Gly-Pro-AMC
General
Type : Coumarin, Peptide, Pyrrolidine, Carboxamide, 7-amido-4-methylcoumarin, Chromen
Chemical_Nomenclature : 1-(2-aminoacetyl)-N-(4-methyl-2-oxochromen-7-yl)pyrrolidine-2-carboxamide, (2S)-1-(2-aminoacetyl)-N-(4-methyl-2-oxochromen-7-yl)pyrrolidine-2-carboxamide
Canonical SMILES : CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)C3CCCN3C(=O)CN || CC1=CC(=O)OC2=C1C=CC(=C2)NC(=O)[C@@H]3CCCN3C(=O)CN
InChI : InChI=1S\/C17H19N3O4\/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18\/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23) || InChI=1S\/C17H19N3O4\/c1-10-7-16(22)24-14-8-11(4-5-12(10)14)19-17(23)13-3-2-6-20(13)15(21)9-18\/h4-5,7-8,13H,2-3,6,9,18H2,1H3,(H,19,23)\/t13-\/m0\/s1
InChIKey : UTDVHCQTKWTQEA-UHFFFAOYSA-N || UTDVHCQTKWTQEA-ZDUSSCGKSA-N
Other name(s) : Gly-Pro-7-amido-4-methylcoumarin hydrobromide || AC1N2LFZ || Gly-Pro-7-amidomethylcoumarin || AMC039 || SCHEMBL11440079 || Gly-pro-mca || GP-AMC || Glycylprolyl-4-methylcoumaryl-7-amide || Gly-pro-4-methylcoumaryl-7-amide || RefChem:144003 || SCHEMBL740253 || SCHEMBL30182028
MW : 329.35
Formula : C17H19N3O4
CAS_number : 67341-40-6
UniChem : UTDVHCQTKWTQEA-UHFFFAOYSA-N, UTDVHCQTKWTQEA-ZDUSSCGKSA-N
Target
Structures : No structure
Families : DPP4N_Peptidase_S9
References (27)
| Title : Macrocyclic phage display for identification of selective protease substrates - Faucher_2025_bioRxiv__ |
| Author(s) : Faucher FF , Lovell S , Bertolini M , Blazkova K , Cosco ED , Bogyo M , Barniol-Xicota M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Faucher_2025_bioRxiv__ |
| PubMedID: 40161698 |
| Gene_locus related to this paper: human-DPP4 , human-FAP |
| Title : Macrocyclic phage display for identification of selective protease substrates - Faucher_2025_bioRxiv__ |
| Author(s) : Faucher FF , Lovell S , Bertolini M , Blazkova K , Cosco ED , Bogyo M , Barniol-Xicota M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Faucher_2025_bioRxiv__ |
| PubMedID: 40161698 |
| Gene_locus related to this paper: human-DPP4 , human-FAP |
| Title : Macrocyclic phage display for identification of selective protease substrates - Faucher_2025_bioRxiv__ |
| Author(s) : Faucher FF , Lovell S , Bertolini M , Blazkova K , Cosco ED , Bogyo M , Barniol-Xicota M |
| Ref : bioRxiv , : , 2025 |
| Abstract : |
| PubMedSearch : Faucher_2025_bioRxiv__ |
| PubMedID: 40161698 |
| Gene_locus related to this paper: human-DPP4 , human-FAP |
| Title : An interdisciplinary approach provides insights into the pronounced selectivity of compound 42 for DPP9 - Beyens_2024_ChemMedChem__e202400700 |
| Author(s) : Beyens O , Corthaut S , Lambeir AM , Van der Veken P , Sterckx YG , De Meester I , De Winter H |
| Ref : ChemMedChem , :e202400700 , 2024 |
| Abstract : |
| PubMedSearch : Beyens_2024_ChemMedChem__e202400700 |
| PubMedID: 39552560 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : An interdisciplinary approach provides insights into the pronounced selectivity of compound 42 for DPP9 - Beyens_2024_ChemMedChem__e202400700 |
| Author(s) : Beyens O , Corthaut S , Lambeir AM , Van der Veken P , Sterckx YG , De Meester I , De Winter H |
| Ref : ChemMedChem , :e202400700 , 2024 |
| Abstract : |
| PubMedSearch : Beyens_2024_ChemMedChem__e202400700 |
| PubMedID: 39552560 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : An interdisciplinary approach provides insights into the pronounced selectivity of compound 42 for DPP9 - Beyens_2024_ChemMedChem__e202400700 |
| Author(s) : Beyens O , Corthaut S , Lambeir AM , Van der Veken P , Sterckx YG , De Meester I , De Winter H |
| Ref : ChemMedChem , :e202400700 , 2024 |
| Abstract : |
| PubMedSearch : Beyens_2024_ChemMedChem__e202400700 |
| PubMedID: 39552560 |
| Gene_locus related to this paper: human-DPP8 , human-DPP9 |
| Title : Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity - Shiina_2016_Sci.Rep_6_26290 |
| Author(s) : Shiina Y , Muto T , Zhang Z , Baihaqie A , Yoshizawa T , Lee HI , Park E , Tsukiji S , Takimoto K |
| Ref : Sci Rep , 6 :26290 , 2016 |
| Abstract : |
| PubMedSearch : Shiina_2016_Sci.Rep_6_26290 |
| PubMedID: 27198182 |
| Gene_locus related to this paper: drome-CG11319 |
| Title : Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity - Shiina_2016_Sci.Rep_6_26290 |
| Author(s) : Shiina Y , Muto T , Zhang Z , Baihaqie A , Yoshizawa T , Lee HI , Park E , Tsukiji S , Takimoto K |
| Ref : Sci Rep , 6 :26290 , 2016 |
| Abstract : |
| PubMedSearch : Shiina_2016_Sci.Rep_6_26290 |
| PubMedID: 27198182 |
| Gene_locus related to this paper: drome-CG11319 |
| Title : Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity - Shiina_2016_Sci.Rep_6_26290 |
| Author(s) : Shiina Y , Muto T , Zhang Z , Baihaqie A , Yoshizawa T , Lee HI , Park E , Tsukiji S , Takimoto K |
| Ref : Sci Rep , 6 :26290 , 2016 |
| Abstract : |
| PubMedSearch : Shiina_2016_Sci.Rep_6_26290 |
| PubMedID: 27198182 |
| Gene_locus related to this paper: drome-CG11319 |
| Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169 |
| Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S |
| Ref : Biol Chem , 392 :169 , 2011 |
| Abstract : |
| PubMedSearch : Bank_2011_Biol.Chem_392_169 |
| PubMedID: 21194378 |
| Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169 |
| Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S |
| Ref : Biol Chem , 392 :169 , 2011 |
| Abstract : |
| PubMedSearch : Bank_2011_Biol.Chem_392_169 |
| PubMedID: 21194378 |
| Title : Outside or inside: role of the subcellular localization of DP4-like enzymes for substrate conversion and inhibitor effects - Bank_2011_Biol.Chem_392_169 |
| Author(s) : Bank U , Heimburg A , Wohlfarth A , Koch G , Nordhoff K , Julius H , Helmuth M , Breyer D , Reinhold D , Tager M , Ansorge S |
| Ref : Biol Chem , 392 :169 , 2011 |
| Abstract : |
| PubMedSearch : Bank_2011_Biol.Chem_392_169 |
| PubMedID: 21194378 |
| Title : Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals - Davis_2010_Indian.J.Pharmacol_42_229 |
| Author(s) : Davis JA , Singh S , Sethi S , Roy S , Mittra S , Rayasam G , Bansal V , Sattigeri J , Ray A |
| Ref : Indian J Pharmacol , 42 :229 , 2010 |
| Abstract : |
| PubMedSearch : Davis_2010_Indian.J.Pharmacol_42_229 |
| PubMedID: 20927248 |
| Title : Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals - Davis_2010_Indian.J.Pharmacol_42_229 |
| Author(s) : Davis JA , Singh S , Sethi S , Roy S , Mittra S , Rayasam G , Bansal V , Sattigeri J , Ray A |
| Ref : Indian J Pharmacol , 42 :229 , 2010 |
| Abstract : |
| PubMedSearch : Davis_2010_Indian.J.Pharmacol_42_229 |
| PubMedID: 20927248 |
| Title : Nature of action of Sitagliptin, the dipeptidyl peptidase-IV inhibitor in diabetic animals - Davis_2010_Indian.J.Pharmacol_42_229 |
| Author(s) : Davis JA , Singh S , Sethi S , Roy S , Mittra S , Rayasam G , Bansal V , Sattigeri J , Ray A |
| Ref : Indian J Pharmacol , 42 :229 , 2010 |
| Abstract : |
| PubMedSearch : Davis_2010_Indian.J.Pharmacol_42_229 |
| PubMedID: 20927248 |
| Title : Isolation and characterisation of dipeptidyl peptidase IV from Prevotella loescheii ATCC 15930 - Koreeda_2001_Arch.Oral.Biol_46_759 |
| Author(s) : Koreeda Y , Hayakawa M , Ikemi T , Abiko Y |
| Ref : Archives of Oral Biology , 46 :759 , 2001 |
| Abstract : |
| PubMedSearch : Koreeda_2001_Arch.Oral.Biol_46_759 |
| PubMedID: 11389867 |
| Title : Isolation and characterisation of dipeptidyl peptidase IV from Prevotella loescheii ATCC 15930 - Koreeda_2001_Arch.Oral.Biol_46_759 |
| Author(s) : Koreeda Y , Hayakawa M , Ikemi T , Abiko Y |
| Ref : Archives of Oral Biology , 46 :759 , 2001 |
| Abstract : |
| PubMedSearch : Koreeda_2001_Arch.Oral.Biol_46_759 |
| PubMedID: 11389867 |
| Title : Isolation and characterisation of dipeptidyl peptidase IV from Prevotella loescheii ATCC 15930 - Koreeda_2001_Arch.Oral.Biol_46_759 |
| Author(s) : Koreeda Y , Hayakawa M , Ikemi T , Abiko Y |
| Ref : Archives of Oral Biology , 46 :759 , 2001 |
| Abstract : |
| PubMedSearch : Koreeda_2001_Arch.Oral.Biol_46_759 |
| PubMedID: 11389867 |
| Title : NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV - Hughes_1999_Biochemistry_38_11597 |
| Author(s) : Hughes TE , Mone MD , Russell ME , Weldon SC , Villhauer EB |
| Ref : Biochemistry , 38 :11597 , 1999 |
| Abstract : |
| PubMedSearch : Hughes_1999_Biochemistry_38_11597 |
| PubMedID: 10512614 |
| Title : NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV - Hughes_1999_Biochemistry_38_11597 |
| Author(s) : Hughes TE , Mone MD , Russell ME , Weldon SC , Villhauer EB |
| Ref : Biochemistry , 38 :11597 , 1999 |
| Abstract : |
| PubMedSearch : Hughes_1999_Biochemistry_38_11597 |
| PubMedID: 10512614 |
| Title : NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl)amino]ethyl]amino]acetyl]-2-cyano-(S)- pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV - Hughes_1999_Biochemistry_38_11597 |
| Author(s) : Hughes TE , Mone MD , Russell ME , Weldon SC , Villhauer EB |
| Ref : Biochemistry , 38 :11597 , 1999 |
| Abstract : |
| PubMedSearch : Hughes_1999_Biochemistry_38_11597 |
| PubMedID: 10512614 |
| Title : Detection of dipeptidyl peptidase IV in glioma C6 and neuroblastoma SK-N-SH cell lines - Sedo_1995_Biochem.Cell.Biol_73_113 |
| Author(s) : Sedo A , Revoltella RP |
| Ref : Biochemistry & Cell Biology , 73 :113 , 1995 |
| Abstract : |
| PubMedSearch : Sedo_1995_Biochem.Cell.Biol_73_113 |
| PubMedID: 7662310 |
| Title : Detection of dipeptidyl peptidase IV in glioma C6 and neuroblastoma SK-N-SH cell lines - Sedo_1995_Biochem.Cell.Biol_73_113 |
| Author(s) : Sedo A , Revoltella RP |
| Ref : Biochemistry & Cell Biology , 73 :113 , 1995 |
| Abstract : |
| PubMedSearch : Sedo_1995_Biochem.Cell.Biol_73_113 |
| PubMedID: 7662310 |
| Title : Detection of dipeptidyl peptidase IV in glioma C6 and neuroblastoma SK-N-SH cell lines - Sedo_1995_Biochem.Cell.Biol_73_113 |
| Author(s) : Sedo A , Revoltella RP |
| Ref : Biochemistry & Cell Biology , 73 :113 , 1995 |
| Abstract : |
| PubMedSearch : Sedo_1995_Biochem.Cell.Biol_73_113 |
| PubMedID: 7662310 |
| Title : Activity of dipeptidyl peptidase IV and post-proline cleaving enzyme in sera from osteoporotic patients - Gotoh_1988_Clin.Chem_34_2499 |
| Author(s) : Gotoh H , Hagihara M , Nagatsu T , Iwata H , Miura T |
| Ref : Clinical Chemistry , 34 :2499 , 1988 |
| Abstract : |
| PubMedSearch : Gotoh_1988_Clin.Chem_34_2499 |
| PubMedID: 2904308 |
| Title : Activity of dipeptidyl peptidase IV and post-proline cleaving enzyme in sera from osteoporotic patients - Gotoh_1988_Clin.Chem_34_2499 |
| Author(s) : Gotoh H , Hagihara M , Nagatsu T , Iwata H , Miura T |
| Ref : Clinical Chemistry , 34 :2499 , 1988 |
| Abstract : |
| PubMedSearch : Gotoh_1988_Clin.Chem_34_2499 |
| PubMedID: 2904308 |
| Title : Activity of dipeptidyl peptidase IV and post-proline cleaving enzyme in sera from osteoporotic patients - Gotoh_1988_Clin.Chem_34_2499 |
| Author(s) : Gotoh H , Hagihara M , Nagatsu T , Iwata H , Miura T |
| Ref : Clinical Chemistry , 34 :2499 , 1988 |
| Abstract : |
| PubMedSearch : Gotoh_1988_Clin.Chem_34_2499 |
| PubMedID: 2904308 |