Lidocaine
Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na(+) channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs)
General
Type : Local anesthetic, Drug, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
Canonical SMILES : CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
InChI : InChI=1S\/C14H22N2O\/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4\/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChIKey : NNJVILVZKWQKPM-UHFFFAOYSA-N
Other name(s) : Lignocaine || Xylocaine || Anestacon || Esracaine || Gravocain || Leostesin || Maricaine || Cappicaine || Xylestesin
MW : 234.34
Formula : C14H22N2O
CAS_number : 137-58-6
PubChem : 3676
UniChem : NNJVILVZKWQKPM-UHFFFAOYSA-N
IUPHAR : 2623
Wikipedia : Lidocaine
Target
Structures : No structure
Families : Carboxylesterase, Carb_B_Chordata
References (6)
| Title : Difference in substrate specificity of carboxylesterase and arylacetamide deacetylase between dogs and humans - Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| Author(s) : Yoshida T , Fukami T , Kurokawa T , Gotoh S , Oda A , Nakajima M |
| Ref : Eur J Pharm Sci , 111 :167 , 2018 |
| Abstract : |
| PubMedSearch : Yoshida_2018_Eur.J.Pharm.Sci_111_167 |
| PubMedID: 28966098 |
| Gene_locus related to this paper: canfa-CESDD1 , canfa-f1p6w8 , canlf-e2r2h2 |
| Title : Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation - Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| Author(s) : Higuchi R , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1220 , 2013 |
| Abstract : |
| PubMedSearch : Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| PubMedID: 23530020 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |
| Title : A structure-based approach to nicotinic receptor pharmacology - Ryan_1999_Mol.Pharmacol_55_348 |
| Author(s) : Ryan SE , Baenziger JE |
| Ref : Molecular Pharmacology , 55 :348 , 1999 |
| Abstract : |
| PubMedSearch : Ryan_1999_Mol.Pharmacol_55_348 |
| PubMedID: 9927628 |
| Title : Adverse effects and drug interactions associated with local and regional anaesthesia - Naguib_1998_Drug.Saf_18_221 |
| Author(s) : Naguib M , Magboul MM , Samarkandi AH , Attia M |
| Ref : Drug Safety , 18 :221 , 1998 |
| Abstract : |
| PubMedSearch : Naguib_1998_Drug.Saf_18_221 |
| PubMedID: 9565736 |
| Title : Clinical pharmacokinetics of local anaesthetics - Tucker_1979_Clin.Pharmacokinet_4_241 |
| Author(s) : Tucker GT , Mather LE |
| Ref : Clinical Pharmacokinetics , 4 :241 , 1979 |
| Abstract : |
| PubMedSearch : Tucker_1979_Clin.Pharmacokinet_4_241 |
| PubMedID: 385208 |