myolu-g1pds0 Colored MSA for ABHD12-PHARC (raw)
MRKRTEPVALEHESCVGLGSSSSGLTASVLDADCRLKRNLRLAGKAPAEP
RCAADAGMKRALGRRKGMWFQLRKILLCILGLYVAIPFLIRLCPGIQAKL
IFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTLGVWHTVPAVWWK
TAQGKDQMWYEDALASSHPVILYLHGNAGTRGGDHRVELYKVLSSLGYHV
VTFDYRGWGDSIGTPSEPGMTYDALHVFDWIKARSGDNPVYIWGHSLGTG
VATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVVYRFFPGFDWF
FLDPITNNGIKFANDENVKHISCSLLILHAEDDPVVPFHLGRKLYNIAAL
SRSFRDFKVQFMPFHSDLGYRHKYIYKSPELPRILREFLGKSEPELQH
Legend
This sequence has been compared to family alignement (MSA) red => minority aminoacid blue => majority aminoacid color intensity => conservation rate title => sequence position(MSA position)aminoacid rate Catalytic site Catalytic site in the MSA
M R K R T E P V A L E H E S C V G L G S S S S G L T A S V L D A D C R L K R N L R L A G K A P A E P R C A A D A G M K R A L G R R K G M W F Q L R K I L L C I L G L Y V A I P F L I R L C P G I Q A K L I F L N F V R V P Y F I D L K K P Q D Q G L N H T C N Y Y L Q P E E D V T L G V W H T V P A V W W K T A Q G K D Q M W Y E D A L A S S H P V I L Y L H G N A G T R G G D H R V E L Y K V L S S L G Y H V V T F D Y R G W G D S I G T P S E P G M T Y D A L H V F D W I K A R S G D N P V Y I W G H S L G T G V A T N L V R R L C E R E T P P D A L I L E S P F T N I R E E A K S H P F S V V Y R F F P G F D W F F L D P I T N N G I K F A N D E N V K H I S C S L L I L H A E D D P V V P F H L G R K L Y N I A A L S R S F R D F K V Q F M P F H S D L G Y R H K Y I Y K S P E L P R I L R E F L G K S E P E L Q H
Reference
Title: A high-resolution map of human evolutionary constraint using 29 mammalsLindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G and Kellis M <76 more author(s)> Lindblad-Toh K , Garber M , Zuk O , Lin MF , Parker BJ , Washietl S , Kheradpour P , Ernst J , Jordan G , Mauceli E , Ward LD , Lowe CB , Holloway AK , Clamp M , Gnerre S , Alfoldi J , Beal K , Chang J , Clawson H , Cuff J , Di Palma F , Fitzgerald S , Flicek P , Guttman M , Hubisz MJ , Jaffe DB , Jungreis I , Kent WJ , Kostka D , Lara M , Martins AL , Massingham T , Moltke I , Raney BJ , Rasmussen MD , Robinson J , Stark A , Vilella AJ , Wen J , Xie X , Zody MC , Baldwin J , Bloom T , Chin CW , Heiman D , Nicol R , Nusbaum C , Young S , Wilkinson J , Worley KC , Kovar CL , Muzny DM , Gibbs RA , Cree A , Dihn HH , Fowler G , Jhangiani S , Joshi V , Lee S , Lewis LR , Nazareth LV , Okwuonu G , Santibanez J , Warren WC , Mardis ER , Weinstock GM , Wilson RK , Delehaunty K , Dooling D , Fronik C , Fulton L , Fulton B , Graves T , Minx P , Sodergren E , Birney E , Margulies EH , Herrero J , Green ED , Haussler D , Siepel A , Goldman N , Pollard KS , Pedersen JS , Lander ES , Kellis M (- 76) Ref: Nature, 478 :476, 2011 : PubMed Abstract ESTHER: Lindblad-Toh_2011_Nature_478_476 PubMedSearch: Lindblad-Toh 2011 Nature 478 476 PubMedID: 21993624 Gene_locus related to this paper: cavpo-1plip ,
cavpo-2plrp ,
cavpo-h0v1b7 ,
cavpo-h0v5v8 ,
cavpo-h0vj36 ,
cavpo-lipli ,
rabit-1hlip ,
rabit-1plip ,
rabit-g1t6x7 ,
rabit-LIPH ,
myolu-l7n1c2 ,
myolu-g1pqd9 ,
cavpo-h0uyz6 ,
cavpo-h0vi56 ,
rabit-g1tbj4 ,
myolu-g1p5c0 ,
rabit-g1sds3 ,
rabit-g1sye0 ,
cavpo-h0v0r2 ,
cavpo-h0v7s5 ,
rabit-g1sp43 ,
myolu-g1p4p3 ,
cavpo-h0vw09 ,
rabit-g1ssu3 ,
myolu-g1pds0 ,
rabit-g1sic4 ,
cavpo-h0v2c4 ,
myolu-g1pg61 ,
myolu-g1pnb1 ,
myolu-g1pu06 ,
myolu-g1qa15 ,
myolu-g1qfu0 ,
rabit-g1sn99 ,
rabit-g1snq9 ,
rabit-g1sns7 ,
rabit-g1tuu8 ,
rabit-g1tzq7 ,
cavpo-h0v2i2 ,
cavpo-h0v2j0 ,
cavpo-h0vsf5 ,
cavpo-a0a286x8d3 ,
cavpo-a0a286xbr3 ,
cavpo-a0a286y0i8 ,
cavpo-a0a286y4p3 ,
myolu-g1q2n9 ,
cavpo-h0v1p4 ,
myolu-g1pan8 ,
myolu-g1paq0 ,
myolu-g1par4 ,
myolu-g1prn3 ,
myolu-g1q3i0 ,
myolu-g1q463 ,
myolu-g1pat6 ,
myolu-g1q859 ,
rabit-g1sul9 ,
rabit-g1sun0 ,
rabit-g1sup0 ,
myolu-l7n125 ,
myolu-g1pan2 ,
rabit-g1sxd0 ,
cavpo-h0v8j4 ,
rabit-d5fit0 ,
rabit-g1tkr5 ,
myolu-g1nty6 ,
myolu-g1p1p3 ,
cavpo-h0vdd5 ,
myolu-g1pdp2 ,
rabit-g1tmm5 ,
cavpo-h0vhq3 ,
myolu-g1nth4 ,
cavpo-h0vqx6 ,
rabit-g1tqr7 ,
myolu-g1p1e9 ,
cavpo-h0v8y6 ,
rabit-g1skt3 ,
myolu-g1nzg3 ,
cavpo-h0v5z0 ,
rabit-g1sgz5 ,
myolu-g1pkg5 ,
rabit-g1tmw5 ,
rabit-g1t134 ,
cavpo-a0a286x9v5 ,
myolu-g1qc57 ,
myolu-g1q061 ,
rabit-g1tnp4 ,
rabit-g1tyf7 ,
cavpo-h0w2w1 ,
rabit-g1ta36 ,
cavpo-h0w342 ,
myolu-g1q4e3 ,
rabit-g1sqa1 ,
cavpo-h0uxk7 ,
myolu-g1p353 ,
cavpo-h0vpm0 ,
rabit-a0a5f9cru6 ,
cavpo-a0a286xtc0 Abstract
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes. We confirm that at least 5.5% of the human genome has undergone purifying selection, and locate constrained elements covering approximately 4.2% of the genome. We use evolutionary signatures and comparisons with experimental data sets to suggest candidate functions for approximately 60% of constrained bases. These elements reveal a small number of new coding exons, candidate stop codon readthrough events and over 10,000 regions of overlapping synonymous constraint within protein-coding exons. We find 220 candidate RNA structural families, and nearly a million elements overlapping potential promoter, enhancer and insulator regions. We report specific amino acid residues that have undergone positive selection, 280,000 non-coding elements exapted from mobile elements and more than 1,000 primate- and human-accelerated elements. Overlap with disease-associated variants indicates that our findings will be relevant for studies of human biology, health and disease.
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