Tacrine-Melatonin-Hybrid-6b
IC50(AChE) = 0.008 nM; IC50(BChE) = 7.8 nM; antioxidant capacity [trolox equ.] = 2.5
General
Type : Derivative of Tacrine, Acridine, Derivative of Tryptamine, Indole, Antioxidant, Organochlorine, Multitarget
Chemical_Nomenclature : 7-[(6,8-dichloro-1,2,3,4-tetrahydroacridin-9-yl)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanamide
Canonical SMILES : C1CCC2=NC3=C(C(=CC(=C3)Cl)Cl)C(=C2C1)NCCCCCCC(=O)NCCC4=CNC5=CC=CC=C54
InChI : InChI=1S\/C30H34Cl2N4O\/c31-21-17-24(32)29-27(18-21)36-26-12-7-5-10-23(26)30(29)34-15-8-2-1-3-13-28(37)33-16-14-20-19-35-25-11-6-4-9-22(20)25\/h4,6,9,11,17-19,35H,1-3,5,7-8,10,12-16H2,(H,33,37)(H,34,36)
InChIKey : ULGJWNIHLSLQPZ-UHFFFAOYSA-N
Other name(s) : CHEMBL199585 || Tacrine-Melatonin Hybrid 6b || BDBM9012
MW : 537.5
Formula : C30H34Cl2N4O
CAS_number :
PubChem : 11706508
UniChem : ULGJWNIHLSLQPZ-UHFFFAOYSA-N
Target
Families : Tacrine-Melatonin-Hybrid-6b ligand of proteins in family
ACHE
BCHE
Protein :
human-ACHE
human-BCHE
References (1)
| Title : Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties - Rodriguez-Franco_2006_J.Med.Chem_49_459 |
| Author(s) : Rodriguez-Franco MI , Fernandez-Bachiller MI , Perez C , Hernandez-Ledesma B , Bartolome B |
| Ref : Journal of Medicinal Chemistry , 49 :459 , 2006 |
| Abstract : |
| PubMedSearch : Rodriguez-Franco_2006_J.Med.Chem_49_459 |
| PubMedID: 16420031 |