Triton-X-100
As chain length vary n=9-10, concentration is expressed in g/l || Non ionic surfactant used to recover membrane associated enzymes. Triton is a reversible inhibitor of some cholinesterases. Triton X-100 increases phosphorylation by metamidophos and carbamoylation by aldicarb but decreases phosphorylation by paraoxon. Triton-X100 chains placed in the active site of the lipase from Geobacillus thermocatenulatus mimick chains of the triglyceride substrate
General
Type : Detergent
Chemical_Nomenclature : t-Octylphenoxypolyethoxyethanol \; 14-[4-(1,1,3,3-Tetramethylbutyl)phenoxy]-3,6,9,12-tetraoxatetradecan-1-ol
Canonical SMILES : CC(C)(C)CC(C)(C)C1=CC=C(C=C1)OCCOCCOCCOCCOCCO
InChI : InChI=1S\/C24H42O6\/c1-23(2,3)20-24(4,5)21-6-8-22(9-7-21)30-19-18-29-17-16-28-15-14-27-13-12-26-11-10-25\/h6-9,25H,10-20H2,1-5H3
InChIKey : WQBPSJIAFZCNBR-UHFFFAOYSA-N
Other name(s) : Octoxynol-10
MW : 426.587
Formula : C24H42O6
CAS_number :
PubChem : 560774
UniChem : WQBPSJIAFZCNBR-UHFFFAOYSA-N
Wikipedia : Triton_X-100
Target
Families : Triton-X-100 ligand of proteins in family
BCHE
ACHE
Bacterial_lip_FamI.5
Hormone-sensitive_lipase_like
RsbQ-like
Structure :
7C8L
5Z89
5Z95
5MIF
2W22
Protein :
bactc-lipas
tubmm-TmEst2
strhe-ShHTL7
References (12)
| Title : Structural basis for specific inhibition of the highly sensitive ShHTL7 receptor - Shahul Hameed_2018_EMBO.Rep_19_e45619 |
| Author(s) : Shahul Hameed U , Haider I , Jamil M , Kountche BA , Guo X , Zarban RA , Kim D , Al-Babili S , Arold ST |
| Ref : EMBO Rep , : , 2018 |
| Abstract : |
| PubMedSearch : Shahul Hameed_2018_EMBO.Rep_19_e45619 |
| PubMedID: 30021834 |
| Gene_locus related to this paper: strhe-ShHTL7 |
| Title : A family of archaea-like carboxylesterases preferentially expressed in the symbiotic phase of the mychorrizal fungus Tuber melanosporum - Cavazzini_2017_Sci.Rep_7_7628 |
| Author(s) : Cavazzini D , Grossi G , Levati E , Vallese F , Montanini B , Bolchi A , Zanotti G , Ottonello S |
| Ref : Sci Rep , 7 :7628 , 2017 |
| Abstract : |
| PubMedSearch : Cavazzini_2017_Sci.Rep_7_7628 |
| PubMedID: 28794466 |
| Gene_locus related to this paper: tubmm-TmEst2 , tubmm-TmEst1 , tubmm-TmEst3 |
| Title : Activation of bacterial thermoalkalophilic lipases is spurred by dramatic structural rearrangements - Carrasco-Lopez_2009_J.Biol.Chem_284_4365 |
| Author(s) : Carrasco-Lopez C , Godoy C , de Las Rivas B , Fernandez-Lorente G , Palomo JM , Guisan JM , Fernandez-Lafuente R , Martinez-Ripoll M , Hermoso JA |
| Ref : Journal of Biological Chemistry , 284 :4365 , 2009 |
| Abstract : |
| PubMedSearch : Carrasco-Lopez_2009_J.Biol.Chem_284_4365 |
| PubMedID: 19056729 |
| Gene_locus related to this paper: bactc-lipas |
| Title : Crystallization and preliminary X-ray diffraction studies of the BTL2 lipase from the extremophilic microorganism Bacillus thermocatenulatus - Carrasco-Lopez_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_1043 |
| Author(s) : Carrasco-Lopez C , Godoy C , de Las Rivas B , Fernandez-Lorente G , Palomo JM , Guisan JM , Fernandez-Lafuente R , Martinez-Ripoll M , Hermoso JA |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 64 :1043 , 2008 |
| Abstract : |
| PubMedSearch : Carrasco-Lopez_2008_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_64_1043 |
| PubMedID: 18997337 |
| Gene_locus related to this paper: bactc-lipas |
| Title : Exploration of the Drosophila acetylcholinesterase substrate activation site using a reversible inhibitor (Triton X-100) and mutated enzymes - Marcel_2000_J.Biol.Chem_275_11603 |
| Author(s) : Marcel V , Estrada-Mondaca S , Magne F , Stojan J , Klaebe A , Fournier D |
| Ref : Journal of Biological Chemistry , 275 :11603 , 2000 |
| Abstract : |
| PubMedSearch : Marcel_2000_J.Biol.Chem_275_11603 |
| PubMedID: 10766776 |
| Title : Interaction of Triton X-100 with acyl pocket of butyrylcholinesterase: effect on esterase activity and inhibitor sensitivity of the enzyme - Jaganathan_1998_Indian.J.Biochem.Biophys_35_142 |
| Author(s) : Jaganathan L , Boopathy R |
| Ref : Indian J Biochem Biophys , 35 :142 , 1998 |
| Abstract : |
| PubMedSearch : Jaganathan_1998_Indian.J.Biochem.Biophys_35_142 |
| PubMedID: 9803662 |
| Title : Effect of Triton X-100 on the inhibition of human erythrocyte acetylcholinesterase by organophosphorus insecticide DDVP - Gazdzik_1989_Pestic.Biochem.Physiol_34_126 |
| Author(s) : Gazdzik D , Sitkiewicz D |
| Ref : Pesticide Biochemistry and Physiology , 34 :126 , 1989 |
| Abstract : |
| PubMedSearch : Gazdzik_1989_Pestic.Biochem.Physiol_34_126 |
| PubMedID: |
| Title : [Mechanism of activation of acetylcholinesterase in brain tissue homogenates by detergents] - Kazennov_1979_Biokhimiia_44_214 |
| Author(s) : Kazennov AM , Maslova MN , Reznik LV |
| Ref : Biokhimiia , 44 :214 , 1979 |
| Abstract : |
| PubMedSearch : Kazennov_1979_Biokhimiia_44_214 |
| PubMedID: 435563 |
| Title : Inhibition of acetylcholinesterase by TX-100 - Millar_1979_Biophys.Chem_10_147 |
| Author(s) : Millar DB , Christopher JP , Bishop WH |
| Ref : Biophysical Chemistry , 10 :147 , 1979 |
| Abstract : |
| PubMedSearch : Millar_1979_Biophys.Chem_10_147 |
| PubMedID: 486700 |
| Title : Evidence that eel acetylcholinesterase is not an integral membrane protein - Millar_1978_Biophys.Chem_9_9 |
| Author(s) : Millar DB , Christopher JP , Burrough DO |
| Ref : Biophysical Chemistry , 9 :9 , 1978 |
| Abstract : |
| PubMedSearch : Millar_1978_Biophys.Chem_9_9 |
| PubMedID: 223681 |
| Title : Inactivation of acetylcholinesterase by propanol and sodium dodecyl sulphate - Dawson_1976_Biochim.Biophys.Acta_452_413 |
| Author(s) : Dawson RM |
| Ref : Biochimica & Biophysica Acta , 452 :413 , 1976 |
| Abstract : |
| PubMedSearch : Dawson_1976_Biochim.Biophys.Acta_452_413 |
| PubMedID: 1009118 |
| Title : Activation of acetylcholinesterase by Triton X-100 - |
| Author(s) : Srinivasan R , Karczmar AG , Bernsohn J |
| Ref : Biochimica & Biophysica Acta , 284 :349 , 1972 |
| PubMedID: 5073767 |