NMDA-BCHE-4a
Memantine Tetrahydrocarbazol conjugate: inhibit BChE (without noticeable suppression of the AChE activity) and block the ifenprodil-binding site of NMDA receptors containing NR2B subunits. AChE inhibition % at 20microM 19.5 +/- 0.3%; BChE IC50 (microM) +/-SEM 0.666 +/- 0.037; Carboxylesterase inhibition % at 20microM 15.6 +/- 0.3%
General
Type : Multitarget, NMDA-Ligand, Carbazol, Adamantyl
Chemical_Nomenclature :
Canonical SMILES : C16=C([N](C2=CC=CC=C12)CCCNC45CC3CC(CC(C3)(C4)C)(C5)C)CCN(C6)C
InChI : InChI=1S\/C27H39N3\/c1-25-13-20-14-26(2,17-25)19-27(15-20,18-25)28-10-6-11-30-23-8-5-4-7-21(23)22-16-29(3)12-9-24(22)30\/h4-5,7-8,20,28H,6,9-19H2,1-3H3\
InChIKey : XATZRBNERUYNKD-UHFFFAOYSA-N
Other name(s) :
Target
Families : NMDA-BCHE-4a ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Conjugation of Aminoadamantane and gamma-Carboline Pharmacophores Gives Rise to Unexpected Properties of Multifunctional Ligands - Bachurin_2021_Molecules_26_ |
| Author(s) : Bachurin SO , Makhaeva GF , Shevtsova EF , Aksinenko AY , Grigoriev VV , Shevtsov PN , Goreva TV , Epishina TA , Kovaleva NV , Pushkareva EA , Boltneva NP , Lushchekina SV , Gabrelyan AV , Zamoyski VL , Dubova LG , Rudakova EV , Fisenko VP , Bovina EV , Richardson RJ |
| Ref : Molecules , 26 : , 2021 |
| Abstract : |
| PubMedSearch : Bachurin_2021_Molecules_26_ |
| PubMedID: 34576998 |