Gene Locus : human-BCHE
Mode of mutation : Site directed mutagenesis
Disease :
Summary : Succinylthiocholine binding No binding of succinylthiocholine Masson_1997_Biochemistry_36_2266 || Substrate activation substrate activation Masson_2001_Biochim.Biophys.Acta_1544_166 || Aging W82A increases half-life of aging by DFP 13 times Masson_1997_Biochem.J_327_601 || Aricept~Donepezil~E2020 inhibition no inhibition at >120uM Saxena_2003_Eur.J.Biochem_270_4447
AAA Change :
Allelic Variant :
Risk Factor :
Inhibitor :
Structure :
Disease by interaction :
Interact Gene Locus :
Xenobiotic sensitivity :
Modification : Succinylthiocholine binding || Substrate activation || Aricept~Donepezil~E2020 inhibition
Torpedo_number : 84
Kinetic Parameter : No kinetic parameter
News : No news
Comment :
p.W82A Trp82Ala (p.W110A Trp110Ala in primary sequence with 28 amino-acids signal peptide) No binding of succinylthiocholine Aging: W82A increases half-life of aging by DFP 13 times, Aricept~Donepezil~E2020 inhibition: no inhibition at >120uM
| Title : Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases - Saxena_2003_Eur.J.Biochem_270_4447 |
| Author(s) : Saxena A , Fedorko JM , Vinayaka CR , Medhekar R , Radic Z , Taylor P , Lockridge O , Doctor BP |
| Ref : European Journal of Biochemistry , 270 :4447 , 2003 |
| Abstract : |
| PubMedSearch : Saxena_2003_Eur.J.Biochem_270_4447 |
| PubMedID: 14622273 |
| Title : Concentration-dependent reversible activation-inhibition of human butyrylcholinesterase by tetraethylammonium ion - Stojan_2002_Eur.J.Biochem_269_1154 |
| Author(s) : Stojan J , Golicnik M , Froment MT , Estour F , Masson P |
| Ref : European Journal of Biochemistry , 269 :1154 , 2002 |
| Abstract : |
| PubMedSearch : Stojan_2002_Eur.J.Biochem_269_1154 |
| PubMedID: 11856351 |
| Title : Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesterase - Masson_2001_Biochim.Biophys.Acta_1544_166 |
| Author(s) : Masson P , Xie W , Froment MT , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1544 :166 , 2001 |
| Abstract : |
| PubMedSearch : Masson_2001_Biochim.Biophys.Acta_1544_166 |
| PubMedID: 11341926 |
| Gene_locus related to this paper: human-BCHE |
| Title : Aging of di-isopropyl-phosphorylated human butyrylcholinesterase - Masson_1997_Biochem.J_327_601 |
| Author(s) : Masson P , Fortier PL , Albaret C , Froment MT , Bartels CF , Lockridge O |
| Ref : Biochemical Journal , 327 ( Pt 2) :601 , 1997 |
| Abstract : |
| PubMedSearch : Masson_1997_Biochem.J_327_601 |
| PubMedID: 9359435 |
| Title : Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase - Masson_1997_Biochemistry_36_2266 |
| Author(s) : Masson P , Legrand P , Bartels CF , Froment MT , Schopfer LM , Lockridge O |
| Ref : Biochemistry , 36 :2266 , 1997 |
| Abstract : |
| PubMedSearch : Masson_1997_Biochemistry_36_2266 |
| PubMedID: 9047329 |