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Butler_2009_Nature_459_657

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Title : Evolution of pathogenicity and sexual reproduction in eight Candida genomes - Butler_2009_Nature_459_657
Author(s) : Butler G , Rasmussen MD , Lin MF , Santos MA , Sakthikumar S , Munro CA , Rheinbay E , Grabherr M , Forche A , Reedy JL , Agrafioti I , Arnaud MB , Bates S , Brown AJ , Brunke S , Costanzo MC , Fitzpatrick DA , de Groot PW , Harris D , Hoyer LL , Hube B , Klis FM , Kodira C , Lennard N , Logue ME , Martin R , Neiman AM , Nikolaou E , Quail MA , Quinn J , Santos MC , Schmitzberger FF , Sherlock G , Shah P , Silverstein KA , Skrzypek MS , Soll D , Staggs R , Stansfield I , Stumpf MP , Sudbery PE , Srikantha T , Zeng Q , Berman J , Berriman M , Heitman J , Gow NA , Lorenz MC , Birren BW , Kellis M , Cuomo CA
Ref : Nature , 459 :657 , 2009
Abstract :

Candida species are the most common cause of opportunistic fungal infection worldwide. Here we report the genome sequences of six Candida species and compare these and related pathogens and non-pathogens. There are significant expansions of cell wall, secreted and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine-to-serine genetic-code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the Candida albicans gene catalogue, identifying many new genes.
PubMedSearch : Butler_2009_Nature_459_657
PubMedID: 19465905
Gene_locus related to this paper: canal-ATG15 , canal-bna7 , canal-c4yl13 , canal-LIP1 , canal-LIP2 , canal-LIP3 , canal-LIP4 , canal-LIP5 , canal-LIP6 , canal-LIP7 , canal-LIP8 , canal-LIP9 , canal-LIP10 , canal-ppme1 , canal-q5a0c9 , canal-q5a2i9 , canal-q5a042 , canal-q5ad17 , canal-q5aeu3 , canal-q5afp8 , canal-q5ag57 , canal-q5ai09 , canal-q5ai12 , canal-q5ajt3 , canal-q5akz5 , canal-q5apu4 , canal-q59l46 , canal-q59m48 , canal-q59nw6 , canal-q59u61 , canal-q59u64 , canal-q59vp0 , canal-q59y97 , canaw-c4ykb1 , canaw-c4yrn6 , canaw-c4yrn9 , canaw-c4yrr3 , canaw-c4yrv3 , canaw-c4ys26 , cantt-c5m3d7 , cantt-c5m3y5 , cantt-c5m4x0 , cantt-c5m5e8 , cantt-c5m5w2 , cantt-c5m8s7 , cantt-c5m9c2 , cantt-c5m465 , cantt-c5m751 , cantt-c5m793 , cantt-c5m893 , cantt-c5ma78 , cantt-c5mag0 , cantt-c5mbb8 , cantt-c5mc53 , cantt-c5md87 , cantt-c5mdy3 , cantt-c5mey7 , cantt-c5mfg0 , cantt-c5mfh8 , cantt-c5mg56 , cantt-c5mgj0 , cantt-c5mh75 , cantt-c5mh80 , cantt-c5mh89 , cantt-c5mhh0 , cantt-c5mhn5 , cantt-c5mij5 , cantt-c5min7 , clal4-c4xvt8 , clal4-c4xwy4 , clal4-c4xy03 , clal4-c4xyx9 , clal4-c4xzz1 , clal4-c4y3e1 , clal4-c4y4f2 , clal4-c4y4w8 , clal4-c4y5j4 , clal4-c4y5j9 , clal4-c4y7z7 , clal4-c4y8q1 , clal4-c4y035 , clal4-c4y481 , clal4-c4y538 , clal4-c4y898 , clal4-c4yas2 , clal4-c4yba6 , clal4-c4yba7 , clal4-c4yc85 , lodel-a5drz3 , lodel-a5ds97 , lodel-a5dsc0 , lodel-a5duu4 , lodel-a5duy7 , lodel-a5dv03 , lodel-a5dv46 , lodel-a5dw16 , lodel-a5dwv7 , lodel-a5dww6 , lodel-a5dxf3 , lodel-a5e0z5 , lodel-a5e1c1 , lodel-a5e1l4 , lodel-a5e1p3 , lodel-a5e2s1 , lodel-a5e2t8 , lodel-a5e2v2 , lodel-a5e4u8 , lodel-a5e5a9 , lodel-a5e5k1 , lodel-a5e5z7 , lodel-a5e6w1 , lodel-a5e028 , lodel-atg15 , lodel-kex1 , picgu-a5d9u2 , picgu-a5dav0 , picgu-a5dbk0 , picgu-a5dc45 , picgu-a5dc73 , picgu-a5dc74 , picgu-a5dc75 , picgu-a5ddt8 , picgu-a5dev7 , picgu-a5dh90 , picgu-a5dhe3 , picgu-a5di38 , picgu-a5dj06 , picgu-a5dkd8 , picgu-a5dle9 , picgu-a5dlj5 , picgu-a5dm19 , picgu-a5dn92 , picgu-a5dnr3 , picgu-a5dnt6 , picgu-a5dqu5 , picgu-a5dr14 , picgu-a5drl3 , picgu-atg15 , picgu-bna7 , picgu-a5d9q3 , picgu-a5dag9 , clal4-c4y5a2 , clal4-c4y0l0 , cantt-c5mcb1 , clal4-c4y8j2 , cantt-c5m494 , clals-a0a202gac7 , canal-hda1 , picgu-a5dks8 , lodel-a5drs6 , canpc-g8bbk1 , cantt-kex1 , clal4-kex1 , picgu-kex1

Related information

Gene_locus canal-ATG15    canal-bna7    canal-c4yl13    canal-LIP1    canal-LIP2    canal-LIP3    canal-LIP4    canal-LIP5    canal-LIP6    canal-LIP7    canal-LIP8    canal-LIP9    canal-LIP10    canal-ppme1    canal-q5a0c9    canal-q5a2i9    canal-q5a042    canal-q5ad17    canal-q5aeu3    canal-q5afp8    canal-q5ag57    canal-q5ai09    canal-q5ai12    canal-q5ajt3    canal-q5akz5    canal-q5apu4    canal-q59l46    canal-q59m48    canal-q59nw6    canal-q59u61    canal-q59u64    canal-q59vp0    canal-q59y97    canaw-c4ykb1    canaw-c4yrn6    canaw-c4yrn9    canaw-c4yrr3    canaw-c4yrv3    canaw-c4ys26    cantt-c5m3d7    cantt-c5m3y5    cantt-c5m4x0    cantt-c5m5e8    cantt-c5m5w2    cantt-c5m8s7    cantt-c5m9c2    cantt-c5m465    cantt-c5m751    cantt-c5m793    cantt-c5m893    cantt-c5ma78    cantt-c5mag0    cantt-c5mbb8    cantt-c5mc53    cantt-c5md87    cantt-c5mdy3    cantt-c5mey7    cantt-c5mfg0    cantt-c5mfh8    cantt-c5mg56    cantt-c5mgj0    cantt-c5mh75    cantt-c5mh80    cantt-c5mh89    cantt-c5mhh0    cantt-c5mhn5    cantt-c5mij5    cantt-c5min7    clal4-c4xvt8    clal4-c4xwy4    clal4-c4xy03    clal4-c4xyx9    clal4-c4xzz1    clal4-c4y3e1    clal4-c4y4f2    clal4-c4y4w8    clal4-c4y5j4    clal4-c4y5j9    clal4-c4y7z7    clal4-c4y8q1    clal4-c4y035    clal4-c4y481    clal4-c4y538    clal4-c4y898    clal4-c4yas2    clal4-c4yba6    clal4-c4yba7    clal4-c4yc85    lodel-a5drz3    lodel-a5ds97    lodel-a5dsc0    lodel-a5duu4    lodel-a5duy7    lodel-a5dv03    lodel-a5dv46    lodel-a5dw16    lodel-a5dwv7    lodel-a5dww6    lodel-a5dxf3    lodel-a5e0z5    lodel-a5e1c1    lodel-a5e1l4    lodel-a5e1p3    lodel-a5e2s1    lodel-a5e2t8    lodel-a5e2v2    lodel-a5e4u8    lodel-a5e5a9    lodel-a5e5k1    lodel-a5e5z7    lodel-a5e6w1    lodel-a5e028    lodel-atg15    lodel-kex1    picgu-a5d9u2    picgu-a5dav0    picgu-a5dbk0    picgu-a5dc45    picgu-a5dc73    picgu-a5dc74    picgu-a5dc75    picgu-a5ddt8    picgu-a5dev7    picgu-a5dh90    picgu-a5dhe3    picgu-a5di38    picgu-a5dj06    picgu-a5dkd8    picgu-a5dle9    picgu-a5dlj5    picgu-a5dm19    picgu-a5dn92    picgu-a5dnr3    picgu-a5dnt6    picgu-a5dqu5    picgu-a5dr14    picgu-a5drl3    picgu-atg15    picgu-bna7    picgu-a5d9q3    picgu-a5dag9    clal4-c4y5a2    clal4-c4y0l0    cantt-c5mcb1    clal4-c4y8j2    cantt-c5m494    clals-a0a202gac7    canal-hda1    picgu-a5dks8    lodel-a5drs6    canpc-g8bbk1    cantt-kex1    clal4-kex1    picgu-kex1
Gene_locus_frgt picgu-a5dre5

Citations formats

Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA (2009)
Evolution of pathogenicity and sexual reproduction in eight Candida genomes
Nature 459 :657

Butler G, Rasmussen MD, Lin MF, Santos MA, Sakthikumar S, Munro CA, Rheinbay E, Grabherr M, Forche A, Reedy JL, Agrafioti I, Arnaud MB, Bates S, Brown AJ, Brunke S, Costanzo MC, Fitzpatrick DA, de Groot PW, Harris D, Hoyer LL, Hube B, Klis FM, Kodira C, Lennard N, Logue ME, Martin R, Neiman AM, Nikolaou E, Quail MA, Quinn J, Santos MC, Schmitzberger FF, Sherlock G, Shah P, Silverstein KA, Skrzypek MS, Soll D, Staggs R, Stansfield I, Stumpf MP, Sudbery PE, Srikantha T, Zeng Q, Berman J, Berriman M, Heitman J, Gow NA, Lorenz MC, Birren BW, Kellis M, Cuomo CA (2009)
Nature 459 :657