Allo-Ile-isoindoline
DP8/9 inhibitor IC50 0.12 micoM DPP8 dipeptidyl peptidase 8 (human). IC50 0.29 microm IC50 DPP9 dipeptidyl peptidase 9 (human)
General
Type : Isoindole
Chemical_Nomenclature : (2S,3R)-2-amino-1-(1,3-dihydroisoindol-2-yl)-3-methylpentan-1-one
Canonical SMILES : CCC(C)C(C(=O)N1CC2=CC=CC=C2C1)N
InChI : InChI=1S\/C14H20N2O\/c1-3-10(2)13(15)14(17)16-8-11-6-4-5-7-12(11)9-16\/h4-7,10,13H,3,8-9,15H2,1-2H3\/t10-,13+\/m1\/s1
InChIKey : UBDCHKXSBGAGNJ-MFKMUULPSA-N
Other name(s) : CHEMBL397070, SCHEMBL14392574, BDBM50225437, ZINC28826977
MW : 232.32
Formula : C14H20N2O
CAS_number :
PubChem : 24784416
UniChem : UBDCHKXSBGAGNJ-MFKMUULPSA-N
Target
Families : Allo-Ile-isoindoline ligand of proteins in family
DPP4N_Peptidase_S9
Protein :
human-DPP8
human-DPP9
References (5)
| Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656 |
| Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR |
| Ref : Nat Chemical Biology , 10 :656 , 2014 |
| PubMedID: 24997602 |
| Gene_locus related to this paper: human-PPME1 |
| Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169 |
| Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S |
| Ref : Biol Chem , 392 :169 , 2011 |
| PubMedID: 21194378 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors - Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159 |
| Author(s) : Van Goethem S , Van der Veken P , Dubois V , Soroka A , Lambeir AM , Chen X , Haemers A , Scharpe S , De Meester I , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4159 , 2008 |
| PubMedID: 18556198 |
| Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads - Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154 |
| Author(s) : Van der Veken P , De Meester I , Dubois V , Soroka A , Van Goethem S , Maes MB , Brandt I , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K |
| Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4154 , 2008 |
| PubMedID: 18556199 |
| Title : Dipeptidyl peptidase 8\/9-like activity in human leukocytes - Maes_2007_J.Leukoc.Biol_81_1252 |
| Author(s) : Maes MB , Dubois V , Brandt I , Lambeir AM , Van der Veken P , Augustyns K , Cheng JD , Chen X , Scharpe S , De Meester I |
| Ref : J Leukoc Biol , 81 :1252 , 2007 |
| PubMedID: 17287297 |