DPH6

MAO A (IC50 = 6.2 +/- 0.7 microM; MAO B (IC50 = 10.2 +/- 0.9 microM); AChE (IC50 = 1.8 +/- 0.1 microM); BuChE (IC50 = 1.6 +/- 0.25 microM)

General

Type : Quinoline, Multitarget, Monoamine-oxidase-inhibitor, Derivative of Donepezil

Chemical_Nomenclature : 4-(1-benzylpiperidin-4-yl)-2-[(8-hydroxyquinolin-5-yl)methyl-prop-2-ynylamino]butanenitrile

Canonical SMILES : C#CCN(CC1=C2C=CC=NC2=C(C=C1)O)C(CCC3CCN(CC3)CC4=CC=CC=C4)C#N

InChI : InChI=1S\/C29H32N4O\/c1-2-17-33(22-25-11-13-28(34)29-27(25)9-6-16-31-29)26(20-30)12-10-23-14-18-32(19-15-23)21-24-7-4-3-5-8-24\/h1,3-9,11,13,16,23,26,34H,10,12,14-15,17-19,21-22H2

InChIKey : ATRSFRGWPPYVGZ-UHFFFAOYSA-N

Other name(s) : 4-(1-Benzylpiperidin-4-yl)-2-(((8-hydroxyquinolin-5-yl)methyl)(prop-2-yny)amino)butanenitrile  ||  CHEMBL3291019  ||  SCHEMBL15663109  ||  BDBM50018671


MW : 452.6

Formula : C29H32N4O

CAS_number :

PubChem : 73671789

UniChem : ATRSFRGWPPYVGZ-UHFFFAOYSA-N

Target

Families : DPH6 ligand of proteins in family
BCHE ACHE

References (1)

Title : Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease - Wang_2014_Eur.J.Med.Chem_80_543
Author(s) : Wang L , Esteban G , Ojima M , Bautista-Aguilera OM , Inokuchi T , Moraleda I , Iriepa I , Samadi A , Youdim MB , Romero A , Soriano E , Herrero R , Fernandez Fernandez AP , Ricardo Martinez M , Marco-Contelles J , Unzeta M
Ref : Eur Journal of Medicinal Chemistry , 80 :543 , 2014
Abstract :
PubMedSearch : Wang_2014_Eur.J.Med.Chem_80_543
PubMedID: 24813882