PROTAC-JSF234
General
Type : PROTAC, Multitarget, Sulfur Compound, Sulfonamide, Trifluoro, Indole, Carboxamide
Chemical_Nomenclature : ~{N}-[[4-(cyclopropylsulfonylamino)-2-(trifluoromethyl)phenyl]methyl]-1-ethylsulfonyl-indole-5-carboxamide
Canonical SMILES : CCS(=O)(=O)n1ccc2c1ccc(c2)C(=O)NCc3ccc(cc3C(F)(F)F)NS(=O)(=O)C4CC4
InChI : InChI=1S\/C22H22F3N3O5S2\/c1-2-34(30,31)28-10-9-14-11-15(4-8-20(14)28)21(29)26-13-16-3-5-17(12-19(16)22(23,24)25)27-35(32,33)18-6-7-18\/h3-5,8-12,18,27H,2,6-7,13H2,1H3,(H,26,29)
InChIKey : VXKRJNXILRHMQS-UHFFFAOYSA-N
Other name(s) : A1H5J || PROTAC JSF234 || JSF234 || Compound 22b
MW : 529.552
Formula : C22H22F3N3O5S2
CAS_number :
PubChem : 172868974
UniChem : VXKRJNXILRHMQS-UHFFFAOYSA-N
Target
Families : PROTAC-JSF234 ligand of proteins in family
Epoxide_hydrolase
Structure :
8S77
Protein :
human-EPHX2
References (1)
| Title : Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase - Schonfeld_2025_J.Med.Chem__ |
| Author(s) : Schonfeld J , Brunst S , Ciomirtan L , Willmer L , Chromik MA , Kumar A , Froemel T , Liebisch N , Hackspacher A , Ehrler JHM , Wintermeier L , Hesse C , Fiedler J , Heering J , Freitag H , Zardo P , Fieguth HG , Bruggerhoff A , Jakob J , Haupl B , Weizel L , Kaiser A , Schubert-Zsilavecz M , Oellerich T , Fleming I , Schebb NH , Furst R , Kannt A , Knapp S , Proschak E , Hiesinger K |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Schonfeld_2025_J.Med.Chem__ |
| PubMedID: 40532036 |