Columbamine
Columbamine is a berberine alkaloid and an organic heterotetracyclic compound. found in Fibraurea chloroleuca, Corydalis ternata
General
Type : Natural, Alkaloid, Not AlphaBeta Hydrolase target, Isoquinoline, Derivative of berberine
Chemical_Nomenclature : 3,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-2-ol
Canonical SMILES : COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)OC)O)OC
InChI : InChI=1S\/C20H19NO4\/c1-23-18-5-4-12-8-16-14-10-17(22)19(24-2)9-13(14)6-7-21(16)11-15(12)20(18)25-3\/h4-5,8-11H,6-7H2,1-3H3\/p+1
InChIKey : YYFOFDHQVIODOQ-UHFFFAOYSA-O
Other name(s) : UNII-7T4808FEJW || 7T4808FEJW || CHEBI:15920 || CHEMBL400345 || SCHEMBL422073
Target
Families : Columbamine ligand of proteins in family
ACHE
Protein :
human-ACHE
References (11)
| Title : Cholinesterase Inhibitory and In Silico Toxicity Assessment of Thirty-Four Isoquinoline Alkaloids - Berberine as the Lead Compound - Senol_2023_CNS.Neurol.Disord.Drug.Targets__ |
| Author(s) : Senol Deniz FS , Ekhteiari Salmas R , Emerce E , Sener B , Erdogan Orhan I |
| Ref : CNS Neurol Disord Drug Targets , : , 2023 |
| Abstract : |
| PubMedSearch : Senol_2023_CNS.Neurol.Disord.Drug.Targets__ |
| PubMedID: 37073143 |
| Title : Characterization of the anti-AChE potential and alkaloids in Rhizoma Coptidis from different Coptis species combined with spectrum-effect relationship and molecular docking - Qi_2022_Front.Plant.Sci_13_1020309 |
| Author(s) : Qi L , Zhong F , Liu N , Wang J , Nie K , Tan Y , Ma Y , Xia L |
| Ref : Front Plant Sci , 13 :1020309 , 2022 |
| Abstract : |
| PubMedSearch : Qi_2022_Front.Plant.Sci_13_1020309 |
| PubMedID: 36388527 |
| Title : Conventional and Non-Conventional Targets of Natural Products in the Management of Diabetes Mellitus and Associated Complications - Mahomoodally_2021_Curr.Med.Chem_28_4638 |
| Author(s) : Mahomoodally MF , Lobine D , Picot-Allain MCN , Sadeer N , Jugreet S , Zengin G |
| Ref : Curr Med Chem , 28 :4638 , 2021 |
| Abstract : |
| PubMedSearch : Mahomoodally_2021_Curr.Med.Chem_28_4638 |
| PubMedID: 33138749 |
| Title : Large-scale separation of acetylcholinesterase inhibitors from Zanthoxylum nitidum by pH-zone-refining counter-current chromatography target-guided by ultrafiltration high-performance liquid chromatography with ultraviolet and mass spectrometry screening - Liu_2019_J.Sep.Sci_42_1194 |
| Author(s) : Liu M , Liu Q , Chen M , Huang X , Chen X |
| Ref : J Sep Sci , 42 :1194 , 2019 |
| Abstract : |
| PubMedSearch : Liu_2019_J.Sep.Sci_42_1194 |
| PubMedID: 30638299 |
| Title : Screening of acetylcholinesterase inhibitors and characterizing of phytochemical constituents from Dichocarpum auriculatum (Franch.) W.T. Wang & P. K. Hsiao through UPLC-MS combined with an acetylcholinesterase inhibition assay in vitro - Li_2019_J.Ethnopharmacol_245_112185 |
| Author(s) : Li P , Liu S , Liu Q , Shen J , Yang R , Jiang B , He C , Xiao P |
| Ref : J Ethnopharmacol , 245 :112185 , 2019 |
| Abstract : |
| PubMedSearch : Li_2019_J.Ethnopharmacol_245_112185 |
| PubMedID: 31446073 |
| Title : Metabolomic profiling of Zanthoxylum species: Identification of anti-cholinesterase alkaloids candidates - Plazas_2019_Phytochemistry_168_112128 |
| Author(s) : Plazas E , Casoti RR , Murillo MA , Da Costa FB , Cuca LE |
| Ref : Phytochemistry , 168 :112128 , 2019 |
| Abstract : |
| PubMedSearch : Plazas_2019_Phytochemistry_168_112128 |
| PubMedID: 31557705 |
| Title : Online screening of acetylcholinesterase inhibitors in natural products using monolith-based immobilized capillary enzyme reactors combined with liquid chromatography-mass spectrometry - Wang_2018_J.Chromatogr.A_1563_135 |
| Author(s) : Wang L , Zhao Y , Zhang Y , Zhang T , Kool J , Somsen GW , Wang Q , Jiang Z |
| Ref : Journal of Chromatography A , 1563 :135 , 2018 |
| Abstract : |
| PubMedSearch : Wang_2018_J.Chromatogr.A_1563_135 |
| PubMedID: 29866504 |
| Title : An in vitro AChE inhibition assay combined with UF-HPLC-ESI-Q-TOF\/MS approach for screening and characterizing of AChE inhibitors from roots of Coptis chinensis Franch - Zhao_2015_J.Pharm.Biomed.Anal_120_235 |
| Author(s) : Zhao H , Zhou S , Zhang M , Feng J , Wang S , Wang D , Geng Y , Wang X |
| Ref : J Pharm Biomed Anal , 120 :235 , 2015 |
| Abstract : |
| PubMedSearch : Zhao_2015_J.Pharm.Biomed.Anal_120_235 |
| PubMedID: 26760241 |
| Title : Anticholinesterase Inhibitory Activity of Quaternary Alkaloids from Tinospora crispa - Yusoff_2014_Molecules_19_1201 |
| Author(s) : Yusoff M , Hamid H , Houghton P |
| Ref : Molecules , 19 :1201 , 2014 |
| Abstract : |
| PubMedSearch : Yusoff_2014_Molecules_19_1201 |
| PubMedID: 24448061 |
| Title : [Screening of the active ingredients in natural products by capillary electrophoresis and high performance liquid chromatography-mass spectrometry] - Zhang_2013_Se.Pu_31_640 |
| Author(s) : Zhang Y , Kang J |
| Ref : Se Pu , 31 :640 , 2013 |
| Abstract : |
| PubMedSearch : Zhang_2013_Se.Pu_31_640 |
| PubMedID: 24164032 |
| Title : Characterization of Acetylcholinesterase Inhibitory Constituents from Annona glabra Assisted by HPLC Microfractionation - Tsai_2010_J.Nat.Prod_73_1632 |
| Author(s) : Tsai SF , Lee SS |
| Ref : Journal of Natural Products , 73 :1632 , 2010 |
| Abstract : |
| PubMedSearch : Tsai_2010_J.Nat.Prod_73_1632 |
| PubMedID: 20828184 |