Lidocaine

Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na(+) channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs)

General

Type : Local anesthetic, Drug, Not AlphaBeta Hydrolase target

Chemical_Nomenclature : 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide

Canonical SMILES : CCN(CC)CC(=O)NC1=C(C=CC=C1C)C

InChI : InChI=1S\/C14H22N2O\/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4\/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChIKey : NNJVILVZKWQKPM-UHFFFAOYSA-N

Other name(s) : Lignocaine  ||  Xylocaine  ||  Anestacon  ||  Esracaine  ||  Gravocain  ||  Leostesin  ||  Maricaine  ||  Cappicaine  ||  Xylestesin


MW : 234.34

Formula : C14H22N2O

CAS_number : 137-58-6

PubChem : 3676

UniChem : NNJVILVZKWQKPM-UHFFFAOYSA-N

IUPHAR : 2623

Wikipedia : Lidocaine

Target

Structures : No structure

Families : Carboxylesterase, Carb_B_Chordata

References (6)

Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167
Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M
Ref : Eur J Pharm Sci , 111 :167 , 2018
Abstract :
PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167
PubMedID: 28966098
Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2

Title : Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation - Higuchi_2013_Drug.Metab.Dispos_41_1220
Author(s) : Higuchi R , Fukami T , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1220 , 2013
Abstract :
PubMedSearch : Higuchi_2013_Drug.Metab.Dispos_41_1220
PubMedID: 23530020

Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876
Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM
Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007
Abstract :
PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876
PubMedID: 17378546

Title : A structure-based approach to nicotinic receptor pharmacology - Ryan_1999_Mol.Pharmacol_55_348
Author(s) : Ryan SE , Baenziger JE
Ref : Molecular Pharmacology , 55 :348 , 1999
Abstract :
PubMedSearch : Ryan_1999_Mol.Pharmacol_55_348
PubMedID: 9927628

Title : Adverse effects and drug interactions associated with local and regional anaesthesia - Naguib_1998_Drug.Saf_18_221
Author(s) : Naguib M , Magboul MM , Samarkandi AH , Attia M
Ref : Drug Safety , 18 :221 , 1998
Abstract :
PubMedSearch : Naguib_1998_Drug.Saf_18_221
PubMedID: 9565736

Title : Clinical pharmacokinetics of local anaesthetics - Tucker_1979_Clin.Pharmacokinet_4_241
Author(s) : Tucker GT , Mather LE
Ref : Clinical Pharmacokinetics , 4 :241 , 1979
Abstract :
PubMedSearch : Tucker_1979_Clin.Pharmacokinet_4_241
PubMedID: 385208