Ethopropazine
Antiparkinsonian, anticholinergic. Inhibitor specific of BChE and used to differentiate BChE activity from AChE activity. Ethopropazine (also known as profenamine hydrochloride) is a medication derived from phenothiazine. It is primarily used as an antidyskinetic to treat parkinsonism. It is sold under the trade names Parsidol in the United States and Parsidan in Canada.
General
Type : Phenothiazine, Drug, Sulfur Compound
Chemical_Nomenclature : 10-(2-diethylaminopropyl)phenothiazine hydrochloride
Canonical SMILES : CCN(CC)C(C)CN1C2=CC=CC=C2SC3=CC=CC=C31
InChI : InChI=1S\/C19H24N2S\/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21\/h6-13,15H,4-5,14H2,1-3H3
InChIKey : CDOZDBSBBXSXLB-UHFFFAOYSA-N
Other name(s) : Lysivane || Dibutil || Parsidol || Rodipal || Parsitan || Parphezin || Phenoprpazine || Profenamine || RP3356 || W-483 || Isothazine || Isothiazine || Parkin || BUW
MW : 312.5
Formula : C19H24N2S
CAS_number : 522-00-9
PubChem : 3290
UniChem : CDOZDBSBBXSXLB-UHFFFAOYSA-N
IUPHAR : 7181
Wikipedia : Profenamine
Target
Families : Ethopropazine ligand of proteins in family
BCHE
ACHE
Structure :
6EQP
Protein :
human-BCHE
References (7)
| Title : Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study - Rosenberry_2017_Molecules_22_ |
| Author(s) : Rosenberry TL , Brazzolotto X , Macdonald IR , Wandhammer M , Trovaslet-Leroy M , Darvesh S , Nachon F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : |
| PubMedSearch : Rosenberry_2017_Molecules_22_ |
| PubMedID: 29186056 |
| Gene_locus related to this paper: human-BCHE |
| Title : Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors - Radic_1993_Biochemistry_32_12074 |
| Author(s) : Radic Z , Pickering NA , Vellom DC , Camp S , Taylor P |
| Ref : Biochemistry , 32 :12074 , 1993 |
| Abstract : |
| PubMedSearch : Radic_1993_Biochemistry_32_12074 |
| PubMedID: 8218285 |
| Title : The effect of pesticides on carp (Cyprinus carpio L). Acetylcholinesterase and its biochemical characterization - Szabo_1992_Ecotoxicol.Environ.Saf_23_39 |
| Author(s) : Szabo A , Nemcsok J , Asztalos B , Rakonczay Z , Kasa P , Hieu LH |
| Ref : Ecotoxicology & Environmental Safety , 23 :39 , 1992 |
| Abstract : |
| PubMedSearch : Szabo_1992_Ecotoxicol.Environ.Saf_23_39 |
| PubMedID: 1375147 |
| Title : A peptidase activity exhibited by human serum pseudocholinesterase - Boopathy_1987_Eur.J.Biochem_162_191 |
| Author(s) : Boopathy R , Balasubramanian AS |
| Ref : European Journal of Biochemistry , 162 :191 , 1987 |
| Abstract : |
| PubMedSearch : Boopathy_1987_Eur.J.Biochem_162_191 |
| PubMedID: 3545820 |
| Title : Chemical modification of the bifunctional human serum pseudocholinesterase. Effect on the pseudocholinesterase and aryl acylamidase activities - Boopathy_1985_Eur.J.Biochem_151_351 |
| Author(s) : Boopathy R , Balasubramanian AS |
| Ref : European Journal of Biochemistry , 151 :351 , 1985 |
| Abstract : |
| PubMedSearch : Boopathy_1985_Eur.J.Biochem_151_351 |
| PubMedID: 2863142 |
| Title : Polymorphism of pseudocholinesterase in Torpedo marmorata tissues: comparative study of the catalytic and molecular properties of this enzyme with acetylcholinesterase - Toutant_1985_J.Neurochem_44_580 |
| Author(s) : Toutant JP , Massoulie J , Bon S |
| Ref : Journal of Neurochemistry , 44 :580 , 1985 |
| Abstract : |
| PubMedSearch : Toutant_1985_J.Neurochem_44_580 |
| PubMedID: 2578181 |
| Title : Acetylcholinesterase and butyrylcholinesterase activity in the atria of the heart of adult albino rats - Slavikova_1982_Physiol.Bohemoslov_31_407 |
| Author(s) : Slavikova J , Vlk J , Hlavickova V |
| Ref : Physiol Bohemoslov , 31 :407 , 1982 |
| Abstract : |
| PubMedSearch : Slavikova_1982_Physiol.Bohemoslov_31_407 |
| PubMedID: 6217470 |