MpPPOX
Also inhibitor of FAAH (not an alpha/beta hydrolase)
General
Type : Oxadiazolone, Oxadiazol, Lipase inhibitor, Phenoxyphenyl
Chemical_Nomenclature : 5-methoxy-3-(4-phenoxyphenyl)-1,3,4-oxadiazol-2-one
Canonical SMILES : COC1=NN(C(=O)O1)C2=CC=C(C=C2)OC3=CC=CC=C3
InChI : InChI=1S\/C15H12N2O4\/c1-19-14-16-17(15(18)21-14)11-7-9-13(10-8-11)20-12-5-3-2-4-6-12\/h2-10H,1H3
InChIKey : YAKCIFSNRAIAJM-UHFFFAOYSA-N
Other name(s) : 5-Methoxy-3-(4-phenoxyphenyl)-1,3,4-oxadiazol-2(3H)-one || 5-methoxy-3-(4-phenoxyphenyl)-3H-[1,3,4]oxadiazol-2-one || CHEMBL2171700 || SCHEMBL6552566 || BDBM50432829 || ATM-114 || Compound 16c
Target
Families : MpPPOX ligand of proteins in family
Acidic_Lipase
Monoglyceridelipase_lysophospholip
Protein :
human-MGLL
References (3)
| Title : (4-Phenoxyphenyl)tetrazolecarboxamides and related compounds as dual inhibitors of fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) - Holtfrerich_2013_Eur.J.Med.Chem_63C_64 |
| Author(s) : Holtfrerich A , Hanekamp W , Lehr M |
| Ref : Eur Journal of Medicinal Chemistry , 63C :64 , 2013 |
| Abstract : |
| PubMedSearch : Holtfrerich_2013_Eur.J.Med.Chem_63C_64 |
| PubMedID: 23455058 |
| Title : Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. - Point_2012_Eur.J.Med.Chem_58_452 |
| Author(s) : Point V , Pavan Kumar KV , Marc S , Delorme V , Parsiegla G , Amara S , Carriere F , Buono G , Fotiadu F , Canaan S , Leclaire J , Cavalier JF |
| Ref : Eur Journal of Medicinal Chemistry , 58 :452 , 2012 |
| Abstract : |
| PubMedSearch : Point_2012_Eur.J.Med.Chem_58_452 |
| PubMedID: 23153815 |
| Gene_locus related to this paper: canfa-1lipg , cavpo-2plrp , human-CEL , human-PNLIP , human-PNLIPRP2 , pig-1plip |
| Title : Screening of various hormone-sensitive lipase inhibitors as endocannabinoid-hydrolyzing enzyme inhibitors - |
| Author(s) : Minkkila A , Savinainen JR , Kasnanen H , Xhaard H , Nevalainen T , Laitinen JT , Poso A , Leppanen J , Saario SM |
| Ref : ChemMedChem , 4 :1253 , 2009 |
| PubMedID: 19472270 |