Allo-Ile-isoindoline

DP8/9 inhibitor IC50 0.12 micoM DPP8 dipeptidyl peptidase 8 (human). IC50 0.29 microm IC50 DPP9 dipeptidyl peptidase 9 (human)

General

Type : Isoindole

Chemical_Nomenclature : (2S,3R)-2-amino-1-(1,3-dihydroisoindol-2-yl)-3-methylpentan-1-one

Canonical SMILES : CCC(C)C(C(=O)N1CC2=CC=CC=C2C1)N

InChI : InChI=1S\/C14H20N2O\/c1-3-10(2)13(15)14(17)16-8-11-6-4-5-7-12(11)9-16\/h4-7,10,13H,3,8-9,15H2,1-2H3\/t10-,13+\/m1\/s1

InChIKey : UBDCHKXSBGAGNJ-MFKMUULPSA-N

Other name(s) : CHEMBL397070  ||  SCHEMBL14392574  ||  BDBM50225437  ||  ZINC28826977


MW : 232.32

Formula : C14H20N2O

CAS_number :

PubChem : 24784416

UniChem : UBDCHKXSBGAGNJ-MFKMUULPSA-N

Target

Families : Allo-Ile-isoindoline ligand of proteins in family
DPP4N_Peptidase_S9

Protein :
human-DPP8 human-DPP9

References (5)

Title : A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity - Bachovchin_2014_Nat.Chem.Biol_10_656
Author(s) : Bachovchin DA , Koblan LW , Wu W , Liu Y , Li Y , Zhao P , Woznica I , Shu Y , Lai JH , Poplawski SE , Kiritsy CP , Healey SE , DiMare M , Sanford DG , Munford RS , Bachovchin WW , Golub TR
Ref : Nat Chemical Biology , 10 :656 , 2014
Abstract :
PubMedSearch : Bachovchin_2014_Nat.Chem.Biol_10_656
PubMedID: 24997602
Gene_locus related to this paper: human-PPME1

Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169
Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S
Ref : Biol Chem , 392 :169 , 2011
Abstract :
PubMedSearch : Bank_2011_Biol.Chem_392_169
PubMedID: 21194378

Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors - Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159
Author(s) : Van Goethem S , Van der Veken P , Dubois V , Soroka A , Lambeir AM , Chen X , Haemers A , Scharpe S , De Meester I , Augustyns K
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4159 , 2008
Abstract :
PubMedSearch : Van Goethem_2008_Bioorg.Med.Chem.Lett_18_4159
PubMedID: 18556198

Title : Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads - Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154
Author(s) : Van der Veken P , De Meester I , Dubois V , Soroka A , Van Goethem S , Maes MB , Brandt I , Lambeir AM , Chen X , Haemers A , Scharpe S , Augustyns K
Ref : Bioorganic & Medicinal Chemistry Lett , 18 :4154 , 2008
Abstract :
PubMedSearch : Van der Veken_2008_Bioorg.Med.Chem.Lett_18_4154
PubMedID: 18556199

Title : Dipeptidyl peptidase 8\/9-like activity in human leukocytes - Maes_2007_J.Leukoc.Biol_81_1252
Author(s) : Maes MB , Dubois V , Brandt I , Lambeir AM , Van der Veken P , Augustyns K , Cheng JD , Chen X , Scharpe S , De Meester I
Ref : J Leukoc Biol , 81 :1252 , 2007
Abstract :
PubMedSearch : Maes_2007_J.Leukoc.Biol_81_1252
PubMedID: 17287297