6o-5-HT3

"rat-5-HT3 Ki = 5.6 nM; h-AChE IC50 = 4.1 nM; h-BChE IC50 = 40nM"

General

Type : Multitarget,5-HT-receptor-ligand,Derivative of Tacrine,Carboxamide,Alkyl linked bis-ligand

Chemical_Nomenclature : 3-methyl-2-(4-methylpiperazin-1-yl)-N-[7-(1,2,3,4-tetrahydroacridin-9-ylamino)heptyl]quinoline-4-carboxamide

Canonical SMILES : CC1=C(C2=CC=CC=C2N=C1N3CCN(CC3)C)C(=O)NCCCCCCCNC4=C5CCCCC5=NC6=CC=CC=C64

InChI : InChI=1S\/C36H46N6O\/c1-26-33(27-14-6-9-17-30(27)40-35(26)42-24-22-41(2)23-25-42)36(43)38-21-13-5-3-4-12-20-37-34-28-15-7-10-18-31(28)39-32-19-11-8-16-29(32)34\/h6-7,9-10,14-15,17-18H,3-5,8,11-13,16,19-25H2,1-2H3,(H,37,39)(H,38,43)

InChIKey : ACKJXXOVSOCBPX-UHFFFAOYSA-N

Other name(s) : CHEMBL195241,BDBM50166984,3-Methyl-2-(4-methyl-piperazin-1-yl)-quinoline-4-carboxylic acid [7-(1,2,3,4-tetrahydro-acridin-9-ylamino)-heptyl]-amide


MW : 578.8

Formula : C36H46N6O

CAS_number :

PubChem : 11376655

UniChem : ACKJXXOVSOCBPX-UHFFFAOYSA-N

IUPHAR :

Wikipedia :

Target

Families : 6o-5-HT3 ligand of proteins in family: BCHE || ACHE

Stucture :

Protein : human-BCHE || human-ACHE

References (1)

Title : Further studies on the interaction of the 5-hydroxytryptamine3 (5-HT3) receptor with arylpiperazine ligands. development of a new 5-HT3 receptor ligand showing potent acetylcholinesterase inhibitory properties - Cappelli_2005_J.Med.Chem_48_3564
Author(s) : Cappelli A , Gallelli A , Manini M , Anzini M , Mennuni L , Makovec F , Menziani MC , Alcaro S , Ortuso F , Vomero S
Ref : Journal of Medicinal Chemistry , 48 :3564 , 2005
Abstract : Cappelli_2005_J.Med.Chem_48_3564
ESTHER : Cappelli_2005_J.Med.Chem_48_3564
PubMedSearch : Cappelli_2005_J.Med.Chem_48_3564
PubMedID: 15887964