Lidocaine
Lidocaine is a commonly used local anaesthetic that, besides blocking voltage-dependent Na(+) channels, has multiple inhibitory effects on muscle-type nicotinic acetylcholine (ACh) receptors (nAChRs)
General
Type : Local anesthetic, Drug, Not AlphaBeta Hydrolase target
Chemical_Nomenclature : 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
Canonical SMILES : CCN(CC)CC(=O)NC1=C(C=CC=C1C)C
InChI : InChI=1S\/C14H22N2O\/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4\/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChIKey : NNJVILVZKWQKPM-UHFFFAOYSA-N
Other name(s) : Lignocaine || Xylocaine || Anestacon || Esracaine || Gravocain || Leostesin || Maricaine || Cappicaine || Xylestesin
MW : 234.34
Formula : C14H22N2O
CAS_number : 137-58-6
PubChem : 3676
UniChem : NNJVILVZKWQKPM-UHFFFAOYSA-N
IUPHAR : 2623
Wikipedia : Lidocaine
Target
Structures : No structure
Families : Carboxylesterase, Carb_B_Chordata
References (2)
| Title : Prilocaine- and lidocaine-induced methemoglobinemia is caused by human carboxylesterase-, CYP2E1-, and CYP3A4-mediated metabolic activation - Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| Author(s) : Higuchi R , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1220 , 2013 |
| Abstract : |
| PubMedSearch : Higuchi_2013_Drug.Metab.Dispos_41_1220 |
| PubMedID: 23530020 |
| Title : Selective inhibition of carboxylesterases by isatins, indole-2,3-diones - Hyatt_2007_J.Med.Chem_50_1876 |
| Author(s) : Hyatt JL , Moak T , Hatfield MJ , Tsurkan L , Edwards CC , Wierdl M , Danks MK , Wadkins RM , Potter PM |
| Ref : Journal of Medicinal Chemistry , 50 :1876 , 2007 |
| Abstract : |
| PubMedSearch : Hyatt_2007_J.Med.Chem_50_1876 |
| PubMedID: 17378546 |