AKU-010
also inhibitor of FAAH (not an alpha beta hydrolase)
General
Type : Piperazine, Triazol
Chemical_Nomenclature : (4-phenylpiperazin-1-yl)-(1,2,4-triazol-1-yl)methanone
Canonical SMILES : C1CN(CCN1C2=CC=CC=C2)C(=O)N3C=NC=N3
InChI : InChI=1S\/C13H15N5O\/c19-13(18-11-14-10-15-18)17-8-6-16(7-9-17)12-4-2-1-3-5-12\/h1-5,10-11H,6-9H2
InChIKey : QJNXPTCCLVHSKB-UHFFFAOYSA-N
Other name(s) : CHEMBL3356960 || BDBM50099604
MW : 257.29
Formula : C13H15N5O
CAS_number :
PubChem : 118721879
UniChem : QJNXPTCCLVHSKB-UHFFFAOYSA-N
Target
Families : AKU-010 ligand of proteins in family
Plasmodium_subtelomeric_PST-A
Monoglyceridelipase_lysophospholip
Protein :
plafa-PF07.0040
human-MGLL
References (4)
| Title : Defining the minimal enzymatic requirements for fatty acid scavenging from lysophosphatidylcholine by erythrocytic Plasmodium falciparum - Liu_2025_Int.J.Parasitol__ |
| Author(s) : Liu J , Fike KR , Dalal S , Dapper C , Klemba M |
| Ref : International Journal for Parasitology , : , 2025 |
| Abstract : |
| PubMedSearch : Liu_2025_Int.J.Parasitol__ |
| PubMedID: 41043577 |
| Gene_locus related to this paper: plafa-PF07.0040 |
| Title : Metabolism of host lysophosphatidylcholine in Plasmodium falciparum-infected erythrocytes - Liu_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2320262121 |
| Author(s) : Liu J , Fike KR , Dapper C , Klemba M |
| Ref : Proc Natl Acad Sci U S A , 121 :e2320262121 , 2024 |
| Abstract : |
| PubMedSearch : Liu_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2320262121 |
| PubMedID: 38349879 |
| Title : Piperazine and piperidine carboxamides and carbamates as inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) - Korhonen_2014_Bioorg.Med.Chem_22_6694 |
| Author(s) : Korhonen J , Kuusisto A , van Bruchem J , Patel JZ , Laitinen T , Navia-Paldanius D , Laitinen JT , Savinainen JR , Parkkari T , Nevalainen TJ |
| Ref : Bioorganic & Medicinal Chemistry , 22 :6694 , 2014 |
| Abstract : |
| PubMedSearch : Korhonen_2014_Bioorg.Med.Chem_22_6694 |
| PubMedID: 25282655 |
| Title : Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase - Aaltonen_2013_Chem.Biol_20_379 |
| Author(s) : Aaltonen N , Savinainen JR , Ribas CR , Ronkko J , Kuusisto A , Korhonen J , Navia-Paldanius D , Hayrinen J , Takabe P , Kasnanen H , Pantsar T , Laitinen T , Lehtonen M , Pasonen-Seppanen S , Poso A , Nevalainen T , Laitinen JT |
| Ref : Chemical Biology , 20 :379 , 2013 |
| Abstract : |
| PubMedSearch : Aaltonen_2013_Chem.Biol_20_379 |
| PubMedID: 23521796 |
| Gene_locus related to this paper: human-MGLL |