1,2-dichloroethane
General
Type : Haloalkane
Chemical_Nomenclature : 1,2-dichloroethane
Canonical SMILES : C(CCl)Cl
InChI : InChI=1S\/C2H4Cl2\/c3-1-2-4\/h1-2H2
InChIKey : WSLDOOZREJYCGB-UHFFFAOYSA-N
Other name(s) : Ethylene dichloride || Ethylene chloride || 1,2-DCA || Ethane, 1,2-dichloro- || Ethane dichloride
MW : 98.95
Formula : C2H4Cl2
CAS_number : 107-06-2
PubChem : 11
UniChem : WSLDOOZREJYCGB-UHFFFAOYSA-N
Wikipedia : 1,2-dichloroethane
Target
Structures : 2O2H, 1G5F, 2DHC, 2DHD
Families : Haloalkane_dehalogenase-HLD1, Haloalkane_dehalogenase-HLD2
References (24)
| Title : Decoding Enzymatic Dechlorination with Multiscale Modeling: Mechanistic Insights into Native Haloalkane Dehalogenase from Xanthobacter autotrophicus and Its Designed Variants - Gelfand_2025_ACS.Catal_15_13657 |
| Author(s) : Gelfand N , Warshel A |
| Ref : ACS Catal , 15 :13657 , 2025 |
| Abstract : |
| PubMedSearch : Gelfand_2025_ACS.Catal_15_13657 |
| PubMedID: 40927817 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Decoding Enzymatic Dechlorination with Multiscale Modeling: Mechanistic Insights into Native Haloalkane Dehalogenase from Xanthobacter autotrophicus and Its Designed Variants - Gelfand_2025_ACS.Catal_15_13657 |
| Author(s) : Gelfand N , Warshel A |
| Ref : ACS Catal , 15 :13657 , 2025 |
| Abstract : |
| PubMedSearch : Gelfand_2025_ACS.Catal_15_13657 |
| PubMedID: 40927817 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Decoding Enzymatic Dechlorination with Multiscale Modeling: Mechanistic Insights into Native Haloalkane Dehalogenase from Xanthobacter autotrophicus and Its Designed Variants - Gelfand_2025_ACS.Catal_15_13657 |
| Author(s) : Gelfand N , Warshel A |
| Ref : ACS Catal , 15 :13657 , 2025 |
| Abstract : |
| PubMedSearch : Gelfand_2025_ACS.Catal_15_13657 |
| PubMedID: 40927817 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : 1,2-DCA biodegradation potential of an aquifer assessed in situ and in aerobic and anaerobic microcosms - Cruciata_2024_Environ.Microbiome_19_106 |
| Author(s) : Cruciata I , Scire Calabrisotto L , Carpani G , Poppa L , Modica A , Pace A , Catania V , Quatrini P |
| Ref : Environ Microbiome , 19 :106 , 2024 |
| Abstract : |
| PubMedSearch : Cruciata_2024_Environ.Microbiome_19_106 |
| PubMedID: 39696724 |
| Title : 1,2-DCA biodegradation potential of an aquifer assessed in situ and in aerobic and anaerobic microcosms - Cruciata_2024_Environ.Microbiome_19_106 |
| Author(s) : Cruciata I , Scire Calabrisotto L , Carpani G , Poppa L , Modica A , Pace A , Catania V , Quatrini P |
| Ref : Environ Microbiome , 19 :106 , 2024 |
| Abstract : |
| PubMedSearch : Cruciata_2024_Environ.Microbiome_19_106 |
| PubMedID: 39696724 |
| Title : 1,2-DCA biodegradation potential of an aquifer assessed in situ and in aerobic and anaerobic microcosms - Cruciata_2024_Environ.Microbiome_19_106 |
| Author(s) : Cruciata I , Scire Calabrisotto L , Carpani G , Poppa L , Modica A , Pace A , Catania V , Quatrini P |
| Ref : Environ Microbiome , 19 :106 , 2024 |
| Abstract : |
| PubMedSearch : Cruciata_2024_Environ.Microbiome_19_106 |
| PubMedID: 39696724 |
| Title : Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17 - Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| Author(s) : Tratsiak K , Degtjarik O , Drienovska I , Chrast L , Rezacova P , Kuty M , Chaloupkova R , Damborsky J , Kuta Smatanova I |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :683 , 2013 |
| Abstract : |
| PubMedSearch : Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| PubMedID: 23722854 |
| Gene_locus related to this paper: 9alte-a3jb27 , psyck-q1qbb9 |
| Title : Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17 - Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| Author(s) : Tratsiak K , Degtjarik O , Drienovska I , Chrast L , Rezacova P , Kuty M , Chaloupkova R , Damborsky J , Kuta Smatanova I |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :683 , 2013 |
| Abstract : |
| PubMedSearch : Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| PubMedID: 23722854 |
| Gene_locus related to this paper: 9alte-a3jb27 , psyck-q1qbb9 |
| Title : Crystallographic analysis of new psychrophilic haloalkane dehalogenases: DpcA from Psychrobacter cryohalolentis K5 and DmxA from Marinobacter sp. ELB17 - Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| Author(s) : Tratsiak K , Degtjarik O , Drienovska I , Chrast L , Rezacova P , Kuty M , Chaloupkova R , Damborsky J , Kuta Smatanova I |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , 69 :683 , 2013 |
| Abstract : |
| PubMedSearch : Tratsiak_2013_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_69_683 |
| PubMedID: 23722854 |
| Gene_locus related to this paper: 9alte-a3jb27 , psyck-q1qbb9 |
| Title : Substrate specificity of haloalkane dehalogenases - Koudelakova_2011_Biochem.J_435_345 |
| Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J |
| Ref : Biochemical Journal , 435 :345 , 2011 |
| Abstract : |
| PubMedSearch : Koudelakova_2011_Biochem.J_435_345 |
| PubMedID: 21294712 |
| Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1 |
| Title : Substrate specificity of haloalkane dehalogenases - Koudelakova_2011_Biochem.J_435_345 |
| Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J |
| Ref : Biochemical Journal , 435 :345 , 2011 |
| Abstract : |
| PubMedSearch : Koudelakova_2011_Biochem.J_435_345 |
| PubMedID: 21294712 |
| Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1 |
| Title : Substrate specificity of haloalkane dehalogenases - Koudelakova_2011_Biochem.J_435_345 |
| Author(s) : Koudelakova T , Chovancova E , Brezovsky J , Monincova M , Fortova A , Jarkovsky J , Damborsky J |
| Ref : Biochemical Journal , 435 :345 , 2011 |
| Abstract : |
| PubMedSearch : Koudelakova_2011_Biochem.J_435_345 |
| PubMedID: 21294712 |
| Gene_locus related to this paper: agrtu-DHAA , brael-e2rv62 , braja-dhaa , myctu-linb , myctu-Rv1833c , rhoba-DHLA , rhoso-halo1 , sphpi-linb , xanau-halo1 |
| Title : X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579 - Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| Author(s) : Mazumdar PA , Hulecki JC , Cherney MM , Garen CR , James MN |
| Ref : Biochimica & Biophysica Acta , 1784 :351 , 2008 |
| Abstract : |
| PubMedSearch : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| PubMedID: 18062934 |
| Gene_locus related to this paper: myctu-linb |
| Title : X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579 - Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| Author(s) : Mazumdar PA , Hulecki JC , Cherney MM , Garen CR , James MN |
| Ref : Biochimica & Biophysica Acta , 1784 :351 , 2008 |
| Abstract : |
| PubMedSearch : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| PubMedID: 18062934 |
| Gene_locus related to this paper: myctu-linb |
| Title : X-ray crystal structure of Mycobacterium tuberculosis haloalkane dehalogenase Rv2579 - Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| Author(s) : Mazumdar PA , Hulecki JC , Cherney MM , Garen CR , James MN |
| Ref : Biochimica & Biophysica Acta , 1784 :351 , 2008 |
| Abstract : |
| PubMedSearch : Mazumdar_2008_Biochim.Biophys.Acta_1784_351 |
| PubMedID: 18062934 |
| Gene_locus related to this paper: myctu-linb |
| Title : Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition - Oakley_2002_Biochemistry_41_4847 |
| Author(s) : Oakley AJ , Prokop Z , Bohac M , Kmunicek J , Jedlicka T , Monincova M , Kuta-Smatanova I , Nagata Y , Damborsky J , Wilce MC |
| Ref : Biochemistry , 41 :4847 , 2002 |
| Abstract : |
| PubMedSearch : Oakley_2002_Biochemistry_41_4847 |
| PubMedID: 11939779 |
| Gene_locus related to this paper: sphpi-linb |
| Title : Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition - Oakley_2002_Biochemistry_41_4847 |
| Author(s) : Oakley AJ , Prokop Z , Bohac M , Kmunicek J , Jedlicka T , Monincova M , Kuta-Smatanova I , Nagata Y , Damborsky J , Wilce MC |
| Ref : Biochemistry , 41 :4847 , 2002 |
| Abstract : |
| PubMedSearch : Oakley_2002_Biochemistry_41_4847 |
| PubMedID: 11939779 |
| Gene_locus related to this paper: sphpi-linb |
| Title : Exploring the structure and activity of haloalkane dehalogenase from Sphingomonas paucimobilis UT26: evidence for product- and water-mediated inhibition - Oakley_2002_Biochemistry_41_4847 |
| Author(s) : Oakley AJ , Prokop Z , Bohac M , Kmunicek J , Jedlicka T , Monincova M , Kuta-Smatanova I , Nagata Y , Damborsky J , Wilce MC |
| Ref : Biochemistry , 41 :4847 , 2002 |
| Abstract : |
| PubMedSearch : Oakley_2002_Biochemistry_41_4847 |
| PubMedID: 11939779 |
| Gene_locus related to this paper: sphpi-linb |
| Title : Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site - Krooshof_1998_Biochemistry_37_15013 |
| Author(s) : Krooshof GH , Ridder IS , Tepper AW , Vos GJ , Rozeboom HJ , Kalk KH , Dijkstra BW , Janssen DB |
| Ref : Biochemistry , 37 :15013 , 1998 |
| Abstract : |
| PubMedSearch : Krooshof_1998_Biochemistry_37_15013 |
| PubMedID: 9790663 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site - Krooshof_1998_Biochemistry_37_15013 |
| Author(s) : Krooshof GH , Ridder IS , Tepper AW , Vos GJ , Rozeboom HJ , Kalk KH , Dijkstra BW , Janssen DB |
| Ref : Biochemistry , 37 :15013 , 1998 |
| Abstract : |
| PubMedSearch : Krooshof_1998_Biochemistry_37_15013 |
| PubMedID: 9790663 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Kinetic analysis and X-ray structure of haloalkane dehalogenase with a modified halide-binding site - Krooshof_1998_Biochemistry_37_15013 |
| Author(s) : Krooshof GH , Ridder IS , Tepper AW , Vos GJ , Rozeboom HJ , Kalk KH , Dijkstra BW , Janssen DB |
| Ref : Biochemistry , 37 :15013 , 1998 |
| Abstract : |
| PubMedSearch : Krooshof_1998_Biochemistry_37_15013 |
| PubMedID: 9790663 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase - Verschueren_1993_Nature_363_693 |
| Author(s) : Verschueren KH , Seljee F , Rozeboom HJ , Kalk KH , Dijkstra BW |
| Ref : Nature , 363 :693 , 1993 |
| Abstract : |
| PubMedSearch : Verschueren_1993_Nature_363_693 |
| PubMedID: 8515812 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase - Verschueren_1993_Nature_363_693 |
| Author(s) : Verschueren KH , Seljee F , Rozeboom HJ , Kalk KH , Dijkstra BW |
| Ref : Nature , 363 :693 , 1993 |
| Abstract : |
| PubMedSearch : Verschueren_1993_Nature_363_693 |
| PubMedID: 8515812 |
| Gene_locus related to this paper: xanau-halo1 |
| Title : Crystallographic analysis of the catalytic mechanism of haloalkane dehalogenase - Verschueren_1993_Nature_363_693 |
| Author(s) : Verschueren KH , Seljee F , Rozeboom HJ , Kalk KH , Dijkstra BW |
| Ref : Nature , 363 :693 , 1993 |
| Abstract : |
| PubMedSearch : Verschueren_1993_Nature_363_693 |
| PubMedID: 8515812 |
| Gene_locus related to this paper: xanau-halo1 |