AChE-Nrf2modulator-1
electric eel AChE IC50 0.07 microM; human AChE IC50 0.38 microM; equine serum BuChE IC50 8.15 microM
General
Type : Pyridine, Oxadiazol, Nrf2 modulator, Derivative of Donepezil, Multitarget
Chemical_Nomenclature : 5-[3-[[1-[(3-fluorophenyl)methyl]piperidin-4-yl]methoxy]phenyl]-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole
Canonical SMILES : CC1=NC=C(C=C1)C2=NOC(=N2)C3=CC(=CC=C3)OCC4CCN(CC4)CC5=CC(=CC=C5)F
InChI : InChI=1S\/C27H27FN4O2\/c1-19-8-9-23(16-29-19)26-30-27(34-31-26)22-5-3-7-25(15-22)33-18-20-10-12-32(13-11-20)17-21-4-2-6-24(28)14-21\/h2-9,14-16,20H,10-13,17-18H2,1H3
InChIKey : RRSJHXGJAMBCDJ-UHFFFAOYSA-N
Other name(s) : AChE\/Nrf2 modulator 1 || CHEMBL5278087 || BDBM50612520 || HY-152037 || CS-0627357
MW : 458.5
Formula : C27H27FN4O2
CAS_number :
PubChem : 166176937
UniChem : RRSJHXGJAMBCDJ-UHFFFAOYSA-N
Target
Families : AChE-Nrf2modulator-1 ligand of proteins in family
ACHE
Protein :
human-ACHE
References (3)
| Title : Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease - Wang_2022_Eur.J.Med.Chem_244_114806 |
| Author(s) : Wang Y , Xiong B , Lin H , Li Q , Yang H , Qiao Y , Xu Z , Lyu W , Qu W , Liu W , Chen Y , Feng F , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 244 :114806 , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Eur.J.Med.Chem_244_114806 |
| PubMedID: 36223681 |
| Title : Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease - Wang_2022_Eur.J.Med.Chem_244_114806 |
| Author(s) : Wang Y , Xiong B , Lin H , Li Q , Yang H , Qiao Y , Xu Z , Lyu W , Qu W , Liu W , Chen Y , Feng F , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 244 :114806 , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Eur.J.Med.Chem_244_114806 |
| PubMedID: 36223681 |
| Title : Design, synthesis and evaluation of fused hybrids with acetylcholinesterase inhibiting and Nrf2 activating functions for Alzheimer's disease - Wang_2022_Eur.J.Med.Chem_244_114806 |
| Author(s) : Wang Y , Xiong B , Lin H , Li Q , Yang H , Qiao Y , Xu Z , Lyu W , Qu W , Liu W , Chen Y , Feng F , Sun H |
| Ref : Eur Journal of Medicinal Chemistry , 244 :114806 , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Eur.J.Med.Chem_244_114806 |
| PubMedID: 36223681 |