Salmeterol-carbamate-Cpd4c
4c (H/heptyl) IC50 BChEeq 1.5 +/- 0.2 nM; IC50 BChE rh 1.0 +/- 0.1 nM; Inhibition AChE at 10-6M 53%
General
Type : Adrenergic-Receptor-ligand, Multitarget
Chemical_Nomenclature : Tert-butyl(2-(4-((heptylcarbamoyl)oxy)-3-(hydroxymethyl)phenyl)-2-hydroxyethyl)(6-(4-phenylbutoxy)hexyl)carbamate
Canonical SMILES : C1(=C(C=CC(=C1)C(CN(CCCCCCOCCCCC2=CC=CC=C2)C(OC(C)(C)C)=O)O)OC(NCCCCCCC)=O)CO
InChI : InChI=1S\/C38H60N2O7\/c1-5-6-7-8-15-24-39-36(43)46-35-23-22-32(28-33(35)30-41)34(42)29-40(37(44)47-38(2,3)4)25-16-9-10-17-26-45-27-18-14-21-31-19-12-11-13-20-31\/h11-13,19-20,22-23,28,34,41-42H,5-10,14-18,21,24-27,29-30H2,1-4H3,(H,39,43)
InChIKey : PQEDDVABPBVZPS-UHFFFAOYSA-N
Other name(s) : Compound 4c
Target
Families : Salmeterol-carbamate-Cpd4c ligand of proteins in family
BCHE
Protein :
human-BCHE
References (1)
| Title : Combining beta(2)-AR agonism with butyrylcholinesterase inhibition, a synergistic neuroprotective action against Alzheimer's disease - Wang_2026_RSC.Med.Chem__ |
| Author(s) : Wang A , Curel T , Claeysen S , Travers-Lesage V , Cadot M , Davis A , Sopkova-de Oliveira Santos J , Modeste F , Brazzolotto X , Nachon F , Dallemagne P , Since M , Rochais C |
| Ref : RSC Med Chem , : , 2026 |
| Abstract : |
| PubMedSearch : Wang_2026_RSC.Med.Chem__ |
| PubMedID: 42416270 |
| Gene_locus related to this paper: human-BCHE |